Organisation : Eq Protéines de synthèse et Chimie bioorthogonale

MALARD Virginie

email : virginie.malar[remplacer_par_at]@cnrs-orleans.fr

Téléphone : 02.38.25.56.23

Ingénieur d’Etudes en analyse chimique au sein de l’équipe « Protéines de synthèse et chimie bioorthogonale »

 


8 documents

Article dans une revue6 document

  • Haifei Gao, Cristine Goncalves, Téo Gallego, Marc Francois-Heude, Virginie Malard, et al.. Comparative binding and uptake of liposomes decorated with mannose oligosaccharides by cells expressing the mannose receptor or DC-SIGN. Carbohydrate Research, 2020, 487, pp.107877. ⟨10.1016/j.carres.2019.107877⟩. ⟨hal-02522179⟩
  • A. Le Moignic, V. Malard, T. Benvegnu, L. Lemiègre, Mathieu Berchel, et al.. Preclinical evaluation of mRNA trimannosylated lipopolyplexes as therapeutic cancer vaccines targeting dendritic cells. Journal of Controlled Release, 2018, 278, pp.110 - 121. ⟨10.1016/j.jconrel.2018.03.035⟩. ⟨hal-01774851⟩
  • Kevin van Der Jeught, Stefaan de Koker, Lukasz Bialkowski, Carlo Heirman, Patrick Tjok Joe, et al.. Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety. ACS Nano, 2018, 12 (10), pp.9815-9829. ⟨10.1021/acsnano.8b00966⟩. ⟨hal-01889829⟩
  • Samuel Guillot, Fabienne Meducin, Kristina Poljak, Virginie Malard, Alexandra Foucault-Collet, et al.. Nanostructured monolinolein miniemulsions as delivery systems: Role of the internal mesophase on cytotoxicity and cell internalization. International Journal of Pharmaceutics, 2017, 523 (1), pp.142 - 150. ⟨10.1016/j.ijpharm.2017.03.012⟩. ⟨hal-01656547⟩
  • J. Barbeau, L. Lemiègre, A. Quelen, V. Malard, H. Gao, et al.. Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes. Carbohydrate Research, 2016, 435, pp.142--148. ⟨10.1016/j.carres.2016.10.003⟩. ⟨hal-01398046⟩
  • Cristine Gonçalves, Mathieu Berchel, Marie-Pierre Gosselin, Virginie Malard, Hervé Cheradame, et al.. Lipopolyplexes comprising imidazole/imidazolium lipophosphoramidate, histidinylated polyethyleneimine and siRNA as efficient formulation for siRNA transfection. International Journal of Pharmaceutics, 2014, 460 (1-2), pp.264-272. ⟨10.1016/j.ijpharm.2013.11.005⟩. ⟨hal-01179049⟩

Communication dans un congrès1 document

  • C Delehedde, G Haifei, C Gonçalves, Virginie Malard, N Rameix, et al.. Influence of the charge of mRNA mannosylated lipopolyplexes on the binding and uptake by dendritic cells. 33e colloque Biotechnocentre, Oct 2021, Seillac, France. ⟨hal-03668427⟩

Poster1 document

  • C Delehedde, G Haifei, Cristine Gonçalves, Virginie Malard, N Rameix, et al.. Influence of the charge of mRNA mannosylated lipopolyplexes on the binding and uptake by dendritic cells. 33e colloque Biotechnocentre, Oct 2021, Seillac, France. ⟨hal-03668442⟩

Documents récupérés de l'archive ouverte HAL logo

CHARPENTIER Stéphane

email : stephane.charpentier[remplacer_par_at]cnrs-orleans.fr

Téléphone : 02.38.25.55.96

Maître de conférence au sein du groupe thématique « Protéines de synthèse et chimie bioorthogonale »

 


23 documents

Article dans une revue18 document

  • Amandine Serrano, Saïd El Haddad, Fréderic Moal, Thierry Prazuck, Eric Legac, et al.. Dysregulation of apoptosis and autophagy gene expression in peripheral blood mononuclear cells of efficiently treated HIV-infected patients. AIDS. Official journal of the international AIDS Society, 2018, 32 (12), pp.1579 - 1587. ⟨10.1097/QAD.0000000000001851⟩. ⟨hal-01936094⟩
  • Saïd El Haddad, Amandine Serrano, Thierry Normand, Chloé Robin, Martine Dubois, et al.. Interaction of Alpha-synuclein with Cytogaligin, a protein encoded by the proapoptotic gene GALIG. Biochemical and Biophysical Research Communications, 2018, 495 (1), pp.787-792. ⟨10.1016/j.bbrc.2017.11.078⟩. ⟨hal-01966108⟩
  • Lucile Mollet, Pauline Robinet, Martine Dubois, Axel Aurouet, Thierry Normand, et al.. Opposing Mcl-1, the GALIG proapoptotic gene is upregulated as neutrophils die and underexpressed in Acute Myeloid Leukemia cells.. Molecular Immunology, 2013, 56 (1-2), pp.123-8. ⟨10.1016/j.molimm.2013.04.012⟩. ⟨hal-00840170⟩
  • Pauline Robinet, Lucile Mollet, Patrick Gonzalez, Thierry Normand, Stephane Charpentier, et al.. The mitogaligin protein is addressed to the nucleus via a non-classical localization signal. Biochemical and Biophysical Research Communications, 2010, 392 (1), pp.53-57. ⟨10.1016/j.bbrc.2009.12.162⟩. ⟨hal-00529397⟩
  • Alexis D. Sennepin, Stéphane Charpentier, Thierry Normand, Cedric Sarre, Alain Legrand, et al.. Multiple reprobing of Western blots after inactivation of peroxidase activity by its substrate, hydrogen peroxide. Analytical Biochemistry, 2009, 393 (1), pp.129-131. ⟨10.1016/j.ab.2009.06.004⟩. ⟨hal-00525339⟩
  • Patrick Gonzalez, Pauline Robinet, Stéphane Charpentier, Lucile Mollet, Thierry Normand, et al.. Apoptotic activity of a nuclear form of mitogaligin, a cell death protein. Biochemical and Biophysical Research Communications, 2009, 378 (4), pp.816-820. ⟨10.1016/j.bbrc.2008.11.133⟩. ⟨hal-00522444⟩
  • Patrick Gonzalez, Mélanie Duneau, Stéphane Charpentier, Thierry Normand, Lucile Mollet, et al.. Destabilization of Membranes Containing Cardiolipin or Its Precursors by Peptides Derived from Mitogaligin, a Cell Death Protein. Biochemistry, 2007, 46 (25), pp.7374-7382. ⟨10.1021/bi700213p⟩. ⟨hal-00159568⟩
  • M. Duneau, M. Boyer Guittaut, P. Gonzalez, S. Charpentier, T. Normand, et al.. Galig, a novel cell death gene that encodes a mitochondrial protein promoting cytochrome c release. Experimental Cell Research, 2005, 302, pp.194-205. ⟨hal-00088588⟩
  • Michaël Guittaut, Stéphane Charpentier, Thierry Normand, Martine Dubois, Jacques Raimond, et al.. Identification of an Internal Gene to the Human Galectin-3 Gene with Two Different Overlapping Reading Frames That Do Not Encode Galectin-3. Journal of Biological Chemistry, 2001, 276 (4), pp.2652-2657. ⟨10.1074/jbc.m002523200⟩. ⟨hal-02137994⟩
  • Stéphane Charpentier, Mohamed Amiche, Jan Mester, Véronique Vouille, Jean-Pierre Le Caer, et al.. Structure, Synthesis, and Molecular Cloning of Dermaseptins B, a Family of Skin Peptide Antibiotics. Journal of Biological Chemistry, 1998, 273 (24), pp.14690-14697. ⟨10.1074/jbc.273.24.14690⟩. ⟨hal-02160836⟩
  • Stéphane Charpentier, Keith Jarvie, Diana Severynse, Marc G. Caron, Mario Tiberi. Silencing of the Constitutive Activity of the Dopamine D1B Receptor. Journal of Biological Chemistry, 1996, 271 (45), pp.28071-28076. ⟨10.1074/jbc.271.45.28071⟩. ⟨hal-02160838⟩
  • Stéphane Charpentier, S. Sagan, M Naim, A Delfour, P. Nicolas. Mechanism of delta-opioid receptor selection by the address domain of dermenkephalin.. European Journal of Pharmacology, 1994, 266 (2), pp.175-80. ⟨10.1016/0922-4106(94)90107-4⟩. ⟨hal-02160840⟩
  • Mohamed Naim, Stéphane Charpentier, Pierre Nicolas, Daniel Baron. Quantitative two-dimensional nmr study of dermenkephalin, a highly potent and selective ?-opioid peptide. Biopolymers, 1993, 33 (12), pp.1889-1900. ⟨10.1002/bip.360331214⟩. ⟨hal-02160842⟩
  • S Sagan, Stéphane Charpentier, M Naim, A Delfour, P Nicolas. Opioid peptides from amphibian skin: contribution of the amino acids of the "address" domain to the -selectivity of dermenkephalin. Peptides, 1992, pp.645-646. ⟨hal-02171902⟩
  • Sandrine Sagan, Stéphane Charpentier, Antoine Delfour, Mohamed Amiche, Pierre Nicolas. The aspartic acid in deltorphin I and dermenkephalin promotes targeting to δ-opioid receptor independently of receptor binding. Biochemical and Biophysical Research Communications, 1992, 187 (3), pp.1203-1210. ⟨10.1016/0006-291X(92)90431-J⟩. ⟨hal-02171853⟩
  • P Simon, Stéphane Charpentier, J. Costentin. An automated method for the assessment of spontaneous and stereotyped climbing behavior in mice. Effects of the selective D1- and D2-dopamine receptor agonists SKF-38393 and RU-24926 and their association.. Methods and findings in experimental and clinical pharmacology, 1991, 13 (2), pp.99-104. ⟨hal-02171886⟩
  • Stéphane Charpentier, Sandrine Sagan, Antoine Delfour, Pierre Nicolas. Dermenkephalin and deltorphin I reveal similarities within ligand-binding domains of μ- and δ-opioid receptors and an additional address subsite on the δ-receptor. Biochemical and Biophysical Research Communications, 1991, 179 (3), pp.1161-1168. ⟨10.1016/0006-291x(91)91693-7⟩. ⟨hal-02171883⟩
  • Jean Bralet, Claude Mossiat, Jeanne-Marie Lecomte, Stéphane Charpentier, Claude Gros, et al.. Diuretic and natriuretic responses in rats treated with enkephalinase inhibitors. European Journal of Pharmacology, 1990, 179 (1-2), pp.57-64. ⟨10.1016/0014-2999(90)90401-q⟩. ⟨hal-02171891⟩

