Organisation : Equipe Biologie cellulaire, Cibles moléculaires et Thérapies innovantes

BÉNÉDETTI Hélène

mail : helene.benedetti[remplacer_par_at]cnrs-orleans.fr

Téléphone : 02.38.25.55.84

Directrice de recherche, Directrice adjointe du CBM, co-coordinatrice du département « Signalisation cellulaire, cibles moléculaires et thérapies innovantes » et co-responsable de l’équipe « Signalisation cellulaire et neurofibromatose »


126 documents

Article dans une revue67 document

  • Anthony Champiré, Rayan Berabez, Abdennour Braka, Aurélie Cosson, Justine Corret, et al.. Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization. European Journal of Medicinal Chemistry, 2024, 271, pp.116391-116391. ⟨10.1016/j.ejmech.2024.116391⟩. ⟨hal-04575964⟩
  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection. Journal of Molecular Biology, 2024, 436 (22), pp.168768. ⟨10.1016/j.jmb.2024.168768⟩. ⟨hal-04771131⟩
  • Hélène Bénédetti, Béatrice Vallée. LIM Kinases: From Molecular to Pathological Features. Cells, 2023, 12 (12), pp.1649. ⟨10.3390/cells12121649⟩. ⟨hal-04208415⟩
  • Elodie Villalonga, Christine Mosrin, Thierry Normand, Caroline Girardin, Amandine Serrano, et al.. LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features. Cells, 2023, 12 (5), pp.805. ⟨10.3390/cells12050805⟩. ⟨hal-04208405⟩
  • Bojan Žunar, Christine Mosrin-Huaman, Hélène Bénédetti, Béatrice Vallée. Re-engineering of CUP1 promoter and Cup2/Ace1 transactivator to convert Saccharomyces cerevisiae into a whole-cell eukaryotic biosensor capable of detecting 10 nM of bioavailable copper. Biosensors and Bioelectronics, 2022, 214, pp.114502. ⟨10.1016/j.bios.2022.114502⟩. ⟨hal-03820214⟩
  • Rayan Berabez, Sylvain Routier, Hélène Bénédetti, Karen Plé, Béatrice Vallée. LIM kinases, promising but reluctant therapeutic targets: chemistry and preclinical validation in vivo. Cells, 2022, 11 (13), pp.2090. ⟨10.3390/cells11132090⟩. ⟨hal-03721458⟩
  • Wissem Deraredj Nadim, Shalina Hassanaly, Hélène Bénédetti, Claudine Kieda, Catherine Grillon, et al.. The GTPase-activating protein-related domain of neurofibromin interacts with MC1R and regulates pigmentation-mediated signaling in human melanocytes. Biochemical and Biophysical Research Communications, 2021, 534, pp.758-764. ⟨10.1016/j.bbrc.2020.11.003⟩. ⟨hal-03007433⟩
  • Frédéric Buron, Nuno Rodrigues, Thibault Saurat, Marie-Aude Hiebel, Stéphane Bourg, et al.. Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-d]Pyrimidine Series as Novel PI3K/mTOR Inhibitors. Molecules, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩. ⟨hal-03348966⟩
  • Skander A Abboud, Hadji H., Michel Doudeau, Hélène Bénédetti, Vincent Aucagne. A straightforward methodology to overcome solubility challenges for N-terminal cysteinyl peptide segments used in native chemical ligation. Chemical Science, 2021, 12, pp.3194 - 3201. ⟨10.1039/d0sc06001a⟩. ⟨hal-03447239⟩
  • Mohammed Bergoug, Michel Doudeau, Fabienne Godin, Christine Mosrin-Huaman, Béatrice Vallée, et al.. Neurofibromin Structure, Functions and Regulation. Cells, 2020, 9, ⟨10.3390/cells9112365⟩. ⟨hal-03070759v2⟩
  • Julie Tastet, Hélène Cuberos, Béatrice Vallée, Annick Toutain, Martine Raynaud, et al.. LIMK2-1 is a Hominidae-Specific Isoform of LIMK2 Expressed in Central Nervous System and Associated with Intellectual Disability. Neuroscience, 2019, 399, pp.199-210. ⟨10.1016/j.neuroscience.2018.12.017⟩. ⟨hal-02067472⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Hélène Bénédetti. Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein. Journal of visualized experiments : JoVE, 2019, 148, pp.e59820. ⟨10.3791/59820⟩. ⟨hal-02282630⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, David Gosset, et al.. LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b. Biochemical Journal, 2018, 475 (23), pp.3745-3761. ⟨hal-01966439⟩
  • Viorel Simion, Wissem Deraredj Nadim, Hélène Bénédetti, Chantal Pichon, Séverine Morisset-Lopez, et al.. Pharmacomodulation of microRNA Expression in Neurocognitive Diseases: Obstacles and Future Opportunities. Current Neuropharmacology, 2017, 15 (2), pp.276 - 290. ⟨10.2174/1570159X14666160630210422⟩. ⟨hal-01618771⟩
  • Wissem Deraredj Nadim, Simion Viorel, Hélène Bénédetti, Chantal Pichon, Patrick Baril, et al.. MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?. Current Neuropharmacology, 2017, 15 (2), pp.260 - 275. ⟨10.2174/1570159X14666160709001441⟩. ⟨hal-01618199⟩
  • Wissem Deraredj Nadim, Séverine Chaumont-Dubel, Fahima Madouri, Laetitia Cobret, Marie-Ludivine de Tauzia, et al.. Physical interaction between neurofibromin and serotonin 5-HT 6 receptor promotes receptor constitutive activity. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (43), pp.12310 - 12315. ⟨10.1073/pnas.1600914113⟩. ⟨hal-01407899⟩
