email : thierry.normand[remplacer_par_at]cnrs-orleans.fr
Téléphone : 02.38.25.55.86
Maître de conférence au sein du groupe thématique “Apoptose et autophagie normales et pathologiques”
- Métadonnées
Publications (Archives Hal)
Contact
isabelle.frapart@cnrs-orleans.fr 02.38.25.55.53
Disciplines
- Sciences du Vivant [q-bio]22
- Informatique [cs]/Bio-informatique [q-bio.QM]2
- Informatique [cs]/Apprentissage [cs.LG]2
- Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Génomique, Transcriptomique et Protéomique [q-bio.GN]2
- Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biologie moléculaire1
- Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire1
Mots-clefs
ANTIGENS Alpha-synuclein Antiretroviral therapy Apoptosis BAX Basal autophagy CELL-DEATH PROTEIN Caspase activation Cytogaligin Dual cellular localization Dual localization ELECTROPHORETIC TRANSFER ENDOGENOUS PEROXIDASE GENE MITOCHONDRIA Mechanism of SUMOylation site selection Model of Nf1-SecPH/Ubc9 interaction Neurofibromin Nf1 and Nf1-SecPH domain SUMOylation SCM- and SIM-independent SUMOylation SUMOylation site selection dependent of 3D structure
- Mechanism of SUMOylation site selection3
- Model of Nf1-SecPH/Ubc9 interaction3
- Neurofibromin Nf1 and Nf1-SecPH domain SUMOylation3
- SCM- and SIM-independent SUMOylation3
- GENE2
- MITOCHONDRIA2
- SUMOylation site selection dependent of 3D structure2
- ANTIGENS1
- Alpha-synuclein1
- Antiretroviral therapy1
- Apoptosis1
- BAX1
- Basal autophagy1
- CELL-DEATH PROTEIN1
- Caspase activation1
- Cytogaligin1
- Dual cellular localization1
- Dual localization1
- ELECTROPHORETIC TRANSFER1
- ENDOGENOUS PEROXIDASE1
- GALIG gene1
- HORSERADISH-PEROXIDASE1
- IDENTIFICATION1
- IMPORTIN1
- INTRACELLULAR-LOCALIZATION1
- LOCALIZATION1
- Luciferase protein-fragment complementation assay1
- MOLECULAR-CLONING1
- Machine learning techniques for biomedical data1
- Mitogaligin1
- NITROCELLULOSE1
- P53 PROTEIN1
- POLYACRYLAMIDE GELS1
- PROTEINS1
- Programmed cell death1
- SEQUENCE1
- SMARF1
- TRANSLOCATION1
- Ubc9 fusion-directed SUMOylation1
- Unconventional nuclear localization signal1
- VIRUS1
Auteurs
Normand Thierry28 Legrand Alain13 Charpentier Stéphane11 Mollet Lucile9 Brulé-Morabito Fabienne8 Dubois Martine6 El Haddad Saïd3 Gagné C3 Gonzalez Patrick3 Julien P3 Serrano Amandine3 Sosic Iva3 Serrano Amandine3 Goffinont Stéphane3 Bénédetti Hélène3 Robin Chloé3 Mosrin-Huaman Christine3 Robinet Pauline3 Adamski J2 Bégué A.2 Dubois M2 Dubois M.2 El Haddad S.2 Haddad S El2 Jean Claude2 Jean-Faucher Christiane2 Leenders F2 Lupien Paul J.2 Narod Steven2 Serrano A2 Serrano A.2 Ven Murthy M2 de Braekeleer M.2 de Launoit Y2 Bergoug Mohammed2 Doudeau Michel2 Godin Fabienne2 Suskiewicz Marcin J.2 Vallée Béatrice2 Normand T.2 Mollet L.2 Bharucha Aoife2 Simard Jacques2 Moal Fréderic2 Aurouet Axel1 Auzou P.1 Auzou Pascal1 Baert J.L1 Bergeron J.1 Bergeron M.1 Bergoug Mohammed1 Bloch Solal1 Blot Lauren1 Boyer Guittaut M.1 Brun D1 Brun L1 Brunzell John1 Carp D1 Charpentier Stéphane1 Chen Wanyin1 Clarke L1 Davignon Jean1 Després P1 Dionne C1 Dionne D1 Doudeau Michel1 Duneau M.1 Duneau Mélanie1 Durocher F.1 Fernandez-Margallo Teresa1 Feunteun Jean1 Flourens A.C1 Gagné Claude1 Garnache-Ottou F1 Garnache-Ottou Francine1 Godin Fabienne1 Grandclement Camille1 Guery T1 Guilbault C.1 Guillemain Anthony1 Guittaut Michaël1 Hayden M1 Hayden Mickael R.1 Henderson Howard1 Husen B.1 Jean C1 Jean-Faucher C.1 Julien Pierre1 Jungblut P1 Labrie F.1 Labrie Femand1 Labrie Fernand1 Lambert M.1 Laouarem Yousra1 Lasko Dana D.1 Leblanc J.1 Legac E1 Legac E.1 Legac Eric1 Lenoir Gilbert1