Communication dans un congrès5 document

  • S. El Haddad, A. Serrano, Thierry Normand, Fabienne Brulé-Morabito, L. Mollet, et al.. Cytogaligin, an additional link between Parkinson’s disease and autophagy pathways?. 7e Congrès du CFATG, Nov 2017, Paris, France. ⟨hal-02934905⟩
  • A. Serrano, Thierry Normand, S. El Haddad, M. Dubois, Stéphane Charpentier, et al.. During efficient Anti-RetroViral (ARV) therapy, the expression of GALIG and its interacting partners involved in macroautophagy are deregulated. 6es Journées Scientifiques du CFATG, Oct 2016, Bordeaux, France. ⟨hal-02934903⟩
  • S El Haddad, A Serrano, C Ozsancak, P. Auzou, F Moal, et al.. Genes de l’autophagie : marqueurs sanguins potentiels de la maladie de Parkinson. Journées de Neurologie de Langue Française, Apr 2016, Nantes, France. ⟨hal-03661930⟩
  • A Serrano, S El Haddad, T Normand, M Dubois, T Guery, et al.. Cytogaligin, one of the proteins produced by the proapoptotic GALIG gene, interacts with autophagy and proteasome molecules. 7th Proteasome Autophagy Workshop, Apr 2016, Clermont-Ferrand, France. ⟨hal-03661923⟩
  • A Serrano, T Guery, S El Haddad, M Dubois, M Schoenwald, et al.. GALIG, gène inducteur de la mort cellulaire, s’exprime au cours de la différenciation myéloïde. 10es Journées du Cancéropole Grand Ouest, Jun 2016, Les Sables d'Olonne, France. ⟨hal-03661932⟩

Documents récupérés de l'archive ouverte HAL logo

AUCAGNE Vincent

email : vincent.aucagne[remplacer_par_at]cnrs-orleans.fr

Téléphone : 02.38.25.55.77

Directeur de Recherche, Responsable de l’équipe « Protéines de synthèse et chimie bioorthogonale »