  • Julie Tastet, Loïc Decalonne, Sylviane Marouillat, Joëlle Malvy, Rose-Anne Thépault, et al.. Mutation screening of the ubiquitin ligase gene RNF135 in French patients with autism. Psychiatric Genetics, 2015, 25 (6), pp.263-267. ⟨10.1097/ypg.0000000000000100⟩. ⟨hal-02072312⟩
  • L Cobret, M L de Tauzia, J Ferent, E Traiffort, I Hénaoui, et al.. Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling. British Journal of Clinical Pharmacology, 2015, 172 (3), pp.841-856. ⟨10.1111/bph.12945⟩. ⟨hal-01170735⟩
  • H. Cuberos, B. Vallée, P. Vourc'H, J. Tastet, C.R. Andres, et al.. Roles of LIM kinases in central nervous system function and dysfunction. FEBS Letters, 2015, 589 (24PartB), pp.3795-3806. ⟨10.1016/j.febslet.2015.10.032⟩. ⟨hal-02072231⟩
  • Solene Guiheneuf, Ludovic Paquin, Francois Carreaux, Emilie Durieu, Helene Benedetti, et al.. Microwave Assisted Organic Synthesis (MAOS) of New Dispacamide A Derivatives Bearing a Thiazolinone Platform, Biological Assays on Inhibition of Protein Kinases and Cell Effects. Current microwave chemistry, 2014, 1 (1), pp.33-40. ⟨10.2174/22133356114019990002⟩. ⟨hal-01114583⟩
  • Amélie Bruel, Romain Beneteau, Mylène Chabanne, Olivier Lozach, Rémy Le Guevel, et al.. Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors. Bioorganic and Medicinal Chemistry Letters, 2014, 24 (21), pp.5037 - 5040. ⟨10.1016/j.bmcl.2014.09.017⟩. ⟨hal-01086026⟩
  • Reine Nehmé, Hala Nehmé, Thibault Saurat, Marie-Ludivine De-Tauzia, Frédéric Buron, et al.. New in-capillary electrophoretic kinase assays to evaluate inhibitors of the PI3k/Akt/mTOR signaling pathway. Analytical and Bioanalytical Chemistry, 2014, 406 (15), pp.3743-3754. ⟨10.1007/s00216-014-7790-z⟩. ⟨hal-01180770⟩
  • Thibault Saurat, Frédéric Buron, Nuno Rodrigues, Marie-Ludivine de Tauzia, Lionel Colliandre, et al.. Design, Synthesis, and Biological Activity of Pyridopyrimidine Scaffolds as Novel PI3K/mTOR Dual Inhibitors. Journal of Medicinal Chemistry, 2014, 57 (3), pp.613-631. ⟨10.1021/jm401138v⟩. ⟨hal-01180887⟩
  • François Hericourt, François Chefdor, Lucie Bertheau, Mirai Tanigawa, Tatsuya Maeda, et al.. Characterization of histidine-aspartate kinase HK1 and identification of histidine phosphotransfer proteins as potential partners in a Populus multistep phosphorelay. Physiologia Plantarum, 2013, 149 (2), pp.188-199. ⟨10.1111/ppl.12024⟩. ⟨hal-02070851⟩
  • Dominique Arnaud, Annabelle Déjardin, Jean-Charles Leplé, Marie-Claude Lesage-Descauses, Nathalie Boizot, et al.. Expression analysis of LIM gene family in poplar, toward an updated phylogenetic classification.. BMC Research Notes, 2012, 5, pp.102. ⟨10.1186/1756-0500-5-102⟩. ⟨hal-00721759⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Aurélie Gombault, Aurélie Tchalikian-Cosson, et al.. Nf1 RasGAP Inhibition of LIMK2 Mediates a New Cross-Talk between Ras and Rho Pathways. PLoS ONE, 2012, 7 (10), pp.e47283. ⟨10.1371/journal.pone.0047283⟩. ⟨hal-03054185⟩
  • A. Bruel, Cedric Logé, M.-L. de Tauzia, M. Ravache, Ronan Le Guével, et al.. Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5Hpyridazino[4,5-b]indoles as PI3Ka inhibitors.. European Journal of Medicinal Chemistry, 2012, 57, pp.225-233. ⟨hal-00764872⟩
  • Fabienne Godin, Sandrine Villette, Béatrice Vallée, Michel Doudeau, Séverine Morisset-Lopez, et al.. A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.. Biochemical and Biophysical Research Communications, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩. ⟨hal-00721861⟩
  • Martine Beaufour, Fabienne Godin, Béatrice Vallée, Martine Cadene, Hélène Bénédetti. Interaction Proteomics Suggests a New Role for the Tfs1 Protein in Yeast.. Journal of Proteome Research, 2012, 11 (6), pp.3211-3218. ⟨10.1021/pr201239t⟩. ⟨hal-00721771⟩
  • Julie Tastet, Patrick Vourc'H, Frédéric Laumonnier, Béatrice Vallée, Carole Michelle, et al.. LIMK2d, a truncated isoform of Lim kinase 2 regulates neurite growth in absence of the LIM kinase domain. Biochemical and Biophysical Research Communications, 2012, 420 (2), pp.247-252. ⟨10.1016/j.bbrc.2012.02.134⟩. ⟨hal-01136281⟩
  • Aurélie Gombault, Jonas Warringer, Robert Caesar, Fabienne Godin, Béatrice Vallée, et al.. A phenotypic study of TFS1 mutants differentially altered in the inhibition of Ira2p or CPY. FEMS Yeast Research, 2009, 9 (6), pp.867-874. ⟨10.1111/j.1567-1364.2009.00535.x⟩. ⟨hal-00522432⟩
