email : jean-francois.morfin[remplacer_par_at]cnrs-orleans.fr
Téléphone : 02.38.25.56.05
Ingénieur de recherche en synthèse chimique au sein du groupe thématique “Complexes métalliques et IRM”
- Métadonnées
Publications (Archives Hal)
Contact
isabelle.frapart@cnrs-orleans.fr 02.38.25.55.53
Disciplines
- Sciences du Vivant [q-bio]16
- Chimie5
- Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire3
- Chimie/Chimie de coordination2
- Sciences du Vivant [q-bio]/Ingénierie biomédicale/Imagerie2
- Sciences du Vivant [q-bio]/Médecine humaine et pathologie2
- Chimie/Matériaux1
- Chimie/Chimie organique1
- Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biophysique1
- Sciences du Vivant [q-bio]/Ingénierie biomédicale/Médecine nucléaire1
- Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Neurobiologie1
- Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]1
Mots-clefs
17O NMR 7-TRIAZACYCLONONANETRIACETATE ACID Agents de contraste Alzheimer's disease Alzheimer’s disease Amyloid Amyloid aggregation Amyloid imaging Amyloid plaques Amyloidoses Anions Bismuth Cyclen Gadolinium Lanthanides NMR spectroscopy PIB Relaxivity Sensors
- Alzheimer’s disease4
- Lanthanides3
- Amyloid imaging2
- Bismuth2
- Cyclen2
- Gadolinium2
- NMR spectroscopy2
- PIB2
- Relaxivity2
- Sensors2
- 17O NMR1
- 7-TRIAZACYCLONONANETRIACETATE1
- ACID1
- Agents de contraste1
- Alzheimer's disease1
- Amyloid1
- Amyloid aggregation1
- Amyloid plaques1
- Amyloidoses1
- Anions1
- Automated radiosynthesis1
- Autoradiography1
- Aβ plaques1
- Beta-amyloid fibrils1
- Brain delivery1
- CEST1
- CRYSTAL-STRUCTURE1
- Carbon nanotubes CNTs1
- Cerebral amyloidopathies1
- Complexation1
- Complexes1
- Contrast agent1
- Contrast agents1
- Cyclam1
- DISSOCIATION1
- DOTAGA1
- Electronic relaxation1
- GADOLINIUMIII1
- GAIII1
- Gadolinium based nanoparticles1
- Gadolinium-based nanoparticles1
- Gallium-681
- Gdiii complex1
- Imagerie par résonance magnétique IRM1
- In-vivo1
- LIGANDS1
- Lipari-Szabo approach1
- Luminescence1
- MRI1
- MRI contrast agent1
- Macrocyclic ligands1
- Metal-ions1
- Nanobody1
- O-17 nmr1
- PET1
- PET-RADIOPHARMACEUTICALS1
- ParaCEST1
- Peptide-targeting1
- Peptides1
- Peptidetargeting1
- Pittsburgh Compound B1
- RMN1
- Radiometabolism1
- Relaxation1
- Resonance-imaging agents1
- STABILITY1
- Water exchange1
- X-ray diffraction1
- Zinc1
Auteurs
Morfin Jean-François23 Tóth Éva19 Malikidogo Kyangwi6 Bonnet Celia ́5 Tripier Raphaël4 Pallier Agnes A.4 Oliveira Alexandre3 Barantin Laurent3 Lacerda S.3 Lacerda Sara3 Allémann Eric2 Baccon Michel Le2 Dumoulin Mireille2 Geraldes Carlos2 Handel Henri2 Martins André F.2 Pansieri Jonathan2 Plissonneau Marie2 Rivory Pascaline2 Stransky-Heilkron Nathalie2 da Silva I.2 Tóth É.2 Bonnet Célia2 Heinrich-Balard Laurence2 Suzenet Franck2 Platas-Iglesias Carlos2 Forge Vincent2 Lux François2 Tillement Olivier2 Marquette Christel2 Aigner Christoph1 Al-Jamal Khuloud1 Arlicot Nicolas1 Barré L1 Burrows Hugh1 Bödenler Markus1 Cao Pham Tt1 Cohen Richard A.1 Costa Pedro Miguel1 Costa Telma1 Cressier D1 Dhilly M1 Dias David M.1 Duyckaerts Charles1 F. G. C. Geraldes Carlos1 Fausto Rui1 Garda Zoltán1 Geraldes C. F G C1 Geraldes Carlos F G C1 Geraldes Carlos F. G. C.1 Geraldes Carlos F.G.C.1 Geraldes Cf1 Guilloteau Denis1 Justino Licinia1 Khanum Tamanna1 Kubícek Vojtěch1 Kubícková Anna1 Laurents Douglas1 Laurents Douglas V.1 Lecointre Alexandre1 Lerondel S.1 Lerondel Stéphanie1 Louis Cédric1 M.P Lima Luis1 Majdoub Saida1 Malikidogo K. P.1 Maria Joao Saraiva1 Martins Af1 Martins André1 Martins André F1 Maïza A1 Relich Inga1 Salerno Milena1 Scharfetter Hermann1 Sobilo J.1 Sobilo Julien1 Sosabowski Jane1 To Wan1 Wang Julie Tzu-Wen1 de Blas Andres1 Buron Frédéric1 da Silva Isidro1 Caillé Fabien1 Hureau Christelle1 Petoud Stéphane1 Pallier Agnès1 Bonnet Célia S.1 Morfin J.-F.1 Morfin Jf1 Fillesoye F1 Boos Anne1 Gourand F1 N. Lazar Adina1 Charbonniere Loic J1 Charbonnière Loïc1 Sauvage T.1 Sauvage Thierry1 Mowat Pierre1 Saraiva Maria João1 Beloeil Jean-Claude1