Revues
- Biochemical and Biophysical Research Communications3
- Human Molecular Genetics2
- Analytical Biochemistry1
- Biochemical Journal1
- Clinical Genetics1
- Cytogenetic and Genome Research1
- Experimental and Clinical Endocrinology1
- International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity1
- Human Genetics1
- AIDS. Official journal of the international AIDS Society1
Année de production
Institutions
- Université d'Orléans18
- Université de Tours18
- Institut National de la Santé et de la Recherche Médicale18
- Institut de Chimie - CNRS Chimie18
- Université Blaise Pascal - Clermont-Ferrand 23
- Faculté de médecine de l'Université Laval [Québec]3
- Centre Hospitalier Régional d'Orléans2
- Université du Québec à Chicoutimi2
- Institut National des Sciences Appliquées - Centre Val de Loire2
- University of British Columbia [Canada]2
- Centre Hospitalier de l'Université de Laval2
- Institut Gustave Roussy1
- Université de Bordeaux1
- Centre Hospitalier Régional Universitaire de Besançon1
- Montreal General Hospital1
- Société GéoHyd1
- Faculty of Medecine, Laval University1
- Creighton University School of Medicine1
- Institut Polytechnique de Bordeaux1
- Etablissement français du sang [Bourgogne-Franche-Comté]1
- Université Grenoble Alpes [2016-2019]1
- Université de Franche-Comté1
- CHU de Québec–Université Laval1
- Organisation Mondiale de la Santé | World Health Organization Office [Genève, Suisse]1
- Université Bordeaux Segalen - Bordeaux 21
- Université Paris-Sud - Paris 111
- Université Sciences et Technologies - Bordeaux 11
Laboratoires
- Centre de biophysique moléculaire18
- Laboratoire d'Oncologie Moléculaire Humaine2
- Laboratoire d'Informatique Fondamentale d'Orléans2
- CHUL Research Center and Department of Molecular Medicine, Laboratory of Endocrinology and Genomics2
- Service d'hématologie1
- Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)1
- Société GéoHyd1
- Molecular Endocrinology and Oncology Research Center1
- Institut de Mathématiques de Bordeaux1
- Laboratoire de Génomique des Cancers1
Départements
Équipes de recherche
30 documents
Article dans une revue24 documents
- Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection. Journal of Molecular Biology, 2024, 436 (22), pp.168768. ⟨10.1016/j.jmb.2024.168768⟩. ⟨hal-04771131⟩
- Anthony Guillemain, Yousra Laouarem, Laetitia Cobret, Dora Štefok, Wanyin Chen, et al.. LINGO family receptors are differentially expressed in the mouse brain and form native multimeric complexes. FASEB Journal, 2020, pp.1-13. ⟨10.1096/fj.202000826R⟩. ⟨hal-02943248⟩
- Saïd El Haddad, Amandine Serrano, Fréderic Moal, Thierry Normand, Chloé Robin, et al.. Disturbed expression of autophagy genes in blood of Parkinson’s disease patients. Gene, 2020, 738, pp.144454. ⟨10.1016/j.gene.2020.144454⟩. ⟨hal-02501027⟩
- Amandine Serrano, Saïd El Haddad, Fréderic Moal, Thierry Prazuck, Eric Legac, et al.. Dysregulation of apoptosis and autophagy gene expression in peripheral blood mononuclear cells of efficiently treated HIV-infected patients. AIDS. Official journal of the international AIDS Society, 2018, 32 (12), pp.1579 - 1587. ⟨10.1097/QAD.0000000000001851⟩. ⟨hal-01936094⟩
- Saïd El Haddad, Amandine Serrano, Thierry Normand, Chloé Robin, Martine Dubois, et al.. Interaction of Alpha-synuclein with Cytogaligin, a protein encoded by the proapoptotic gene GALIG. Biochemical and Biophysical Research Communications, 2018, 495 (1), pp.787-792. ⟨10.1016/j.bbrc.2017.11.078⟩. ⟨hal-01966108⟩
