Organisation : Eq Signalisation cellulaire et neurofibromatose

MOSRIN-HUAMAN Christine

email : christine.mosrin[remplacer_par_at]cnrs-orleans.fr

Téléphone : 02.38.25.76.11

Chargée de recherche au sein du Groupe thématique « Signalisation cellulaire et neurofibromatose »

 

 


38 documents

Article dans une revue21 document

  • Valentin Beauvais, Kevin Moreau, Bojan Žunar, Nadège Hervouet-Coste, Ana Novačić, et al.. Tho2 is critical for the recruitment of Rrp6 to chromatin in response to perturbed mRNP biogenesis. RNA, 2024, 30 (1), pp.rna.079707.123. ⟨10.1261/rna.079707.123⟩. ⟨hal-04286417⟩
  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection. Journal of Molecular Biology, 2024, 436 (22), pp.168768. ⟨10.1016/j.jmb.2024.168768⟩. ⟨hal-04771131⟩
  • Elodie Villalonga, Christine Mosrin, Thierry Normand, Caroline Girardin, Amandine Serrano, et al.. LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features. Cells, 2023, 12 (5), pp.805. ⟨10.3390/cells12050805⟩. ⟨hal-04208405⟩
  • Bojan Žunar, Christine Mosrin-Huaman, Hélène Bénédetti, Béatrice Vallée. Re-engineering of CUP1 promoter and Cup2/Ace1 transactivator to convert Saccharomyces cerevisiae into a whole-cell eukaryotic biosensor capable of detecting 10 nM of bioavailable copper. Biosensors and Bioelectronics, 2022, 214, pp.114502. ⟨10.1016/j.bios.2022.114502⟩. ⟨hal-03820214⟩
  • Mohammed Bergoug, Michel Doudeau, Fabienne Godin, Christine Mosrin-Huaman, Béatrice Vallée, et al.. Neurofibromin Structure, Functions and Regulation. Cells, 2020, 9, ⟨10.3390/cells9112365⟩. ⟨hal-03070759v2⟩
  • Kévin Moreau, Aurélia Le Dantec, Christine Mosrin-Huaman, Yves Bigot, Benoit Piegu, et al.. Perturbation of mRNP biogenesis reveals a dynamic landscape of the Rrp6-dependent surveillance machinery trafficking along the yeast genome. RNA Biology, 2019, 16 (7), pp.879-889. ⟨10.1080/15476286.2019.1593745⟩. ⟨hal-02117640⟩
  • Kévin Moreau, Justine Surand, Aurélia Le Dantec, Christine Mosrin-Huaman, Alain Legrand, et al.. Recombinant yeast and human cells as screening tools to search for antibacterial agents targeting the transcription termination factor Rho. Journal of Antibiotics, 2018, 71 (4), pp.447-455. ⟨hal-01966171⟩
  • Christine Mosrin-Huaman, Nadège Hervouet-Coste, A. Rachid Rahmouni. Co-transcriptional degradation by the 5′-3′ exonuclease Rat1p mediates quality control of HXK1 mRNP biogenesis in S. cerevisiae. RNA Biology, 2016, 13 (6), pp.582 - 592. ⟨10.1080/15476286.2016.1181255⟩. ⟨hal-01407513⟩
  • Rachid A. Rahmouni, Christine Mosrin-Huaman. In Situ Footprinting of E. coli Transcription Elongation Complex with Chloroacetaldehyde. Methods in Molecular Biology, 2015, Methods in Molecular Biology, 1276, pp.229-240. ⟨10.1007/978-1-4939-2392-2_13⟩. ⟨hal-01171857⟩
  • Christine Mosrin-Huaman, Nadege Hervouet-Coste, Aurélia Le Dantec, Igor Stuparevic, A. Rachid Rahmouni. Bacterial Rho helicase: a new tool to dissect mRNP biogenesis and quality control in yeast. Trends in cell and molecular biology, 2014, 9, pp.79 - 93. ⟨hal-01179495⟩
  • Igor Stuparevic, Christine Mosrin-Huaman, Nadège Hervouet-Coste, Mateja Remenaric, A. Rachid Rahmouni. Co-transcriptional recruitment of the RNA exosome cofactors Rrp47p, Mpp6p and two distinct TRAMP complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant mRNP in yeast. Journal of Biological Chemistry, 2013, ⟨10.1074/jbc.M113.491290⟩. ⟨hal-00874892⟩
  • Romy Honorine, Christine Mosrin-Huaman, Nadege Hervouet-Coste, Domenico Libri, Rachid A. Rahmouni. Nuclear mRNA quality control in yeast is mediated by Nrd1 co-transcriptional recruitment, as revealed by the targeting of Rho-induced aberrant transcripts. Nucleic Acids Research, 2011, 39 (7), pp.2809-2820. ⟨10.1093/nar/gkq1192⟩. ⟨hal-00602376⟩
  • Christine Mosrin-Huaman, Romy Honorine, A. Rachid Rahmouni. Expression of Bacterial Rho Factor in Yeast Identifies New Factors Involved in the Functional Interplay between Transcription and mRNP Biogenesis. Molecular and Cellular Biology, 2009, 29 (15), pp.4033-4044. ⟨10.1128/MCB.00272-09⟩. ⟨hal-00525149⟩
  • F. Toulmé, C. Mosrin-Huaman, I. Artsimovitch, A.R. Rahmouni. Transcriptional pausing in vivo: a nascent RNA hairpin restricts lateral movements of RNA polymerase in both forward and reverse directions. Journal of Molecular Biology, 2005, 351, pp.39-51. ⟨hal-00088714⟩
  • C. Mosrin-Huaman, C.L. Turnbough, A.R. Rahmouni. Translocation of Escherichia coli RNA polymerase against a protein roadblock in vivo highlights a passive sliding mechanism for transcript elongation. Molecular Microbiology, 2004, 51, pp.1471-1481. ⟨hal-00113075⟩
  • M. Decoville, M Giraud-Panis, M Mosrin-Huaman, M. Leng, D. Locker. HMG boxes of DSP1 protein interact with the Rel homology domain of transcription factors. Nucleic Acids Research, 2000, 28 (2), pp.454-462. ⟨10.1093/nar/28.2.454⟩. ⟨hal-02119310⟩
  • F Toulmé, M Mosrin-Huaman, J Sparkowski, A. Das, M. Leng, et al.. GreA and GreB proteins revive backtracked RNA polymerase in vivo by promoting transcript trimming. EMBO Journal, 2000, 19 (24), pp.6853-6859. ⟨10.1093/emboj/19.24.6853⟩. ⟨hal-02127250⟩
  • M Mosrin-Huaman, L. Canaple, D. Locker, M. Decoville. DSP1Gene ofDrosophila melanogaster encodes an HMG-domain protein that plays multiple roles in development. Developmental Genetics, 1998, 23 (4), pp.324-334. ⟨10.1002/(SICI)1520-6408(1998)23:4<324::AID-DVG7>3.0.CO;2-T⟩. ⟨hal-02119315⟩
  • Christine Mosrin-Huaman, M. Riva, M Beltrame, E Cassar, A. Sentenac, et al.. The RPC31 gene of Saccharomyces cerevisiae encodes a subunit of RNA polymerase C (III) with an acidic tail.. Molecular and Cellular Biology, 1990, 10 (9), pp.4737-4743. ⟨10.1128/mcb.10.9.4737⟩. ⟨hal-02266468⟩
  • Sabine Kreps, Fabrice Ferino, Christine Mosrin-Huaman, Jozef Gerits, Max Mergeay, et al.. Conjugative transfer and autonomous replication of a promiscuous IncQ plasmid in the cyanobacterium Synechocystis PCC 6803. Molecular and General Genetics MGG, 1990, 221 (1), pp.129-133. ⟨10.1007/BF00280378⟩. ⟨hal-02266473⟩
  • Christine Mosrin-Huaman, P Thuriaux. The genetics of RNA polymerases in yeasts.. Current Genetics, 1990, 17 (5), pp.367-373. ⟨hal-02266470⟩

Communication dans un congrès1 document

  • Béatrice Vallée, Christine Mosrin-Huaman, Hélène Bénédetti, Régis Guégan, Bojan Zunar. Life in the bioink: Physiology and energetics of Saccharomyces cerevisiae embedded in polymerized Pluronic F127-DMA, a “smart” thermoresponsive hydrogel. ICY15 meets 30ICYGMB, The spirit of Yeast, Aug 2021, Vienne, virtual, Austria. ⟨hal-03559939⟩