Revues
Institutions
- Institut de Chimie - CNRS Chimie25
- Institut National de la Santé et de la Recherche Médicale22
- Université d'Orléans21
- Université de Tours21
- Universidade de Coimbra = University of Coimbra [Portugal]6
- Commissariat à l'énergie atomique et aux énergies alternatives4
- Université de Brest4
- Université de Genève = University of Geneva2
- Université Claude Bernard Lyon 12
- Université de Strasbourg2
- Institut National des Sciences Appliquées de Lyon2
- Université de Haute-Alsace (UHA) Mulhouse - Colmar2
- Institut National de Physique Nucléaire et de Physique des Particules du CNRS2
- Universidade da Coruña2
- Université Grenoble Alpes [2016-2019]2
- Université de Liège2
- Université européenne de Bretagne - European University of Brittany1
- University of Debrecen1
- Université Toulouse III - Paul Sabatier1
- Télécom Bretagne1
- Queen Mary University of London1
- Institute for Molecular and Cell Biology1
- King‘s College London1
- Centre Hospitalier Lyon Sud [CHU - HCL]1
- Centre Hospitalier Régional Universitaire de Brest1
- Université Paris-Saclay1
- University of Coimbra, Coimbra Chemistry Center1
- Institut National Polytechnique (Toulouse)1
- Universidade do Estado do Rio de Janeiro - Faculdade de Geologia1
- Nano-H SAS, 38070, Saint Quentin Fallavier, France1
- Nano-H S.A.S, 38070 Saint Quentin Fallavier, France1
- Molecular Neurobiology Group, IBMC - Institute for Molecular & Cell Biology, University of Porto, 4150-180 Porto, Portugal.1
- Institut de Recherche pour le Développement1
- Université de Caen Normandie1
- University of Texas at Dallas [Richardson]1
Laboratoires
- Centre de biophysique moléculaire21
- Chimie, Electrochimie Moléculaires et Chimie Analytique4
- Department of Life Sciences - Faculty of Sciences and Technology2
- Institut Lumière Matière [Villeurbanne]2
- Matériaux, ingénierie et science [Villeurbanne]2
- Departamento de Química Fundamental2
- Institut de Recherche Interdisciplinaire de Grenoble2
- Institut Pluridisciplinaire Hubert Curien2
- Transgenèse et archivage d'animaux modèles1
- Institut de Chimie Organique et Analytique1
- Laboratoire de biochimie et biologie moléculaire1
- Departamento de Bioquímica Centro de RMN e Centro de Neurociências e Biologia Celular1
- Centre d'Études et de Recherches par Irradiation1
- Department of Molecular Neurobiology1
- Instituto de Ciências Biomédicas de Abel Salazar1
- Laboratoire de Traitement de l'Information Medicale1
- Service Hospitalier Frédéric Joliot1
- School of Pharmaceutical Sciences1
- Universidade do Estado do Rio de Janeiro - Faculdade de Geologia1
- Laboratoire de chimie de coordination1
- Laboratoire d’Enzymologie et Repliement des Protéines1
- Nano-H SAS, 38070, Saint Quentin Fallavier, France.1
- Nano-H S.A.S1
- School of Pharmaceutical Sciences1
- Laboratoire d'Enzymologie et Repliement des Protéines, Centre d'Ingénierie des Protéines1
- Instituto de Inovação e Investigação em Saúde (I3S), University of Porto, Portugal1
- Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales1