- Lucile Mollet, Pauline Robinet, Martine Dubois, Axel Aurouet, Thierry Normand, et al.. Opposing Mcl-1, the GALIG proapoptotic gene is upregulated as neutrophils die and underexpressed in Acute Myeloid Leukemia cells.. Molecular Immunology, 2013, 56 (1-2), pp.123-8. ⟨10.1016/j.molimm.2013.04.012⟩. ⟨hal-00840170⟩
- Pauline Robinet, Lucile Mollet, Patrick Gonzalez, Thierry Normand, Stephane Charpentier, et al.. The mitogaligin protein is addressed to the nucleus via a non-classical localization signal. Biochemical and Biophysical Research Communications, 2010, 392 (1), pp.53-57. ⟨10.1016/j.bbrc.2009.12.162⟩. ⟨hal-00529397⟩
- Patrick Gonzalez, Pauline Robinet, Stéphane Charpentier, Lucile Mollet, Thierry Normand, et al.. Apoptotic activity of a nuclear form of mitogaligin, a cell death protein. Biochemical and Biophysical Research Communications, 2009, 378 (4), pp.816-820. ⟨10.1016/j.bbrc.2008.11.133⟩. ⟨hal-00522444⟩
- Alexis D. Sennepin, Stéphane Charpentier, Thierry Normand, Cedric Sarre, Alain Legrand, et al.. Multiple reprobing of Western blots after inactivation of peroxidase activity by its substrate, hydrogen peroxide. Analytical Biochemistry, 2009, 393 (1), pp.129-131. ⟨10.1016/j.ab.2009.06.004⟩. ⟨hal-00525339⟩
- Patrick Gonzalez, Mélanie Duneau, Stéphane Charpentier, Thierry Normand, Lucile Mollet, et al.. Destabilization of Membranes Containing Cardiolipin or Its Precursors by Peptides Derived from Mitogaligin, a Cell Death Protein. Biochemistry, 2007, 46 (25), pp.7374-7382. ⟨10.1021/bi700213p⟩. ⟨hal-00159568⟩
- M. Duneau, M. Boyer Guittaut, P. Gonzalez, S. Charpentier, T. Normand, et al.. Galig, a novel cell death gene that encodes a mitochondrial protein promoting cytochrome c release. Experimental Cell Research, 2005, 302, pp.194-205. ⟨hal-00088588⟩
- Michaël Guittaut, Stéphane Charpentier, Thierry Normand, Martine Dubois, Jacques Raimond, et al.. Identification of an Internal Gene to the Human Galectin-3 Gene with Two Different Overlapping Reading Frames That Do Not Encode Galectin-3. Journal of Biological Chemistry, 2001, 276 (4), pp.2652-2657. ⟨10.1074/jbc.m002523200⟩. ⟨hal-02137994⟩
- J. Morissette, F. Durocher, J. Leblanc, T. Normand, F. Labrie, et al.. Genetic linkage mapping of the human steroid 5α-reductase type 2 gene (SRD5A2) close to D2S352 on chromosome region 2p23→p22. Cytogenetic and Genome Research, 1996, 73 (4), pp.304-307. ⟨10.1159/000134362⟩. ⟨hal-02160041⟩
- A.M. Simon, C. Guilbault, Thierry Normand, Christiane Jean-Faucher, Georges Veyssière, et al.. Developmental and hormonal regulation of specific proteins in mouse seminal vesicles. Isolation and characterization of genomic and cDNA clones for androgen-regulated secretory protein. Experimental and Clinical Endocrinology, 1995, 14, pp.73-82. ⟨hal-02167152⟩
- Thierry Normand, B. Husen, F Leenders, H Pelczar, J.L Baert, et al.. Molecular characterization of mouse 17 beta-hydroxysteroid dehydrogenase IV.. Journal of Steroid Biochemistry and Molecular Biology, 1995, 55 (5-6), pp.541-8. ⟨10.1016/0960-0760(95)00204-9⟩. ⟨hal-02160020⟩
- J Adamski, Thierry Normand, F Leenders, D Monté, A. Bégué, et al.. Molecular cloning of a novel widely expressed human 80 kDa 17 β -hydroxysteroid dehydrogenase IV. Biochemical Journal, 1995, 311 (2), pp.437-443. ⟨10.1042/bj3110437⟩. ⟨hal-02160026⟩
