email :

Phone : +33

Office A309

Research director, coordinator of the team “Molecular, Structural and Chemical Biology” and responsible of the thematic group “Synthetic protein and bioorthogonal chemistry”

55 documents

Article dans une revue

  • Monika Cieslikiewicz-Bouet, Svetlana Eliseeva, Vincent Aucagne, Agnès Delmas, Isabelle Gillaizeau, et al.. Near-infrared emitting lanthanide( iii ) complexes as prototypes of optical imaging agents with peptide targeting ability: a methodological approach. RSC Advances, Royal Society of Chemistry, 2019, 9 (3), pp.1747-1751. ⟨10.1039/c8ra09419e⟩. ⟨hal-02064990⟩
  • Julien Diharce, Mickaël Cueto, Massimiliano Beltramo, Vincent Aucagne, Pascal Bonnet. In Silico Peptide Ligation: Iterative Residue Docking and Linking as a New Approach to Predict Protein-Peptide Interactions. Molecules, MDPI, 2019, 24 (7), pp.1351. ⟨10.3390/molecules24071351⟩. ⟨hal-02095312⟩
  • P.A. Parker, E.A. Coffman, K.G. Pohler, J.A. Daniel, V. Aucagne, et al.. Acute and subacute effects of a synthetic kisspeptin analog, C6, on serum concentrations of luteinizing hormone, follicle stimulating hormone, and testosterone in prepubertal bull calves. Theriogenology, Elsevier, 2019, 130, pp.111-119. ⟨10.1016/j.theriogenology.2019.03.002⟩. ⟨hal-02088608⟩
  • Caroline Decourt, Vincent Robert, Didier Lomet, Karine Anger, Marion Georgelin, et al.. The kisspeptin analog C6 is a possible alternative to PMSG (pregnant mare serum gonadotropin) for triggering synchronized and fertile ovulations in the Alpine goat. PLoS ONE, Public Library of Science, 2019, 14 (3), pp.e0214424. ⟨10.1371/journal.pone.0214424⟩. ⟨hal-02088631⟩
  • Mylène Wartenberg, Ahlame Saidi, Mathieu Galibert, Alix Joulin-Giet, Julien Burlaud-Gaillard, et al.. Imaging of extracellular cathepsin S activity by a selective near infrared fluorescence substrate-based probe. Biochimie, Elsevier, 2019, ⟨10.1016/j.biochi.2019.03.013⟩. ⟨hal-02088627⟩
  • Matthieu Galibert, Mylène Wartenberg, Fabien Lecaille, Ahlame Saidi, Sylvie Mavel, et al.. Substrate-derived triazolo- and azapeptides as inhibitors of cathepsins K and S. European Journal of Medicinal Chemistry, Elsevier, 2018, 144, pp.201 - 210. ⟨10.1016/j.ejmech.2017.12.012⟩. ⟨hal-01702303⟩
  • David Montoir, Mehdi Amoura, Zine El Abidine Ababsa, T. Vishwanatha, Expédite Yen-Pon, et al.. Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation. Chemical Science , The Royal Society of Chemistry, 2018, 9 (46), pp.8753-8759. ⟨hal-01966170⟩
  • Guillaume Martinez, Jean-Pascal Hograindleur, Sébastien Voisin, Roland Abi Nahed, Tarek M. Abd El Aziz, et al.. Spermaurin, an La1-like peptide from the venom of the scorpion Scorpio maurus palmatus , improves sperm motility and fertilization in different mammalian species. Molecular Human Reproduction, Oxford University Press (OUP), 2017. ⟨hal-01618630⟩
  • Victor Terrier, Agnès F. Delmas, Vincent Aucagne. Efficient synthesis of cysteine-rich cyclic peptides through intramolecular native chemical ligation of N-Hnb-Cys peptide crypto-thioesters. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2017, 15 (2), pp.316 - 319. ⟨10.1039/c6ob02546c⟩. ⟨hal-01618781⟩
  • Michael T. Jacobsen, Mark E. Petersen, Xiang Ye, Mathieu Galibert, George H. Lorimer, et al.. A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis. Journal of the American Chemical Society, American Chemical Society, 2016, 138 (36), pp.11775 - 11782. ⟨10.1021/jacs.6b05719⟩. ⟨hal-01407028⟩
