Organisation : Equipe Biologie cellulaire, Cibles moléculaires et Thérapies innovantes

MOSRIN-HUAMAN Christine

email : christine.mosrin[remplacer_par_at]cnrs-orleans.fr

Téléphone : 02.38.25.76.11

Chargée de recherche au sein du Groupe thématique « Signalisation cellulaire et neurofibromatose »

 

 


38 documents

Article dans une revue21 document

  • Valentin Beauvais, Kevin Moreau, Bojan Žunar, Nadège Hervouet-Coste, Ana Novačić, et al.. Tho2 is critical for the recruitment of Rrp6 to chromatin in response to perturbed mRNP biogenesis. RNA, 2024, 30 (1), pp.rna.079707.123. ⟨10.1261/rna.079707.123⟩. ⟨hal-04286417⟩
  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection. Journal of Molecular Biology, 2024, 436 (22), pp.168768. ⟨10.1016/j.jmb.2024.168768⟩. ⟨hal-04771131⟩
  • Elodie Villalonga, Christine Mosrin, Thierry Normand, Caroline Girardin, Amandine Serrano, et al.. LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features. Cells, 2023, 12 (5), pp.805. ⟨10.3390/cells12050805⟩. ⟨hal-04208405⟩
  • Bojan Žunar, Christine Mosrin-Huaman, Hélène Bénédetti, Béatrice Vallée. Re-engineering of CUP1 promoter and Cup2/Ace1 transactivator to convert Saccharomyces cerevisiae into a whole-cell eukaryotic biosensor capable of detecting 10 nM of bioavailable copper. Biosensors and Bioelectronics, 2022, 214, pp.114502. ⟨10.1016/j.bios.2022.114502⟩. ⟨hal-03820214⟩
  • Mohammed Bergoug, Michel Doudeau, Fabienne Godin, Christine Mosrin-Huaman, Béatrice Vallée, et al.. Neurofibromin Structure, Functions and Regulation. Cells, 2020, 9, ⟨10.3390/cells9112365⟩. ⟨hal-03070759v2⟩
  • Kévin Moreau, Aurélia Le Dantec, Christine Mosrin-Huaman, Yves Bigot, Benoit Piegu, et al.. Perturbation of mRNP biogenesis reveals a dynamic landscape of the Rrp6-dependent surveillance machinery trafficking along the yeast genome. RNA Biology, 2019, 16 (7), pp.879-889. ⟨10.1080/15476286.2019.1593745⟩. ⟨hal-02117640⟩
  • Kévin Moreau, Justine Surand, Aurélia Le Dantec, Christine Mosrin-Huaman, Alain Legrand, et al.. Recombinant yeast and human cells as screening tools to search for antibacterial agents targeting the transcription termination factor Rho. Journal of Antibiotics, 2018, 71 (4), pp.447-455. ⟨hal-01966171⟩
  • Christine Mosrin-Huaman, Nadège Hervouet-Coste, A. Rachid Rahmouni. Co-transcriptional degradation by the 5′-3′ exonuclease Rat1p mediates quality control of HXK1 mRNP biogenesis in S. cerevisiae. RNA Biology, 2016, 13 (6), pp.582 - 592. ⟨10.1080/15476286.2016.1181255⟩. ⟨hal-01407513⟩
  • Rachid A. Rahmouni, Christine Mosrin-Huaman. In Situ Footprinting of E. coli Transcription Elongation Complex with Chloroacetaldehyde. Methods in Molecular Biology, 2015, Methods in Molecular Biology, 1276, pp.229-240. ⟨10.1007/978-1-4939-2392-2_13⟩. ⟨hal-01171857⟩
  • Christine Mosrin-Huaman, Nadege Hervouet-Coste, Aurélia Le Dantec, Igor Stuparevic, A. Rachid Rahmouni. Bacterial Rho helicase: a new tool to dissect mRNP biogenesis and quality control in yeast. Trends in cell and molecular biology, 2014, 9, pp.79 - 93. ⟨hal-01179495⟩