  • Aurélie Gombault, Fabienne Godin, Denise Sy, Baptiste Legrand, Hélène Chautard, et al.. Molecular Basis of the Tfs1/Ira2 Interaction: A Combined Protein Engineering and Molecular Modelling Study. Journal of Molecular Biology, 2007, 374 (3), pp.604-617. ⟨10.1016/j.jmb.2007.09.057⟩. ⟨hal-00181161⟩
  • F. Chefdor, H. Bénédetti, C. Depierreux, Franck Delmotte, D. Morabito, et al.. Osmotic stress sensing in Populus: components identification of a phosphorelay system. FEBS Letters, 2006, 580 (1), pp.77-81. ⟨10.1016/j.febslet.2005.11.051⟩. ⟨hal-00088838⟩
  • S. Quevillon-Cheruel, N. Leulliot, M. Graille, N. Hervouet, F. Coste, et al.. Crystal structure of yeast YHR049W/FSH1, a member of the serine hydrolase family. Protein science : a publication of the Protein Society., 2005, 14, pp.1350-1356. ⟨hal-00088667⟩
  • H. Chautard, M. Jacquer, F. Schoentgen, N. Bureaud, H. Bénédetti. Tfs1, a member of the PEBP family, inhibits the Ira2p but not the Ira1p Ras GTPase activating protein in Saccharomyces cerevisiae. Eukaryotic Cell, 2004, 3 (2), pp.459-470. ⟨10.1128/EC.3.2.459-470.2004⟩. ⟨hal-00112967⟩
  • S. Castella, Hélène Bénédetti, R. de Llorens, J.L. Dacheux, F. Dacheux. Train A, an RNase-A-like protein without RNase activity is secreted and reabsorbed by the same epididymal cells under testicular control. Biology of Reproduction, 2004, 71 (5), pp.1677-1687. ⟨10.1095/biolreprod.104.031666⟩. ⟨hal-00112960⟩
  • Emmanuelle Bouveret, Laure Journet, Anne Walburger, E. Cascales, Hélène Bénédetti, et al.. Analysis of the Escherichia coli Tol-Pal and TonB systems by periplasmic production of Tol, TonB, colicin, or phage capsid soluble domains.. Biochimie, 2002, 84 (5-6), pp.413-21. ⟨hal-02130103⟩
  • Laurence Serre, F Serre, Charles Zelwer, Nicole Bureaud, Francoise Schoentgen, et al.. Crystal structures of YBHB and YBCL from Escherichia coli , two bacterial homologues to a Raf kinase inhibitor protein 1 1Edited by R. Huber. Journal of Molecular Biology, 2001, 310 (3), pp.617-634. ⟨10.1006/jmbi.2001.4784⟩. ⟨hal-02130120⟩
  • Laure Journet, E. Bouveret, A. Rigal, R Lloubes, C Lazdunski, et al.. Import of colicins across the outer membrane of Escherichia coli involves multiple protein interactions in the periplasm.. Molecular Microbiology, 2001, 42 (2), pp.331-44. ⟨hal-02130124⟩
  • C. Lazdunski, E. Bouveret, A Rigal, Laure Journet, R. Lloubes, et al.. Colicin import into Escherichia coli cells requires the proximity of the inner and outer membranes and other factors. International Journal of Medical Microbiology, 2000, 290 (4-5), pp.337-344. ⟨10.1016/S1438-4221(00)80037-5⟩. ⟨hal-02130686⟩
  • Chantal Abergel, E. Bouveret, J.M Claverie, K Brown, A Rigal, et al.. Structure of the Escherichia coli TolB protein determined by MAD methods at 1.95 A resolution.. Structure, 1999, 7 (10), pp.1291-300. ⟨hal-02130130⟩
  • E Bouveret, H Bénédetti, A Rigal, E. Loret, C Lazdunski. In vitro characterization of peptidoglycan-associated lipoprotein (PAL)-peptidoglycan and PAL-TolB interactions.. Journal of Bacteriology, 1999, 181 (20), pp.6306-11. ⟨hal-02130134⟩
  • Laure Journet, A Rigal, C Lazdunski, H Bénédetti. Role of TolR N-terminal, central, and C-terminal domains in dimerization and interaction with TolA and tolQ.. Journal of Bacteriology, 1999, 181 (15), pp.4476-84. ⟨hal-02130149⟩
  • Chantal Abergel, A Rigal, S Chenivesse, C Lazdunski, J.M Claverie, et al.. Crystallization and preliminary crystallographic study of a component of the Escherichia coli tol system: TolB.. Acta crystallographica Section D : Structural biology [1993-..], 1998, 54 (Pt 1), pp.102-4. ⟨hal-02130160⟩
  • C.J Lazdunski, E. Bouveret, A. Rigal, Laure Journet, R Lloubès, et al.. Colicin import into Escherichia coli cells.. Journal of Bacteriology, 1998, 180 (19), pp.4993-5002. ⟨hal-02130152⟩
  • E Bouveret, A Rigal, C Lazdunski, H Bénédetti. Distinct regions of the colicin A translocation domain are involved in the interaction with TolA and TolB proteins upon import into Escherichia coli.. Molecular Microbiology, 1998, 27 (1), pp.143-57. ⟨hal-02130155⟩
  • E Bouveret, A Rigal, C Lazdunski, H Bénédetti. The N-terminal domain of colicin E3 interacts with TolB which is involved in the colicin translocation step.. Molecular Microbiology, 1997, 23 (5), pp.909-20. ⟨hal-02130173⟩
  • A Rigal, E. Bouveret, R Lloubes, C Lazdunski, H Bénédetti. The TolB protein interacts with the porins of Escherichia coli.. Journal of Bacteriology, 1997, 179 (23), pp.7274-7279. ⟨10.1128/jb.179.23.7274-7279.1997⟩. ⟨hal-02130169⟩
  • R Derouiche, M Gavioli, H Bénédetti, A Prilipov, C Lazdunski, et al.. TolA central domain interacts with Escherichia coli porins.. EMBO Journal, 1996, 15 (23), pp.6408-15. ⟨hal-02130175⟩