  • Dominique Lelièvre, Victor P. Terrier, Agnès F. Delmas, Vincent Aucagne. Native Chemical Ligation Strategy to Overcome Side Reactions during Fmoc-Based Synthesis of C-Terminal Cysteine-Containing Peptides. Organic Letters, American Chemical Society, 2016, 18 (5), pp.920 - 923. ⟨10.1021/acs.orglett.5b03612⟩. ⟨hal-01407492⟩
  • Victor P. Terrier, Hélène Adihou, Mathieu Arnould, Agnès F. Delmas, Vincent Aucagne. A straightforward method for automated Fmoc-based synthesis of bio-inspired peptide crypto-thioesters. Chemical Science , The Royal Society of Chemistry, 2016, 7 (1), pp.339 - 345. ⟨10.1039/C5SC02630J⟩. ⟨hal-01407765⟩
  • Karine Loth, Soha Abou Ibrahim Alami, Chahrazed Habès, Solène Garrido, Vincent Aucagne, et al.. Complete 1H, 15N and 13C assignment of trappin-2 and 1H assignment of its two domains, elafin and cementoin. Biomolecular NMR Assignments, Springer, 2016, 10 (1), pp.223 - 226. ⟨10.1007/s12104-016-9671-1⟩. ⟨hal-01407495⟩
  • Audrey Gambade, Sami Zreika, Maxime Guéguinou, Igor Chourpa, Gaëlle Fromont, et al.. Activation of TRPV2 and BKCa channels by the LL-37 enantiomers stimulates calcium entry and migration of cancer cells.. Oncotarget, Impact journals, 2016, 7 (17), pp.23785-23800. ⟨⟩. ⟨10.18632/oncotarget.8122⟩. ⟨hal-01387061⟩
  • Caroline Decourt, Vincent Robert, Karine Anger, Mathieu Galibert, Jean-Baptiste Madinier, et al.. A synthetic kisspeptin analog that triggers ovulation and advances puberty. Scientific Reports, Nature Publishing Group, 2016, 6, pp.26908. ⟨10.1038/srep26908⟩. ⟨hal-01406943⟩
  • Massimiliano Beltramo, Vincent Robert, Mathieu Galibert, Jean-Baptiste Madinier, Philippe Marceau, et al.. Rational Design of Triazololipopeptides Analogs of Kisspeptin Inducing a Long-Lasting Increase of Gonadotropins. Journal of Medicinal Chemistry, American Chemical Society, 2015, 58 (8), pp.3459-3470. ⟨10.1021/jm5019675⟩. ⟨hal-01170460⟩
  • Mathieu Galibert, Véronique Piller, Friedrich Piller, Vincent Aucagne, Agnès F. Delmas. Combining triazole ligation and enzymatic glycosylation on solid phase simplifies the synthesis of very long glycoprotein analogues. Chemical Science , The Royal Society of Chemistry, 2015, 6 (6), pp.3617-3623. ⟨10.1039/C5SC00773A⟩. ⟨hal-01178852⟩
  • Romain Barat, Thibaut Legigan, Isabelle Tranoy-Opalinski, Brigitte Renoux, Elodie Péraudeau, et al.. A mechanically interlocked molecular system programmed for the delivery of an anticancer drug. Chemical Science , The Royal Society of Chemistry, 2015, 6 (4), pp.2608-2613. ⟨10.1039/C5SC00648A⟩. ⟨hal-01170448⟩
  • Isidore E. Decostaire, Dominique Lelièvre, Vincent Aucagne, Agnès F. Delmas. Solid phase oxime ligations for the iterative synthesis of polypeptide conjugates. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2014, 12 (29), pp.5536-5543. ⟨10.1039/c4ob00760c⟩. ⟨hal-01178857⟩
  • Fanny Meindre, Dominique Lelièvre, Karine Loth, Oriane Mith, Vincent Aucagne, et al.. The nuclear magnetic resonance solution structure of the synthetic AhPDF1.1b plant defensin evidences the structural feature within the γ-motif. Biochemistry, American Chemical Society, 2014, 53 (49), pp.7745-54. ⟨10.1021/bi501285k⟩. ⟨hal-01118914⟩
