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Fajac, I; Briand, P; Monsigny, M

Gene therapy of cystic fibrosis: The glycofection approach

Glycoconjugate Journal 18 (9) 723-729

by Administrateur - published on , updated on


Many cells express surface membrane lectins that selectively bind and carry glycoconjugates into intracellular endosomes; in addition, various intracellular membrane and soluble lectins act as shuttles between different compartments. On this basis, we developed glycosylated polycations, now called glycofectins (glycosylated polylysine and polyethyleneimine). Recently, we set up a simple way to transform oligosaccharides into glycosynthons suitable to substitute proteins or polymers. Glycofectins bind plasmid DNA leading to compact glycoplexes.