MORISSET-LOPEZ Séverine

By Laetitia Legoupil on 28 août 2018

email : severine.morisset-lopez[remplacer_par_at]cnrs-orleans.fr

Téléphone : 02.38.25.78.58

Directrice de recherche, responsable de l’équipe “Neurobiologie des récepteurs et innovations thérapeutiques”

PAGE PERSONNELLE DE SEVERINE MORISSET-LOPEZ

Profil sur ORCID

Profil sur ResearchID

 


Contact

Mots-clefs

Année de production

Institutions

Laboratoires

Équipes de recherche

94 documents

Article dans une revue59 documents

  • Ana Novak, Florian Kersaudy, Sylvie Berger, Séverine Morisset-Lopez, François Lefoulon, et al.. An efficient site-selective, dual bioconjugation approach exploiting N-terminal cysteines as minimalistic handles to engineer tailored anti-HER2 affibody conjugates. European Journal of Medicinal Chemistry, 2023, 260, pp.115747. ⟨10.1016/j.ejmech.2023.115747⟩. ⟨hal-04222710⟩
  • Marylène Bertrand, Frédéric Szeremeta, Nadège Hervouet-Coste, Vincent Sarou-Kanian, Céline Landon, et al.. An adult Drosophila glioma model to highlight metabolic dysfunctions and evaluate the role of the serotonin 5‐HT 7 receptor as a potential therapeutic target. FASEB Journal, 2023, 37 (11), ⟨10.1096/fj.202300783RR⟩. ⟨hal-04301912⟩
  • Flora Reverchon, Colleen Guillard, Lucile Mollet, Pascal Auzou, David Gosset, et al.. T Lymphocyte Serotonin 5-HT7 Receptor Is Dysregulated in Natalizumab-Treated Multiple Sclerosis Patients. Biomedicines, 2022, 10 (10), pp.2418. ⟨10.3390/biomedicines10102418⟩. ⟨hal-03806213⟩
  • Flora Reverchon, Colleen Guillard, Lucile Mollet, Pascal Auzou, David Gosset, et al.. T Lymphocyte Serotonin 5-HT7 Receptor Is Dysregulated in Natalizumab-Treated Multiple Sclerosis Patients. Biomedicines, 2022, 10 (10), pp.2418. ⟨10.3390/biomedicines10102418⟩. ⟨hal-03846032⟩
  • Florestan Courant, Marion Maravat, Wanyin Chen, David Gosset, Lauren Blot, et al.. Expression of the Human Serotonin 5-HT7 Receptor Rescues Phenotype Profile and Restores Dysregulated Biomarkers in a Drosophila melanogaster Glioma Model. Cells, 2022, 11 (8), pp.1281. ⟨10.3390/cells11081281⟩. ⟨hal-03846028⟩
  • Elisabeth Traiffort, Séverine Morisset-Lopez, Mireille Moussaed, Amina Zahaf. Defective Oligodendroglial Lineage and Demyelination in Amyotrophic Lateral Sclerosis. International Journal of Molecular Sciences, 2021, 22 (7), pp.3426. ⟨10.3390/ijms22073426⟩. ⟨hal-03436366⟩
  • Wissem Deraredj Nadim, Shalina Hassanaly, Hélène Bénédetti, Claudine Kieda, Catherine Grillon, et al.. The GTPase-activating protein-related domain of neurofibromin interacts with MC1R and regulates pigmentation-mediated signaling in human melanocytes. Biochemical and Biophysical Research Communications, 2021, 534, pp.758-764. ⟨10.1016/j.bbrc.2020.11.003⟩. ⟨hal-03007433⟩
  • Chayma El Khamlichi, Laetitia Cobret, Séverine Morisset-Lopez, Séverine Morisset-Lopez. BRET Analysis of GPCR Dimers in Neurons and Non-Neuronal Cells: Evidence for Inactive, Agonist, and Constitutive Conformations. International Journal of Molecular Sciences, 2021, 22 (19), pp.10638. ⟨10.3390/ijms221910638⟩. ⟨hal-03436322⟩
  • Marion Maravat, Marylène Bertrand, Céline Landon, Franck Fayon, Séverine Morisset-Lopez, et al.. Complementary Nuclear Magnetic Resonance-Based Metabolomics Approaches for Glioma Biomarker Identification in a Drosophila melanogaster Model. Journal of Proteome Research, 2021, 20 (8), pp.3977-3991. ⟨10.1021/acs.jproteome.1c00304⟩. ⟨hal-03335927⟩
