email : alain.legrand[remplacer_par_at]cnrs-orleans.fr
Téléphone : 02.38.25.55.36
Professeur émérite au sein de l’équipe “DAIV : Dérégulation de l’Autophagie lors de l’Inflammation due au VIH”
- Métadonnées
Publications (Archives Hal)
Contact
isabelle.frapart@cnrs-orleans.fr 02.38.25.55.53
Disciplines
- Sciences du Vivant [q-bio]37
- Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire3
- Informatique [cs]/Bio-informatique [q-bio.QM]2
- Informatique [cs]/Apprentissage [cs.LG]2
- Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Génomique, Transcriptomique et Protéomique [q-bio.GN]2
- Chimie/Chimie analytique1
- Chimie/Chimie organique1
- Chimie/Chimie théorique et/ou physique1
- Chimie1
- Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Gériatrie et gérontologie1
- Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Gynécologie et obstétrique1
- Sciences du Vivant [q-bio]/Santé publique et épidémiologie1
Mots-clefs
ANTIGENS Alpha-synuclein Antiretroviral therapy Apoptosis BAX Basal autophagy CELL-DEATH PROTEIN Caspase activation Cytogaligin DNA methylation Dual cellular localization Dual localization ELECTROPHORETIC TRANSFER ENDOGENOUS PEROXIDASE Experimental atherosclerosis GALIG gene GENE Gene cloning MITOCHONDRIA Promoter
- GENE2
- MITOCHONDRIA2
- Promoter2
- ANTIGENS1
- Alpha-synuclein1
- Antiretroviral therapy1
- Apoptosis1
- BAX1
- Basal autophagy1
- CELL-DEATH PROTEIN1
- Caspase activation1
- Cytogaligin1
- DNA methylation1
- Dual cellular localization1
- Dual localization1
- ELECTROPHORETIC TRANSFER1
- ENDOGENOUS PEROXIDASE1
- Experimental atherosclerosis1
- GALIG gene1
- Gene cloning1
- HORSERADISH-PEROXIDASE1
- IDENTIFICATION1
- IMPORTIN1
- INTRACELLULAR-LOCALIZATION1
- LOCALIZATION1
- Luciferase protein-fragment complementation assay1
- MOLECULAR-CLONING1
- Machine learning techniques for biomedical data1
- Mitogaligin1
- NITROCELLULOSE1
- P53 PROTEIN1
- POLYACRYLAMIDE GELS1
- PROTEINS1
- Programmed cell death1
- Reverse transcription polymerase chain reaction1
- SEQUENCE1
- SMARF1
- Soluble galactose binding lectin1
- TRANSLOCATION1
- Unconventional nuclear localization signal1
- VIRUS1
- Vascular smooth muscle cells1
Auteurs
Legrand Alain44 Normand Thierry13 Charpentier Stéphane12 Mollet Lucile11 Brulé-Morabito Fabienne9 Monsigny M.8 Dubois Martine6 Monsigny Michel5 Dubois M4 Haddad S El4 Nachtigal M4 Serrano A4 El Haddad Saïd3 Gonzalez Patrick3 Greenspan P3 Nachtigal Maurice3 Nachtigal S3 Nagpal M3 Nicolau C.3 Serrano Amandine3 Robin Chloé3 Robinet Pauline3 Arar C2 Arar Chantal2 Auzou P.2 Carp D2 Dubois M.2 El Haddad S.2 Guery T2 Hebert E.2 Legac E2 Mattei M.2 Mayer Roger2 Mignon C.2 Ozsancak C2 Raimond J.2 Raimond Jacques2 Schoenwald M2 Serrano A.2 Legrand A.2 Midoux Patrick2 Mollet L.2 Moal Fréderic2 Aurouet Axel1 Auzou Pascal1 Bizouarne N1 Bonnefont-Rousselot Dominique1 Boutin Valerie1 Boyer Guittaut M.1 Boyer L.1 Caer Jean-Pierre Le1 Capron L1 Carpentier Valérie1 Carrière V.1 Charpentier Stéphane1 Chauveau B.1 Dalvi S1 Desvergne Jean-Pierre1 Dijkstra J1 Duneau M.1 Duneau Mélanie1 