Poster12 document

  • Hélène Bénédetti, Christine Mosrin-Huaman, Mohammed Bergoug, Amandine Serrano, Fabienne Godin, et al.. Deciphering the Molecular Mechanism of Pathogenicity in Destabilized variants of Neurofibromin mutated in its SecPH domain. 2024 Global NF Conference, Jun 2024, Brussels (Belgium), Belgium. ⟨hal-04779581⟩
  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation. 2024 Global NF Conference, Jun 2024, Brussels, Belgium. ⟨hal-03679991⟩
  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation. 2024 Global NF Conference, Jun 2024, Brussels, Belgium. ⟨hal-04778711⟩
  • Bojan Zunar, Christine Mosrin-Huaman, Hélène Bénédetti, Régis Guégan, Béatrice Vallée. Life in the bioink: Physiology and energetics of Saccharomyces cerevisiae embedded in polymerized Pluronic F127-DMA, a “smart” thermoresponsive hydrogel. ICY15 meets 30ICYGMB, The spirit of Yeast, Aug 2021, Vienne, virtual, Austria. ⟨hal-03679966⟩
  • Bojan Zunar, Christine Mosrin-Huaman, Hélène Bénédetti, Régis Guégan, Béatrice Vallée. Stressed by hydrogel? Physiological response of yeast cells embedded in thermoresponsive Pluronic F127: a prerequisite for bioreactor development. FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, Slovenia. ⟨hal-03679975⟩
  • Christine Mosrin-Huaman, Mohammed Bergoug, Fabienne Godin, Michel Doudeau, Iva Sosic, et al.. Sumoylation of Neurofibromin and its SecPH Domain Plays a Role in Their Functions and Implies Unexpected Structural Requirements. 2021 NF1 virtual conference, Jun 2021, Virtual, France. ⟨hal-03680001⟩
  • Christine Mosrin-Huaman, B. Handelaoui, H. Bénédetti, Béatrice Vallée. Yeast biosensors to detect environmental pollutants into effluent waters. ICYGMB XXIX International Congress on Yeast Genetics and Molecular Biology, Aug 2019, Göteborg, Sweden. ⟨hal-02924111⟩
  • K. Moreau, A. Le Dantec, C. Mosrin-Huaman, Benoit Piegu, Y. Bigot, et al.. High resolution maps of the nuclear RNA surveillance components trafficking along the yeast genome. EMBL Symposium: Transcription and Chromatin 2018, Aug 2018, Heidelberg, Germany. ⟨hal-02920318⟩
  • Kevin Moreau, Aurélia Le Dantec, Christine Mosrin-Huaman, Benoit Piegu, Y. Bigot, et al.. Metagenomic analysis of Nuclear Quality Control & Degradation mechanisms of Eukaryotic RNA. Colloque international du Studium : Messenger RNA therapeutics: advances and perspectives, Mar 2017, Orléans, France. ⟨hal-02920331⟩
  • K. Moreau, A. Le Dantec, C. Mosrin-Huaman, Benoit Piegu, Y. Bigot, et al.. Etude métagénomique des mécanismes nucléaires de contrôle qualité et dégradation de l’ARN. 30e Colloque Biotechnocentre, Oct 2017, Seillac, France. ⟨hal-02934894⟩
  • Kévin Moreau, Aurélia Le Dantec, Christine Mosrin-Huaman, Benoit Piegu, Yves Bigot, et al.. Analyse métagénomique du mécanisme de discrimination entre les transcrits codants et non-codants par la machinerie de dégradation de l’ARN. 29e colloque Biotechnocentre, Oct 2016, Seillac, France. ⟨hal-02453482⟩
  • A. Rachid Rahmouni, Christine Mosrin-Huaman, Nadege Hervouet-Coste. Co-transcriptional degradation by the 5’-3’ exonuclease Rat1p mediates quality control of HXK1 mRNP biogenesis in S. cerevisiae. EMBO EMBL Symposium: The Complex Life of mRNA, Oct 2016, Heidelberg, Germany. . ⟨hal-02453485⟩

Chapitre d'ouvrage3 document

  • P. Thuriaux, Christine Mosrin-Huaman. La génétique moléculaire des levures. Biotechnologie des levures, elsevier masson, pp.49-80, 1991. ⟨hal-02181574⟩
  • D. Gallwitz, J. Becker, M. Benli, L. Hengst, C. Mosrin-Huaman, et al.. The YPT-Branch of the ras Superfamily of GTP-Binding Proteins in Yeast: Functional Importance of the Putative Effector Region. The Superfamily of ras-Related Genes, Springer US, pp.121-128, 1991, 978-1-4684-6020-9. ⟨hal-02181563⟩
  • Christine Mosrin-Huaman, P. Thuriaux. Les outils du génie génétique. Biotechnologies des levures, Masson, pp.81-96, 1991. ⟨hal-02266466⟩

Pré-publication, Document de travail1 document

  • Mohammed Bergoug, Christine Mosrin, Fabienne Godin, Michel Doudeau, Iva Sosic, et al.. Noncanonical structural requirements of neurofibromin SUMOylation reveal a folding-deficiency of several pathogenic mutants. 2022. ⟨hal-03668582⟩

Documents récupérés de l'archive ouverte HAL logo

 

NORMAND Thierry

 

email : thierry.normand[remplacer_par_at]cnrs-orleans.fr

Téléphone : 02.38.25.55.86

Maître de conférence au sein du groupe thématique « Apoptose et autophagie normales et pathologiques »

 