  • E. Bouveret, R Derouiche, R. Rigal, R Lloubès, C Lazdunski, et al.. Peptidoglycan-associated lipoprotein-TolB interaction. A possible key to explaining the formation of contact sites between the inner and outer membranes of Escherichia coli. Journal of Biological Chemistry, 1995, 270 (19), pp.11071-11077. ⟨10.1074/jbc.270.19.11071⟩. ⟨hal-02130195⟩
  • R Derouiche, H Bénédetti, Jc Lazzaroni, C Lazdunski, R Lloubès. Protein complex within Escherichia coli inner membrane. TolA N-terminal domain interacts with TolQ and TolR proteins. Journal of Biological Chemistry, 1995, 270 (19), pp.11078-11084. ⟨10.1074/jbc.270.19.11078⟩. ⟨hal-02130187⟩
  • Denis Duché, L. Letellier, V. Geli, H. Bénédetti, D. Baty. Quantification of group A colicin import sites.. Journal of Bacteriology, 1995, 177 (17), pp.4935-4939. ⟨10.1128/jb.177.17.4935-4939.1995⟩. ⟨hal-02440962⟩
  • Denis Duché, L. Letellier, V Géli, H Bénédetti, D. Baty. Quantification of group A colicin import sites.. Journal of Bacteriology, 1995, 177 (17), pp.4935-4939. ⟨10.1128/jb.177.17.4935-4939.1995⟩. ⟨hal-02130183⟩
  • Jean Claude Lazzaroni, Anne Vianney, V Vianney, Jean Luc Popot, Hélène Bénédetti, et al.. Transmembrane α-Helix Interactions are Required for the Functional Assembly of theEscherichia coliTol Complex. Journal of Molecular Biology, 1995, 246 (1), pp.1-7. ⟨10.1006/jmbi.1994.0058⟩. ⟨hal-02130202⟩
  • G. Guihard, P. Boulanger, H Bénédetti, R Lloubés, M Besnard, et al.. Colicin A and the Tol proteins involved in its translocation are preferentially located in the contact sites between the inner and outer membranes of Escherichia coli cells.. Journal of Biological Chemistry, 1994, 269 (8), pp.5874-80. ⟨hal-02130218⟩
  • David Espesset, Yves Corda, Kyle Cunningham, Hélène Bénédetti, Roland Lloubes, et al.. The colicin A pore-forming domain fused to mitochondrial intermembrane space sorting signals can be functionally inserted into the Escherichia coli plasma membrane by a mechanism that bypasses the Tol proteins. Molecular Microbiology, 1994, 13 (6), pp.1121-1131. ⟨10.1111/j.1365-2958.1994.tb00503.x⟩. ⟨hal-02130213⟩
  • H Bénédetti, S Raths, F Crausaz, H. Riezman. The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast.. Molecular Biology of the Cell, 1994, 5 (9), pp.1023-37. ⟨hal-02130204⟩
  • J Rohrer, H Bénédetti, B Zanolari, H. Riezman. Identification of a novel sequence mediating regulated endocytosis of the G protein-coupled alpha-pheromone receptor in yeast.. Molecular Biology of the Cell, 1993, 4 (5), pp.511-21. ⟨hal-02130242⟩
  • G. Guihard, H Bénédetti, M Besnard, L. Letellier. Phosphate efflux through the channels formed by colicins and phage T5 in Escherichia coli cells is responsible for the fall in cytoplasmic ATP.. Journal of Biological Chemistry, 1993, 268 (24), pp.17775-80. ⟨hal-02130233⟩
  • V Geli, R Lloubes, S Zaat, R van Spaendonk, C Rollin, et al.. Recognition of the colicin A N-terminal epitope 1C11 in vitro and in vivo in Escherichia coli by its cognate monoclonal antibody. FEMS Microbiology Letters, 1993, 109 (2-3), pp.335-342. ⟨10.1016/0378-1097(93)90042-z⟩. ⟨hal-02130222⟩
  • Hélène Bénédetti, R Lloubès, C Lazdunski, L. Letellier. Colicin A unfolds during its translocation in Escherichia coli cells and spans the whole cell envelope when its pore has formed.. EMBO Journal, 1992, 11 (2), pp.441-7. ⟨hal-02130272⟩
  • Hélène Bénédetti, C Lazdunski, R Lloubès. Protein import into Escherichia coli: colicins A and E1 interact with a component of their translocation system.. EMBO Journal, 1991, 10 (8), pp.1989-95. ⟨hal-02130277⟩
  • Hélène Bénédetti, M Frenette, D. Baty, M Knibiehler, F. Pattus, et al.. Individual domains of colicins confer specificity in colicin uptake, in pore-properties and in immunity requirement.. Journal of Molecular Biology, 1991, 217 (3), pp.429-39. ⟨hal-02130283⟩
  • M Frenette, H Bénédetti, A. Bernadac, D. Baty, C Lazdunski. Construction, expression and release of hybrid colicins.. Journal of Molecular Biology, 1991, 217 (3), pp.421-8. ⟨hal-02130287⟩
  • C. Lazdunski, H Bénédetti. Insertion and translocation of proteins into and through membranes.. FEBS Letters, 1990, 268 (2), pp.408-14. ⟨hal-02130669⟩
  • D. Baty, F. Pattus, M. Parker, H. Bénédetti, M. Frenette, et al.. Uptake across the cell envelope and insertion into the inner membrane of ion channel-forming colicins in E coli. Biochimie, 1990, 72 (2-3), pp.123-130. ⟨10.1016/0300-9084(90)90137-6⟩. ⟨hal-02130296⟩
  • H. Bénédetti, M. Frenette, D. Baty, R Lloubès, V. Geli, et al.. Comparison of the Uptake Systems for the Entry of Various BtuB Group Colicins into Escherichia coli. Microbiology, 1989, 135 (12), pp.3413-3420. ⟨10.1099/00221287-135-12-3413⟩. ⟨hal-02130300⟩