Fargette F.1 Fleury Maurice-Bernard1 Fogel S.1 Garnache-Ottou F1 Garnache-Ottou Francine1 Gaudin J-C1 Gaudin J.C1 Grandclement Camille1 Greenspan P.1 Grosse E.1 Guittaut M.1 Guittaut Michaël1 Hocqueloux L1 Hévor T1 Jimonjic Drazen B.1 Kieda C.1 Legac E.1 Legac Eric1 Lelievre Dominique1 Londos-Gagliardi D.1 Lémery D.1 Mangione R.1 Mayer E.P1 Mendes Christina1 Moal F1 Moal F.1 Moreau Kévin1 Nachtigal A1 Nachtigal M.1 Nagpal M.1 Nandi P1 Neudörffer Anne1 Normand T1 Ozsancak Canan1 Piller V.1 Plessis C.1 Popescu N1 Popescu Nicolae C.1 Prazuck T1
Revues
- Biochemical and Biophysical Research Communications4
- American Journal of Pathology3
- Glycobiology3
- Journal of Biological Chemistry3
- Intervirology2
- FEBS Letters2
- Mammalian Genome2
- Experimental Cell Research2
- Gene2
- Analytical Biochemistry1
- Biology of the Cell1
- ChemBioChem1
- DNA Research1
- Drug Delivery1
- Glia1
- In vitro cellular & developmental biology : journal of the Tissue Culture Association1
- AIDS. Official journal of the international AIDS Society1
- Methods in Enzymology1
- Molecular Immunology1
- Plasmid1
- Nucleic Acids Research1
- Ultrasound in Obstetrics and Gynecology = Ultrasound in Obstetrics & Gynecology1
- Journal of Antibiotics1
- Biochemistry1
- Journal of Agricultural and Food Chemistry1
- Proceedings of the National Academy of Sciences of the United States of America1
Année de production
Institutions
- Université d'Orléans38
- Institut de Chimie - CNRS Chimie38
- Université de Tours37
- Institut National de la Santé et de la Recherche Médicale37
- University of South Carolina [Columbia]8
- Centre Hospitalier Régional d'Orléans3
- Institut National des Sciences Appliquées - Centre Val de Loire2
- Université Sciences et Technologies - Bordeaux 12
- Université de Bordeaux1
- Hôpital de la Timone [CHU - APHM]1
- Centre Hospitalier Régional Universitaire de Besançon1
- École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)1
- Université Paris Descartes - Paris 51
- Société GéoHyd1
- SIGMA Clermont1
- CHU Pitié-Salpêtrière [AP-HP]1
- Institut Polytechnique de Bordeaux1
- Université de Montpellier1
- Université Clermont Auvergne [2017-2020]1
- Etablissement français du sang [Bourgogne-Franche-Comté]1
- Université Grenoble Alpes [2016-2019]1
- Université de Franche-Comté1
- Université Montesquieu - Bordeaux 41
- Université Bordeaux Segalen - Bordeaux 21
- Université Paris-Sud - Paris 111
- Université Pierre et Marie Curie - Paris 61
Laboratoires
- Centre de biophysique moléculaire37
- Laboratoire d'Informatique Fondamentale d'Orléans2
- Service d'hématologie1
- Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)1
- Institut de Neurobiologie Alfred Fessard1
- Société GéoHyd1
- Institut des Sciences Moléculaires1
- Institut Pierre Louis d'Epidémiologie et de Santé Publique1
- Institut de Mathématiques de Bordeaux1
- Laboratoire Paul Painlevé - UMR 85241
Départements
Équipes de recherche
46 documents
Article dans une revue40 documents