30 documents

Article dans une revue24 document

  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection. Journal of Molecular Biology, 2024, 436 (22), pp.168768. ⟨10.1016/j.jmb.2024.168768⟩. ⟨hal-04771131⟩
  • Saïd El Haddad, Amandine Serrano, Fréderic Moal, Thierry Normand, Chloé Robin, et al.. Disturbed expression of autophagy genes in blood of Parkinson’s disease patients. Gene, 2020, 738, pp.144454. ⟨10.1016/j.gene.2020.144454⟩. ⟨hal-02501027⟩
  • Anthony Guillemain, Yousra Laouarem, Laetitia Cobret, Dora Štefok, Wanyin Chen, et al.. LINGO family receptors are differentially expressed in the mouse brain and form native multimeric complexes. FASEB Journal, 2020, pp.1-13. ⟨10.1096/fj.202000826R⟩. ⟨hal-02943248⟩
  • Amandine Serrano, Saïd El Haddad, Fréderic Moal, Thierry Prazuck, Eric Legac, et al.. Dysregulation of apoptosis and autophagy gene expression in peripheral blood mononuclear cells of efficiently treated HIV-infected patients. AIDS. Official journal of the international AIDS Society, 2018, 32 (12), pp.1579 - 1587. ⟨10.1097/QAD.0000000000001851⟩. ⟨hal-01936094⟩
  • Saïd El Haddad, Amandine Serrano, Thierry Normand, Chloé Robin, Martine Dubois, et al.. Interaction of Alpha-synuclein with Cytogaligin, a protein encoded by the proapoptotic gene GALIG. Biochemical and Biophysical Research Communications, 2018, 495 (1), pp.787-792. ⟨10.1016/j.bbrc.2017.11.078⟩. ⟨hal-01966108⟩
  • Lucile Mollet, Pauline Robinet, Martine Dubois, Axel Aurouet, Thierry Normand, et al.. Opposing Mcl-1, the GALIG proapoptotic gene is upregulated as neutrophils die and underexpressed in Acute Myeloid Leukemia cells.. Molecular Immunology, 2013, 56 (1-2), pp.123-8. ⟨10.1016/j.molimm.2013.04.012⟩. ⟨hal-00840170⟩
  • Pauline Robinet, Lucile Mollet, Patrick Gonzalez, Thierry Normand, Stephane Charpentier, et al.. The mitogaligin protein is addressed to the nucleus via a non-classical localization signal. Biochemical and Biophysical Research Communications, 2010, 392 (1), pp.53-57. ⟨10.1016/j.bbrc.2009.12.162⟩. ⟨hal-00529397⟩
  • Patrick Gonzalez, Pauline Robinet, Stéphane Charpentier, Lucile Mollet, Thierry Normand, et al.. Apoptotic activity of a nuclear form of mitogaligin, a cell death protein. Biochemical and Biophysical Research Communications, 2009, 378 (4), pp.816-820. ⟨10.1016/j.bbrc.2008.11.133⟩. ⟨hal-00522444⟩
  • Alexis D. Sennepin, Stéphane Charpentier, Thierry Normand, Cedric Sarre, Alain Legrand, et al.. Multiple reprobing of Western blots after inactivation of peroxidase activity by its substrate, hydrogen peroxide. Analytical Biochemistry, 2009, 393 (1), pp.129-131. ⟨10.1016/j.ab.2009.06.004⟩. ⟨hal-00525339⟩
  • Patrick Gonzalez, Mélanie Duneau, Stéphane Charpentier, Thierry Normand, Lucile Mollet, et al.. Destabilization of Membranes Containing Cardiolipin or Its Precursors by Peptides Derived from Mitogaligin, a Cell Death Protein. Biochemistry, 2007, 46 (25), pp.7374-7382. ⟨10.1021/bi700213p⟩. ⟨hal-00159568⟩
  • M. Duneau, M. Boyer Guittaut, P. Gonzalez, S. Charpentier, T. Normand, et al.. Galig, a novel cell death gene that encodes a mitochondrial protein promoting cytochrome c release. Experimental Cell Research, 2005, 302, pp.194-205. ⟨hal-00088588⟩
  • Michaël Guittaut, Stéphane Charpentier, Thierry Normand, Martine Dubois, Jacques Raimond, et al.. Identification of an Internal Gene to the Human Galectin-3 Gene with Two Different Overlapping Reading Frames That Do Not Encode Galectin-3. Journal of Biological Chemistry, 2001, 276 (4), pp.2652-2657. ⟨10.1074/jbc.m002523200⟩. ⟨hal-02137994⟩
  • J. Morissette, F. Durocher, J. Leblanc, T. Normand, F. Labrie, et al.. Genetic linkage mapping of the human steroid 5α-reductase type 2 gene (SRD5A2) close to D2S352 on chromosome region 2p23→p22. Cytogenetic and Genome Research, 1996, 73 (4), pp.304-307. ⟨10.1159/000134362⟩. ⟨hal-02160041⟩
  • A.M. Simon, C. Guilbault, Thierry Normand, Christiane Jean-Faucher, Georges Veyssière, et al.. Developmental and hormonal regulation of specific proteins in mouse seminal vesicles. Isolation and characterization of genomic and cDNA clones for androgen-regulated secretory protein. Experimental and Clinical Endocrinology, 1995, 14, pp.73-82. ⟨hal-02167152⟩
  • Thierry Normand, B. Husen, F Leenders, H Pelczar, J.L Baert, et al.. Molecular characterization of mouse 17 beta-hydroxysteroid dehydrogenase IV.. Journal of Steroid Biochemistry and Molecular Biology, 1995, 55 (5-6), pp.541-8. ⟨10.1016/0960-0760(95)00204-9⟩. ⟨hal-02160020⟩
  • J Adamski, Thierry Normand, F Leenders, D Monté, A. Bégué, et al.. Molecular cloning of a novel widely expressed human 80 kDa 17 β -hydroxysteroid dehydrogenase IV. Biochemical Journal, 1995, 311 (2), pp.437-443. ⟨10.1042/bj3110437⟩. ⟨hal-02160026⟩
  • Thierry Normand, Steven Narod, Fernand Labrie, Jacques Simard. Detection of polymorphisms in the estradiol 17β-hydroxysteroid dehydrogenase II gene at the EDH17B2 locus on 17q11–q21. Human Molecular Genetics, 1993, 2 (4), pp.479-483. ⟨10.1093/hmg/2.4.479⟩. ⟨hal-02160210⟩
  • J Simard, Jean Feunteun, Gilbert Lenoir, T Tonin, Thierry Normand, et al.. Genetic mapping of the breast-ovarian cancer syndrome to a small interval on chromosome 17q12–21: exclusion of candidate genes EDH17B2 and RARA. Human Molecular Genetics, 1993, 2 (8), pp.1193-1199. ⟨10.1093/hmg/2.8.1193⟩. ⟨hal-02160208⟩
  • M. Bergeron, Thierry Normand, Aoife Bharucha, M Ven Murthy, P Julien, et al.. Prevalence, geographical distribution and genealogical investigations of mutation 188 of lipoprotein lipase gene in the French Canadian population of Québec.. Clinical Genetics, 1992, 41 (4), pp.206-10. ⟨10.1111/j.1399-0004.1992.tb03664.x⟩. ⟨hal-02160230⟩
  • P Peeva, L Brun, M Ven Murthy, P Després, Thierry Normand, et al.. Adipose cell size and distribution in familial lipoprotein lipase deficiency.. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1992, 16 (10), pp.737-44. ⟨hal-02160233⟩
  • Thierry Normand, J. Bergeron, Teresa Fernandez-Margallo, Aoife Bharucha, R Ven Murthy, et al.. Geographic distribution and genealogy of mutation 207 of the lipoprotein lipase gene in the French Canadian population of Québec.. Human Genetics, 1992, 89 (6), pp.671-5. ⟨10.1007/BF00221960⟩. ⟨hal-02160222⟩
  • Y. Ma, Howard Henderson, V Murthy, Ghislaine Roederer, M. Monsalve, et al.. A Mutation in the Human Lipoprotein Lipase Gene as the Most Common Cause of Familial Chylomicronemia in French Canadians. New England Journal of Medicine, 1991, 324 (25), pp.1761-1766. ⟨10.1056/NEJM199106203242502⟩. ⟨hal-02160241⟩
  • Thierry Normand, Christiane Jean-Faucher, Claude Jean. Neonatal exposure to oestrogens alters the protein profiles and gene expression in the genital tract of adult male mice. Journal of Steroid Biochemistry, 1990, 36 (5), pp.415-423. ⟨10.1016/0022-4731(90)90082-4⟩. ⟨hal-02160254⟩
  • Thierry Normand, C. Jean-Faucher, C Jean. Developmental pattern of androgen-regulated proteins in seminal vesicles from the mouse.. International Journal of Andrology, 1989, 12 (3), pp.219-30. ⟨hal-02160364⟩

Communication dans un congrès4 document

  • S. El Haddad, A. Serrano, Thierry Normand, Fabienne Brulé-Morabito, L. Mollet, et al.. Cytogaligin, an additional link between Parkinson’s disease and autophagy pathways?. 7e Congrès du CFATG, Nov 2017, Paris, France. ⟨hal-02934905⟩
  • S El Haddad, A Serrano, C Ozsancak, P. Auzou, F Moal, et al.. Genes de l’autophagie : marqueurs sanguins potentiels de la maladie de Parkinson. Journées de Neurologie de Langue Française, Apr 2016, Nantes, France. ⟨hal-03661930⟩
  • A Serrano, T Guery, S El Haddad, M Dubois, M Schoenwald, et al.. GALIG, gène inducteur de la mort cellulaire, s’exprime au cours de la différenciation myéloïde. 10es Journées du Cancéropole Grand Ouest, Jun 2016, Les Sables d'Olonne, France. ⟨hal-03661932⟩
  • A. Serrano, Thierry Normand, S. El Haddad, M. Dubois, Stéphane Charpentier, et al.. During efficient Anti-RetroViral (ARV) therapy, the expression of GALIG and its interacting partners involved in macroautophagy are deregulated. 6es Journées Scientifiques du CFATG, Oct 2016, Bordeaux, France. ⟨hal-02934903⟩

Poster2 document

  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation. 2024 Global NF Conference, Jun 2024, Brussels, Belgium. ⟨hal-03679991⟩
  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation. 2024 Global NF Conference, Jun 2024, Brussels, Belgium. ⟨hal-04778711⟩

Documents récupérés de l'archive ouverte HAL logo

VALLÉE-MÉHEUST Béatrice

 

email : beatrice.vallee[remplacer_par]cnrs-orleans.fr

Téléphone : 02.38.25.76.11

Chargée de recherche au sein du groupe thématique Signalisation cellulaire et neurofibromatose

 