Communication dans un congrès16 document

  • Anthony Champiré, Margaux Sainjon, Abdennour Braka, Samia Aci-Seche, Pascal Bonnet, et al.. Synthesis and preclinical validation of LIMKs inhibitors: Promising drugs for osteosarcoma treatment?. XXVII EFMC International Symposium on Medicinal Chemistry, Sep 2022, NICE, France. ⟨hal-04823073⟩
  • Rayan Berabez, Anthony Champiré, Margaux Sainjon, Abdennour Braka, Samia Aci-Seche, et al.. Synthesis and preclinical validation of LIMKs inhibitors: Promising drugs for osteosarcoma treatment?. SCT 29th Young Research Fellow Meeting, Jul 2022, Nantes, France. ⟨hal-04822252⟩
  • N Laroui, C Delehedde, C Goncalves, F Godin, Federico Perche, et al.. High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells. SFNano 2021, Dec 2021, Angers, France. ⟨hal-03668422⟩
  • Justine Corret, Sokaina Hammoud, Frédéric Buron, Pierre Daligaux, Christophe Chesné, et al.. Development of a bio­active fluorescent inhibitor probe targeting the Rho kinase ROCK for monitoring inhibition action. FEBS 2021, the 45th FEBS Congress, Jul 2021, Virtual, France. ⟨hal-03668584⟩
  • Béatrice Vallée, Christine Mosrin-Huaman, Hélène Bénédetti, Régis Guégan, Bojan Zunar. Life in the bioink: Physiology and energetics of Saccharomyces cerevisiae embedded in polymerized Pluronic F127-DMA, a “smart” thermoresponsive hydrogel. ICY15 meets 30ICYGMB, The spirit of Yeast, Aug 2021, Vienne, virtual, Austria. ⟨hal-03559939⟩
  • Béatrice Vallée, Hélène Bénédetti. Séminaire invité : Signalisation cellulaire et Neurofibromatose. Journées NF, Sep 2021, Orléans, France. ⟨hal-03560050⟩
  • Béatrice Vallée, K. Plé, A. Cosson, M. Doudeau, F. Godin, et al.. Détermination et mise en œuvre d’un modèle in vivo pour tester de nouveaux inhibiteurs originaux des LIM kinases, cibles thérapeutiques émergentes dans le cancer. Cancéropôle Grand Ouest, Colloque du Réseau Molécules marines, métabolisme et cancer, May 2019, Mansigné, France. ⟨hal-02928507⟩
  • H. Bénédetti, Béatrice Vallée, A. Cosson, F. Godin, M. Doudeau. Les LIM kinases : nouvelles cibles thérapeutiques anti-cancer. Journée scientifique du réseau « Cancers hormonaux–dépendants » du Cancéropôle Grand-Ouest, Apr 2019, Nantes, France. ⟨hal-02928496⟩
  • M. Bergoug, A. Cosson, D. Casas, M. Doudeau, F. Godin, et al.. Neurofibromin, a new SUMO target involved in neurofibromatosis type 1 disease. 6th LIA Workshop on "Biomarkers and mediators of diseases and new approaches in repair/regenerative therapies, Jun 2019, Varsovie, Poland. ⟨hal-02928511⟩
  • M. Bergoug, A. Cosson, M. Doudeau, F. Godin, Béatrice Vallée, et al.. Study of the sumoylation of neurofibromin, the protein responsible for neurofibromatosis type 1. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France. ⟨hal-02928220⟩
  • Béatrice Vallée, S. Routier, A. Cosson, M. Doudeau, F. Godin, et al.. Développement de modulateurs des LIM kinases. Cancéropôle Grand Ouest - 14e colloque du Réseau Produits de la mer en cancérologie - 5e colloque du Réseau Canaux ioniques et cancer, May 2018, Mansigné, France. ⟨hal-02928559⟩
  • Béatrice Vallée, Karen Plé, A. Cosson, M. Doudeau, F. Godin, et al.. Développement de petites molécules inhibitrices des LIM kinases, nouvelles cibles thérapeutiques pour lutter contre le cancer, les maladies neurologiques et la neurofibromatose. Journée Fédération CBM-ICOA, Jan 2018, Orléans, France. ⟨hal-02928530⟩
  • Béatrice Vallée, A. Cosson, M. Doudeau, F Godin, A. Braka, et al.. Neurofibromatosis type I: from basic to applied research. 4th LIA Workshop, Jun 2017, Cracovie, Poland. ⟨hal-02928517⟩
  • Béatrice Vallée, Hélène Bénédetti, F. Godin, M. Doudeau. Study of new partners of neurofibromin: an approach to identify novel therapeutic targets for neurofibromatosis type 1. 17th European Neurofibromatosis meeting, Sep 2016, Albano-Terme, Italy. ⟨hal-02928226⟩
  • Wassim Lakhal, Nathalie Boizot, Marie-Claude Lesage Descauses, Odile Rogier, Véronique Laine-Prade, et al.. Both ChIP-SEQ and in planta gene modification demonstrate the involvement of MYB090 and MYB156 in secondary cell wall formation in poplar. INUPRAG-Meeting 2015, Oct 2015, Nancy, France. ⟨hal-01604786⟩
  • J. Tastet, P. Vourc'H, F. Laumonnier, C. Michelle, Anne Duittoz, et al.. Expression des isoformes de LIM Kinase 2 pendant la neurogenèse et la stimulation des neurones. 22. Colloque Biotechnocentre, Oct 2009, Seillac, France. ⟨hal-02753426⟩