170 documents

Article dans une revue69 document

  • Kang Zhu, Chatrin Chatrin, Marcin J Suskiewicz, Vincent Aucagne, Benjamin Foster, et al.. Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L. EMBO Reports, 2024, 25 (10), pp.4172-4189. ⟨10.1038/s44319-024-00235-1⟩. ⟨hal-04739061⟩
  • Ana Novak, Florian Kersaudy, Sylvie Berger, Séverine Morisset-Lopez, François Lefoulon, et al.. An efficient site-selective, dual bioconjugation approach exploiting N-terminal cysteines as minimalistic handles to engineer tailored anti-HER2 affibody conjugates. European Journal of Medicinal Chemistry, 2023, 260, pp.115747. ⟨10.1016/j.ejmech.2023.115747⟩. ⟨hal-04222710⟩
  • Diana Fanelli, Massimiliano Beltramo, Giuseppe Conte, Benedetta Cerretini, Didier Lomet, et al.. The Kisspeptin analogue C6 induces ovulation in jennies. Theriogenology, 2022, 189, pp.107-112. ⟨10.1016/j.theriogenology.2022.06.014⟩. ⟨hal-03746194⟩
  • Karine Loth, Nicolas Parisot, Françoise Paquet, Hugo Terrasson, Catherine Sivignon, et al.. Aphid BCR4 Structure and Activity Uncover a New Defensin Peptide Superfamily. International Journal of Molecular Sciences, 2022, 23 (20), pp.12480. ⟨10.3390/ijms232012480⟩. ⟨hal-03862651⟩
  • Céline Landon, Yanyu Zhu, Mainak Mustafi, Jean-Baptiste Madinier, Dominique Lelièvre, et al.. Real-Time Fluorescence Microscopy on Living E. coli Sheds New Light on the Antibacterial Effects of the King Penguin beta-Defensin AvBD103b. International Journal of Molecular Sciences, 2022, This article belongs to the Special Issue Antimicrobial Peptides: Structure and Mechanism of Biological Activity, 23 (2057), pp.2057. ⟨10.3390/ijms23042057⟩. ⟨hal-03860107⟩
  • Flavie Derouin Tochon, Didier Lomet, Vincent Robert, Fabrice Reigner, Philippe Barrière, et al.. Treating mares with the long-acting kisspeptin analog C6 increases circulating gonadotropins but does not trigger ovulation. Agriculture, 2022, 12 (11), pp.1846. ⟨10.3390/agriculture12111846⟩. ⟨hal-03862471⟩
  • Kang Zhu, Marcin Suskiewicz, Andrea Hloušek-Kasun, Hervé Meudal, Andreja Mikoč, et al.. DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates. Science Advances , 2022, 8 (40), ⟨10.1126/sciadv.add4253⟩. ⟨hal-03862525⟩
  • Noémie de San Nicolas, Aromal Asokan, Rafael D Rosa, Sébastien N Voisin, Marie-Agnès Travers, et al.. Functional Diversification of Oyster Big Defensins Generates Antimicrobial Specificity and Synergy against Members of the Microbiota. Marine drugs, 2022, 20 (12), pp.745. ⟨10.3390/md20120745⟩. ⟨hal-04246173⟩
  • Skander Abboud, Mehdi Amoura, Jean-Baptiste Madinier, Brigitte Renoux, Sébastien Papot, et al.. Enzyme‐Cleavable Linkers for Protein Chemical Synthesis through Solid‐Phase Ligations. Angewandte Chemie International Edition, 2021, 60 (34), pp.18612-18618. ⟨10.1002/anie.202103768⟩. ⟨hal-05019646⟩
  • Ahlame Saidi, Mylène Wartenberg, J.B Madinier, Guy Ilango, Seda Seren, et al.. Monitoring Human Neutrophil Activation by a Proteinase 3 Near-Infrared Fluorescence Substrate-Based Probe. Bioconjugate Chemistry, 2021, 32 (8), pp.1782-1790. ⟨10.1021/acs.bioconjchem.1c00267⟩. ⟨hal-03525228⟩
  • Skander A Abboud, Hadji H., Michel Doudeau, Hélène Bénédetti, Vincent Aucagne. A straightforward methodology to overcome solubility challenges for N-terminal cysteinyl peptide segments used in native chemical ligation. Chemical Science, 2021, 12, pp.3194 - 3201. ⟨10.1039/d0sc06001a⟩. ⟨hal-03447239⟩
  • Skander A Abboud, Mehdi Amoura, J.B Madinier, Brigitte Renoux, Sébastien Papot, et al.. Enzyme‐Cleavable Linkers for Protein Chemical Synthesis through Solid‐Phase Ligations. Angewandte Chemie International Edition, 2021, 60 (34), pp.18612-18618. ⟨10.1002/anie.202103768⟩. ⟨hal-03335485⟩
  • Vincent Aucagne, Fabienne Burlina, Oleg Melnyk, Vladimir Torbeev. Des protéines de synthèse taillées sur mesure pour investiguer le vivant. L'Actualité Chimique, 2021, 468, pp.26-28. ⟨hal-02959387⟩
  • Sophie Laine, Jean-François Morfin, Mathieu Galibert, Vincent Aucagne, Celia ́ Bonnet, et al.. Lanthanide DO3A-Complexes Bearing Peptide Substrates: The Effect of Peptidic Side Chains on Metal Coordination and Relaxivity. Molecules, 2021, 26 (8), pp.2176. ⟨10.3390/molecules26082176⟩. ⟨hal-03437152⟩
  • Nicolas Guyot, Herve Meudal, Sascha Trapp, Sophie Iochmann, Anne Silvestre, et al.. Structure, function, and evolution of Gga -AvBD11, the archetype of the structural avian-double-β-defensin family. Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (1), pp.337-345. ⟨10.1073/pnas.1912941117⟩. ⟨hal-02522250⟩
  • Charlotte Rieux, Stéphane Goffinont, Franck Coste, Zahira Tber, Julien Cros, et al.. Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights. International Journal of Molecular Sciences, 2020, 21 (6), pp.2058. ⟨10.3390/ijms21062058⟩. ⟨hal-03082414⟩
  • Skander A. Abboud, Vincent Aucagne. An optimized protocol for the synthesis of N -2-hydroxybenzyl-cysteine peptide crypto-thioesters. Organic & Biomolecular Chemistry, 2020, 18 (40), pp.8199-8208. ⟨10.1039/d0ob01737j⟩. ⟨hal-02975540⟩
  • Mylène Wartenberg, Ahlame Saidi, Mathieu Galibert, Alix Joulin-Giet, Julien Burlaud-Gaillard, et al.. Imaging of extracellular cathepsin S activity by a selective near infrared fluorescence substrate-based probe. Biochimie, 2019, 166, pp.84-93. ⟨10.1016/j.biochi.2019.03.013⟩. ⟨hal-02088627⟩
  • Mylène Wartenberg, Ahlame Saidi, Mathieu Galibert, Alix Joulin-Giet, Julien Burlaud-Gaillard, et al.. Imaging of extracellular cathepsin S activity by a selective near infrared fluorescence substrate-based probe. Biochimie, 2019, 166, pp.84-93. ⟨10.1016/j.biochi.2019.03.013⟩. ⟨hal-03677252⟩
  • Monika Cieslikiewicz-Bouet, Svetlana Eliseeva, Vincent Aucagne, A.F. Delmas, Isabelle Gillaizeau, et al.. Near-infrared emitting lanthanide(III) complexes as prototypes of optical imaging agents with peptide targeting ability: a methodological approach. RSC Advances, 2019, 9 (3), pp.1747-1751. ⟨10.1039/c8ra09419e⟩. ⟨hal-02064990⟩
  • P.A. Parker, E.A. Coffman, K.G. Pohler, J.A. Daniel, V. Aucagne, et al.. Acute and subacute effects of a synthetic kisspeptin analog, C6, on serum concentrations of luteinizing hormone, follicle stimulating hormone, and testosterone in prepubertal bull calves. Theriogenology, 2019, 130, pp.111-119. ⟨10.1016/j.theriogenology.2019.03.002⟩. ⟨hal-02088608⟩
  • Caroline Decourt, Vincent Robert, Didier Lomet, Karine Anger, Marion Georgelin, et al.. The kisspeptin analog C6 is a possible alternative to PMSG (pregnant mare serum gonadotropin) for triggering synchronized and fertile ovulations in the Alpine goat. PLoS ONE, 2019, 14 (3), pp.e0214424. ⟨10.1371/journal.pone.0214424⟩. ⟨hal-02088631⟩
  • Julien Diharce, Mickaël Cueto, Massimiliano Beltramo, Vincent Aucagne, Pascal Bonnet. In silico peptide ligation: Iterative Residue Docking and Linking as a new approach to predict protein-peptide interactions. Molecules, 2019, 24 (7), pp.1-14. ⟨10.3390/molecules24071351⟩. ⟨hal-03525312⟩
  • Karine Loth, Agnès Vergnes, Cairé Barreto, Sébastien N Voisin, Hervé Meudal, et al.. The Ancestral N-Terminal Domain of Big Defensins Drives Bacterially Triggered Assembly into Antimicrobial Nanonets. mBio, 2019, 10 (5), pii: e01821-19. ⟨10.1128/mBio.01821-19⟩. ⟨hal-02328576⟩
  • Matthieu Galibert, Mylène Wartenberg, Fabien Lecaille, Ahlame Saidi, Sylvie Mavel, et al.. Substrate-derived triazolo- and azapeptides as inhibitors of cathepsins K and S. European Journal of Medicinal Chemistry, 2018, 144, pp.201 - 210. ⟨10.1016/j.ejmech.2017.12.012⟩. ⟨hal-01702303⟩
  • Matthieu Galibert, Mylène Wartenberg, Fabien Lecaille, Ahlame Saidi, Sylvie Mavel, et al.. Substrate-derived triazolo- and azapeptides as inhibitors of cathepsins K and S. European Journal of Medicinal Chemistry, 2018, 144, pp.201-210. ⟨10.1016/j.ejmech.2017.12.012⟩. ⟨hal-03677245⟩
  • David Montoir, Mehdi Amora, Zine El Abidine Aabasa, Thimmalapura Marulappa Vishwanatha, Expédite Yen-Pon, et al.. Synthesis of aryl-thioglycopeptides through chemoselective Pd-Mediated conjugation. Chemical Science, 2018, 9 (46), pp.8753-8759. ⟨10.1039/C8SC02370K⟩. ⟨hal-02622102⟩
  • Guillaume Martinez, Jean-Pascal Hograindleur, Sébastien Voisin, Roland Abi Nahed, Tarek M. Abd El Aziz, et al.. Spermaurin, an La1-like peptide from the venom of the scorpion Scorpio maurus palmatus , improves sperm motility and fertilization in different mammalian species. Molecular Human Reproduction, 2017, 23 (2), pp.116-131. ⟨10.1093/molehr/gaw075⟩. ⟨hal-01618630⟩
  • Victor Terrier, Agnès F. Delmas, Vincent Aucagne. Efficient synthesis of cysteine-rich cyclic peptides through intramolecular native chemical ligation of N-Hnb-Cys peptide crypto-thioesters. Organic & Biomolecular Chemistry, 2017, 15 (2), pp.316 - 319. ⟨10.1039/c6ob02546c⟩. ⟨hal-01618781⟩
  • Dominique Lelièvre, Victor P. Terrier, Agnès F. Delmas, Vincent Aucagne. Native Chemical Ligation Strategy to Overcome Side Reactions during Fmoc-Based Synthesis of C-Terminal Cysteine-Containing Peptides. Organic Letters, 2016, 18 (5), pp.920 - 923. ⟨10.1021/acs.orglett.5b03612⟩. ⟨hal-01407492⟩
  • Victor P. Terrier, Hélène Adihou, Mathieu Arnould, Agnès F. Delmas, Vincent Aucagne. A straightforward method for automated Fmoc-based synthesis of bio-inspired peptide crypto-thioesters. Chemical Science, 2016, 7 (1), pp.339 - 345. ⟨10.1039/C5SC02630J⟩. ⟨hal-01407765⟩
  • Michael T. Jacobsen, Mark E. Petersen, Xiang Ye, Mathieu Galibert, George H. Lorimer, et al.. A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis. Journal of the American Chemical Society, 2016, 138 (36), pp.11775 - 11782. ⟨10.1021/jacs.6b05719⟩. ⟨hal-01407028⟩
  • Caroline Decourt, Vincent Robert, Karine Anger, Mathieu Galibert, Jean-Baptiste Madinier, et al.. A synthetic kisspeptin analog that triggers ovulation and advances puberty. Scientific Reports, 2016, 6 (1), pp.26908. ⟨10.1038/srep26908⟩. ⟨hal-01406943⟩