- Thierry Normand, Steven Narod, Fernand Labrie, Jacques Simard. Detection of polymorphisms in the estradiol 17β-hydroxysteroid dehydrogenase II gene at the EDH17B2 locus on 17q11–q21. Human Molecular Genetics, 1993, 2 (4), pp.479-483. ⟨10.1093/hmg/2.4.479⟩. ⟨hal-02160210⟩
- J Simard, Jean Feunteun, Gilbert Lenoir, T Tonin, Thierry Normand, et al.. Genetic mapping of the breast-ovarian cancer syndrome to a small interval on chromosome 17q12–21: exclusion of candidate genes EDH17B2 and RARA. Human Molecular Genetics, 1993, 2 (8), pp.1193-1199. ⟨10.1093/hmg/2.8.1193⟩. ⟨hal-02160208⟩
- P Peeva, L Brun, M Ven Murthy, P Després, Thierry Normand, et al.. Adipose cell size and distribution in familial lipoprotein lipase deficiency.. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1992, 16 (10), pp.737-44. ⟨hal-02160233⟩
- M. Bergeron, Thierry Normand, Aoife Bharucha, M Ven Murthy, P Julien, et al.. Prevalence, geographical distribution and genealogical investigations of mutation 188 of lipoprotein lipase gene in the French Canadian population of Québec.. Clinical Genetics, 1992, 41 (4), pp.206-10. ⟨10.1111/j.1399-0004.1992.tb03664.x⟩. ⟨hal-02160230⟩
- Thierry Normand, J. Bergeron, Teresa Fernandez-Margallo, Aoife Bharucha, R Ven Murthy, et al.. Geographic distribution and genealogy of mutation 207 of the lipoprotein lipase gene in the French Canadian population of Québec.. Human Genetics, 1992, 89 (6), pp.671-5. ⟨10.1007/BF00221960⟩. ⟨hal-02160222⟩
- Y. Ma, Howard Henderson, V Murthy, Ghislaine Roederer, M. Monsalve, et al.. A Mutation in the Human Lipoprotein Lipase Gene as the Most Common Cause of Familial Chylomicronemia in French Canadians. New England Journal of Medicine, 1991, 324 (25), pp.1761-1766. ⟨10.1056/NEJM199106203242502⟩. ⟨hal-02160241⟩
- Thierry Normand, Christiane Jean-Faucher, Claude Jean. Neonatal exposure to oestrogens alters the protein profiles and gene expression in the genital tract of adult male mice. Journal of Steroid Biochemistry, 1990, 36 (5), pp.415-423. ⟨10.1016/0022-4731(90)90082-4⟩. ⟨hal-02160254⟩
- Thierry Normand, C. Jean-Faucher, C Jean. Developmental pattern of androgen-regulated proteins in seminal vesicles from the mouse.. International Journal of Andrology, 1989, 12 (3), pp.219-30. ⟨hal-02160364⟩
Communication dans un congrès4 documents
- S. El Haddad, A. Serrano, Thierry Normand, Fabienne Brulé-Morabito, L. Mollet, et al.. Cytogaligin, an additional link between Parkinson’s disease and autophagy pathways?. 7e Congrès du CFATG, Nov 2017, Paris, France. ⟨hal-02934905⟩
- S El Haddad, A Serrano, C Ozsancak, P. Auzou, F Moal, et al.. Genes de l’autophagie : marqueurs sanguins potentiels de la maladie de Parkinson. Journées de Neurologie de Langue Française, Apr 2016, Nantes, France. ⟨hal-03661930⟩
- A Serrano, T Guery, S El Haddad, M Dubois, M Schoenwald, et al.. GALIG, gène inducteur de la mort cellulaire, s’exprime au cours de la différenciation myéloïde. 10es Journées du Cancéropole Grand Ouest, Jun 2016, Les Sables d'Olonne, France. ⟨hal-03661932⟩
- A. Serrano, Thierry Normand, S. El Haddad, M. Dubois, Stéphane Charpentier, et al.. During efficient Anti-RetroViral (ARV) therapy, the expression of GALIG and its interacting partners involved in macroautophagy are deregulated. 6es Journées Scientifiques du CFATG, Oct 2016, Bordeaux, France. ⟨hal-02934903⟩
Poster2 documents
- Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation. 2024 Global NF Conference, Jun 2024, Brussels, Belgium. ⟨hal-03679991⟩
- Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation. 2024 Global NF Conference, Jun 2024, Brussels, Belgium. ⟨hal-04778711⟩