Poster32 document

  • Hélène Bénédetti, Christine Mosrin-Huaman, Mohammed Bergoug, Amandine Serrano, Fabienne Godin, et al.. Deciphering the Molecular Mechanism of Pathogenicity in Destabilized variants of Neurofibromin mutated in its SecPH domain. 2024 Global NF Conference, Jun 2024, Brussels (Belgium), Belgium. ⟨hal-04779581⟩
  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation. 2024 Global NF Conference, Jun 2024, Brussels, Belgium. ⟨hal-03679991⟩
  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation. 2024 Global NF Conference, Jun 2024, Brussels, Belgium. ⟨hal-04778711⟩
  • Karen Plé, B. Vallée, R. Berabez, A. Champiré, M. Sainjon, et al.. Les LIM kinases, des cibles thérapeutiques prometteuses pour le traitement du glioblastome : de la conception de petites molécules inhibitrices aux tests cellulo. CCCancéropôle Grand Ouest, colloque du réseau Molécules marines, métabolisme et cancer, May 2023, Mansigné, France. ⟨hal-04556346⟩
  • Justine Corret, Sokaina Hammoud, Frédéric Buron, Pierre Daligaux, Christophe Chesné, et al.. Development of a bio­active fluorescent inhibitor probe targeting the Rho kinase ROCK for monitoring inhibition action. FEBS 2021, the 45th FEBS Congress, Jul 2021, Lnubljana, virtual, Slovenia. ⟨hal-03679980⟩
  • Mélissa Thomas, Lauren Blot, Kevin Lesage, Fabienne Godin, Michel Doudeau, et al.. New molecular insights into the crosstalk between Rho/ROCK/LIMK2/cofilin signalling pathway and Nf1. 2021 NF1 virtual conference, Jun 2021, Virtual, France. ⟨hal-03679999⟩
  • Elodie Villalonga, Célina Chalal, Déborah Cassas, Michel Doudeau, Fabienne Godin, et al.. New insights into the regulation of actin cytoskeleton dynamics via the Rho/ROCK/LIMK2/cofilin signalling pathway: a novel mechanism of regulation of cofilin by LIMK2. FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, virtual, Slovenia. ⟨hal-03680139⟩
  • Christine Mosrin-Huaman, Mohammed Bergoug, Fabienne Godin, Michel Doudeau, Iva Sosic, et al.. Sumoylation of Neurofibromin and its SecPH Domain Plays a Role in Their Functions and Implies Unexpected Structural Requirements. 2021 NF1 virtual conference, Jun 2021, Virtual, France. ⟨hal-03680001⟩
  • N Laroui, C Delehedde, Cristine Gonçalves, F Godin, F Perche, et al.. High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells. 10th mRNA Health Conference, Nov 2021, Berlin, Germany. ⟨hal-03668434⟩
  • Bojan Zunar, Christine Mosrin-Huaman, Hélène Bénédetti, Régis Guégan, Béatrice Vallée. Stressed by hydrogel? Physiological response of yeast cells embedded in thermoresponsive Pluronic F127: a prerequisite for bioreactor development. FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, Slovenia. ⟨hal-03679975⟩
  • Bojan Zunar, Christine Mosrin-Huaman, Hélène Bénédetti, Régis Guégan, Béatrice Vallée. Life in the bioink: Physiology and energetics of Saccharomyces cerevisiae embedded in polymerized Pluronic F127-DMA, a “smart” thermoresponsive hydrogel. ICY15 meets 30ICYGMB, The spirit of Yeast, Aug 2021, Vienne, virtual, Austria. ⟨hal-03679966⟩
  • H. Bénédetti, M. Bergoug, I. Sošic, M. Doudeau, F. Godin, et al.. Study of the different forms of sumoylation of the neurofibromin SecPH domain. EMBO Workshop "The ubiquitin system: Biology, mechanisms and roles in disease", Sep 2019, Cavtat, Croatia. ⟨hal-02924090⟩
  • H. Bénédetti, Béatrice Vallée, J. Tastet, H. Cubéros, A. Toutain, et al.. Molecular and functional characterization of LIMK2-1, a hominidae-specific isoform of LIMK2 associated with intellectual disability. NeuroFrance 2019, May 2019, Marseille, France. ⟨hal-02924881⟩
  • Christine Mosrin-Huaman, B. Handelaoui, H. Bénédetti, Béatrice Vallée. Yeast biosensors to detect environmental pollutants into effluent waters. ICYGMB XXIX International Congress on Yeast Genetics and Molecular Biology, Aug 2019, Göteborg, Sweden. ⟨hal-02924111⟩
  • M. Bergoug, I. Sošic, M. Doudeau, F. Godin, Béatrice Vallée, et al.. Neurofibromin, a new SUMO target involved in neurofibromatosis type 1 disease. EMBO Workshop "The ubiquitin system: Biology, mechanisms and roles in disease", Sep 2019, Cavtat, Croatia. ⟨hal-02924095⟩
  • Béatrice Vallée, A. Cosson, M. Doudeau, F. Godin, A. Champiré, et al.. LIM kinases, new therapeutic targets to treat cancers, neurological disorders and Neurofibromatosis: development of small molecule inhibitors. FEBS Meeting 2019, Jul 2019, Cracovie, Poland. ⟨hal-02924140⟩
