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Maget-Dana, R ; Lelièvre, D

Comparative interaction of a-helical and ß-sheet amphiphilic isopeptides with phospholipid monolayers

Biopolymers 59 (1) 1-10

par Administrateur - publié le

Abstract :

The two sequential amphiphilic peptide isomers, (Leu-Lys-Lys-Leu)(4) and (Leu-Lys)(8), were chosen as models for a -helical and ß -sheet peptides, respectively. In order to evaluate the contribution of the secondary structure of a peptide to its penetration into cellular membranes, interactions of these isopeptides with L-a -dimyristoyl phosphatidylcholine (DMPC) monolayers were studied. Both isopeptides penetrate into DMPC monolayers up to an exclusion pressure of similar to 27 mN/m, but a discontinuity is observed in the penetration profile of the a -helical (LKKL)(4).