Collaborations
Partenaires hospitaliers
Centre Hospitalier Universitaire d’Orléans (CHRO)
- Dr. Laurent HOCQUELOUX et Dr. Thierry PRAZUCK : Service des Maladies Infectieuses et Tropicales
- Dr. Canan OZSANCAK et Dr. Pascal AUZOU : Service de Neurologie
- Dr Thomas GUERY : Unité de Génétique
- Dr Éric LEGAC : Unité d’Hématologie (Pôle Biopathologie)
Groupe hospitalier l'Archet, Nice
- Pr Pierre-Simon ROHRLICH : Service d’Hématologie Clinique
Partenaires académiques
- Michaël GUITTAUT, Paul PEIXOTO, Éric HERVOUET : Université de Franche-Comté, Besançon - Unité RIGHT (UMR1098), Groupe « Autophagy, Epigenetics and T-cell Immunity in Cancer (AETIC) » et plateforme EPIGENExp (épigénétique)
- Christophe Hano, LBLGC UPRES EA 1207, Equipe Lignanes de plantes, Orléans
- Arnaud Menuet, Flora Reverchon : INEM CNRS UMR 7355, Orléans
Partenaires industriels
- Little Green Pharma, Perth - Australie et IntSel Chimos, St Cloud - France
- Overseed, Orléans - France.
Expertises
Principales publications :
- Tastet J., Cuberos H., Vallée B., Toutain A., Raynaud M., Marouillat S., Thépault R.-A., Laumonnier F., Bonnet-Brilhault F., Vourc’h P., Andres C. R. and Bénédetti H. (2019) LIMK2-1 is a Hominidae-Specific Isoform of LIMK2 Expressed in Central Nervous System and Associated with Intellectual Disability. Neuroscience, (2019) 399, 199-210.
- Vallée B., Cuberos H., Doudeau M., Godin F., Gosset D., Vourc’h P., Andres C. R. and Bénédetti H. (2018) IMK2-1, a new isoform of Human-LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than its two homologs, LIMK2a/2b.Biochemical Journal (2018) 475 () 3745-3761.
- Deraredj Nadim W., Chaumont-Dubel S., Madouri F., Cobret L., De Tauzia M.-L., Zajdel P., Bénédetti H., Marin P. and Morisset-Lopez S. (2016) A Physical Interaction between Neurofibromin and Serotonin 5-HT6 Receptor Promotes Receptor Constitutive Activity., Proc Natl Acad Sci U S A 113(43) 12310-12315 -doi: 10.1073/pnas.1600914113
- Saurat T., Buron F., Rodriguès N., de Tauzia M.-L., Colliandre L., Bourg S., Bonnet P., Guillaumet G., Akssira M., Corlu A., Guillouzo C., Berthier P., Rio P., Jourdan ML., Bénédetti H. and Routier S. (2014) Design, Synthesis and Biological Activity of Pyridopyrimidine Scaffolds as Novel PI3K/ mTOR Dual Inhibitors. J. Med. Chem., 57, 613-631.
- Vallée B., Doudeau M., Godin F., Gombault A., Tchalikian A., de Tauzia M.-L., and Bénédetti H. (2012) Nf1 RasGAP Inhibition of LIMK2 Mediates a New Cross- Talk between Ras and Rho Pathways. PLOS One, 7, e47283.
- Godin F., Villette S., Vallée B., Doudeau M., Morisset-Lopez S., Ardourel M., Hevor T., Pichon C. and Bénédetti H. (2012) A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line. BBRC, 418, 689-694.