- Imaging, Brain & Neuropsychiatry1
- Conditions Extrêmes et Matériaux : Haute Température et Irradiation1
- Instituto de Química Física Rocasolano1
- Institut de Chimie Organique et Analytique1
Départements
Équipes de recherche
25 documents
Article dans une revue20 documents
- Saida Majdoub, Zoltán Garda, Alexandre Oliveira, Inga Relich, Agnes A. Pallier, et al.. Concentration‐dependent interactions of amphiphilic PiB‐ derivative metal complexes with amyloid peptides Aβ and amylin. Chemistry - A European Journal, 2021, 27, pp.2009-2020. ⟨10.1002/chem.202004000⟩. ⟨hal-03011656⟩
- Alexandre Oliveira, Telma Costa, Licinia Justino, Rui Fausto, Jean-François Morfin, et al.. Photophysical studies on lanthanide( iii ) chelates conjugated to Pittsburgh compound B as luminescent probes targeted to Aβ amyloid aggregates. Photochemical & Photobiological Sciences , 2020, 19 (11), pp.1522-1537. ⟨10.1039/D0PP00214C⟩. ⟨hal-03011501⟩
- Markus Bödenler, Kyangwi Malikidogo, Jean-François Morfin, Christoph Aigner, Éva Tóth, et al.. High‐Field Detection of biomarkers with Fast Field‐Cycling MRI: The Example of Zinc Sensing. Chemistry - A European Journal, 2019, ⟨10.1002/chem.201901157⟩. ⟨hal-02117697⟩
- Pedro Miguel Costa, Julie Tzu-Wen Wang, Jean-François Morfin, Tamanna Khanum, Wan To, et al.. Functionalised Carbon Nanotubes Enhance Brain Delivery of Amyloid-Targeting Pittsburgh Compound B (PiB)-Derived Ligands. Nanotheranostics, 2018, 2 (2), pp.168-183. ⟨10.7150/ntno.23125⟩. ⟨hal-02080078⟩
- Kyangwi Malikidogo, Isidro da Silva, Jean-François Morfin, Sara Lacerda, Laurent Barantin, et al.. A cocktail of 165 Er( iii ) and Gd( iii ) complexes for quantitative detection of zinc using SPECT and MRI. Chemical Communications, 2018, 54 (55), pp.7597 - 7600. ⟨10.1039/c8cc03407a⟩. ⟨hal-01904447⟩
- S. Lacerda, J.-F. Morfin, C. F G C Geraldes, É. Tóth. Metal complexes for multimodal imaging of misfolded protein-related diseases. Dalton Transactions, 2017, 46 (42), pp.14461-14474. ⟨10.1039/C7DT02371E⟩. ⟨hal-02068723⟩
- Jonathan Pansieri, Marie Plissonneau, Nathalie Stransky-Heilkron, Mireille Dumoulin, Laurence Heinrich-Balard, et al.. Multimodal imaging Gd-nanoparticles functionalized with Pittsburgh compound B or a nanobody for amyloid plaques targeting.. Nanomedicine, 2017, 12 (14), pp.1675-1687. ⟨10.2217/nnm-2017-0079⟩. ⟨hal-01561318⟩
- André Martins, Alexandre Oliveira, Jean-François Morfin, Douglas Laurents, Éva Tóth, et al.. Associating a negatively charged GdDOTA-derivative to the Pittsburgh compound B for targeting Aβ amyloid aggregates. Journal of Biological Inorganic Chemistry, 2016, 21 (1), pp.83-99. ⟨10.1007/s00775-015-1316-9⟩. ⟨hal-02069097⟩
- D Cressier, M Dhilly, Tt Cao Pham, F Fillesoye, F Gourand, et al.. Gallium-68 Complexes Conjugated to Pittsburgh Compound B: Radiolabeling and Biological Evaluation. Molecular Imaging and Biology, 2016, 18 (3), pp.334-43. ⟨10.1007/s11307-015-0906-9⟩. ⟨hal-01575680⟩
- Marie Plissonneau, Jonathan Pansieri, Laurence Heinrich-Balard, Jean-François Morfin, Nathalie Stransky-Heilkron, et al.. Gd-nanoparticles functionalization with specific peptides for ß-amyloid plaques targeting.. Journal of Nanobiotechnology, 2016, 14 (1), pp.60. ⟨10.1186/s12951-016-0212-y⟩. ⟨hal-01356748⟩
- André F. Martins, David M. Dias, Jean-François Morfin, Sara Lacerda, Douglas V. Laurents, et al.. Interaction of PiB-Derivative Metal Complexes with Beta-Amyloid Peptides: Selective Recognition of the Aggregated Forms. Chemistry - A European Journal, 2015, 21 (14), pp.5413-5422. ⟨10.1002/chem.201406152⟩. ⟨hal-01171718⟩