  • Nayara Braga Emidio, Rajeshwari Meli, Hue Tran, Hayeon Baik, Séverine Morisset-Lopez, et al.. Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite. Journal of Medicinal Chemistry, 2021, 64 (13), pp.9484-9495. ⟨10.1021/acs.jmedchem.1c00767⟩. ⟨hal-03335490⟩
  • Anthony Guillemain, Yousra Laouarem, Laetitia Cobret, Dora Štefok, Wanyin Chen, et al.. LINGO family receptors are differentially expressed in the mouse brain and form native multimeric complexes. FASEB Journal, 2020, pp.1-13. ⟨10.1096/fj.202000826R⟩. ⟨hal-02943248⟩
  • Chayma El Khamlichi, Flora Reverchon-Assadi, Nadège Hervouet-Coste, Lauren Blot, Eric Reiter, et al.. Bioluminescence Resonance Energy Transfer as a Method to Study Protein-Protein Interactions: Application to G Protein Coupled Receptor Biology. Molecules, 2019, 24 (3), pp.537. ⟨10.3390/molecules24030537⟩. ⟨hal-02067271⟩
  • Céline Dubourg, Flora Reverchon-Assadi, Maryvonne Ardourel, Olivier Richard, Séverine Morisset-Lopez, et al.. Votre cerveau est-il grignoté par les neuromythes ?. The Conversation France, 2018, https://bit.ly/2CBaykM. ⟨hal-02972757⟩
  • Viorel Simion, Wissem Deraredj Nadim, Hélène Bénédetti, Chantal Pichon, Séverine Morisset-Lopez, et al.. Pharmacomodulation of microRNA Expression in Neurocognitive Diseases: Obstacles and Future Opportunities. Current Neuropharmacology, 2017, 15 (2), pp.276 - 290. ⟨10.2174/1570159X14666160630210422⟩. ⟨hal-01618771⟩
  • Wissem Deraredj Nadim, Simion Viorel, Hélène Bénédetti, Chantal Pichon, Patrick Baril, et al.. MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?. Current Neuropharmacology, 2017, 15 (2), pp.260 - 275. ⟨10.2174/1570159X14666160709001441⟩. ⟨hal-01618199⟩
  • Wissem Deraredj Nadim, Séverine Chaumont-Dubel, Fahima Madouri, Laetitia Cobret, Marie-Ludivine de Tauzia, et al.. Physical interaction between neurofibromin and serotonin 5-HT 6 receptor promotes receptor constitutive activity. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (43), pp.12310 - 12315. ⟨10.1073/pnas.1600914113⟩. ⟨hal-01407899⟩
  • Yacine Chebani, Candice Marion, Philippe Zizzari, Khadidja Chettab, Marie Pastor, et al.. Enhanced responsiveness of Ghsr Q343X rats to ghrelin results in enhanced adiposity without increased appetite. Science Signaling, 2016, 9 (424), pp.ra39. ⟨10.1126/scisignal.aae0374⟩. ⟨inserm-01463897⟩
  • L Cobret, M L de Tauzia, J Ferent, E Traiffort, I Hénaoui, et al.. Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling. British Journal of Clinical Pharmacology, 2015, 172 (3), pp.841-856. ⟨10.1111/bph.12945⟩. ⟨hal-01170735⟩
  • Emmanuel Deau, Elodie Robin, Raluca Voinea, Nathalie Percina, Grzegorz Satała, et al.. Rational Design, Pharmacomodulation, and Synthesis of Dual 5-Hydroxytryptamine 7 (5-HT 7 )/5-Hydroxytryptamine 2A (5-HT 2A ) Receptor Antagonists and Evaluation by [ 18 F]-PET Imaging in a Primate Brain. Journal of Medicinal Chemistry, 2015, 58 (20), pp.8066-8096. ⟨10.1021/acs.jmedchem.5b00874⟩. ⟨hal-03082898⟩
  • Fanny Duhr, Paul Déléris, F. Raynaud, Martial Séveno, Séverine Morisset-Lopez, et al.. Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth. Nature Chemical Biology, 2014, 10 (7), pp.590-597. ⟨10.1038/nchembio.1547⟩. ⟨hal-01178901⟩
  • Fabienne Godin, Sandrine Villette, Béatrice Vallée, Michel Doudeau, Séverine Morisset-Lopez, et al.. A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.. Biochemical and Biophysical Research Communications, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩. ⟨hal-00721861⟩
