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Accueil > Publications > Recherche par années > Années 1990 > 1997

Hommel, M ; Attar, Z ; Fargeas, C ; Dourado, C ; Monsigny, M ; Mayer, R ; Chance, ML

The direct agglutination test : a non-specific test specific for the diagnosis of visceral leishmaniasis ?

Annals of Tropical Medicine and Parasitology 91 (7) 795-802

par Administrateur - publié le

Abstract :

Serology has an important role to play in the diagnosis of the severe clinical syndrome of visceral leishmaniasis (VL). The direct agglutination test (DAT), a simple agglutination test which requires no laboratory facilities, has become the preferred test, particularly for field studies. The nature of the antigens responsible for the agglutination of leishmanial promastigotes by the serum of VL patients is not known. A series of experiments which provide some clues to the molecular basis for the test and which indicate that there might be more in DAT than meets the eye is reported.