  • Igor Stuparevic, Christine Mosrin-Huaman, Nadège Hervouet-Coste, Mateja Remenaric, A. Rachid Rahmouni. Co-transcriptional recruitment of the RNA exosome cofactors Rrp47p, Mpp6p and two distinct TRAMP complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant mRNP in yeast. Journal of Biological Chemistry, 2013, ⟨10.1074/jbc.M113.491290⟩. ⟨hal-00874892⟩
  • Romy Honorine, Christine Mosrin-Huaman, Nadege Hervouet-Coste, Domenico Libri, Rachid A. Rahmouni. Nuclear mRNA quality control in yeast is mediated by Nrd1 co-transcriptional recruitment, as revealed by the targeting of Rho-induced aberrant transcripts. Nucleic Acids Research, 2011, 39 (7), pp.2809-2820. ⟨10.1093/nar/gkq1192⟩. ⟨hal-00602376⟩
  • Christine Mosrin-Huaman, Romy Honorine, A. Rachid Rahmouni. Expression of Bacterial Rho Factor in Yeast Identifies New Factors Involved in the Functional Interplay between Transcription and mRNP Biogenesis. Molecular and Cellular Biology, 2009, 29 (15), pp.4033-4044. ⟨10.1128/MCB.00272-09⟩. ⟨hal-00525149⟩
  • F. Toulmé, C. Mosrin-Huaman, I. Artsimovitch, A.R. Rahmouni. Transcriptional pausing in vivo: a nascent RNA hairpin restricts lateral movements of RNA polymerase in both forward and reverse directions. Journal of Molecular Biology, 2005, 351, pp.39-51. ⟨hal-00088714⟩
  • C. Mosrin-Huaman, C.L. Turnbough, A.R. Rahmouni. Translocation of Escherichia coli RNA polymerase against a protein roadblock in vivo highlights a passive sliding mechanism for transcript elongation. Molecular Microbiology, 2004, 51, pp.1471-1481. ⟨hal-00113075⟩
  • M. Decoville, M Giraud-Panis, M Mosrin-Huaman, M. Leng, D. Locker. HMG boxes of DSP1 protein interact with the Rel homology domain of transcription factors. Nucleic Acids Research, 2000, 28 (2), pp.454-462. ⟨10.1093/nar/28.2.454⟩. ⟨hal-02119310⟩
  • F Toulmé, M Mosrin-Huaman, J Sparkowski, A. Das, M. Leng, et al.. GreA and GreB proteins revive backtracked RNA polymerase in vivo by promoting transcript trimming. EMBO Journal, 2000, 19 (24), pp.6853-6859. ⟨10.1093/emboj/19.24.6853⟩. ⟨hal-02127250⟩
  • M Mosrin-Huaman, L. Canaple, D. Locker, M. Decoville. DSP1Gene ofDrosophila melanogaster encodes an HMG-domain protein that plays multiple roles in development. Developmental Genetics, 1998, 23 (4), pp.324-334. ⟨10.1002/(SICI)1520-6408(1998)23:4<324::AID-DVG7>3.0.CO;2-T⟩. ⟨hal-02119315⟩
  • Christine Mosrin-Huaman, M. Riva, M Beltrame, E Cassar, A. Sentenac, et al.. The RPC31 gene of Saccharomyces cerevisiae encodes a subunit of RNA polymerase C (III) with an acidic tail.. Molecular and Cellular Biology, 1990, 10 (9), pp.4737-4743. ⟨10.1128/mcb.10.9.4737⟩. ⟨hal-02266468⟩
  • Sabine Kreps, Fabrice Ferino, Christine Mosrin-Huaman, Jozef Gerits, Max Mergeay, et al.. Conjugative transfer and autonomous replication of a promiscuous IncQ plasmid in the cyanobacterium Synechocystis PCC 6803. Molecular and General Genetics MGG, 1990, 221 (1), pp.129-133. ⟨10.1007/BF00280378⟩. ⟨hal-02266473⟩
  • Christine Mosrin-Huaman, P Thuriaux. The genetics of RNA polymerases in yeasts.. Current Genetics, 1990, 17 (5), pp.367-373. ⟨hal-02266470⟩