  • F. Gbahou, E. Davenas, S. Morisset, J.- Arrang. Effects of Betahistine at Histamine H3 Receptors: Mixed Inverse Agonism/Agonism In Vitro and Partial Inverse Agonism In Vivo. Journal of Pharmacology and Experimental Therapeutics, 2010, 334 (3), pp.945-954. ⟨10.1124/jpet.110.168633⟩. ⟨hal-02071192⟩
  • M. Picard, S. Morisset, J.F. Cloix, J.C. Bizot, M. Guerin, et al.. Pharmacological, neurochemical, and behavioral profile of JB-788, a new 5-HT1A agonist. Neuroscience, 2010, 169 (3), pp.1337-1346. ⟨10.1016/j.neuroscience.2010.05.040⟩. ⟨hal-02071835⟩
  • Mouhammad Motawaj, Aude Burban, Elisabeth Davenas, Florence Gbahou, Raphaël Faucard, et al.. Le système histaminergique : une cible pour de nouveaux traitements des deficits cognitifs. Thérapie, 2010, 65 (5), pp.415-422. ⟨10.2515/therapie/2010058⟩. ⟨hal-02071208⟩
  • Jacques Pantel, Marie Legendre, Sylvie Nivot, Séverine Morisset, Marie Vie-Luton, et al.. Recessive Isolated Growth Hormone Deficiency and Mutations in the Ghrelin Receptor. Journal of Clinical Endocrinology and Metabolism, 2009, 94 (11), pp.4334-4341. ⟨10.1210/jc.2009-1327⟩. ⟨hal-02081574⟩
  • W. Beghdadi, A. Porcherie, Schneider B.S., S. Morisset, D. Dubayle, et al.. Histamine H3 receptor-mediated signaling protects mice from cerebral malaria.. PLoS ONE, 2009, 4, pp.e6004. ⟨hal-00397938⟩
  • E. Davenas, A. Rouleau, S. Morisset, J. Arrang. Autoregulation of McA-RH7777 Hepatoma Cell Proliferation by Histamine H3 Receptors. Journal of Pharmacology and Experimental Therapeutics, 2008, 326 (2), pp.406-413. ⟨10.1124/jpet.107.135368⟩. ⟨hal-02081595⟩
  • Marie Humbert-Claude, Séverine Morisset, Florence Gbahou, Séverine Morisset-Lopez. Histamine H3 and dopamine D2 receptor-mediated [35S]GTPγ[S] binding in rat striatum: Evidence for additive effects but lack of interactions. Biochemical Pharmacology, 2007, 73 (8), pp.1172-1181. ⟨10.1016/j.bcp.2007.01.006⟩. ⟨hal-02081605⟩
  • Xavier Ligneau, Laurent Landais, David Perrin, Johanne Piriou, Marilyne Uguen, et al.. Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649.. Biochemical Pharmacology, 2007, 73 (8), pp.1215-24. ⟨10.1016/j.bcp.2007.01.023⟩. ⟨inserm-00150117⟩
  • Séverine Morisset-Lopez, Séverine Morisset, Florence Gbahou. Constitutive activity of the histamine H3 receptor. Trends in Pharmacological Sciences, 2007, 28 (7), pp.350-357. ⟨10.1016/j.tips.2007.05.002⟩. ⟨hal-02081603⟩
  • M. Humbert-Claude, S Morisset-Lopez, F. Gbahou, M. Arrang. Potential molecular interactions between the histamine H3 receptor and the dopamine D2 receptor in the rat striatum. European Neuropsychopharmacology, 2006, 16, pp.S16-S17. ⟨10.1016/s0924-977x(06)80021-0⟩. ⟨hal-02082149⟩
  • J. Pantel, Marie Legendre, Sylvie Cabrol, Latifa Hilal, Yassir Hajaji, et al.. Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature. Journal of Clinical Investigation, 2006, 116 (3), pp.760-768. ⟨10.1172/JCI25303⟩. ⟨hal-02082146⟩
  • S Morisset-Lopez, C. Chabret, J.M. Arrang. P.1.31 Constitutive dimerization of the histamineH3 receptor in living cells. European Neuropsychopharmacology, 2005, 15, pp.S25-S26. ⟨10.1016/s0924-977x(05)80136-1⟩. ⟨hal-02082151⟩
  • F. Gbahou, A. Rouleau, S Morisset-Lopez, X. Ligneau, J. Tardivel-Lacombe, et al.. P.1.03 Constitutive activity of the recombinant and native histamine H3 receptor: effects of inverse agonists and protean agonists. European Neuropsychopharmacology, 2004, 14, pp.S4-S5. ⟨10.1016/s0924-977x(04)90004-1⟩. ⟨hal-02081569⟩
