UPR 4301
Center for Molecular Biophysics, CNRS - Orleans
The Center for Molecular Biophysics (CBM) develops research at the interface of chemistry, biology and physics to study the molecular mechanisms that sustain life or dysfunctions leading to diseases.
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19 septembre 2025 : séminaire d'Arielle Nzoussi Loubota
"Impact of nutritional status on zonation of glucose metabolism in the liver: contribution of the FXR receptor."
2025, September 19: Arielle Nzoussi Loubota seminar
"Impact of nutritional status on zonation of glucose metabolism in the liver: contribution of the FXR receptor."
16 septembre 2025 : séminaire de Swati Biswas
"Multifunctional stimuli-responsive Nanotherapeutics platforms for cancer and infectious diseases"
2025, September 16: Swati Biswas seminar
"Multifunctional stimuli-responsive Nanotherapeutics platforms for cancer and infectious diseases"
12 septembre 2025 : séminaire d'Aranyadip Gayen
"Protein:nucleic acid interactions and PTMs in fundamental biology: studying translation initiation and nucleosome SUMOylation"
2025, September 12: Aranyadip seminar
"Protein:nucleic acid interactions and PTMs in fundamental biology: studying translation initiation and nucleosome SUMOylation"
CBM Newsletter n° 33
Discover the latest CBM Newsletter!
Lettre d'actualité du CBM n° 33
Découvrez la dernière Lettre d'actualité du CBM !
Évaluation d’ARNm synthétique avec des séquences UTR sélectionnées et une queue Poly(A) alternative, in vitro et in vivo
L'efficacité de l'ARNm dépend de son expression dans les cellules et les organismes. Nous avons sélectionné des séquences 3'UTR et poly(A) permettant une expression aussi efficace que celles utilisées dans le vaccin Pfizer-BioNTech dans des cellules primaires et chez la souris.
Evaluation of synthetic mRNA with selected UTR sequences and alternative Poly(A) tail, in vitro and in vivo
mRNA efficacy relies on efficient expression in cells and organisms. CBM researchers selected 3’UTR and poly(A) sequences yielding efficient mRNA expression in primary cells and mice. Their sequences were on par with the ones used in the Pfizer-Biontech vaccine both for expression and for mouse immunization.
Prochains évènements
Retour à l'agenda12 September 2025
12 septembre 2025 : séminaire d'Aranyadip Gaen
"Protein:nucleic acid interactions and PTMs in fundamental biology: studying translation initiation and nucleosome SUMOylation"
12 September 2025
2025, September 12: Aranyadip Gayen seminar
"Protein:nucleic acid interactions and PTMs in fundamental biology: studying translation initiation and nucleosome SUMOylation"