  • Karine Loth, Soha Abou Ibrahim Alami, Chahrazed Habès, Solène Garrido, Vincent Aucagne, et al.. Complete 1H, 15N and 13C assignment of trappin-2 and 1H assignment of its two domains, elafin and cementoin. Biomolecular NMR Assignments, 2016, 10 (1), pp.223 - 226. ⟨10.1007/s12104-016-9671-1⟩. ⟨hal-01407495⟩
  • Audrey Gambade, Sami Zreika, Maxime Guéguinou, Igor Chourpa, Gaëlle Fromont, et al.. Activation of TRPV2 and BKCa channels by the LL-37 enantiomers stimulates calcium entry and migration of cancer cells.. Oncotarget, 2016, 7 (17), pp.23785-23800. ⟨10.18632/oncotarget.8122⟩. ⟨hal-01387061⟩
  • Mathieu Galibert, Véronique Piller, Friedrich Piller, Vincent Aucagne, Agnès F. Delmas. Combining triazole ligation and enzymatic glycosylation on solid phase simplifies the synthesis of very long glycoprotein analogues. Chemical Science, 2015, 6 (6), pp.3617-3623. ⟨10.1039/C5SC00773A⟩. ⟨hal-01178852⟩
  • Romain Barat, Thibaut Legigan, I. Tranoy-Opalinski, Brigitte Renoux, Elodie Peraudeau, et al.. A mechanically interlocked molecular system programmed for the delivery of an anticancer drug. Chemical Science, 2015, 6 (4), pp.2608-2613. ⟨10.1039/c5sc00648a⟩. ⟨hal-03127729⟩
  • Massimiliano Beltramo, Vincent Robert, Mathieu Galibert, Jean-Baptiste Madinier, Philippe Marceau, et al.. Rational Design of Triazololipopeptides Analogs of Kisspeptin Inducing a Long-Lasting Increase of Gonadotropins. Journal of Medicinal Chemistry, 2015, 58 (8), pp.3459-3470. ⟨10.1021/jm5019675⟩. ⟨hal-01170460⟩
  • Isidore E. Decostaire, Dominique Lelièvre, Vincent Aucagne, Agnès F. Delmas. Solid phase oxime ligations for the iterative synthesis of polypeptide conjugates. Organic & Biomolecular Chemistry, 2014, 12 (29), pp.5536-5543. ⟨10.1039/c4ob00760c⟩. ⟨hal-01178857⟩
  • Fanny Meindre, Dominique Lelièvre, Karine Loth, Oriane Mith, Vincent Aucagne, et al.. The nuclear magnetic resonance solution structure of the synthetic AhPDF1.1b plant defensin evidences the structural feature within the γ-motif. Biochemistry, 2014, 53 (49), pp.7745-54. ⟨10.1021/bi501285k⟩. ⟨hal-01118914⟩
  • Laurent Raibaut, Hélène Adihou, Rémi Desmet, Agnès F. Delmas, Vincent Aucagne, et al.. Highly efficient solid phase synthesis of large polypeptides by iterative ligations of bis(2-sulfanylethyl)amido (SEA) peptide segments. Chemical Science, 2013, 4, pp.4061-4066. ⟨10.1039/c3sc51824h⟩. ⟨hal-00944814v2⟩
  • Vincent Aucagne, Ibai E Valverde, Philippe Marceau, Mathieu Galibert, Nabil Dendane, et al.. Towards the simplification of protein synthesis: iterative solid-supported ligations with concomitant purifications.. Angewandte Chemie International Edition, 2012, 51 (45), pp.11320-4. ⟨10.1002/anie.201206428⟩. ⟨hal-00748170⟩
  • Christelle Gaulier, Audrey Hospital, Bertrand Legeret, Delmas A.F., Vincent Aucagne, et al.. A water soluble Cu-I-NHC for CuAAC ligation of unprotected peptides under open air conditions.. Chemical Communications, 2012, 48, pp.4005-4007. ⟨hal-00711780⟩
  • Ibai E Valverde, Fabien Lecaille, Gilles Lalmanach, Vincent Aucagne, Agnès F Delmas. Synthesis of a biologically active triazole-containing analogue of cystatin A through successive peptidomimetic alkyne-azide ligations.. Angewandte Chemie International Edition, 2012, 51 (3), pp.718-22. ⟨10.1002/anie.201107222⟩. ⟨hal-00726293⟩
  • Antony Fernandes, Aurélien Viterisi, Vincent Aucagne, David A Leigh, Sébastien Papot. Second generation specific-enzyme-activated rotaxane propeptides.. Chemical Communications, 2012, 48 (15), pp.2083-5. ⟨10.1039/c2cc17458h⟩. ⟨hal-00678757⟩
  • Chrystelle Derache, Hervé Meudal, Vincent Aucagne, Kevin J Mark, Martine Cadène, et al.. Initial insights into structure-activity relationships of avian defensins.. Journal of Biological Chemistry, 2012, 287 (10), pp.7746-55. ⟨10.1074/jbc.M111.312108⟩. ⟨hal-00721842⟩
  • Andrea Altieri, Vincent Aucagne, Romen Carrillo, Guy Clarkson, Daniel d'Souza, et al.. Sulfur-containing amide-based [2]rotaxanes and molecular shuttles. Chemical Science, 2011, 2 (10), pp.1922. ⟨10.1039/C1SC00335F⟩. ⟨hal-02088663⟩
  • Anthony Fernandes, Aurélien Viterisi, Frédéric Coutrot, Stéphanie Potok, David A. Leigh, et al.. Rotaxane-based propeptides: protection and enzymatic release of a bioactive pentapeptide.. Angewandte Chemie International Edition, 2009, 48 (35), pp.6443-7. ⟨10.1002/anie.200903215⟩. ⟨hal-00467015⟩
  • Ibai E. Valverde, Agnès F. Delmas, Vincent Aucagne. Click a la carte: robust semi-orthogonal alkyne protecting groups for multiple successive azide/alkyne cycloadditions. Tetrahedron, 2009, 65 (36), pp.7597-7602. ⟨10.1016/j.tet.2009.06.093⟩. ⟨hal-00525398⟩
  • Chrystelle Derache, Valérie Labas, Vincent Aucagne, Hervé Meudal, Céline Landon, et al.. Primary Structure and Antibacterial Activity of Chicken Bone Marrow-Derived beta-Defensins. Antimicrobial Agents and Chemotherapy, 2009, 53 (11), pp.4647-4655. ⟨10.1128/AAC.00301-09⟩. ⟨hal-00522326⟩
  • Vincent Aucagne, A. Tatibouët, Patrick Rollin. Thermodynamics versus kinetics in hetero-Michael cyclizations: a highly stereoselective approach to access both epimers of a C-D-mannopyranoside. Tetrahedron Letters, 2008, 49, pp.4750-4753. ⟨10.1016/j.tetlet.2008.05.117⟩. ⟨hal-00512453⟩
  • Dominique Lelièvre, P. Barta, Vincent Aucagne, A.F. Delmas. Preparation of peptide thioesters using Fmoc strategy through hydroxyl side chain anchoring. Tetrahedron Letters, 2008, 49 (25), pp.4016-4019. ⟨10.1016/j.tetlet.2008.04.087⟩. ⟨hal-00518141⟩
  • Julie Broggi, Nicolas Joubert, Vincent Aucagne, Sabine Berteina-Raboin, S. Diez-Gonzalez, et al.. Alkyne-Azide Click Chemistry Mediated Carbanucleosides Synthesis. Nucleosides, Nucleotides and Nucleic Acids, 2007, 26 (10-12), pp.1391-1394. ⟨10.1080/15257770701534139⟩. ⟨hal-02086003⟩
  • Vincent Aucagne, J. Berna, Jd Crowley, Sm Goldup, Kd Haenni, et al.. Catalytic "Active-Metal" template synthesis of [2]rotaxanes, [3]rotaxanes, and molecular shuttles, and some observations on the mechanism of the Cu(I)-catalyzed azide-alkyne 1,3-cycloaddition. Journal of the American Chemical Society, 2007, 129, pp.11950-11963. ⟨hal-00275210⟩
  • J. Broggi, N. Joubert, Vincent Aucagne, T. Zevaco, S. Berteina-Raboin, et al.. Study of different copper(I) catalysts for the "click chemistry" approach to carbanucleosides. Nucleosides, Nucleotides and Nucleic Acids, 2007, 26, pp.779-783. ⟨hal-00275217⟩
  • Isidore P. Decostaire, Dominique Lelièvre, Vincent Aucagne, Agnès F. Delmas. Synergic effect of hydride and proton donors in the Pd(0)-mediated deprotection of Nα-Aloc proline derivatives. Tetrahedron Letters, 2007, 48, pp.6523-6526. ⟨10.1016/j.tetlet.2007.07.061⟩. ⟨hal-00166600⟩
  • Vincent Aucagne, Kevin Hänni, David Leigh, Paul Lusby, D Barney Walker. Catalytic “Click” Rotaxanes: A Substoichiometric Metal-Template Pathway to Mechanically Interlocked Architectures. Journal of the American Chemical Society, 2006, 128 (7), pp.2186-2187. ⟨10.1021/ja056903f⟩. ⟨hal-02086010⟩
  • Vincent Aucagne, David Leigh, Julia Lock, Andrew Thomson. Rotaxanes of Cyclic Peptides. Journal of the American Chemical Society, 2006, 128 (6), pp.1784-1785. ⟨10.1021/ja057206q⟩. ⟨hal-02086005⟩
  • Vincent Aucagne, David A. Leigh. Chemoselective formation of successive triazole linkages in one pot: "click-click" chemistry. Organic Letters, 2006, 8 (20), pp.4505-4507. ⟨10.1021/ol061657d⟩. ⟨hal-00387909⟩
  • Franck Amblard, Vincent Aucagne, Pierre Guenot, Raymond Schinazi, Luigi Agrofoglio. Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series. Bioorganic and Medicinal Chemistry, 2005, 13 (4), pp.1239-1248. ⟨10.1016/j.bmc.2004.11.057⟩. ⟨hal-02086014⟩
  • Vanessa Escuret, Vincent Aucagne, Nicolas Joubert, David Durantel, Kimberly Rapp, et al.. Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: Antiviral activity and cellular toxicity. Bioorganic and Medicinal Chemistry, 2005, 13 (21), pp.6015-6024. ⟨10.1016/j.bmc.2005.06.021⟩. ⟨hal-02086013⟩
  • V. Aucagne, C. Lorin, A. Tatibouët, P. Rollin. Regioselective Michael-induced cyclisation of γ- and δ-hydroxy vinyl sulfides and vinyl dithiocarbamates. Tetrahedron Letters, 2005, 46 (25), pp.4349-4352. ⟨10.1016/j.tetlet.2005.04.112⟩. ⟨hal-02086017⟩
  • Vincent Aucagne, Franck Amblard, Luigi Agrofoglio. Highly Efficient AgNO3-Catalyzed Preparation of Substituted Furanopyrimidine Nucleosides [cf. (III)].. ChemInform, 2005, 36 (18), ⟨10.1002/chin.200518181⟩. ⟨hal-02086027⟩
  • Vincent Aucagne, Arnaud Tatibouët, Patrick Rollin. Wittig approach to carbohydrate-derived vinyl sulfides, new substrates for regiocontrolled ring-closure reactions. Tetrahedron, 2004, 60 (8), pp.1817-1826. ⟨10.1016/j.tet.2003.12.040⟩. ⟨hal-02086021⟩
  • Vincent Aucagne, Sabine Berteina-Raboin, Pierre Guenot, Luigi Agrofoglio. Palladium-Catalyzed Synthesis of Uridines on Polystyrene-Based Solid Supports. Journal of Combinatorial Chemistry, 2004, 6 (5), pp.717-723. ⟨10.1021/cc049976o⟩. ⟨hal-02086022⟩
  • Isabelle Gillaizeau, Irene m. Lagoja, Steve p. Nolan, Vincent Aucagne, Jef Rozenski, et al.. Straightforward Synthesis of Labeled and Unlabeled Pyrimidine d4Ns via 2′,3′-Diyne seco Analogues through Olefin Metathesis Reactions. European Journal of Organic Chemistry, 2003, 2003 (4), pp.666-671. ⟨10.1002/ejoc.200390107⟩. ⟨hal-02086029⟩
  • Vincent Aucagne, Maria Aversa, Anna Barattucci, Paola Bonaccorsi, Placido Giannetto, et al.. Sulfenic acids in the carbohydrate field. Synthesis of transient glycosulfenic acids and their addition to unsaturated acceptors.. Journal of Organic Chemistry, 2002, 67 (20), pp.6925-30. ⟨hal-02086034⟩
  • Vincent Aucagne, David Gueyrard, Arnaud Tatibouët, Alain Quinsac, Patrick Rollin. Synthetic Approaches to C-Glucosinolates. Tetrahedron, 2000, 56 (17), pp.2647-2654. ⟨10.1016/S0040-4020(00)00153-8⟩. ⟨hal-02086037⟩
  • V. Aucagne, D. Gueyrard, A. Tatibout, S. Cottaz, H. Driguez, et al.. the first synthesis of c-glucotropeolin. Tetrahedron Letters, 1999, pp.7319-7321. ⟨hal-00309763⟩