- Saïd El Haddad, Amandine Serrano, Fréderic Moal, Thierry Normand, Chloé Robin, et al.. Disturbed expression of autophagy genes in blood of Parkinson’s disease patients. Gene, 2020, 738, pp.144454. ⟨10.1016/j.gene.2020.144454⟩. ⟨hal-02501027⟩
- B. Chauveau, C. Auclair, A. Legrand, R. Mangione, Laurent Gerbaud, et al.. Reply. Ultrasound in Obstetrics and Gynecology = Ultrasound in Obstetrics & Gynecology, 2019, 53 (2), pp.276-277. ⟨10.1002/uog.20164⟩. ⟨hal-03049060⟩
- Saïd El Haddad, Amandine Serrano, Thierry Normand, Chloé Robin, Martine Dubois, et al.. Interaction of Alpha-synuclein with Cytogaligin, a protein encoded by the proapoptotic gene GALIG. Biochemical and Biophysical Research Communications, 2018, 495 (1), pp.787-792. ⟨10.1016/j.bbrc.2017.11.078⟩. ⟨hal-01966108⟩
- Amandine Serrano, Saïd El Haddad, Fréderic Moal, Thierry Prazuck, Eric Legac, et al.. Dysregulation of apoptosis and autophagy gene expression in peripheral blood mononuclear cells of efficiently treated HIV-infected patients. AIDS. Official journal of the international AIDS Society, 2018, 32 (12), pp.1579 - 1587. ⟨10.1097/QAD.0000000000001851⟩. ⟨hal-01936094⟩
- Kévin Moreau, Justine Surand, Aurélia Le Dantec, Christine Mosrin-Huaman, Alain Legrand, et al.. Recombinant yeast and human cells as screening tools to search for antibacterial agents targeting the transcription termination factor Rho. Journal of Antibiotics, 2018, 71 (4), pp.447-455. ⟨hal-01966171⟩
- Violette Senille, Dominique Lelievre, Françoise Paquet, Norbert Garnier, Ned Lamb, et al.. The addressing fragment of mitogaligin: first insights into functional and structural properties.. ChemBioChem, 2013, 14 (6), pp.711-20. ⟨10.1002/cbic.201200715⟩. ⟨hal-00817503⟩
- Lucile Mollet, Pauline Robinet, Martine Dubois, Axel Aurouet, Thierry Normand, et al.. Opposing Mcl-1, the GALIG proapoptotic gene is upregulated as neutrophils die and underexpressed in Acute Myeloid Leukemia cells.. Molecular Immunology, 2013, 56 (1-2), pp.123-8. ⟨10.1016/j.molimm.2013.04.012⟩. ⟨hal-00840170⟩
- Pauline Robinet, Lucile Mollet, Patrick Gonzalez, Thierry Normand, Stephane Charpentier, et al.. The mitogaligin protein is addressed to the nucleus via a non-classical localization signal. Biochemical and Biophysical Research Communications, 2010, 392 (1), pp.53-57. ⟨10.1016/j.bbrc.2009.12.162⟩. ⟨hal-00529397⟩
- Patrick Gonzalez, Pauline Robinet, Stéphane Charpentier, Lucile Mollet, Thierry Normand, et al.. Apoptotic activity of a nuclear form of mitogaligin, a cell death protein. Biochemical and Biophysical Research Communications, 2009, 378 (4), pp.816-820. ⟨10.1016/j.bbrc.2008.11.133⟩. ⟨hal-00522444⟩
- Alexis D. Sennepin, Stéphane Charpentier, Thierry Normand, Cedric Sarre, Alain Legrand, et al.. Multiple reprobing of Western blots after inactivation of peroxidase activity by its substrate, hydrogen peroxide. Analytical Biochemistry, 2009, 393 (1), pp.129-131. ⟨10.1016/j.ab.2009.06.004⟩. ⟨hal-00525339⟩
- Valerie Boutin, Alain Legrand, Roger Mayer, Maurice Nachtigal, Michel Monsigny, et al.. Glycofection: The Ubiquitous Roles of Sugar Bound on Glycoplexes. Drug Delivery, 2008, 6 (1), pp.45-50. ⟨10.1080/107175499267156⟩. ⟨hal-02138035⟩