  • J. C. Schwartz, S Morisset-Lopez, A. Rouleau, X. Ligneau, F. Gbahou, et al.. Therapeutic implications of constitutive activity of receptors: the example of the histamine H3 receptor.. Journal of Neural Transmission Supplementum, 2003, 64, pp.1-16. ⟨hal-02081590⟩
  • J.M. Arrang, S. Morisset, A. Rouleau, F. Gbahou, X. Ligneau, et al.. Constitutive activity of the recombinant and native histamine H3 receptor. International Congress Series, 2003, 1249, pp.139-151. ⟨10.1016/S0531-5131(03)00617-4⟩. ⟨hal-02081573⟩
  • F. Gbahou, A. Rouleau, S Morisset-Lopez, R. Parmentier, S. Crochet, et al.. Protean agonism at histamine H3 receptors in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America, 2003, 100 (19), pp.11086-11091. ⟨10.1073/pnas.1932276100⟩. ⟨hal-02081588⟩
  • J.M. Arrang, S Morisset-Lopez, A. Rouleau, F. Gbahou, X. Ligneau, et al.. S.16.04 Histamine H3-receptor ligands: Effects of inverse agonists and protean ligands. European Neuropsychopharmacology, 2003, 13, pp.S141. ⟨10.1016/s0924-977x(03)91663-4⟩. ⟨hal-02081585⟩
  • Brigitte Ilien, Christelle Franchet, Philippe Bernard, Séverine Morisset, Claire Odile Weill, et al.. Fluorescence resonance energy transfer to probe human M1 muscarinic receptor structure and drug binding properties.. Journal of Neurochemistry, 2003, 85 (3), pp.768-78. ⟨hal-02081577⟩
  • A. Rouleau, X Ligneau, J. Tardivel-Lacombe, S Morisset-Lopez, F Gbahou, et al.. Histamine H 3 -receptor-mediated [ 35 S]GTPγ[S] binding: evidence for constitutive activity of the recombinant and native rat and human H 3 receptors. British Journal of Pharmacology, 2002, 135 (2), pp.383-392. ⟨10.1038/sj.bjp.0704490⟩. ⟨hal-02082155⟩
  • C. Chotard, T. Ouimet, S. Morisset, U. Sahm, C. Schwartz, et al.. Effects of histamine H 3 receptor agonist and antagonist on histamine co-transmitter expression in rat brain. Journal of Neural Transmission, 2002, 109 (3), pp.293-306. ⟨10.1007/s007020200024⟩. ⟨hal-02081594⟩
  • Séverine Morisset-Lopez, Catherine Pilon, Joël Tardivel-Lacombe, D Weinstein, William Rostene, et al.. Acute and chronic effects of methamphetamine on tele-methylhistamine levels in mouse brain: selective involvement of the D(2) and not D(3) receptor.. Journal of Pharmacology and Experimental Therapeutics, 2002, 300 (2), pp.621-8. ⟨10.1124/jpet.300.2.621⟩. ⟨hal-02082246⟩
  • Catherine Pillot, Jordi Ortiz, Anne Héron, Sophie Ridray, Jean-Charles Schwartz, et al.. Ciproxifan, a Histamine H 3 -Receptor Antagonist/Inverse Agonist, Potentiates Neurochemical and Behavioral Effects of Haloperidol in the Rat. Journal of Neuroscience, 2002, 22 (16), pp.7272-7280. ⟨hal-01490023⟩
  • Joël Tardivel-Lacombe, Séverine Morisset, Florence Gbahou, Jean-Charles Schwartz, Séverine Morisset-Lopez. Chromosomal mapping and organization of the human histamine H3 receptor gene. NeuroReport, 2001, 12 (2), pp.321-324. ⟨10.1097/00001756-200102120-00028⟩. ⟨hal-02082162⟩
  • Jean-Charles Schwartz, Séverine Morisset, Agnès Rouleau, Joël Tardivel-Lacombe, Florence Gbahou, et al.. Application of genomics to drug design: the example of the histamine H3 receptor. European Neuropsychopharmacology, 2001, 11 (6), pp.441-448. ⟨10.1016/s0924-977x(01)00121-3⟩. ⟨hal-02129745⟩
  • Séverine Morisset, Astrid Sasse, Florence Gbahou, Anne Héron, Xavier Ligneau, et al.. The Rat H3 Receptor: Gene Organization and Multiple Isoforms. Biochemical and Biophysical Research Communications, 2001, 280 (1), pp.75-80. ⟨10.1006/bbrc.2000.4073⟩. ⟨hal-02082164⟩