Communication dans un congrès39 document

  • Noémie de San Nicolas, A. Jouault, Aromal Asokan, Lhousseine Touqui, K Loth, et al.. Big-Defensin Diversification in Oysters: Implications for Host Defense and Microbiota Management (D. Destoumieux-Garzon INVITED SPEAKER). IMAP 2024 International Meeting on Antimicrobial Peptides, Sep 2024, Londres, United Kingdom. ⟨hal-04882843⟩
  • Ross Ballantine, Ameni Hadj Mohamed, Mingxiang Zhu, Aromal Asokan, Linhua Shen, et al.. Palladium-mediated S-arylation and S-allylation for late-stage peptide functionalisation and protein conjugation. 37. European Peptide Symposium. 14. International Peptide Symposium, Aug 2024, Florence, Italy. pp.692-P2.010. ⟨hal-05075799⟩
  • Hugo Terrasson, Karine Loth, Nicolas Parisot, Françoise Paquet, Isabelle Rahioui, et al.. Bacteriocyte-specific Cysteine-Rich (BCR) peptides form a new aphid-specific defensin-like family and are promising regulators of aphid symbiosis. Rencontres du Réseau Ecologie des Interactions Durables (REID), May 2023, Poitiers, France. ⟨hal-04633283⟩
  • Noémie de San Nicolas, Aromal Asokan, Rafaela da Rosa, Vincent Aucagne, K. Loth, et al.. Big defensins: A Diversified Family of Antimicrobial Peptides Confronting Versatile Microbial Environments (DELPHINE DESTOUMIEUX-GARZON INVITED SPEAKER). Antimicrobial Peptides. Yesterday, Today, and Tomorrow, Oct 2023, Omaha, Nebraska, USA, United States. ⟨hal-04885227⟩
  • Noémie de San Nicolas, A. Asokan, R.D. Rosa, S.N. Voisin, Marie Agnès Travers, et al.. Functional DIversification of Big-Defensins and the shaping of oyster microbiota. AMP 2022 7th International Symposium on Antimicrobial Peptides, Nov 2022, Paris, France. ⟨hal-03976756⟩
  • A. Asokan, Noémie de San Nicolas, H. Meudal, K. Loth, Delphine Destoumieux-Garzon, et al.. Enabling the synthesis of hydrophobic proteins using NCL-labile solubilizing tags: a case study of Crassostrea gigas big defensin 3. 22nd GFPP & 5th BPGM French-Belgian Joint Meeting, Groupe Français des Peptides et Protéines, May 2022, Port Leucate, France. ⟨hal-03976595⟩
  • Hugo Terrasson, Karine Loth, Nicolas Parisot, Françoise Paquet, Isabelle Rahioui, et al.. Peptides « Bacteriocyte-specific Cysteine Rich » (BCR) : un rôle dans le contrôle de la symbiose ? Focus sur BCR4 chez le puceron du pois.. 12èmes rencontres du réseau français de Biologie Adaptative des Pucerons et Organismes Associés (BAPOA), May 2022, Nice, France. ⟨hal-04771966⟩
  • Hugo Terrasson, Karine Loth, Nicolas Parisot, Françoise Paquet, Isabelle Rahioui, et al.. Les peptides « Bacteriocyte-specific Cystein-Rich » : une nouvelle famille de défensine. Régulateurs de la symbiose chez les pucerons ?. 9ème Journées du GDR "MultiFonction des Peptides AntiMicrobiens" (MuFoPAM), Oct 2022, Amboise, France. ⟨hal-04633233⟩
  • Vincent Aucagne. Développements méthodologiques pour la synthèse chimique de protéines. 33e colloque Biotechnocentre, Oct 2021, Chaumont-sur-Tharonne, France. ⟨hal-03563421⟩
  • Vincent Aucagne. A chemical toolbox for simplifying chemical protein synthesis. Congrès annuel de la Société Française de Biochimie et Biologie Moléculaire (SFBBM21), Jul 2021, Paris, France. ⟨hal-03563426⟩
  • Josef Hamacek, Edina Numanovic, Vincent Aucagne. Determination of Binding Affinities with Flow-Induced Dispersion Analysis: The Case of Synthetic Affibodies. NECTAR, annual meeting, Aug 2021, Lisbon, Portugal. ⟨hal-03482197⟩
  • David Montoir, Mehdi Amoura, Zine El Abidine Ababsa, T.M. Vishwanatha, Expédite Yen-Pon, et al.. Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation. 4. GFPP Chemical Ligation Meeting (Ligation2020), Jan 2020, Orléans, France. ⟨hal-02892772⟩
  • K Loth, Agnès Vergnes, C Barreto, S Voisin, H. Meudal, et al.. Exploring ancestral traits lost during molecular evolution of Big-Defensins Towards β-defensins (DELPHINE DESTOUMIEUX-GARZON, INVITED SPEAKER). Gordon Research Conference "Antimicrobial Peptides", Feb 2019, Barga, Italy. ⟨hal-04891216⟩
  • Vincent Aucagne. Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteins. Institut de Chimie des Substances Naturelles, Mar 2019, Gif-sur-Yvette, France. ⟨hal-02974369⟩
  • S. Abboud, Mehdi Amoura, V. P. Terrier, A. F. Delmas, V. Aucagne. An improved synthesis of N-Hnb-Cys peptide crypto-thioesters ‒studies on the epimerization of cysteine during solid-phase reductive amination. 21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France. ⟨hal-02892784⟩
  • H. Meudal, Nicolas Guyot, K. Loth, G. Jousset, S. Trapp, et al.. Gga-AvBD11, the archetype of a new structural family of defensins. 21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France. ⟨hal-02892790⟩
  • D. Montoir, Mehdi Amoura, A. Ababsa Z. E., M. Vishwanatha T., E. Yen-Pon, et al.. ”Tag and modify” strategy for the Pd-catalyzed Thioglycoconjugation of peptides. Noncanonical amino acids (ncAAs): Tools for biological and biophysical investigations, Oct 2019, Paris, France. ⟨hal-02892775⟩
  • G. Lalmanach, M. Wartenberg, M. Galibert, A. Saidi, F. Lecaille, et al.. Design of both pseudopeptide inhibitors and imaging probes derived from a unique substrate sequence: a versatile molecular toolbox for studying proteases. 21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France. ⟨hal-02892793⟩
  • S. Abboud, V. Piller, S. Papot, V. Aucagne. Développement de bras enzymo-labiles pour la synthèse totale de protéines par ligations chimiques sur support solide. 32e Colloque Biotechnocentre, Oct 2019, Seillac, France. ⟨hal-02893386⟩
  • Julien Diharce, Mickaël Cueto, Vincent Aucagne, Massimiliano Beltramo, Pascal Bonnet. Fragment covalent docking (FCD) approach: An innovative in silico tools for the prediction of peptide-protein interaction. 256th National Meeting and Exposition of the American-Chemical-Society Nanoscience, Nanotechnology and Beyond (ACS), American Chemical Society (ACS). USA., Aug 2018, Boston, United States. pp.2. ⟨hal-02734800⟩
  • T.M. Vishwanatha, C. Decourt, V.P. Terrier, V. Robert, M. Galibert, et al.. Rational design of kisspeptin analogs for the control of reproduction. 4th Belgian Peptide Group Meeting, Feb 2018, Bruxelles, Belgium. ⟨hal-02892809⟩
  • Mehdi Amoura, D. Sarraf, L. Nauton, V.P. Terrier, D. Lelièvre, et al.. N-2-hydroxybenzyl-cysteine peptide crypto-thioesters for native chemical ligation. 35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland. ⟨hal-02892802⟩
  • Nicolas Guyot, Hervé Meudal, Karine Loth, Guillaume Jousset, Anne Silvestre, et al.. 1ère structure 3D d’une défensine à double motif β-défensine, Gga-AvBD11 du poulet Gallus gallus, et explorations fonctionnelles. 5es Journées GDR MuFoPAM, Centre National de la Recherche Scientifique (CNRS). FRA., Oct 2018, Paris, France. ⟨hal-02788993⟩
  • A.F. Delmas, Vincent Aucagne. Synthesis and structural characterization of naturally-occuring disulfide rich antimicrobial peptides Gyros Protein Technologies. European peptide symposium, Aug 2018, Dublin, Ireland. ⟨hal-02919154⟩
  • Vincent Aucagne. Séminaire invité : Développement d’une boîte à outils pour simplifier la synthèse chimique de protéines. Institut des Biomolécules Max Mousseron, Nov 2018, Montpellier, France. ⟨hal-02974372⟩
  • Vincent Aucagne. Séminaire invité : Développement d'une boîte à outils pour simplifier la synthèse chimique de protéines. Laboratoire BioCIS - Biomolécules : Conception, Isolement et Synthèse, Université Paris-Sud, Apr 2017, Châtenay-Malabry, France. ⟨hal-02974390⟩
  • Vincent Aucagne. Simplifier la synthèse totale de protéines et de mini-protéines riches en pont disulfures. 7e Symposium Francophone de Synthèse Totale (SFST7), Jun 2017, Orsay, France. ⟨hal-02892762⟩
  • Vincent Aucagne. Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteins and constrained peptides natural products. Institut Européen de Chimie et Biologie, Apr 2017, Bordeaux, France. ⟨hal-02974400⟩
  • Vincent Aucagne. Séminaire invité : Triazolopeptides as proteolysis-resistant, highly potent KISS1R agonists. Universiteit Gent, May 2017, Gand, Belgium. ⟨hal-02974376⟩
  • A. Casas-Mora, M. Galibert, A.F. Delmas, V. Aucagne. A non-chromatographic catch-and-release purification method to simplify the synthesis of cysteine-rich peptides. 20e réunion du Groupe Français des Peptides et des Protéines (GFPP 20), Mar 2017, Arcachon, France. ⟨hal-02893392⟩
  • Vincent Aucagne. Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteins and constrained peptides natural products. Vrije Universiteit Brussel, May 2017, Bruxelles, Belgium. ⟨hal-02974374⟩
  • A.F. Delmas, V.P. Terrier, R.D. Rosa, A. Bressan, P. Marceau, et al.. Native Chemical ligation simplifies the access of multidomain antimicrobial peptides: application to the study of big-defensins. International symposium on AntiMicrobial Peptides (AMP2016), Jun 2016, Montpellier, France. ⟨hal-02892834⟩
  • Vincent Aucagne. Séminaire invité : A molecular toolbox for exploring new chemical spaces: making simpler the synthesis of biologically- and therapeutically-relevant small proteins and complex peptides. Sanofi, Sep 2016, Francfort, Germany. ⟨hal-02974403⟩
  • Vincent Aucagne. Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteins.. Institut Curie, Jun 2016, Paris, France. ⟨hal-02974405⟩
  • Massimiliano Beltramo, Vincent Aucagne, Vincent Robert, Mathieu Galibert, Jean-Baptiste Madinier, et al.. New KISS1R agonists with potential for the treatment of reproductive disorder. 11. International Symposium on GnRH: The hypothalamic-pituitary-gonadal axis in cancer and reproduction, Kenes International. USA., Feb 2014, Salzburg, Austria. ⟨hal-02742248⟩
  • Massimiliano Beltramo, Vincent Aucagne, Vincent Robert, Mathieu Galibert, Jean-Baptiste Madinier, et al.. Design and profiling of new selective KISS1R agonists that stimulate the reproductive system. 8. International Congress of Neuroendocrinology, Society for Behavioral Neuroendocrinology (SBN). USA., Aug 2014, Sydney, Australia. ⟨hal-02738894⟩
  • Chrystelle Derache, Hervé Meudal, Vincent Aucagne, Martine Cadène, Agnès Delmas, et al.. First insights into the structure-activity relationships of avian beta-defensins.. 2nd International Symposium on Antimicrobial Peptides - Food Veterinary Medical and Novel Applications., 2009, Saint-Malo, France. ⟨hal-02753345⟩
  • Anne-Christine Lalmanach, Chrystelle Derache, Evelyne Esnault, Valérie Labas, V. Aucagne, et al.. Avian beta-defensins in the control of bacterial pathogens of chicken digestive tract. 2. International Symposium on Antimicrobial Peptides. Food Veterinary Medical and Novel Applications, Jun 2009, Saint-Malo, France. ⟨hal-02751627⟩
  • P. da Silva, I. Rahioui, C. Laugier, Yvan Rahbé, A. Delmas, et al.. PA1b, un peptide à activité insecticide : relations structure/fonction. XVème Colloque de Physiologie de l'Insecte, 2007, Rennes (France), juillet 2007, France. pp.1-1. ⟨hal-00391295⟩