  • Béatrice Vallée, A. Cosson, M. Doudeau, F. Godin, A. Champiré, et al.. Development of small molecule inhibitors of LIM kinases, new therapeutic targets to treat Neurofibromatosis type I. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France. ⟨hal-02924077⟩
  • H. Bénédetti, M. Doudeau, F. Godin, Béatrice Vallée, A. Cosson, et al.. LARP6, a RNA−binding protein involved in translation and stability of collagen mRNA, is a new partner of Neurofibromin: Molecular studies and functional implications. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France. ⟨hal-02924084⟩
  • A. Champiré, A. Braka, B. Vallée, M. Doudeau, F. Godin, et al.. LIM kinases as new therapeutic targets for the treatment of neurofibromatosis type 1. VII International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC) –, Aug 2017, Vienne, Austria. ⟨hal-02904794⟩
  • Séverine Morisset-Lopez, W. Deraredj Nadim, S. Chaumont−dubel, F. Madouri, L. Cobret, et al.. Neurofibromin 1 promotes constitutive activity of native 5−HT6 receptors expressed in mouse prefrontal cortex. Neurofrance, May 2017, Bordeaux, France. ⟨hal-02973767⟩
  • M. Bergoug, A. Cosson, M. Doudeau, F. Godin, Béatrice Vallée, et al.. Study of the sumoylation of neurofibromin, the protein responsible for neurofibromatosis type 1. EMBO Conference "Ubiquitin and SUMO: from molecular mechanisms to system-wide responses, Sep 2017, Cavtat, Croatia. ⟨hal-02924070⟩
  • A. Champiré, A. Braka, Béatrice Vallée, M. Doudeau, F. Godin, et al.. Design, synthesis and biological evaluation of LIMK inhibitors. XXIVe Journées Jeunes Chercheurs (SCT), Feb 2017, Châtenay-Malabry, France. ⟨hal-02904837⟩
  • Béatrice Vallée, A. Cosson, M. Doudeau, F. Godin, Anthony Champiré, et al.. LIM Kinases: new anticancer therapeutic targets. Breast Cancer Symposium, Jun 2017, Nantes, France. ⟨hal-03680148⟩
  • Annabelle Dejardin, Wassim Lakhal, Nathalie Boizot, Marie-Claude Lesage Descauses, Odile Rogier, et al.. Unraveling the function of MYB090 and MYB156 in secondary cell wall formation in poplar using both ChIP-SEQ and in planta gene modification approach. XIV Cell Wall Meeting, Jun 2016, Chania, Grèce. , 2016, XIV Cell Wall Meeting. Programme and Book of Abstracts. ⟨hal-02740921⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Anthony Champiré, Karen Plé, et al.. LIM kinases: new therapeutic targets to treat Neurofibromatosis type I. The 7th EMBO meeting, Sep 2016, Mannheim, Germany. . ⟨hal-02453490⟩
  • A. Champiré, A. Braka, Béatrice Vallée, M. Doudeau, F. Godin, et al.. Conception, synthèse et évaluation biologique d’inhibiteurs de LIM kinases. 29e colloque de Biotechnocentre, Oct 2016, Seillac, France. ⟨hal-02904847⟩
  • Béatrice Vallée, Michel Doudeau, F. Godin, H. Cubéros, A. Champiré, et al.. Projet Région LiCorNe: LIMK protein inhibitors, new therapeutic agents for treatment of cognitive disorders associated with type I Neurofibromatosis. Journée Fédération PCV FR2708, Jan 2016, Orléans, France. ⟨hal-02924056⟩
  • W. Deraredj Nadim, S. Chaumont-Dubel, F. Madouri, L. Cobret, M.-L. de Tauzia, et al.. A Physical Interaction between Neurofibromin and Serotonin 5-HT6 Receptor Promotes Receptor Constitutive Activity. 5th annual meeting of the GDR 3545 RCPG-PhysioMed 2016, Nov 2016, Tours, France. ⟨hal-02973912⟩
  • Béatrice Vallée, Hélène Cuberos, Julie Tastet, Michel Doudeau, Fabienne Godin, et al.. LIMK2-1, a new primate-specific isoform of LIMK2, is associated with intellectual disability. 10 th FENS (Forum of Neurosciences), Jul 2016, Copenhague, Denmark. . ⟨hal-02453486⟩
  • Hélène Bénédetti, Fabienne Godin, Michel Doudeau, Béatrice Vallée, Marie-Ludivine De Tauzia, et al.. LINGO-1, a protein involved in various neurodevelopmental processes, interacts with neurofibromin (Nf1), the protein responsible for neurofibromatosis type I: molecular studies and functional implications. 10 th FENS (Forum of Neuroscience), Jul 2016, Copenhague, Denmark. ⟨hal-02453487⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, Patrick Vourc’h, et al.. The three isoforms of human LIMK2 regulate actin cytoskeleton remodeling via different pathways. EMBL Symposium, Actin in action: From Molecules to Cellular Functions, Sep 2016, Heidelberg, Germany. . ⟨hal-02453489⟩
  • J. Tastet, P. Vourc'H, F. Laumonnier, C. Michelle, Anne Duittoz, et al.. LIMK2 (LIM kinase2) isoforms are differentially expressed during neuronal differentiation. 7. FENS Forum of European Neuroscience, Jul 2010, Amsterdam, Netherlands. n.p., 2010. ⟨hal-02818145⟩