  • S Morisset-Lopez, Agnés Rouleau, Anne Héron, Joël Tardivel-Lacombe, Séverine Morisset, et al.. Cloning and cerebral expression of the guinea pig histamine H3 receptor. NeuroReport, 2000, 11 (4), pp.755-759. ⟨10.1097/00001756-200003200-00020⟩. ⟨hal-02082171⟩
  • C Ito, S Morisset-Lopez, J-P Olié, H Lôo, M-F Poirier, et al.. Histamine H2 receptor gene variants: lack of association with schizophrenia. Molecular Psychiatry, 2000, 5 (2), pp.159-164. ⟨10.1038/sj.mp.4000664⟩. ⟨hal-02082207⟩
  • S. Morisset, E. Traiffort, J. M. Arrang, J. C. Schwartz. Changes in histamine H3 receptor responsiveness in mouse brain.. Journal of Neurochemistry, 2000, 74 (1), pp.339-46. ⟨hal-00347608⟩
  • X. Ligneau, S Morisset-Lopez, J. Tardivel-Lacombe, F Gbahou, C Ganellin, et al.. Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain.. British Journal of Pharmacology, 2000, 131 (7), pp.1247-50. ⟨10.1038/sj.bjp.0703712⟩. ⟨hal-02081534⟩
  • S. Morisset, A. Rouleau, X Ligneau, F Gbahou, J. Tardivel-Lacombe, et al.. High constitutive activity of native H3 receptors regulates histamine neurons in brain.. Nature, 2000, 408 (6814), pp.860-4. ⟨10.1038/35048583⟩. ⟨hal-02081523⟩
  • S. Morisset, U. G. Sahm, E. Traiffort, J. Tardivel-Lacombe, J. M. Arrang, et al.. Atypical neuroleptics enhance histamine turnover in brain via 5-Hydroxytryptamine2A receptor blockade.. Journal of Pharmacology and Experimental Therapeutics, 1999, 288 (2), pp.590-6. ⟨hal-00347619⟩
  • Séverine Morisset, Elisabeth Traiffort, Jean-Charles Schwartz. Inhibition of histamine versus acetylcholine metabolism as a mechanism of tacrine activity. European Journal of Pharmacology, 1996, 315 (1), pp.R1-R2. ⟨10.1016/s0014-2999(96)00738-8⟩. ⟨hal-02081407⟩
  • Guillaume Drutel, Markus Kathmann, Anne Héron, Jean-Charles Schwartz, Séverine Morisset-Lopez. Cloning and Selective Expression in Brain and Kidney of ARNT2 Homologous to the Ah Receptor Nuclear Translocator (ARNT). Biochemical and Biophysical Research Communications, 1996, 225, pp.333-339. ⟨10.1006/bbrc.1996.1176⟩. ⟨hal-01560437⟩
  • Séverine Morisset-Lopez, Guillaume Drutel, Monique Garbarg, Martial Ruat, Elisabeth Traiffort, et al.. Molecular and Functional Diversity of Histamine Receptor Subtypes. Annals of the New York Academy of Sciences, 1995, 757 (1), pp.314-323. ⟨10.1111/j.1749-6632.1995.tb17489.x⟩. ⟨hal-03534121⟩
  • Maryvonne Le Coniat, Elisabeth Traiffort, Martial Ruat, Séverine Morisset-Lopez, Roland Berger. Chromosomal localization of the human histamine H1-receptor gene. Human Genetics, 1994, 94 (2), pp.186-188. ⟨10.1007/BF00202867⟩. ⟨hal-03535137⟩
  • Jean-Charles Schwartz, Séverine Morisset-Lopez, Monique Garbarg, Hélène Pollard, Martial Ruat. Histaminergic transmission in the mammalian brain. Physiological Reviews, 1991, 71 (1), pp.1-51. ⟨10.1152/physrev.1991.71.1.1⟩. ⟨hal-03536845⟩
  • Martial Ruat, Elisabeth Traiffort, Séverine Morisset-Lopez, Rob Leurs, Jean-Charles Schwartz. Cloning and tissue expression of a rat histamine H2-receptor gene. Biochemical and Biophysical Research Communications, 1991, 179 (3), pp.1470-1478. ⟨10.1016/0006-291x(91)91738-x⟩. ⟨hal-03536798⟩
  • M.I. Martinez-Mir, H. Pollard, J. Moreau, Séverine Morisset-Lopez, Martial Ruat, et al.. Three histamine receptors (H1, H2 and H3) visualized in the brain of human and non-human primates. Brain Research, In press, 526 (2), pp.322-327. ⟨10.1016/0006-8993(90)91240-h⟩. ⟨hal-03536911⟩