75 documents

Article dans une revue32 document

  • Anthony Champiré, Rayan Berabez, Abdennour Braka, Aurélie Cosson, Justine Corret, et al.. Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization. European Journal of Medicinal Chemistry, 2024, 271, pp.116391-116391. ⟨10.1016/j.ejmech.2024.116391⟩. ⟨hal-04575964⟩
  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection. Journal of Molecular Biology, 2024, 436 (22), pp.168768. ⟨10.1016/j.jmb.2024.168768⟩. ⟨hal-04771131⟩
  • Tea Martinić Cezar, Mateja Lozančić, Ana Novačić, Ana Matičević, Dominik Matijević, et al.. Streamlining N-terminally anchored yeast surface display via structural insights into S. cerevisiae Pir proteins. Microbial Cell Factories, 2023, 22 (1), pp.174. ⟨10.1186/s12934-023-02183-2⟩. ⟨hal-04208410⟩
  • Elodie Villalonga, Christine Mosrin, Thierry Normand, Caroline Girardin, Amandine Serrano, et al.. LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features. Cells, 2023, 12 (5), pp.805. ⟨10.3390/cells12050805⟩. ⟨hal-04208405⟩
  • Hélène Bénédetti, Béatrice Vallée. LIM Kinases: From Molecular to Pathological Features. Cells, 2023, 12 (12), pp.1649. ⟨10.3390/cells12121649⟩. ⟨hal-04208415⟩
  • Rayan Berabez, Sylvain Routier, Hélène Bénédetti, Karen Plé, Béatrice Vallée. LIM kinases, promising but reluctant therapeutic targets: chemistry and preclinical validation in vivo. Cells, 2022, 11 (13), pp.2090. ⟨10.3390/cells11132090⟩. ⟨hal-03721458⟩
  • Bojan Žunar, Christine Mosrin-Huaman, Hélène Bénédetti, Béatrice Vallée. Re-engineering of CUP1 promoter and Cup2/Ace1 transactivator to convert Saccharomyces cerevisiae into a whole-cell eukaryotic biosensor capable of detecting 10 nM of bioavailable copper. Biosensors and Bioelectronics, 2022, 214, pp.114502. ⟨10.1016/j.bios.2022.114502⟩. ⟨hal-03820214⟩
  • Bojan Žunar, Taiga Ito, Christine Mosrin, Yoshiyuki Sugahara, Hélène Bénédetti, et al.. Confocal imaging of biomarkers at a single-cell resolution: quantifying 'living' in 3D-printable engineered living material based on Pluronic F-127 and yeast Saccharomyces cerevisiae. Biomaterials Research, 2022, 26, pp.85. ⟨10.1186/s40824-022-00337-8⟩. ⟨hal-03926884⟩
  • Frédéric Buron, Nuno Rodrigues, Thibault Saurat, Marie-Aude Hiebel, Stéphane Bourg, et al.. Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-d]Pyrimidine Series as Novel PI3K/mTOR Inhibitors. Molecules, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩. ⟨hal-03348966⟩
  • Kossi Efouako Soklou, Hamid Marzag, Béatrice Vallée, Sylvain Routier, Karen Plé. Synthesis of Heterospirocycles through Gold‐(I) Catalysis, Useful Building Blocks for Medicinal Chemistry. Advanced Synthesis and Catalysis, 2021, ⟨10.1002/adsc.202101080⟩. ⟨hal-03411162⟩
  • Mohammed Bergoug, Michel Doudeau, Fabienne Godin, Christine Mosrin-Huaman, Béatrice Vallée, et al.. Neurofibromin Structure, Functions and Regulation. Cells, 2020, 9, ⟨10.3390/cells9112365⟩. ⟨hal-03070759v2⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Hélène Bénédetti. Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein. Journal of visualized experiments : JoVE, 2019, 148, pp.e59820. ⟨10.3791/59820⟩. ⟨hal-02282630⟩
  • Julie Tastet, Hélène Cuberos, Béatrice Vallée, Annick Toutain, Martine Raynaud, et al.. LIMK2-1 is a Hominidae-Specific Isoform of LIMK2 Expressed in Central Nervous System and Associated with Intellectual Disability. Neuroscience, 2019, 399, pp.199-210. ⟨10.1016/j.neuroscience.2018.12.017⟩. ⟨hal-02067472⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, David Gosset, et al.. LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b. Biochemical Journal, 2018, 475 (23), pp.3745-3761. ⟨hal-01966439⟩
  • A. de Cola, M. Franceschini, A. Di Matteo, G. Colotti, R. Celani, et al.. N6L pseudopeptide interferes with nucleophosmin protein-protein interactions and sensitizes leukemic cells to chemotherapy. Cancer Letters, 2018, 412, pp.272-282. ⟨10.1016/j.canlet.2017.10.038⟩. ⟨hal-02350445⟩
  • B. Vallée, L. Larrède, V. Willaume, A. Pascual, S. Meineri. Effets à long terme d’une stratégie engageante : augmenter le nombre d’adhésions de l’association sportive d’un collège mahorais. Pratiques Psychologiques, 2016, 22 (4), pp.353-362. ⟨10.1016/j.prps.2016.07.002⟩. ⟨hal-02493232⟩
  • H. Cuberos, B. Vallée, P. Vourc'H, J. Tastet, C.R. Andres, et al.. Roles of LIM kinases in central nervous system function and dysfunction. FEBS Letters, 2015, 589 (24PartB), pp.3795-3806. ⟨10.1016/j.febslet.2015.10.032⟩. ⟨hal-02072231⟩
  • Martine Beaufour, Fabienne Godin, Béatrice Vallée, Martine Cadene, Hélène Bénédetti. Interaction Proteomics Suggests a New Role for the Tfs1 Protein in Yeast.. Journal of Proteome Research, 2012, 11 (6), pp.3211-3218. ⟨10.1021/pr201239t⟩. ⟨hal-00721771⟩
  • Julie Tastet, Patrick Vourc'H, Frédéric Laumonnier, Béatrice Vallée, Carole Michelle, et al.. LIMK2d, a truncated isoform of Lim kinase 2 regulates neurite growth in absence of the LIM kinase domain. Biochemical and Biophysical Research Communications, 2012, 420 (2), pp.247-252. ⟨10.1016/j.bbrc.2012.02.134⟩. ⟨hal-01136281⟩
  • Fabienne Godin, Sandrine Villette, Béatrice Vallée, Michel Doudeau, Séverine Morisset-Lopez, et al.. A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.. Biochemical and Biophysical Research Communications, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩. ⟨hal-00721861⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Aurélie Gombault, Aurélie Tchalikian-Cosson, et al.. Nf1 RasGAP Inhibition of LIMK2 Mediates a New Cross-Talk between Ras and Rho Pathways. PLoS ONE, 2012, 7 (10), pp.e47283. ⟨10.1371/journal.pone.0047283⟩. ⟨hal-03054185⟩
  • A. Pascual, L. Dagot, B. Vallée, N. Gueguen. Soumission sans pression, médiatisation d’un tsunami et don d’argent : efficacité comparée de la porte-au-nez et du « vous êtes libre de… ». European Review of Applied Psychology / Revue Européenne de Psychologie Appliquée, 2009, 59 (1), pp.79-84. ⟨10.1016/j.erap.2006.07.003⟩. ⟨hal-02493142⟩
  • Aurélie Gombault, Jonas Warringer, Robert Caesar, Fabienne Godin, Béatrice Vallée, et al.. A phenotypic study of TFS1 mutants differentially altered in the inhibition of Ira2p or CPY. FEMS Yeast Research, 2009, 9 (6), pp.867-874. ⟨10.1111/j.1567-1364.2009.00535.x⟩. ⟨hal-00522432⟩
  • Aurélie Gombault, Fabienne Godin, Denise Sy, Baptiste Legrand, Hélène Chautard, et al.. Molecular Basis of the Tfs1/Ira2 Interaction: A Combined Protein Engineering and Molecular Modelling Study. Journal of Molecular Biology, 2007, 374 (3), pp.604-617. ⟨10.1016/j.jmb.2007.09.057⟩. ⟨hal-00181161⟩
  • Béatrice Vallée, H. Riezman. Lip 1p: a novel subunit of acyl-CoA ceramide synthase. EMBO Journal, 2005, 24, pp.730-741. ⟨hal-00088715⟩
  • Béatrice Vallée, G Coadou, H. Labbé, D. Sy, F. Vovelle, et al.. Peptides corresponding to the N- and C-terminal parts of PEBP are well-structured in solution: new insights into their possible interaction with partners in vivo.. Journal of Peptide Research, 2003, 61 (2), pp.47-57. ⟨hal-02118669⟩
  • Kouichi Funato, Ruben Lombardi, Béatrice Vallée, Howard Riezman. Lcb4p Is a Key Regulator of Ceramide Synthesis from Exogenous Long Chain Sphingoid Base in Saccharomyces cerevisiae. Journal of Biological Chemistry, 2003, 278 (9), pp.7325-7334. ⟨10.1074/jbc.M209925200⟩. ⟨hal-02118660⟩
  • Kouichi Funato, Béatrice Vallée, Howard Riezman. Biosynthesis and Trafficking of Sphingolipids in the Yeast Saccharomyces cerevisiae †. Biochemistry, 2002, 41 (51), pp.15105-15114. ⟨10.1021/bi026616d⟩. ⟨hal-02118664⟩
  • D Schorling, Béatrice Vallée, Wolfgang Barz, Howard Riezman, Dieter Oesterhelt. Lag1p and Lac1p Are Essential for the Acyl-CoA–dependent Ceramide Synthase Reaction in Saccharomyces cerevisae. Molecular Biology of the Cell, 2001, 12 (11), pp.3417-3427. ⟨10.1091/mbc.12.11.3417⟩. ⟨hal-02118674⟩
  • Béatrice Vallée, P Tauc, J Brochon, M Maget-Dana, D. Lelièvre, et al.. Behaviour of bovine phosphatidylethanolamine-binding protein with model membranes. Evidence of affinity for negatively charged membranes.. European Journal of Biochemistry, 2001, 268 (22), pp.5831-41. ⟨hal-02118681⟩
  • Béatrice Vallée, Caroline Teyssier, R. Maget-Dana, J. Ramstein, N. Bureaud, et al.. Stability and physicochemical properties of the bovine brain phosphatidylethanolamine-binding protein.. European Journal of Biochemistry, 1999, 266 (1), pp.40-52. ⟨hal-02118686⟩
  • C. Serre, Béatrice Vallée, N. Bureaud, F. Schoentgen, C. Zelwer. Crystal structure of the phosphatidylethanolamine-binding protein from bovine brain: a novel structural class of phospholipid-binding proteins.. Structure, 1998, 6 (10), pp.1255-65. ⟨hal-02118689⟩