Chapitre d'ouvrage7 document

  • Emmanuelle Bouveret, Claude Lazdunski, Hélène Bénédetti. The Tol/PAL and TonB systems : two envelope-spanning protein complexes involved in colicin import in E. coli.. Molecular Dynamics of Biomembranes, Springer Berlin Heidelberg, pp.59-69, 1996. ⟨hal-02130680⟩
  • H. Bénédetti, V. Geli. Colicin transport, channel formation and inhibition. Handbook of Biological Physics, pp.665-691, 1996. ⟨hal-02130677⟩
  • Vincent Géli, Hélène Bénédetti. Insertion of Proteins into Membranes A Survey. Membrane biogenesis, pp.21-69, 1994, Subcellular Biochemistry, 978-1-4613-6018-6. ⟨hal-02130265⟩
  • Hélène Bénédetti, Lucienne Letellier, Roland Lloubes, Vincent Géli, Daniel Baty, et al.. Import of Colicins into Escherichia Coli. Dynamics of Membrane Assembly, 63, Springer Berlin Heidelberg, pp.315-332, 1992. ⟨hal-02130670⟩
  • L. Letellier, C. Lazdunski, H. Bénédetti, J. Bourdineaud, P. Boulanger. In Vivo Properties of Colicin A: Channel Activity and Translocation. Bacteriocins, Microcins and Lantibiotics, Springer Berlin Heidelberg, pp.119-125, 1992. ⟨hal-02130671⟩
  • C. Lazdunski, D. Baty, V. Geli, R. Lloubes, H. Bénédetti, et al.. Molecular Mechanism of Action of Pore-Forming Colicins and of their Immunity Proteins. Membrane Proteins: Structures, Interactions and Models, pp.413-425, 1992. ⟨hal-02130675⟩
  • Hélène Bénédetti, Lucienne Letellier, Roland Lloubes, Vincent Géli, Daniel Baty, et al.. Study of the Import Mechanisms of Colicins Through Protein Engineering and K+ Efflux Kinetics. Bacteriocins, Microcins and Lantibiotics, Springer Berlin Heidelberg, pp.215-223, 1992. ⟨hal-02130674⟩

Brevet3 document

  • Sylvain Routier, Hélène Bénédetti, Béatrice Vallée, Pascal Bonnet, Karen Plé, et al.. 4-(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-3,6-dihydropyridine-(2H)-carboxamide derivatives as Limk and/or Rock kinases inhibitors for use in the treatment of cancer. France, Patent n° : WO2021239727 A1. AMV. 2021. ⟨hal-03555349⟩
  • Sylvain Routier, Hélène Bénédetti, Frederic Buron, Marie-Aude Hiebel, Thibault Saurat, et al.. TRISUBSTITUTED PYRIDO[2,3-D]PYRIMIDINES, METHODS FOR PREPARING SAME AND THERAPEUTIC USES THEREOF. France, Patent n° : WO2014027081. 2014. ⟨hal-02131560⟩
  • Séverine Morisset-Lopez, Hélène Bénédetti. Tools for the identification od LINGO-1, LINGO-2, LINGO-3 and LINGO-4, ligands, and uses thereof. France, Patent n° : WO2011121257. BCT. 2011. ⟨hal-02130935⟩

Pré-publication, Document de travail1 document

  • Mohammed Bergoug, Christine Mosrin, Fabienne Godin, Michel Doudeau, Iva Sosic, et al.. Noncanonical structural requirements of neurofibromin SUMOylation reveal a folding-deficiency of several pathogenic mutants. 2022. ⟨hal-03668582⟩

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