Communication dans un congrès10 documents

  • Séverine Morisset-Lopez. Innovations pharmacologiques pour l'étude des neurorécepteurs : intérêt du BRET et de la technologie AlphaScreen. Journée scientifique de l’axe protéomique des plateformes de Biogenouest, Feb 2020, Roscoff, France. ⟨hal-02973392⟩
  • Wanyin Chen, Anthony Guillemain, Lauren Blot, Fabienne Fasani, Esther Kellenberger, et al.. Anti-tumor activity of new ligands targeting LINGO1- a protein primarily expressed in CNS for the treatment of glioblastomas. Colloque Niche et épigénétique des tumeurs, Jul 2020, Online, France. ⟨hal-03686680⟩
  • Séverine Morisset-Lopez. Utilisation de la technologie Alpha Screen pour étudier les neurorécepteurs : du binding à la signalisation. Séminaire technologique organisé par Perkin Elmer, Sep 2019, Paris, France. ⟨hal-02973431⟩
  • W. Chen, A. Guillemain, L. Blot, Fabienne Fasani, E. Kellenberger, et al.. The research of new therapeutic targets and small chemical molecules for glioblastoma therapies. Central South University in HuNan, Dec 2019, Changsha, China. ⟨hal-03686683⟩
  • Séverine Morisset-Lopez. Séminaire invité : Ligands biaisés du récepteur 5-HT7: outils pharmacologiques, d'imagerie et applications thérapeutiques. PRC INRA, Nouzilly, Apr 2019, Nouzilly, France. ⟨hal-02974178⟩
  • Séverine Morisset-Lopez. Le récepteur 5-HT7 de la sérotonine : de la pharmacologie moléculaire vers la physiopathologie. ESBS, Apr 2018, Strasbourg, France. ⟨hal-02974183⟩
  • Séverine Morisset-Lopez. Le récepteur 5-HT7 de la sérotonine : de la pharmacologie moléculaire vers la physiopathologie. ESBS, Apr 2018, Strasbourg, France. ⟨hal-03331436⟩
  • Séverine Morisset-Lopez. Les neurorécepteurs : Bases moléculaires de leur activation et intérêts physiopathologiques,. Journée de la SFR Neuroimagerie, May 2018, La Riche, France. ⟨hal-02973456⟩
  • Séverine Morisset-Lopez. Le récepteur 5-HT7 de la sérotonine, un acteur dans les neuropathologies: signalisation cellulaire et modèles animaux. INEM, Jul 2017, Orléans, France. ⟨hal-03331443⟩
  • Shalina Hassanaly, Alexia Perrin, Séverine Morisset-Lopez, Catherine Grillon. Modèles pour l’étude de la pigmentation. 1er atelier thématique du GDR Cosm’actifs Quel modèle pour tester l’activité d’un composé : de la molécule à l’homme, Mar 2016, Lyon, France. ⟨hal-03668561⟩

