Vendredi 17 février 2012 à 11 h 00
à l’invitation de Jean-Marc Malinge
« Telomeres, potential targets of platinum complexes »
Docteur Sophie BOMBARD
Université Paris Descartes
45 rue des Saints-Pères
Telomeres are DNA-protein structures that cap chromosome ends, protecting them from degradation and end-to-end fusions. Telomeric DNA consists of highly repetitive short sequences of guanine residues (TTAGGG)n followed by an overhang at the 3’ end of the G-rich strand. Telomeric DNA is able to adopt G-quadruplex structures whose stabilisation by small molecules induces telomere dysfunctions. We will discuss the fact that a new class of platinum complexes, targeting G-quadruplex structures, is able to disturb the telomeric complex in vitro and in cellulo and constitutes an attractive new class of compounds targeting specifically telomeres of cancer cells.
“Imaging of diagnostic and therapeutic biomarkers in Oncology” Workshop.
TAX2 peptide: from discovery to clinical development.