Poster56 document

  • Hugo Terrasson, Karine Loth, Nicolas Parisot, Françoise Paquet, Isabelle Rahioui, et al.. The aphid BCR4 structure and activity uncover a new defensin peptide superfamily. XXVII International Congress of Entomology, Aug 2024, Kyoto, Japan. ⟨hal-04702878⟩
  • Hugo Terrasson, Karine Loth, Françoise Paquet, Nicolas Parisot, Isabelle Rahioui, et al.. The Bacteriocyte-specific Cysteine-Rich (BCR) proteins: a role in the control of aphid symbiosis ?. Journée scientifique enjeu « santé globale et bio‐ingénierie » de l'INSA Lyon, Apr 2023, Villeurbanne, France. ⟨hal-04633269⟩
  • Hugo Terrasson, Karine Loth, Nicolas Parisot, Françoise Paquet, Isabelle Rahioui, et al.. Bacteriocyte specific Cystein Rich peptides, a new defensin like protein family , are promising regulators of aphid symbiosis. 10th congress of the International Symbiosis Society (ISS) - 3rd International Conference on Holobionts (joint meeting), Jul 2022, Lyon, France. ⟨hal-04771990⟩
  • Noémie de San Nicolas, A Asokan, S Voisin, A Delmas, Vincent Aucagne, et al.. Role of big-defensins in the control of oyster microbiota. 8ème journées du GDR MuFoPAM, Oct 2021, Marseille, France. . ⟨hal-04888804⟩
  • S. Abboud, A.F. Delmas, V. Aucagne. Synthesis of N-Hnb-Cys peptide crypto-thioesters: identification of imadozolidinone and epimerized side products, and development of an optimized protocol. 4th GFPP Chemical Ligation Meeting (Ligation2020), Jan 2020, Orléans, France. ⟨hal-02893398⟩
  • T.M. Vishwanatha, D. Montoir, Mehdi Amoura, Z. El Ababsa, E. Yen-Pon, et al.. Synthesis of aryl-thioglycopeptides through chemoselective Pd-catalyzed conjugation. 26. American Peptide Symposium (APS 2019), Jun 2019, Monterey, Californie, United States. ⟨hal-02893419⟩
  • T.M. Vishwanatha, D. Montoir, Mehdi Amoura, Z. El Ababsa, E. Yen-Pon, et al.. Synthesis of aryl-thioglycopeptides through chemoselective Pd-catalyzed conjugation. 21. Réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France. ⟨hal-02893488⟩
  • Françoise Paquet, K. Loth, C. Arnoult, V. Aucagne, A.F. Delmas. Spermaurin, a scorpion venom disulfide-rich miniprotein that improves sperm motility and fertilization in mammals.. 21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France. ⟨hal-02893462⟩
  • H. Meudal, K. Loth, G. Jousset, V. Aucagne, Nicolas Guyot, et al.. A new structural family for antimicrobial defensins. NMR : a tool for biology XIth, Jan 2019, Paris, France. ⟨hal-02919171⟩
  • F. Coste, G. Chaume, J.-B. Madinier, I. Rahioui, B. Castaing, et al.. Incorporation of trifluoromethylated pseudoproline in an entomotoxic knottin: effects on oxidative folding, 3D structure and biological activity. 21e congrès du Groupe Français des Peptides et des Protéines (GFPP), May 2019, Amboise, France. ⟨hal-02893471⟩
  • Vincent Robert, Vishwanatha Thimmalapura Marulappa, Didier Lomet, Caroline Decourt, Laia Miret, et al.. Design of GPR54 (Kiss1r) crosslinker peptides: new tools to study G protein-coupled receptors (GPCR) localization and function. SNE, Oct 2019, Tours, France. ⟨hal-03381932⟩
  • S. Abboud, Mehdi Amoura, V.P. Terrier, A.F. Delmas, V. Aucagne. An improved synthesis of N-Hnb-Cys peptide crypto-thioesters - studies on the epimerization of cysteine during solid-phase reductive amination. 8th Chemical Protein Synthesis meeting (CPS2019), Jun 2019, Berlin, Germany. ⟨hal-02893426⟩
  • Herve Meudal, Françoise Paquet, Laurence Jouvensal, V. Aucagne, A.F. Delmas, et al.. Chemical synthesis and natural abundance NMR: an efficient tandem to unravel 3D structures of unlabeled disulfide rich peptides. 21e congrès du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France. ⟨hal-02919180⟩
  • S. Abboud, Mehdi Amoura, P. Terrier V., A.F. Delmas, V. Aucagne. N-Hnb-Cys peptide crypto-thioesters: optimized synthetic protocol and second generation device. Noncanonical amino acids (ncAAs): Tools for biological and biophysical investigations, Oct 2019, Paris, France. ⟨hal-02893409⟩
  • David Montoir, Mehdi Amoura, Zine El Abidine Ababsa, Thimmalapura Marulappa Vishwanatha, Expédite Yen-Pon, et al.. Synthesis of aryl-Thioglycopeptides through chemoselective Pd-catalyzed conjugation. 35 th European Peptide Symposium, Aug 2018, Dublin, Ireland. 2018. ⟨hal-02734043⟩
  • Mehdi Amoura, V.P. Terrier, A.F. Delmas, V. Aucagne. N-2-Hydroxybenzyl-Cysteine Peptides as Efficient Thioester Surrogates for Native Chemical Ligation. 4th Belgian Peptide Group Meeting, Feb 2018, Bruxelles, Belgium. ⟨hal-02894279⟩
  • H. Meudal, Laurence Jouvensal, K. Loth, Françoise Paquet, V. Aucagne, et al.. Chemical synthesis and natural abundance NMR: An efficient tandem to unravel 3D structures of Disulfide Rich Miniproteins. 35th European Peptide Symposium, Aug 2018, Dublin, Ireland. ⟨hal-02920483⟩
  • F. Coste, G. Chaume, J.-B. Madinier, I. Rahioui, B. Castaing, et al.. Incorporation of trifluoromethylated pseudoproline in an entomotoxic knottin: effects on oxidative folding, 3D structure and biological activity. 35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland. ⟨hal-02894161⟩
  • Massimiliano Beltramo, Caroline Decourt, Vincent Robert, Didier Lomet, Vincent Aucagne. In non-breeding ewes the kisspeptin analog c6 triggers ovulation without progestogen priming. 9th International Congress of Neuroendocrinology, Jul 2018, Toronto, Canada. , 2018, The 9th International Congress of Neuroendocrinology. Abstract book. ⟨hal-02735160⟩
  • Françoise Paquet, H. Meudal, Laurence Jouvensal, K. Loth, V. Aucagne, et al.. Synthèse chimique et RMN en abondance naturelle : un tandem efficace pour résoudre les structures 3D de peptides/protéines riches en ponts disulfure. 5es journées annuelles du GDR MuFoPAM, Oct 2018, Paris, France. ⟨hal-02920025⟩
  • R. Cameron, R. Kirkwood, M. Beltramo, V. Aucagne, A. Tilbrook. A single injection of compound 6 evoked an LH surge and ovulation in 18 week old gilts. 100th annual meeting of the Endocrine Society (ENDO 2018), Mar 2018, Chicago, Illinois, United States. Endocrine Reviews, 39 (Suppl. 1), pp.281-282, The Endocrine Society’s 100th Annual Meeting and Expo. ⟨10.1093/edrv/39.supp.1⟩. ⟨hal-02894272⟩
  • Mehdi Amoura, V.P. Terrier, A.F. Delmas, V. Aucagne. Design and optimization of alternative thioester precursors to simplify protein synthesis by native chemical ligation. 25th SCT Young Research Fellows meeting, Mar 2018, Orléans, France. ⟨hal-02894273⟩
  • Mehdi Amoura, V.P. Terrier, A.F. Delmas, V. Aucagne. Second generation N-2-hydroxybenzyl-cysteine peptide crypto-thioesters for native chemical ligation. 35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland. ⟨hal-02894157⟩
  • T.M. Vishwanatha, C. Decourt C, V. Robert, M. Galibert, J.-B. Madinier, et al.. Long-lasting increase of gonadotropins by rational design of lipophilic kisspeptin analogs. 2018 International Symposium on Chemical Biology, Jan 2018, Genève, Switzerland. ⟨hal-02894282⟩
  • C. Decourt, V. Robert, Didier Lomet, V. Aucagne, Massimiliano Beltramo. The kisspeptin analog C6 triggers ovulation in non-breeding ewe in the absence of progestogen priming. 9. International Congress of Neuroendocrinology (ICN 2018), Jul 2018, Toronto, Canada. ⟨hal-02894264⟩
  • S.V. Eliseeva, V. Aucagne, A.F. Delmas, S. Petoud, I. Gillaizeau. Near-infrared emitting lanthanide molecules, macromolecules and nanomaterials: New perspectives of optical biological imaging of living systems. GDR AIm 2018 - 1ères Journées du GDR AİM: "Agents d'imagerie moléculaire", Jun 2018, Orléans, France. ⟨hal-03326661⟩
  • S. Abboud, V. Piller, S. Papot, A.F. Delmas, V. Aucagne. Development of chemo-enzymatic methodologies for the total synthesis of proteins through solid-supported chemical ligation. 31e Colloque Biotechnocentre, Oct 2018, Seillac, France. ⟨hal-02894152⟩
  • T.M. Vishwanatha, C. Decourt, V.P. Terrier, V. Robert, J.-B. Madinier, et al.. Rational design of kisspeptin analogs for the control of the reproductive system. 25th SCT Young Research Fellows meeting, Mar 2018, Orléans, France. ⟨hal-02894277⟩
  • Mehdi Amoura, V.P. Terrier, D. Lelièvre, A.F. Delmas, V. Aucagne. N-2-Hydroxybenzyl-Cysteine Peptides as Efficient Thioester Surrogates for Native Chemical Ligation. 7th Chemical Protein Synthesis meeting (CPS 2017), Sep 2017, Haifa, Israel. ⟨hal-02894290⟩