Poster22 documents

  • Khadidja Sidelarbi, Fabienne Fasani, Séverine Morisset-Lopez, Catherine Grillon. Rôle différentiel de Lingo1 et Lingo3 dans la prolifération et la migration des cellules de glioblastome. 16èmes journées du Cancéropôle Grand Ouest, Jun 2021, Angers, France. ⟨hal-03838122⟩
  • Marion Maravat, Marylène Bertrand, M. Decoville, C. Landon, Séverine Morisset-Lopez, et al.. Biomarkers involved in glioma development in Drosophila melanogaster model. European RFMF Metabomeeting 2020, Jan 2020, Toulouse, France. ⟨hal-02919170⟩
  • Wanyin Chen, Anthony Guillemain, Lauren Blot, Fabienne Fasani, Esther Kellenberger, et al.. Anti-tumor activity of new ligands targeting LINGO1- a protein primarily expressed in CNS for the treatment of glioblastomas. Colloque Niche et épigénétique des tumeurs, Jul 2020, Online, France. . ⟨hal-03686675⟩
  • Wanyin Chen, Anthony Guillemain, Lauren Blot, Fabienne Fasani, Esther Kellenberger, et al.. Etude de l’activité anti-tumorale de nouveaux ligands ciblant LINGO-1 pour le traitement des glioblastomes. Colloque de l’ADOC, Jul 2019, Orléans, France. ⟨hal-03686230⟩
  • F. Courant, Marion Maravat, L. Blot, David Gosset, Séverine Morisset-Lopez, et al.. Etude d’une nouvelle cible thérapeutique dans un modèle de gliome chez Drosophila melanogaster. 13es journées du cancéropôle Grand Ouest, Jul 2019, Tours, France. ⟨hal-02973627⟩
  • Marion Maravat, Martine Decoville, Marylène Bertrand, Celine Landon, Séverine Morisset-Lopez, et al.. NMR-based metabolomics for glioma biomarker discovery in a Drosophila melanogaster model. 3rd edition Metabolism & Cancer, Apr 2019, Marseille, France. ⟨hal-02986792⟩
  • W. Chen, A. Guillemain, L. Blot, F. Fasani, E. Kellenberger, et al.. Nouvelles molécules chimiques anti-tumorales pour le traitement du glioblastomes. 13es journées du Cancéropôle Grand Ouest, Jul 2019, Tours, France. ⟨hal-02973622⟩
  • Wanyin Chen, Anthony Guillemain, Lauren Blot, Fabienne Fasani, Esther Kellenberger, et al.. Etude de l’activité anti-tumorale de nouveaux ligands ciblant LINGO-1 pour le traitement des glioblastomes. Journée Fédération FR2708 Physique et Chimie du Vivant, Apr 2019, Orléans, France. ⟨hal-03625295⟩
  • L. Blot, Y. Makhloufi, V. Sarou-Kainian, A. Guillemain, C. Grillon, et al.. Développement des gliomes chez Drosophila Melanogaster: rôle du récepteur 5-HT7 de la sérotonine. Journée Scientifique de la fédération de Recherche FR 2708, Jan 2018, Orléans, France. ⟨hal-02973683⟩
  • Séverine Morisset-Lopez, L. Blot, A. Guillemain, C. Grillon, D. Decoville. Identification of new partner of EGF receptor: functional interaction and interest for the treatment of glioma. Studium conference Stem cells and cancer stem cells, Jun 2018, Orléans, France. ⟨hal-02973700⟩
  • C. El Khamlichi, Flora Reverchon, Eric Robin, N. Chopin, E. Deau, et al.. Identification of biased ligands of 5-HT7 receptor: Molecular bases of their action. 7th Annual meeting GDR 3545, Oct 2018, Strasbourg, France. ⟨hal-02973734⟩
  • L. Blot, A. Guillemain, C. Grillon, D. Decoville, Séverine Morisset-Lopez. Identification d’un nouveau partenaire de l’EGFR : interaction fonctionnelle et intérêt pour le traitement des tumeurs cérébrales. 12es journées du cancéropôle Grand Ouest, Jul 2018, Vannes, France. ⟨hal-02973707⟩
  • C. El Khamlichi, Flora Reverchon, Eric Robin, Arnaud Menuet, N. Chopin, et al.. Serotonin 5-HT7 receptor: characterization of new potent ligands with therapeutical properties. 31e colloque Biotechnocentre, Oct 2018, Seillac, France. ⟨hal-02973722⟩