Communication dans un congrès16 document

  • Karen Plé, Béatrice Vallée. Les LIM kinases, des cibles thérapeutiques d’intérêt : de la conception de petites molécules inhibitrices aux premiers essais précliniques. Journée scientifique du réseau Cancers des Tissus Hormono-dépendants (CASTHOR), Cancéropôle Grand Ouest, Dec 2022, Nantes, France. ⟨hal-04823051⟩
  • Rayan Berabez, Anthony Champiré, Margaux Sainjon, Abdennour Braka, Samia Aci-Seche, et al.. Synthesis and preclinical validation of LIMKs inhibitors: Promising drugs for osteosarcoma treatment?. SCT 29th Young Research Fellow Meeting, Jul 2022, Nantes, France. ⟨hal-04822252⟩
  • Anthony Champiré, Margaux Sainjon, Abdennour Braka, Samia Aci-Seche, Pascal Bonnet, et al.. Synthesis and preclinical validation of LIMKs inhibitors: Promising drugs for osteosarcoma treatment?. XXVII EFMC International Symposium on Medicinal Chemistry, Sep 2022, NICE, France. ⟨hal-04823073⟩
  • Karen Plé, Franck Verrecchia, Béatrice Vallée, Régis Brion, Rayan Berabez, et al.. Un nouvel inhibiteur des LIMKs, l'AC429, bloque la croissance des tumeurs primaires d'ostéosarcome. Cancéropôle Grand Ouest, colloque du réseau Molécules marines, métabolisme et cancer, May 2022, Mansigné, France. ⟨hal-04820416⟩
  • Justine Corret, Sokaina Hammoud, Frédéric Buron, Pierre Daligaux, Christophe Chesné, et al.. Development of a bio­active fluorescent inhibitor probe targeting the Rho kinase ROCK for monitoring inhibition action. FEBS 2021, the 45th FEBS Congress, Jul 2021, Virtual, France. ⟨hal-03668584⟩
  • Béatrice Vallée, Christine Mosrin-Huaman, Hélène Bénédetti, Régis Guégan, Bojan Zunar. Life in the bioink: Physiology and energetics of Saccharomyces cerevisiae embedded in polymerized Pluronic F127-DMA, a “smart” thermoresponsive hydrogel. ICY15 meets 30ICYGMB, The spirit of Yeast, Aug 2021, Vienne, virtual, Austria. ⟨hal-03559939⟩
  • Béatrice Vallée, Hélène Bénédetti. Séminaire invité : Signalisation cellulaire et Neurofibromatose. Journées NF, Sep 2021, Orléans, France. ⟨hal-03560050⟩
  • N Laroui, C Delehedde, C Goncalves, F Godin, Federico Perche, et al.. High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells. SFNano 2021, Dec 2021, Angers, France. ⟨hal-03668422⟩
  • M. Bergoug, A. Cosson, D. Casas, M. Doudeau, F. Godin, et al.. Neurofibromin, a new SUMO target involved in neurofibromatosis type 1 disease. 6th LIA Workshop on "Biomarkers and mediators of diseases and new approaches in repair/regenerative therapies, Jun 2019, Varsovie, Poland. ⟨hal-02928511⟩
  • H. Bénédetti, Béatrice Vallée, A. Cosson, F. Godin, M. Doudeau. Les LIM kinases : nouvelles cibles thérapeutiques anti-cancer. Journée scientifique du réseau « Cancers hormonaux–dépendants » du Cancéropôle Grand-Ouest, Apr 2019, Nantes, France. ⟨hal-02928496⟩
  • Béatrice Vallée, K. Plé, A. Cosson, M. Doudeau, F. Godin, et al.. Détermination et mise en œuvre d’un modèle in vivo pour tester de nouveaux inhibiteurs originaux des LIM kinases, cibles thérapeutiques émergentes dans le cancer. Cancéropôle Grand Ouest, Colloque du Réseau Molécules marines, métabolisme et cancer, May 2019, Mansigné, France. ⟨hal-02928507⟩
  • Béatrice Vallée, S. Routier, A. Cosson, M. Doudeau, F. Godin, et al.. Développement de modulateurs des LIM kinases. Cancéropôle Grand Ouest - 14e colloque du Réseau Produits de la mer en cancérologie - 5e colloque du Réseau Canaux ioniques et cancer, May 2018, Mansigné, France. ⟨hal-02928559⟩
  • Béatrice Vallée, Karen Plé, A. Cosson, M. Doudeau, F. Godin, et al.. Développement de petites molécules inhibitrices des LIM kinases, nouvelles cibles thérapeutiques pour lutter contre le cancer, les maladies neurologiques et la neurofibromatose. Journée Fédération CBM-ICOA, Jan 2018, Orléans, France. ⟨hal-02928530⟩
  • M. Bergoug, A. Cosson, M. Doudeau, F. Godin, Béatrice Vallée, et al.. Study of the sumoylation of neurofibromin, the protein responsible for neurofibromatosis type 1. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France. ⟨hal-02928220⟩
  • Béatrice Vallée, A. Cosson, M. Doudeau, F Godin, A. Braka, et al.. Neurofibromatosis type I: from basic to applied research. 4th LIA Workshop, Jun 2017, Cracovie, Poland. ⟨hal-02928517⟩
  • Béatrice Vallée, Hélène Bénédetti, F. Godin, M. Doudeau. Study of new partners of neurofibromin: an approach to identify novel therapeutic targets for neurofibromatosis type 1. 17th European Neurofibromatosis meeting, Sep 2016, Albano-Terme, Italy. ⟨hal-02928226⟩