- Patrick Gonzalez, Mélanie Duneau, Stéphane Charpentier, Thierry Normand, Lucile Mollet, et al.. Destabilization of Membranes Containing Cardiolipin or Its Precursors by Peptides Derived from Mitogaligin, a Cell Death Protein. Biochemistry, 2007, 46 (25), pp.7374-7382. ⟨10.1021/bi700213p⟩. ⟨hal-00159568⟩
- Anne Neudörffer, Jean-Pierre Desvergne, Dominique Bonnefont-Rousselot, Alain Legrand, Maurice-Bernard Fleury, et al.. Protective Effects of 4-Hydroxycinnamic Ethyl Ester Derivatives and Related Dehydrodimers against Oxidation of LDL: Radical Scavengers or Metal Chelators?. Journal of Agricultural and Food Chemistry, 2006, 54 (5), pp.1898-1905. ⟨10.1021/jf052923p⟩. ⟨hal-02384987⟩
- M. Duneau, M. Boyer Guittaut, P. Gonzalez, S. Charpentier, T. Normand, et al.. Galig, a novel cell death gene that encodes a mitochondrial protein promoting cytochrome c release. Experimental Cell Research, 2005, 302, pp.194-205. ⟨hal-00088588⟩
- Michaël Guittaut, Stéphane Charpentier, Thierry Normand, Martine Dubois, Jacques Raimond, et al.. Identification of an Internal Gene to the Human Galectin-3 Gene with Two Different Overlapping Reading Frames That Do Not Encode Galectin-3. Journal of Biological Chemistry, 2001, 276 (4), pp.2652-2657. ⟨10.1074/jbc.m002523200⟩. ⟨hal-02137994⟩
- S. Fogel, M. Guittaut, Alain Legrand, M. Monsigny, E. Hebert. The Tat protein of HIV-1 induces galectin-3 expression. Glycobiology, 1999, 9 (4), pp.383-387. ⟨10.1093/glycob/9.4.383⟩. ⟨hal-02138044⟩
- V. Carrière, V. Piller, Alain Legrand, M. Monsigny, A.C. Roche. The sugar binding activity of MR60, a mannose-specific shuttling lectin, requires a dimeric state. Glycobiology, 1999, 9 (10), pp.995-1002. ⟨10.1093/glycob/9.10.995⟩. ⟨hal-02138032⟩
- Alain Legrand, Drazen B. Jimonjic, Nicolae C. Popescu, Maurice Nachtigal. A Chromosome 4 Satellite I DNA Isolated from SV40-Transformed Human Cells. DNA Research, 1998, 5 (5), pp.271-276. ⟨10.1093/dnares/5.5.271⟩. ⟨hal-02138074⟩
- C Arar, J.C Gaudin, L Capron, Alain Legrand. Galectin-3 gene (LGALS3) expression in experimental atherosclerosis and cultured smooth muscle cells.. FEBS Letters, 1998, 430 (3), pp.307-311. ⟨10.1016/S0014-5793(98)00683-8⟩. ⟨hal-02138144⟩
- Alain Legrand, E.P Mayer, S Dalvi, M Nachtigal. Transformation of rabbit vascular smooth muscle cells by human cytomegalovirus morphological transforming region I.. American Journal of Pathology, 1997, 151 (5), pp.1387-95. ⟨hal-02138369⟩
- Jean-Charles Gaudin, Chantal Arar, Michel Monsigny, Alain Legrand. Modulation of the expression of the rabbit galectin-3 gene by p53 and c-Ha-ras proteins and PMA. Glycobiology, 1997, 7 (8), pp.1089-1098. ⟨10.1093/glycob/7.8.1089⟩. ⟨hal-02138352⟩
- J. Raimond, D Zimonjic, C. Mignon, M. Mattei, N Popescu, et al.. Mapping of the galectin-3 gene (LGALS3) to human chromosome 14 at region 14q21-22.. Mammalian Genome, 1997, 8 (9), pp.706-707. ⟨hal-02138375⟩