  • L. Blot, Y. Makhloufi, A. Guillemain, C. Grillon, Séverine Morisset-Lopez, et al.. Rôle du récepteur 5-HT7 de la sérotonine dans le développement des gliomes chez Drosophila Melanogaster. 11es journées du Cancéropôle Grand Ouest, Jun 2017, Vannes, France. ⟨hal-02973773⟩
  • Séverine Morisset-Lopez, W. Deraredj Nadim, S. Chaumont−dubel, F. Madouri, L. Cobret, et al.. Neurofibromin 1 promotes constitutive activity of native 5−HT6 receptors expressed in mouse prefrontal cortex. Neurofrance, May 2017, Bordeaux, France. ⟨hal-02973767⟩
  • Martine Decoville, Anthony Guillemain, Catherine Grillon, Séverine Morisset. Effect of the serotonin 5-HT7 recepteur on cellular proliferation in Drosophila melanogaster. 5th annual meeting of the GDR 3545 RCPG-PhysioMed 2016, Nov 2016, Tours, France. ⟨hal-02453412⟩
  • Shalina Hassanaly, Wissem Deraredj Nadim, Claudine Kieda, Séverine Morisset, Catherine Grillon. Regulation of MC1R-mediated pigmentation in human melanocytes by the GRD domain of neurofibromin. 5th annual meeting of the GDR 3545 RCPG-PhysioMed 2016, Nov 2016, Tours, France. ⟨hal-02453410⟩
  • Hélène Bénédetti, Fabienne Godin, Michel Doudeau, Béatrice Vallée, Marie-Ludivine De Tauzia, et al.. LINGO-1, a protein involved in various neurodevelopmental processes, interacts with neurofibromin (Nf1), the protein responsible for neurofibromatosis type I: molecular studies and functional implications. 10 th FENS (Forum of Neuroscience), Jul 2016, Copenhague, Denmark. ⟨hal-02453487⟩
  • W. Deraredj Nadim, S. Chaumont-Dubel, F. Madouri, L. Cobret, M.-L. de Tauzia, et al.. A Physical Interaction between Neurofibromin and Serotonin 5-HT6 Receptor Promotes Receptor Constitutive Activity. 5th annual meeting of the GDR 3545 RCPG-PhysioMed 2016, Nov 2016, Tours, France. ⟨hal-02973912⟩
  • A. Guillemain, L. Blot, L. Cobret, M. Decoville, Séverine Morisset-Lopez. Etude d’une nouvelle cible thérapeutique LINGO-1 pour le traitement des tumeurs cérébrales. 10es Journées du Cancéropôle Grand Ouest, Jun 2016, Les-Sables-d'Olonne, France. ⟨hal-02973806⟩
  • Shalina Hassanaly, Wissem Deraredj Nadim, Claudine Kieda, Séverine Morisset, Catherine Grillon. Regulation of MC1R-mediated pigmentation by the GRD domain of neurofibromin in human melanocytes. 20th ESPCR Meeting, Sep 2016, Milan, Italy. ⟨hal-02453404⟩
  • Anne Héron, Véronique Cochois, Valérie Biran, Séverine Morisset-Lopez, Christiane Charriaut-Marlangue. Etude de l'histamine au cours du développement des lesions consecutives à une ischémie cérébrale néonatale. 7e colloque de la Société des neurosciences, 2005, Lille, France. ⟨hal-01610437⟩

Ouvrage (y compris édition critique et traduction)1 document

  • Séverine Morisset-Lopez. Voyage au centre du cerveau avec le Professeur Ciboulot. édité dans le cadre du Labo Tour’80. 100 p., 2019. ⟨hal-02973919⟩

Brevet2 documents

  • Séverine Morisset-Lopez, F. Suzenet, G. Guillaumet, E. Deau, E. Robin, et al.. Applications of biased ligands of the serotonin 5-HT7 receptor for the treatment of pain, multiple sclerosis and the control of thermoregulation. France, Patent n° : Patent BET 20P3848 (STL-SED) - EUROPE 21315045.1. BIOBRAT. 2021. ⟨hal-03668557⟩
  • Séverine Morisset-Lopez, Hélène Bénédetti. Tools for the identification od LINGO-1, LINGO-2, LINGO-3 and LINGO-4, ligands, and uses thereof. France, Patent n° : WO2011121257. BCT. 2011. ⟨hal-02130935⟩

Documents récupérés de l'archive ouverte HAL