Communication dans un congrès1 document

  • Béatrice Vallée, Christine Mosrin-Huaman, Hélène Bénédetti, Régis Guégan, Bojan Zunar. Life in the bioink: Physiology and energetics of Saccharomyces cerevisiae embedded in polymerized Pluronic F127-DMA, a “smart” thermoresponsive hydrogel. ICY15 meets 30ICYGMB, The spirit of Yeast, Aug 2021, Vienne, virtual, Austria. ⟨hal-03559939⟩

Poster12 document

  • Hélène Bénédetti, Christine Mosrin-Huaman, Mohammed Bergoug, Amandine Serrano, Fabienne Godin, et al.. Deciphering the Molecular Mechanism of Pathogenicity in Destabilized variants of Neurofibromin mutated in its SecPH domain. 2024 Global NF Conference, Jun 2024, Brussels (Belgium), Belgium. ⟨hal-04779581⟩
  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation. 2024 Global NF Conference, Jun 2024, Brussels, Belgium. ⟨hal-03679991⟩
  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation. 2024 Global NF Conference, Jun 2024, Brussels, Belgium. ⟨hal-04778711⟩
  • Bojan Zunar, Christine Mosrin-Huaman, Hélène Bénédetti, Régis Guégan, Béatrice Vallée. Life in the bioink: Physiology and energetics of Saccharomyces cerevisiae embedded in polymerized Pluronic F127-DMA, a “smart” thermoresponsive hydrogel. ICY15 meets 30ICYGMB, The spirit of Yeast, Aug 2021, Vienne, virtual, Austria. ⟨hal-03679966⟩
  • Christine Mosrin-Huaman, Mohammed Bergoug, Fabienne Godin, Michel Doudeau, Iva Sosic, et al.. Sumoylation of Neurofibromin and its SecPH Domain Plays a Role in Their Functions and Implies Unexpected Structural Requirements. 2021 NF1 virtual conference, Jun 2021, Virtual, France. ⟨hal-03680001⟩
  • Bojan Zunar, Christine Mosrin-Huaman, Hélène Bénédetti, Régis Guégan, Béatrice Vallée. Stressed by hydrogel? Physiological response of yeast cells embedded in thermoresponsive Pluronic F127: a prerequisite for bioreactor development. FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, Slovenia. ⟨hal-03679975⟩
  • Christine Mosrin-Huaman, B. Handelaoui, H. Bénédetti, Béatrice Vallée. Yeast biosensors to detect environmental pollutants into effluent waters. ICYGMB XXIX International Congress on Yeast Genetics and Molecular Biology, Aug 2019, Göteborg, Sweden. ⟨hal-02924111⟩
  • K. Moreau, A. Le Dantec, C. Mosrin-Huaman, Benoit Piegu, Y. Bigot, et al.. High resolution maps of the nuclear RNA surveillance components trafficking along the yeast genome. EMBL Symposium: Transcription and Chromatin 2018, Aug 2018, Heidelberg, Germany. ⟨hal-02920318⟩
  • K. Moreau, A. Le Dantec, C. Mosrin-Huaman, Benoit Piegu, Y. Bigot, et al.. Etude métagénomique des mécanismes nucléaires de contrôle qualité et dégradation de l’ARN. 30e Colloque Biotechnocentre, Oct 2017, Seillac, France. ⟨hal-02934894⟩
  • Kevin Moreau, Aurélia Le Dantec, Christine Mosrin-Huaman, Benoit Piegu, Y. Bigot, et al.. Metagenomic analysis of Nuclear Quality Control & Degradation mechanisms of Eukaryotic RNA. Colloque international du Studium : Messenger RNA therapeutics: advances and perspectives, Mar 2017, Orléans, France. ⟨hal-02920331⟩
  • Kévin Moreau, Aurélia Le Dantec, Christine Mosrin-Huaman, Benoit Piegu, Yves Bigot, et al.. Analyse métagénomique du mécanisme de discrimination entre les transcrits codants et non-codants par la machinerie de dégradation de l’ARN. 29e colloque Biotechnocentre, Oct 2016, Seillac, France. ⟨hal-02453482⟩
  • A. Rachid Rahmouni, Christine Mosrin-Huaman, Nadege Hervouet-Coste. Co-transcriptional degradation by the 5’-3’ exonuclease Rat1p mediates quality control of HXK1 mRNP biogenesis in S. cerevisiae. EMBO EMBL Symposium: The Complex Life of mRNA, Oct 2016, Heidelberg, Germany. . ⟨hal-02453485⟩

Chapitre d'ouvrage3 document

  • P. Thuriaux, Christine Mosrin-Huaman. La génétique moléculaire des levures. Biotechnologie des levures, elsevier masson, pp.49-80, 1991. ⟨hal-02181574⟩
  • D. Gallwitz, J. Becker, M. Benli, L. Hengst, C. Mosrin-Huaman, et al.. The YPT-Branch of the ras Superfamily of GTP-Binding Proteins in Yeast: Functional Importance of the Putative Effector Region. The Superfamily of ras-Related Genes, Springer US, pp.121-128, 1991, 978-1-4684-6020-9. ⟨hal-02181563⟩
  • Christine Mosrin-Huaman, P. Thuriaux. Les outils du génie génétique. Biotechnologies des levures, Masson, pp.81-96, 1991. ⟨hal-02266466⟩

Pré-publication, Document de travail1 document

  • Mohammed Bergoug, Christine Mosrin, Fabienne Godin, Michel Doudeau, Iva Sosic, et al.. Noncanonical structural requirements of neurofibromin SUMOylation reveal a folding-deficiency of several pathogenic mutants. 2022. ⟨hal-03668582⟩

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