- C Arar, C. Mignon, M. Mattei, M. Monsigny, Alexis Roche, et al.. Mapping of the MR60/ERGIC-53 gene to human chromosome 18q21.3-18q22 by in situ hybridization.. Mammalian Genome, 1996, 7 (10), pp.791-2. ⟨10.1007/s003359900238⟩. ⟨hal-02138384⟩
- V Vergé, Alain Legrand, T Hévor. Isolation of carbohydrate metabolic clones from cultured astrocytes. Glia, 1996, 18 (3), pp.244-254. 3.0.CO;2-Z">⟨10.1002/(SICI)1098-1136(199611)18:3<244::AID-GLIA8>3.0.CO;2-Z⟩. ⟨hal-02138380⟩
- Chantal Arar, Valérie Carpentier, Jean-Pierre Le Caer, Michel Monsigny, Alain Legrand, et al.. ERGIC-53, a Membrane Protein of the Endoplasmic Reticulum-Golgi Intermediate Compartment, Is Identical to MR60, an Intracellular Mannose-specific Lectin of Myelomonocytic Cells. Journal of Biological Chemistry, 1995, 270 (8), pp.3551-3553. ⟨10.1074/jbc.270.8.3551⟩. ⟨hal-02138409⟩
- F Rouleux-Bonnin, M. Monsigny, Alain Legrand. Transcriptional expression of mannose receptor gene during differentiation of human macrophages.. Biochemical and Biophysical Research Communications, 1995, 217 (1), pp.106-12. ⟨hal-02138393⟩
- J Raimond, F Rouleux, M. Monsigny, Alain Legrand. The second intron of the human galectin-3 gene has a strong promoter activity down-regulated by p53.. FEBS Letters, 1995, 363 (1-2), pp.165-9. ⟨10.1016/0014-5793(95)00310-6⟩. ⟨hal-02138402⟩
- J-C Gaudin, M. Monsigny, Alain Legrand. Cloning of the cDNA encoding rabbit galectin-3.. Gene, 1995, 163 (2), pp.249-52. ⟨10.1016/0378-1119(95)00388-M⟩. ⟨hal-02138396⟩
- Florence Rouleux, Michel Monsigny, Alain Legrand. A Negative Regulatory Element of the Macrophage-Specific Human Mannose Receptor Gene Represses Its Expression in Nonmyeloid Cells. Experimental Cell Research, 1994, 214 (1), pp.113-119. ⟨10.1006/excr.1994.1239⟩. ⟨hal-02138011⟩
- J. Raimond, C. Plessis, F. Fargette, Alain Legrand, E. Hebert. An EBV-Based Vector Allowing a High Level of LTRHIV-Directed Expression in Human Cells. Plasmid, 1994, 32 (1), pp.70-74. ⟨10.1006/plas.1994.1045⟩. ⟨hal-02138444⟩
- Patrick Midoux, Christina Mendes, Alain Legrand, Jacques Raimond, Roger Mayer, et al.. Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells. Nucleic Acids Research, 1993, 21 (4), pp.871-878. ⟨10.1093/nar/21.4.871⟩. ⟨hal-02138456⟩
- N Bizouarne, V. Denis, Alain Legrand, M. Monsigny, C. Kieda. A SV-40 immortalized murine endothelial cell line from peripheral lymph node high endothelium expresses a new alpha-L-fucose binding protein.. Biology of the Cell, 1993, 79 (3), pp.209-18. ⟨10.1016/0248-4900(93)90139-6⟩. ⟨hal-02138452⟩
- Alain Legrand, P Greenspan, M Nagpal, S Nachtigal, M Nachtigal. Characterization of human vascular smooth muscle cells transformed by the early genetic region of SV40 virus.. American Journal of Pathology, 1991, 139 (3), pp.629-640. ⟨hal-02138458⟩
- Alain Legrand, Maurice Nachtigal. Homologous Recombination of a Plasmid Containing the SV40 Early Region in Rabbit Cells. Intervirology, 1991, 32 (3), pp.173-184. ⟨10.1159/000150197⟩. ⟨hal-02138462⟩
- M Nachtigal, Alain Legrand, M Nagpal, S Nachtigal, P Greenspan. Transformation of rabbit vascular smooth muscle cells by transfection with the early region of SV40 DNA.. American Journal of Pathology, 1990, 136 (2), pp.297-306. ⟨hal-02138474⟩