Poster24 document

  • Hélène Bénédetti, Christine Mosrin-Huaman, Mohammed Bergoug, Amandine Serrano, Fabienne Godin, et al.. Deciphering the Molecular Mechanism of Pathogenicity in Destabilized variants of Neurofibromin mutated in its SecPH domain. 2024 Global NF Conference, Jun 2024, Brussels (Belgium), Belgium. ⟨hal-04779581⟩
  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation. 2024 Global NF Conference, Jun 2024, Brussels, Belgium. ⟨hal-03679991⟩
  • Bojan Zunar, Christine Mosrin-Huaman, Hélène Bénédetti, Régis Guégan, Béatrice Vallée. Stressed by hydrogel? Physiological response of yeast cells embedded in thermoresponsive Pluronic F127: a prerequisite for bioreactor development. FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, Slovenia. ⟨hal-03679975⟩
  • Elodie Villalonga, Célina Chalal, Déborah Cassas, Michel Doudeau, Fabienne Godin, et al.. New insights into the regulation of actin cytoskeleton dynamics via the Rho/ROCK/LIMK2/cofilin signalling pathway: a novel mechanism of regulation of cofilin by LIMK2. FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, virtual, Slovenia. ⟨hal-03680139⟩
  • N Laroui, C Delehedde, Cristine Gonçalves, F Godin, F Perche, et al.. High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells. 10th mRNA Health Conference, Nov 2021, Berlin, Germany. ⟨hal-03668434⟩
  • Christine Mosrin-Huaman, Mohammed Bergoug, Fabienne Godin, Michel Doudeau, Iva Sosic, et al.. Sumoylation of Neurofibromin and its SecPH Domain Plays a Role in Their Functions and Implies Unexpected Structural Requirements. 2021 NF1 virtual conference, Jun 2021, Virtual, France. ⟨hal-03680001⟩
  • Mélissa Thomas, Lauren Blot, Kevin Lesage, Fabienne Godin, Michel Doudeau, et al.. New molecular insights into the crosstalk between Rho/ROCK/LIMK2/cofilin signalling pathway and Nf1. 2021 NF1 virtual conference, Jun 2021, Virtual, France. ⟨hal-03679999⟩
  • Justine Corret, Sokaina Hammoud, Frédéric Buron, Pierre Daligaux, Christophe Chesné, et al.. Development of a bio­active fluorescent inhibitor probe targeting the Rho kinase ROCK for monitoring inhibition action. FEBS 2021, the 45th FEBS Congress, Jul 2021, Lnubljana, virtual, Slovenia. ⟨hal-03679980⟩
  • Christine Mosrin-Huaman, B. Handelaoui, H. Bénédetti, Béatrice Vallée. Yeast biosensors to detect environmental pollutants into effluent waters. ICYGMB XXIX International Congress on Yeast Genetics and Molecular Biology, Aug 2019, Göteborg, Sweden. ⟨hal-02924111⟩
  • M. Bergoug, I. Sošic, M. Doudeau, F. Godin, Béatrice Vallée, et al.. Neurofibromin, a new SUMO target involved in neurofibromatosis type 1 disease. EMBO Workshop "The ubiquitin system: Biology, mechanisms and roles in disease", Sep 2019, Cavtat, Croatia. ⟨hal-02924095⟩
  • Béatrice Vallée, A. Cosson, M. Doudeau, F. Godin, A. Champiré, et al.. LIM kinases, new therapeutic targets to treat cancers, neurological disorders and Neurofibromatosis: development of small molecule inhibitors. FEBS Meeting 2019, Jul 2019, Cracovie, Poland. ⟨hal-02924140⟩
  • H. Bénédetti, Béatrice Vallée, J. Tastet, H. Cubéros, A. Toutain, et al.. Molecular and functional characterization of LIMK2-1, a hominidae-specific isoform of LIMK2 associated with intellectual disability. NeuroFrance 2019, May 2019, Marseille, France. ⟨hal-02924881⟩
  • H. Bénédetti, M. Bergoug, I. Sošic, M. Doudeau, F. Godin, et al.. Study of the different forms of sumoylation of the neurofibromin SecPH domain. EMBO Workshop "The ubiquitin system: Biology, mechanisms and roles in disease", Sep 2019, Cavtat, Croatia. ⟨hal-02924090⟩
  • H. Bénédetti, M. Doudeau, F. Godin, Béatrice Vallée, A. Cosson, et al.. LARP6, a RNA−binding protein involved in translation and stability of collagen mRNA, is a new partner of Neurofibromin: Molecular studies and functional implications. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France. ⟨hal-02924084⟩
  • Béatrice Vallée, A. Cosson, M. Doudeau, F. Godin, A. Champiré, et al.. Development of small molecule inhibitors of LIM kinases, new therapeutic targets to treat Neurofibromatosis type I. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France. ⟨hal-02924077⟩
  • M. Bergoug, A. Cosson, M. Doudeau, F. Godin, Béatrice Vallée, et al.. Study of the sumoylation of neurofibromin, the protein responsible for neurofibromatosis type 1. EMBO Conference "Ubiquitin and SUMO: from molecular mechanisms to system-wide responses, Sep 2017, Cavtat, Croatia. ⟨hal-02924070⟩
  • A. Champiré, A. Braka, Béatrice Vallée, M. Doudeau, F. Godin, et al.. Design, synthesis and biological evaluation of LIMK inhibitors. XXIVe Journées Jeunes Chercheurs (SCT), Feb 2017, Châtenay-Malabry, France. ⟨hal-02904837⟩
  • Béatrice Vallée, A. Cosson, M. Doudeau, F. Godin, Anthony Champiré, et al.. LIM Kinases: new anticancer therapeutic targets. Breast Cancer Symposium, Jun 2017, Nantes, France. ⟨hal-03680148⟩
  • Béatrice Vallée, Michel Doudeau, F. Godin, H. Cubéros, A. Champiré, et al.. Projet Région LiCorNe: LIMK protein inhibitors, new therapeutic agents for treatment of cognitive disorders associated with type I Neurofibromatosis. Journée Fédération PCV FR2708, Jan 2016, Orléans, France. ⟨hal-02924056⟩
  • Béatrice Vallée, Hélène Cuberos, Julie Tastet, Michel Doudeau, Fabienne Godin, et al.. LIMK2-1, a new primate-specific isoform of LIMK2, is associated with intellectual disability. 10 th FENS (Forum of Neurosciences), Jul 2016, Copenhague, Denmark. . ⟨hal-02453486⟩
  • Hélène Bénédetti, Fabienne Godin, Michel Doudeau, Béatrice Vallée, Marie-Ludivine De Tauzia, et al.. LINGO-1, a protein involved in various neurodevelopmental processes, interacts with neurofibromin (Nf1), the protein responsible for neurofibromatosis type I: molecular studies and functional implications. 10 th FENS (Forum of Neuroscience), Jul 2016, Copenhague, Denmark. ⟨hal-02453487⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, Patrick Vourc’h, et al.. The three isoforms of human LIMK2 regulate actin cytoskeleton remodeling via different pathways. EMBL Symposium, Actin in action: From Molecules to Cellular Functions, Sep 2016, Heidelberg, Germany. . ⟨hal-02453489⟩
  • A. Champiré, A. Braka, Béatrice Vallée, M. Doudeau, F. Godin, et al.. Conception, synthèse et évaluation biologique d’inhibiteurs de LIM kinases. 29e colloque de Biotechnocentre, Oct 2016, Seillac, France. ⟨hal-02904847⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Anthony Champiré, Karen Plé, et al.. LIM kinases: new therapeutic targets to treat Neurofibromatosis type I. The 7th EMBO meeting, Sep 2016, Mannheim, Germany. . ⟨hal-02453490⟩

Brevet1 document

  • Sylvain Routier, Hélène Bénédetti, Béatrice Vallée, Pascal Bonnet, Karen Plé, et al.. 4-(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-3,6-dihydropyridine-(2H)-carboxamide derivatives as Limk and/or Rock kinases inhibitors for use in the treatment of cancer. France, Patent n° : WO2021239727 A1. AMV. 2021. ⟨hal-03555349⟩

Pré-publication, Document de travail1 document

  • Mohammed Bergoug, Christine Mosrin, Fabienne Godin, Michel Doudeau, Iva Sosic, et al.. Noncanonical structural requirements of neurofibromin SUMOylation reveal a folding-deficiency of several pathogenic mutants. 2022. ⟨hal-03668582⟩

HDR1 document

  • Béatrice Vallée. Etudes de différentes voies de transduction du signal afin de mettre à jour de nouveaux mécanismes moléculaires et de nouvelles cibles thérapeutiques. Biochimie, Biologie Moléculaire. Université d'Orléans, 2020. ⟨tel-03560017⟩

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GODIN Fabienne

email : fabienne.godin[remplacer_par_at]cnrs-orleans.fr

Téléphone : 02.38.25.76.05

Ingénieure en techniques biologiques au sein du groupe thématique « Signalisation cellulaire et neurofibromatose »

 


