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Pichon, C ; Guerin, B ; Refregiers, M ; Goncalves, C ; Vigny, P ; Midoux, P

Zinc improves gene transfer mediated by DNA/cationic polymer complexes

Journal of Gene Medicine 4 (5) 548-559

par Administrateur - publié le

Abstract :

Background : The weak efficiency of plasmid transfer into the cytosol remains one of the major limiting factors to achieve an efficient transfection with DNA/cationic polymer complexes. We found that divalent metal Zn2+ can improve the polyfection efficiency, especially with DNA/histidylated polylysine (His-pLK) complexes.