- M. Nachtigal, Alain Legrand, P. Greenspan, S Nachtigal, M. Nagpal. Immortalization of Rabbit Vascular Smooth Muscle Cells after Transfection with a Fragment of the BglII N Region of Herpes Simplex Virus Type 2 DNA. Intervirology, 1990, 31 (2-4), pp.166-174. ⟨10.1159/000150151⟩. ⟨hal-02138469⟩
- M Nachtigal, M Nagpal, P Greenspan, A Nachtigal, Alain Legrand. Characterization of a continuous smooth muscle cell line derived from rabbit aorta.. In vitro cellular & developmental biology : journal of the Tissue Culture Association, 1989, 25 (10), pp.892-8. ⟨10.1007/BF02624001⟩. ⟨hal-02138476⟩
- C. Nicolau, Alain Legrand, E. Grosse. Liposomes as carriers for in vivo gene transfer and expression.. Methods in Enzymology, 1987, 149, pp.157-76. ⟨10.1016/0076-6879(87)49054-X⟩. ⟨hal-02138481⟩
- P Nandi, Alain Legrand, C. Nicolau. Biologically active, recombinant DNA in clathrin-coated vesicles isolated from rat livers after in vivo injection of liposome-encapsulated DNA.. Journal of Biological Chemistry, 1986, 261 (35), pp.16722-6. ⟨hal-02138484⟩
- P. Soriano, J Dijkstra, Alain Legrand, H. Spanjer, D. Londos-Gagliardi, et al.. Targeted and nontargeted liposomes for in vivo transfer to rat liver cells of a plasmid containing the preproinsulin I gene.. Proceedings of the National Academy of Sciences of the United States of America, 1983, 80 (23), pp.7128-7131. ⟨10.1073/pnas.80.23.7128⟩. ⟨hal-02138490⟩
Communication dans un congrès6 documents
- S. El Haddad, A. Serrano, Thierry Normand, Fabienne Brulé-Morabito, L. Mollet, et al.. Cytogaligin, an additional link between Parkinson’s disease and autophagy pathways?. 7e Congrès du CFATG, Nov 2017, Paris, France. ⟨hal-02934905⟩
- A. Serrano, Thierry Normand, S. El Haddad, M. Dubois, Stéphane Charpentier, et al.. During efficient Anti-RetroViral (ARV) therapy, the expression of GALIG and its interacting partners involved in macroautophagy are deregulated. 6es Journées Scientifiques du CFATG, Oct 2016, Bordeaux, France. ⟨hal-02934903⟩
- A Serrano, T Guery, S El Haddad, M Dubois, M Schoenwald, et al.. GALIG, gène inducteur de la mort cellulaire, s’exprime au cours de la différenciation myéloïde. 10es Journées du Cancéropole Grand Ouest, Jun 2016, Les Sables d'Olonne, France. ⟨hal-03661932⟩
- A Serrano, S El Haddad, T Normand, M Dubois, T Guery, et al.. Cytogaligin, one of the proteins produced by the proapoptotic GALIG gene, interacts with autophagy and proteasome molecules. 7th Proteasome Autophagy Workshop, Apr 2016, Clermont-Ferrand, France. ⟨hal-03661923⟩
- S El Haddad, A Serrano, C Ozsancak, P. Auzou, F Moal, et al.. Genes de l’autophagie : marqueurs sanguins potentiels de la maladie de Parkinson. Journées de Neurologie de Langue Française, Apr 2016, Nantes, France. ⟨hal-03661930⟩
- S El Haddad, C Ozsancak, A Serrano, M Dubois, P. Auzou, et al.. Etude de l’expression génique dans la maladie de Parkinson. Journées de Neurologie de Langue Française, Apr 2016, Nantes, France. ⟨hal-03661927⟩