0 documents

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BÉNÉDETTI Hélène

mail : helene.benedetti[remplacer_par_at]cnrs-orleans.fr

Téléphone : 02.38.25.55.84

Directrice de recherche, Directrice adjointe du CBM, co-coordinatrice du département « Signalisation cellulaire, cibles moléculaires et thérapies innovantes » et co-responsable de l’équipe « Signalisation cellulaire et neurofibromatose »


126 documents

Article dans une revue67 document

  • Anthony Champiré, Rayan Berabez, Abdennour Braka, Aurélie Cosson, Justine Corret, et al.. Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization. European Journal of Medicinal Chemistry, 2024, 271, pp.116391-116391. ⟨10.1016/j.ejmech.2024.116391⟩. ⟨hal-04575964⟩
  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection. Journal of Molecular Biology, 2024, 436 (22), pp.168768. ⟨10.1016/j.jmb.2024.168768⟩. ⟨hal-04771131⟩
  • Hélène Bénédetti, Béatrice Vallée. LIM Kinases: From Molecular to Pathological Features. Cells, 2023, 12 (12), pp.1649. ⟨10.3390/cells12121649⟩. ⟨hal-04208415⟩
  • Elodie Villalonga, Christine Mosrin, Thierry Normand, Caroline Girardin, Amandine Serrano, et al.. LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features. Cells, 2023, 12 (5), pp.805. ⟨10.3390/cells12050805⟩. ⟨hal-04208405⟩
  • Rayan Berabez, Sylvain Routier, Hélène Bénédetti, Karen Plé, Béatrice Vallée. LIM kinases, promising but reluctant therapeutic targets: chemistry and preclinical validation in vivo. Cells, 2022, 11 (13), pp.2090. ⟨10.3390/cells11132090⟩. ⟨hal-03721458⟩
  • Bojan Žunar, Christine Mosrin-Huaman, Hélène Bénédetti, Béatrice Vallée. Re-engineering of CUP1 promoter and Cup2/Ace1 transactivator to convert Saccharomyces cerevisiae into a whole-cell eukaryotic biosensor capable of detecting 10 nM of bioavailable copper. Biosensors and Bioelectronics, 2022, 214, pp.114502. ⟨10.1016/j.bios.2022.114502⟩. ⟨hal-03820214⟩
  • Wissem Deraredj Nadim, Shalina Hassanaly, Hélène Bénédetti, Claudine Kieda, Catherine Grillon, et al.. The GTPase-activating protein-related domain of neurofibromin interacts with MC1R and regulates pigmentation-mediated signaling in human melanocytes. Biochemical and Biophysical Research Communications, 2021, 534, pp.758-764. ⟨10.1016/j.bbrc.2020.11.003⟩. ⟨hal-03007433⟩
  • Skander A Abboud, Hadji H., Michel Doudeau, Hélène Bénédetti, Vincent Aucagne. A straightforward methodology to overcome solubility challenges for N-terminal cysteinyl peptide segments used in native chemical ligation. Chemical Science, 2021, 12, pp.3194 - 3201. ⟨10.1039/d0sc06001a⟩. ⟨hal-03447239⟩
  • Frédéric Buron, Nuno Rodrigues, Thibault Saurat, Marie-Aude Hiebel, Stéphane Bourg, et al.. Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-d]Pyrimidine Series as Novel PI3K/mTOR Inhibitors. Molecules, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩. ⟨hal-03348966⟩
  • Mohammed Bergoug, Michel Doudeau, Fabienne Godin, Christine Mosrin-Huaman, Béatrice Vallée, et al.. Neurofibromin Structure, Functions and Regulation. Cells, 2020, 9, ⟨10.3390/cells9112365⟩. ⟨hal-03070759v2⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Hélène Bénédetti. Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein. Journal of visualized experiments : JoVE, 2019, 148, pp.e59820. ⟨10.3791/59820⟩. ⟨hal-02282630⟩
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Communication dans un congrès16 document

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  • N Laroui, C Delehedde, C Goncalves, F Godin, Federico Perche, et al.. High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells. SFNano 2021, Dec 2021, Angers, France. ⟨hal-03668422⟩
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  • J. Tastet, P. Vourc'H, F. Laumonnier, C. Michelle, Anne Duittoz, et al.. Expression des isoformes de LIM Kinase 2 pendant la neurogenèse et la stimulation des neurones. 22. Colloque Biotechnocentre, Oct 2009, Seillac, France. ⟨hal-02753426⟩