  • Mehdi Amoura, V. P. Terrier, A.F. Delmas, Vincent Aucagne. Second generation N-2-hydroxybenzyl-cysteine peptide crypto-thioesters: achieving very fast NCL kinetics at neutral pH. 20e congrès annuel du Groupe Français des Peptides et Protéines (GFPP), Mar 2017, Arcachon, France. ⟨hal-02453275⟩
  • A.F. Delmas, K. Loth, Herve Meudal, V.P. Terrier, R.D. Rosa, et al.. NCL-based synthesis, 3D structure and first insight into antimicrobial properties of Cg-BigDef1, an oyster big defensin active at high salinity. 20e congrès annuel du Groupe Français des Peptides et Protéines (GFPP), Mar 2017, Arcachon, France. ⟨hal-02894301⟩
  • Caroline Decourt, Vincent Robert, Didier Lomet, Vincent Aucagne, Greg Anderson, et al.. Investigation of a kisspeptin analog effects both on synchronization of ovulation and puberty onset in domestic mammals and in rodents. ReproSciences 2017, Apr 2017, Tours, France. 75 p., 2017, 2èmes Journées Scientifiques du GdR Repro. ⟨hal-01603310⟩
  • N. J. Stanley, D. Lelièvre, A.F. Delmas, Vincent Aucagne. Development of highly base-labile linkers for the catch-and-release purification of difficult peptides. Application to Avian beta-defensin 2. 20e congrès annuel du Groupe Français des Peptides et Protéines (GFPP), Mar 2017, Arcachon, France. . ⟨hal-02453245⟩
  • A. Delmas, K. Loth, Herve Meudal, V. Terrier, R.D. Rosa, et al.. NCL-based synthesis, 3D structure and first insight into antimicrobial properties of Cg-BigDef1, an oyster big defensin active at high salinity. NMR: a tool for Biology Xth, Jan 2017, Paris, France. ⟨hal-02453460⟩
  • Vincent Robert, Vincent Aucagne, Caroline Decourt, Massimiliano Beltramo. Do endogenous kisspeptins and synthetic agonist C6 trigger different intracellular responses?. 42e colloque de la société de neuroendocrinologie (SNE 2017), Sep 2017, Dijon, France. 2017, 42ème Colloque de la Société de Neuroendocrinologie. ⟨hal-02733747⟩
  • A. Casas-Mora, M. Galibert, A.F. Delmas, V. Aucagne. Design of a New N-Terminal Linker for the Capture-and-Release Purification of Biologically-Relevant Disulfide-Rich Peptides. 25th American Peptide Symposium (APS 25), Jun 2017, Whistler, Canada. ⟨hal-02894295⟩
  • Vincent Aucagne, E. Schmitt, P. Bulet, C. Arnoult.. NCL-based total synthesis of spermaurin, a scorpion venom disulfide-rich miniprotein that improves sperm motility and fertilization in mammals. 20e congrès annuel du Groupe Français des Peptides et Protéines (GFPP), Mar 2017, Arcachon, France. . ⟨hal-02453195⟩
  • Caroline Decourt, Vincent Robert, Didier Lomet, Karine Anger, A. Delmas, et al.. Investigation of tachyphylaxis of LH response following repeated injections of the kisspeptin analog C6. Colloque International NeuroFrance 2017, May 2017, Bordeaux, France. 2017, Colloque International NeuroFrance 2017. ⟨hal-01605114⟩
  • C. Decourt, V. Robert, D. Lomet, Vincent Aucagne, G. Anderson, et al.. Pattern of LH secretion after repeated treatment with kisspeptin analog C6 reveals differential sensitivity between mice and ewes. 42. Colloque de la société de neuroendocrinologie (SNE 2017), Sep 2017, Dijon, France. ⟨hal-02894288⟩
  • Mehdi Amoura, V.P. Terrier, D. Lelièvre, A.F. Delmas, V. Aucagne. N-2-Hydroxybenzyl-Cysteine Peptides as Efficient Thioester Surrogates for Native Chemical Ligation. 25th American Peptide Symposium (APS 25), Jun 2017, Whistler, Canada. ⟨hal-02894293⟩
  • Agnes Vergnes, Victor P. Terrier, Bressan Albert, Rafael Diego Rosa, Vincent Aucagne, et al.. Laligation native simplifie l’étude de l’activité etdu mécanismed’action des peptides antimicrobiens à multiples domaines :cas des Big défensines d’huître.. IIIèmes journées annuelles MuFoPAM « MultiFonction des Peptides AntiMicrobiens », Oct 2016, Tours, France. ⟨hal-02128427⟩
  • A. Casas-Mora, M. Galibert, A.F. Delmas, V. Aucagne. A capture-and-release purification strategy to simplify the synthesis of disulfide-rich peptides. 1st PSL Chemical Biology Meeting, Dec 2016, Paris, France. . ⟨hal-02453303⟩
  • Caroline Decourt, Vincent Robert, Didier Lomet, Karine Anger, M. Galibert, et al.. Induction of fertile ovulation and puberty advancement by a new kisspeptin analog. 18th International Congress on Animal Reproduction (ICAR), Jun 2016, Tours, France. 676 p., 2016, 18th International Congress on Animal Reproduction (ICAR). ⟨hal-01604087⟩
  • V. P. Terrier, H. Adihou, D. Lelièvre, Mehdi Amoura, A.F. Delmas, et al.. A straightforward strategy for automated Fmoc-based synthesis of peptide “crypto-thioesters”. Application to the total synthesis of biologically-relevant disulfide-rich peptides. Journées de Chimie Organique de la Société Chimique de France (JCO2016), Dec 2016, Palaiseau, France. . ⟨hal-02453318⟩
  • A.F. Delmas, V.P. Terrier, R.D. Rosa, A. Bressan, P. Marceau, et al.. Native Chemical ligation simplifies the access of multi-domain antimicrobial peptides: application to the study of big-defensins. 34th European Peptide Symposium 2016 (EPS2016), Sep 2016, Leipzig, Germany. ⟨hal-02895296⟩
  • M. Beltramo, V. Robert, D. Lomet, K. Anger, M. Galibert, et al.. A new selective kisspeptin analog, C6, that advance puberty in mice and stimulate fertile ovulation in ewe. British Society for Neuroendocrinology Annual Meeting, Sep 2016, Glasgow, United Kingdom. ⟨hal-02453336⟩
  • Caroline Decourt, Vincent Robert, Didier Lomet, Karine Anger, Mathieu Galibert, et al.. Induction of synchronized fertile ovulation by a new selective agonist of kisspeptin receptor. 1 Journées du GdR 3606 Repro, Apr 2015, Rennes, France. 105 p., 2015, 1ères Journées Scientifiques du GdR Repro. ⟨hal-02742326⟩
  • Vincent Aucagne, Vincent Robert, Mathieu Galibert, Jean-Baptiste Madinier, P. Marceau, et al.. Rational design of triazolo-lipopeptides analogs of kisspeptin inducing a long-lasting increase of gonadotropins. 24. Meeting of the American Peptide Society, Jun 2015, Orlando, United States. 2015, 24th Meeting of the American Peptide Society. ⟨hal-02741835⟩
  • Vincent Aucagne, Vincent Robert, Mathieu Galibert, Jean-Baptiste Madinier, P. Marceau, et al.. Rational design of triazolo-lipopeptides analogs of kisspeptin inducing a long-lasting increase of gonadotrophins. 19. Congrès du Groupe Français des Peptides et des Protéines, May 2015, Port-Bail, United States. 2015. ⟨hal-02793091⟩
  • Caroline Decourt, Karine Anger, Vincent Robert, Vincent Aucagne, Mathieu Galibert, et al.. Development of new kisspeptin analogs to stimulate the reproductive system. International Conference on Gonadotropins & Receptors, Sep 2014, Tours, France. , 2014, ICGRIII International Conference on Gonadotropins & Receptors. ⟨hal-02744014⟩
  • Massimiliano Beltramo, V. Aucagne, R. Vincent, M. Galibert, J.B. Madinier, et al.. La kisspeptine : une nouvelle voie pour maitriser l’ovulation chez les petits ruminants ?. 5. Journées d'Animation Scientifique du département Phase (JAS Phase 2013), Oct 2013, Paris, France. 2013. ⟨hal-02805330⟩
  • Massimiliano Beltramo, V. Aucagne, Vincent Robert, M. Galibert, J.B. Madinier, et al.. Design and functional profiling of new KISS1R agonists. 2. Annual Meeting of the GDR RCPG-PhysioMed, Oct 2013, Illkirch, France. 2013, 2nd Annual Meeting of the GDR RCPG-PhysioMed. ⟨hal-02745908⟩
  • Mathieu Galibert, Chrystelle Derache, Franck Coste, Hervé Meudal, Anne-Christine Lalmanach, et al.. Improvement of the chemical production of β-defensins including straightforward attribution of disulfide bridges. 18. Réunion du GFPP, May 2013, Sète, France. 1 p., 2013. ⟨hal-02805308⟩
  • M. Galibert, Chrystelle Derache, F. Coste, H. Meudal, Anne-Christine Lalmanach, et al.. Improvement of the chemical production of β-defensins including straighforward attribution of disulfide bridges. 3. International Symposium on Antimicrobial Peptides: Today knowledge and future applications, Jun 2012, Lille, France. , pp.C-43, 2012, AMP 2012 - Antimicrobial peptide symposium. ⟨hal-02748134⟩
  • Chrystelle Derache, Emmanuel Kut, Hervé Meudal, Vincent Aucagne, Agnès Delmas, et al.. Antibacterial spectrum of avian defensin 2: peculiarities in relationship with structural features. 3. International Symposium on Antimicrobial Peptides: Today knowledge and future applications (AMP 2012), Jun 2012, Lille, France. , pp.D-97, 2012. ⟨hal-02807349⟩
  • Chrystelle Derache, Hervé Meudal, Vincent Aucagne, Anne-Christine Lalmanach, Céline Landon, et al.. Synthesis and oxidative folding of functional miniproteins containing three disulfide bridges. 21e Colloque Biotechnocentre, 2008, Seillac, France. 1 p, 2008. ⟨hal-02818274⟩

