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Fajac, I ; Briand, P ; Monsigny, M

Gene therapy of cystic fibrosis : The glycofection approach

Glycoconjugate Journal 18 (9) 723-729

par Administrateur - publié le , mis à jour le

Abstract :

Many cells express surface membrane lectins that selectively bind and carry glycoconjugates into intracellular endosomes ; in addition, various intracellular membrane and soluble lectins act as shuttles between different compartments. On this basis, we developed glycosylated polycations, now called glycofectins (glycosylated polylysine and polyethyleneimine). Recently, we set up a simple way to transform oligosaccharides into glycosynthons suitable to substitute proteins or polymers. Glycofectins bind plasmid DNA leading to compact glycoplexes.