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  • Bojan Zunar, Christine Mosrin-Huaman, Hélène Bénédetti, Régis Guégan, Béatrice Vallée. Stressed by hydrogel? Physiological response of yeast cells embedded in thermoresponsive Pluronic F127: a prerequisite for bioreactor development. FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, Slovenia. ⟨hal-03679975⟩
  • Elodie Villalonga, Célina Chalal, Déborah Cassas, Michel Doudeau, Fabienne Godin, et al.. New insights into the regulation of actin cytoskeleton dynamics via the Rho/ROCK/LIMK2/cofilin signalling pathway: a novel mechanism of regulation of cofilin by LIMK2. FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, virtual, Slovenia. ⟨hal-03680139⟩
  • N Laroui, C Delehedde, Cristine Gonçalves, F Godin, F Perche, et al.. High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells. 10th mRNA Health Conference, Nov 2021, Berlin, Germany. ⟨hal-03668434⟩
  • Christine Mosrin-Huaman, Mohammed Bergoug, Fabienne Godin, Michel Doudeau, Iva Sosic, et al.. Sumoylation of Neurofibromin and its SecPH Domain Plays a Role in Their Functions and Implies Unexpected Structural Requirements. 2021 NF1 virtual conference, Jun 2021, Virtual, France. ⟨hal-03680001⟩
  • Mélissa Thomas, Lauren Blot, Kevin Lesage, Fabienne Godin, Michel Doudeau, et al.. New molecular insights into the crosstalk between Rho/ROCK/LIMK2/cofilin signalling pathway and Nf1. 2021 NF1 virtual conference, Jun 2021, Virtual, France. ⟨hal-03679999⟩
  • Justine Corret, Sokaina Hammoud, Frédéric Buron, Pierre Daligaux, Christophe Chesné, et al.. Development of a bio­active fluorescent inhibitor probe targeting the Rho kinase ROCK for monitoring inhibition action. FEBS 2021, the 45th FEBS Congress, Jul 2021, Lnubljana, virtual, Slovenia. ⟨hal-03679980⟩
  • H. Bénédetti, Béatrice Vallée, J. Tastet, H. Cubéros, A. Toutain, et al.. Molecular and functional characterization of LIMK2-1, a hominidae-specific isoform of LIMK2 associated with intellectual disability. NeuroFrance 2019, May 2019, Marseille, France. ⟨hal-02924881⟩
  • H. Bénédetti, M. Bergoug, I. Sošic, M. Doudeau, F. Godin, et al.. Study of the different forms of sumoylation of the neurofibromin SecPH domain. EMBO Workshop "The ubiquitin system: Biology, mechanisms and roles in disease", Sep 2019, Cavtat, Croatia. ⟨hal-02924090⟩
  • Christine Mosrin-Huaman, B. Handelaoui, H. Bénédetti, Béatrice Vallée. Yeast biosensors to detect environmental pollutants into effluent waters. ICYGMB XXIX International Congress on Yeast Genetics and Molecular Biology, Aug 2019, Göteborg, Sweden. ⟨hal-02924111⟩
  • M. Bergoug, I. Sošic, M. Doudeau, F. Godin, Béatrice Vallée, et al.. Neurofibromin, a new SUMO target involved in neurofibromatosis type 1 disease. EMBO Workshop "The ubiquitin system: Biology, mechanisms and roles in disease", Sep 2019, Cavtat, Croatia. ⟨hal-02924095⟩
  • Béatrice Vallée, A. Cosson, M. Doudeau, F. Godin, A. Champiré, et al.. LIM kinases, new therapeutic targets to treat cancers, neurological disorders and Neurofibromatosis: development of small molecule inhibitors. FEBS Meeting 2019, Jul 2019, Cracovie, Poland. ⟨hal-02924140⟩
  • Béatrice Vallée, A. Cosson, M. Doudeau, F. Godin, A. Champiré, et al.. Development of small molecule inhibitors of LIM kinases, new therapeutic targets to treat Neurofibromatosis type I. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France. ⟨hal-02924077⟩
  • H. Bénédetti, M. Doudeau, F. Godin, Béatrice Vallée, A. Cosson, et al.. LARP6, a RNA−binding protein involved in translation and stability of collagen mRNA, is a new partner of Neurofibromin: Molecular studies and functional implications. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France. ⟨hal-02924084⟩
  • Séverine Morisset-Lopez, W. Deraredj Nadim, S. Chaumont−dubel, F. Madouri, L. Cobret, et al.. Neurofibromin 1 promotes constitutive activity of native 5−HT6 receptors expressed in mouse prefrontal cortex. Neurofrance, May 2017, Bordeaux, France. ⟨hal-02973767⟩
  • M. Bergoug, A. Cosson, M. Doudeau, F. Godin, Béatrice Vallée, et al.. Study of the sumoylation of neurofibromin, the protein responsible for neurofibromatosis type 1. EMBO Conference "Ubiquitin and SUMO: from molecular mechanisms to system-wide responses, Sep 2017, Cavtat, Croatia. ⟨hal-02924070⟩
  • A. Champiré, A. Braka, Béatrice Vallée, M. Doudeau, F. Godin, et al.. Design, synthesis and biological evaluation of LIMK inhibitors. XXIVe Journées Jeunes Chercheurs (SCT), Feb 2017, Châtenay-Malabry, France. ⟨hal-02904837⟩
  • A. Champiré, A. Braka, B. Vallée, M. Doudeau, F. Godin, et al.. LIM kinases as new therapeutic targets for the treatment of neurofibromatosis type 1. VII International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC) –, Aug 2017, Vienne, Austria. ⟨hal-02904794⟩
  • Béatrice Vallée, A. Cosson, M. Doudeau, F. Godin, Anthony Champiré, et al.. LIM Kinases: new anticancer therapeutic targets. Breast Cancer Symposium, Jun 2017, Nantes, France. ⟨hal-03680148⟩
  • W. Deraredj Nadim, S. Chaumont-Dubel, F. Madouri, L. Cobret, M.-L. de Tauzia, et al.. A Physical Interaction between Neurofibromin and Serotonin 5-HT6 Receptor Promotes Receptor Constitutive Activity. 5th annual meeting of the GDR 3545 RCPG-PhysioMed 2016, Nov 2016, Tours, France. ⟨hal-02973912⟩
  • Béatrice Vallée, Michel Doudeau, F. Godin, H. Cubéros, A. Champiré, et al.. Projet Région LiCorNe: LIMK protein inhibitors, new therapeutic agents for treatment of cognitive disorders associated with type I Neurofibromatosis. Journée Fédération PCV FR2708, Jan 2016, Orléans, France. ⟨hal-02924056⟩
  • Béatrice Vallée, Hélène Cuberos, Julie Tastet, Michel Doudeau, Fabienne Godin, et al.. LIMK2-1, a new primate-specific isoform of LIMK2, is associated with intellectual disability. 10 th FENS (Forum of Neurosciences), Jul 2016, Copenhague, Denmark. . ⟨hal-02453486⟩
  • A. Champiré, A. Braka, Béatrice Vallée, M. Doudeau, F. Godin, et al.. Conception, synthèse et évaluation biologique d’inhibiteurs de LIM kinases. 29e colloque de Biotechnocentre, Oct 2016, Seillac, France. ⟨hal-02904847⟩
  • Annabelle Dejardin, Wassim Lakhal, Nathalie Boizot, Marie-Claude Lesage Descauses, Odile Rogier, et al.. Unraveling the function of MYB090 and MYB156 in secondary cell wall formation in poplar using both ChIP-SEQ and in planta gene modification approach. XIV Cell Wall Meeting, Jun 2016, Chania, Grèce. , 2016, XIV Cell Wall Meeting. Programme and Book of Abstracts. ⟨hal-02740921⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Anthony Champiré, Karen Plé, et al.. LIM kinases: new therapeutic targets to treat Neurofibromatosis type I. The 7th EMBO meeting, Sep 2016, Mannheim, Germany. . ⟨hal-02453490⟩
  • Hélène Bénédetti, Fabienne Godin, Michel Doudeau, Béatrice Vallée, Marie-Ludivine De Tauzia, et al.. LINGO-1, a protein involved in various neurodevelopmental processes, interacts with neurofibromin (Nf1), the protein responsible for neurofibromatosis type I: molecular studies and functional implications. 10 th FENS (Forum of Neuroscience), Jul 2016, Copenhague, Denmark. ⟨hal-02453487⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, Patrick Vourc’h, et al.. The three isoforms of human LIMK2 regulate actin cytoskeleton remodeling via different pathways. EMBL Symposium, Actin in action: From Molecules to Cellular Functions, Sep 2016, Heidelberg, Germany. . ⟨hal-02453489⟩
  • J. Tastet, P. Vourc'H, F. Laumonnier, C. Michelle, Anne Duittoz, et al.. LIMK2 (LIM kinase2) isoforms are differentially expressed during neuronal differentiation. 7. FENS Forum of European Neuroscience, Jul 2010, Amsterdam, Netherlands. n.p., 2010. ⟨hal-02818145⟩

Chapitre d'ouvrage7 document

  • Emmanuelle Bouveret, Claude Lazdunski, Hélène Bénédetti. The Tol/PAL and TonB systems : two envelope-spanning protein complexes involved in colicin import in E. coli.. Molecular Dynamics of Biomembranes, Springer Berlin Heidelberg, pp.59-69, 1996. ⟨hal-02130680⟩
  • H. Bénédetti, V. Geli. Colicin transport, channel formation and inhibition. Handbook of Biological Physics, pp.665-691, 1996. ⟨hal-02130677⟩
  • Vincent Géli, Hélène Bénédetti. Insertion of Proteins into Membranes A Survey. Membrane biogenesis, pp.21-69, 1994, Subcellular Biochemistry, 978-1-4613-6018-6. ⟨hal-02130265⟩
  • L. Letellier, C. Lazdunski, H. Bénédetti, J. Bourdineaud, P. Boulanger. In Vivo Properties of Colicin A: Channel Activity and Translocation. Bacteriocins, Microcins and Lantibiotics, Springer Berlin Heidelberg, pp.119-125, 1992. ⟨hal-02130671⟩
  • C. Lazdunski, D. Baty, V. Geli, R. Lloubes, H. Bénédetti, et al.. Molecular Mechanism of Action of Pore-Forming Colicins and of their Immunity Proteins. Membrane Proteins: Structures, Interactions and Models, pp.413-425, 1992. ⟨hal-02130675⟩
  • Hélène Bénédetti, Lucienne Letellier, Roland Lloubes, Vincent Géli, Daniel Baty, et al.. Import of Colicins into Escherichia Coli. Dynamics of Membrane Assembly, 63, Springer Berlin Heidelberg, pp.315-332, 1992. ⟨hal-02130670⟩
  • Hélène Bénédetti, Lucienne Letellier, Roland Lloubes, Vincent Géli, Daniel Baty, et al.. Study of the Import Mechanisms of Colicins Through Protein Engineering and K+ Efflux Kinetics. Bacteriocins, Microcins and Lantibiotics, Springer Berlin Heidelberg, pp.215-223, 1992. ⟨hal-02130674⟩

Brevet3 document

  • Sylvain Routier, Hélène Bénédetti, Béatrice Vallée, Pascal Bonnet, Karen Plé, et al.. 4-(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-3,6-dihydropyridine-(2H)-carboxamide derivatives as Limk and/or Rock kinases inhibitors for use in the treatment of cancer. France, Patent n° : WO2021239727 A1. AMV. 2021. ⟨hal-03555349⟩
  • Sylvain Routier, Hélène Bénédetti, Frederic Buron, Marie-Aude Hiebel, Thibault Saurat, et al.. TRISUBSTITUTED PYRIDO[2,3-D]PYRIMIDINES, METHODS FOR PREPARING SAME AND THERAPEUTIC USES THEREOF. France, Patent n° : WO2014027081. 2014. ⟨hal-02131560⟩
  • Séverine Morisset-Lopez, Hélène Bénédetti. Tools for the identification od LINGO-1, LINGO-2, LINGO-3 and LINGO-4, ligands, and uses thereof. France, Patent n° : WO2011121257. BCT. 2011. ⟨hal-02130935⟩

Pré-publication, Document de travail1 document

  • Mohammed Bergoug, Christine Mosrin, Fabienne Godin, Michel Doudeau, Iva Sosic, et al.. Noncanonical structural requirements of neurofibromin SUMOylation reveal a folding-deficiency of several pathogenic mutants. 2022. ⟨hal-03668582⟩

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