Chapitre d'ouvrage2 document

  • S. Abboud, A.F. Delmas, V. Aucagne. Solid phase chemical ligation. Brik Asharf, Dawson Philip, Liu Lei. Total Chemical Protein Synthesis, Wiley, 2021, 978-3-527-34660-8. ⟨hal-02974365⟩
  • Vincent Aucagne. (9H‐Fluoren‐9‐yl)methanethiol. Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd, 2011, ⟨10.1002/047084289X.rn01287⟩. ⟨hal-02071829⟩

Brevet3 document

  • Nicolas Guyot, Sophie Réhault-Godbert, Anne Silvestre, Sascha Trapp, Sophie Iochmann, et al.. Peptides dérivés d'une beta-défensine 11 aviaire et leurs utilisations. France, N° de brevet: WO 2020/030773 A1. AMV; SA, 3IMo, AIM. 2020. ⟨hal-02595638⟩
  • Massimiliano Beltramo, Vincent Aucagne, Alain Caraty, Agnès Delmas, Mathieu Galibert. KISS1R receptor agonist compounds and use thereof for inducing ovulation in mammals. Patent n° : WO2014118318 (A1). 2014, 49 p. + 12 p. annexes. ⟨hal-02793004⟩
  • Massimiliano Beltramo, Vincent Aucagne, Alain Caraty, Agnès Delmas. Composés agonistes du récepteur KISS1R et leur utilisation pour induire l’ovulation chez les mammiféres. N° de brevet: FR3001455 (A1). 2013, 34 p. + 10 p. annexes. ⟨hal-02808772⟩

Pré-publication, Document de travail1 document

  • El Hadji Cisse, Vincent Aucagne. A straightforward method to prevent the under-estimated problem of aspartimide formation during chemical ligation-mediated protein synthesis. 2024. ⟨hal-04797697⟩

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