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Gaulier, C., Hospital, A., Legeret, B., Delmas, A.F., Aucagne, V., Cisnetti, F. and Gautier, A.

A Water Soluble CuI–NHC for CuAAC ligation of unprotected peptides under open air conditions

Chemical Communications 48 (33) 4005-4007

par Frapart - publié le , mis à jour le

Abstract :

A reducing agent–free version of CuAAC able to operate
under open air conditions is reported. A readily–synthesizable, hydrophilic and highly stable CuI–NHC allows the clean ligations of unprotected peptides comprising sensitive side chains, at millimolar concentrations.