- Célia S. Bonnet, Fabien Caillé, Agnès Pallier, Jean-François Morfin, Stéphane Petoud, et al.. Mechanistic studies of Gd$^{3+}$-based MRI contrast agents for Zn$^{2+}$ detection: towards rational design. Chemistry - A European Journal, 2014, 20 (35), pp.10959-10969. ⟨10.1002/chem.201403043⟩. ⟨hal-01178456⟩
- André F Martins, Jean-François Morfin, Carlos F G C Geraldes, Éva Tóth. Gd(3+) complexes conjugated to Pittsburgh compound B: potential MRI markers of β-amyloid plaques.. European Journal of Biochemistry, 2014, 19 (2), pp.281-295. ⟨hal-01179355⟩
- Jean-François Morfin, Jean-Claude Beloeil, Éva Tóth. Agents de contraste pour l'IRM. Techniques de l'Ingénieur, 2014, pp.AF6818-1 - AF6818-19. ⟨hal-01179490⟩
- André F. Martins, Jean-François Morfin, Anna Kubícková, Vojtěch Kubícek, Frédéric Buron, et al.. PiB-Conjugated, Metal-Based Imaging Probes: Multimodal Approaches for the Visualization of β-Amyloid Plaques. Planetary and Space Science, 2013, 4 (5), pp.436-440. ⟨10.1021/ml400042w⟩. ⟨hal-00840181⟩
- Luis M.P Lima, Alexandre Lecointre, Jean-François Morfin, Andres de Blas, Dimitris Visvikis, et al.. Positively Charged Lanthanide Complexes with Cyclen-Based Ligands : Synthesis, Solid-State and Solution Structure, and Fluoride Interaction. Inorganic Chemistry, 2011, 50 (24), pp.12508-12521. ⟨10.1021/ic201447c⟩. ⟨hal-00703687⟩
- Jean-François Morfin, Éva Tóth. Kinetics of Ga(NOTA) formation from weak Ga-citrate complexes.. Inorganic Chemistry, 2011, 50 (20), pp.10371-8. ⟨10.1021/ic201445e⟩. ⟨hal-00720677⟩
- Raphaël Tripier, Carlos Platas-Iglesias, Anne Boos, Jean-François Morfin, Loïc Charbonnière. Towards Fluoride Sensing with Positively Charged Lanthanide Complexes. European Journal of Inorganic Chemistry, 2010, 2010 (18), pp.2735 - 2745. ⟨10.1002/ejic.200901045⟩. ⟨hal-01577344⟩
- Jean-François Morfin, Raphaël Tripier, Michel Le Baccon, Henri Handel. Bismuth (III) coordination to cyclen and cyclam bearing four appended groups. Polyhedron, 2009, 28 (17), pp.3691 - 3698. ⟨10.1016/j.poly.2009.08.003⟩. ⟨hal-01580260⟩
- Jean-François Morfin, Raphaël Tripier, Michel Le Baccon, Henri Handel. Bismuth(III) complexes with tetra-pyridylmethyl-cyclen. Inorganica Chimica Acta Reviews, 2009, 362 (6), pp.1781 - 1786. ⟨10.1016/j.ica.2008.08.013⟩. ⟨hal-01580209⟩
Poster5 documents
- Kyangwi Malikidogo, I. da Silva, Jean-François Morfin, S. Lacerda, Laurent Barantin, et al.. SPECT / MRI quantitative detection of zinc using a cocktail of 165Er(III) and Gd(III) complexes. 14th European Molecular Imaging Meeting, Mar 2019, Glasgow, United Kingdom. ⟨hal-03292258⟩
- P. Malikidogo K., Jean-François Morfin, S. Lacerda, I. da Silva, Laurent Barantin, et al.. MRI contrast agents for quantitative zinc detection. GDR Agents d’Imagerie Moléculaire (AIM), Jun 2018, Orléans, France. ⟨hal-03296044⟩
- Kyangwi Malikidogo, Agnes A. Pallier, Jean-François Morfin, Éva Tóth, Celia ́ Bonnet. Smart MRI contrast agents for zinc detection. Le Studium conférence “Being smart in coordination chemistry: Medical Applications”, Sep 2016, Orléans, France. ⟨hal-03300683⟩
- Kyangwi Malikidogo, Agnes A. Pallier, Jean-François Morfin, Éva Tóth, Celia ́ Bonnet. Zinc responsive contrast agents. International Conference on Coordination Chemistry (ICCC), Jul 2016, Brest, France. ⟨hal-03300659⟩
- Kyangwi Malikidogo, Agnes A. Pallier, Jean-François Morfin, Éva Tóth, Celia ́ Bonnet. Smart MRI contrast agents for zinc detection. Colloque association des doctorants du CBM, Feb 2016, Orléans, France. ⟨hal-03300628⟩