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Valverde, I., Lecaille, F., Lalmanach, G., Aucagne, V. & Delmas, A.F.

Synthesis of a biologically active triazole-containing analogue of cystatin A through successive peptidomimetic alkyne–azide ligations

Angewandte Chemie International Edition 51 (3) 718-722

par Frapart - publié le , mis à jour le

Abstract :

“Click” protein : CuI-catalyzed cycloaddition of azides and terminal alkynes has been applied to the successive ligations of three unprotected peptide fragments. Peptidomimetic triazole ligation (PTL, see scheme) as a new method for the chemical production of bioactive proteins is applied for the synthesis of a triazole-containing analogue of the 97 amino acid protein cystatin A.