  • Laurent Raibaut, Hélène Adihou, Rémi Desmet, Agnès F. Delmas, Vincent Aucagne, et al.. Highly efficient solid phase synthesis of large polypeptides by iterative ligations of bis(2-sulfanylethyl)amido (SEA) peptide segments. Chemical Science , The Royal Society of Chemistry, 2013, 4, pp.4061-4066. ⟨10.1039/c3sc51824h⟩. ⟨hal-00944814v2⟩
  • Vincent Aucagne, Ibai E Valverde, Philippe Marceau, Mathieu Galibert, Nabil Dendane, et al.. Towards the simplification of protein synthesis: iterative solid-supported ligations with concomitant purifications.. Angewandte Chemie (English Edition), John Wiley & Sons, 2012, 51 (45), pp.11320-4. ⟨10.1002/anie.201206428⟩. ⟨hal-00748170⟩
  • Christelle Gaulier, Audrey Hospital, Bertrand Legeret, Delmas A.F., Vincent Aucagne, et al.. A water soluble Cu-I-NHC for CuAAC ligation of unprotected peptides under open air conditions.. Chemical Communications, Royal Society of Chemistry, 2012, 48, pp.4005-4007. ⟨hal-00711780⟩
  • Ibai E Valverde, Fabien Lecaille, Gilles Lalmanach, Vincent Aucagne, Agnès F Delmas. Synthesis of a biologically active triazole-containing analogue of cystatin A through successive peptidomimetic alkyne-azide ligations.. Angewandte Chemie (English Edition), John Wiley & Sons, 2012, 51 (3), pp.718-22. ⟨10.1002/anie.201107222⟩. ⟨hal-00726293⟩
  • Antony Fernandes, Aurélien Viterisi, Vincent Aucagne, David A Leigh, Sébastien Papot. Second generation specific-enzyme-activated rotaxane propeptides.. Chemical Communications, Royal Society of Chemistry, 2012, 48 (15), pp.2083-5. ⟨10.1039/c2cc17458h⟩. ⟨hal-00678757⟩
  • Chrystelle Derache, Hervé Meudal, Vincent Aucagne, Kevin J Mark, Martine Cadène, et al.. Initial insights into structure-activity relationships of avian defensins.. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (10), pp.7746-55. ⟨10.1074/jbc.M111.312108⟩. ⟨hal-00721842⟩
  • Andrea Altieri, Vincent Aucagne, Romen Carrillo, Guy Clarkson, Daniel d'Souza, et al.. Sulfur-containing amide-based [2]rotaxanes and molecular shuttles. Chemical Science , The Royal Society of Chemistry, 2011, 2 (10), pp.1922. ⟨10.1039/C1SC00335F⟩. ⟨hal-02088663⟩
  • Ibai E. Valverde, Agnès F. Delmas, Vincent Aucagne. Click a la carte: robust semi-orthogonal alkyne protecting groups for multiple successive azide/alkyne cycloadditions. Tetrahedron, Elsevier, 2009, 65 (36), pp.7597-7602. ⟨10.1016/j.tet.2009.06.093⟩. ⟨hal-00525398⟩
  • Anthony Fernandes, Aurélien Viterisi, Frédéric Coutrot, Stéphanie Potok, David A. Leigh, et al.. Rotaxane-based propeptides: protection and enzymatic release of a bioactive pentapeptide.. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2009, 48 (35), pp.6443-7. ⟨10.1002/anie.200903215⟩. ⟨hal-00467015⟩
  • Chrystelle Derache, Valérie Labas, Vincent Aucagne, Hervé Meudal, Céline Landon, et al.. Primary Structure and Antibacterial Activity of Chicken Bone Marrow-Derived beta-Defensins. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2009, 53 (11), pp.4647-4655. ⟨10.1128/AAC.00301-09⟩. ⟨hal-00522326⟩
  • Dominique Lelièvre, P. Barta, Vincent Aucagne, A.F. Delmas. Preparation of peptide thioesters using Fmoc strategy through hydroxyl side chain anchoring. Tetrahedron Letters, Elsevier, 2008, 49 (25), pp.4016-4019. ⟨10.1016/j.tetlet.2008.04.087⟩. ⟨hal-00518141⟩
  • Vincent Aucagne, A. Tatibouët, Patrick Rollin. Thermodynamics versus kinetics in hetero-Michael cyclizations: a highly stereoselective approach to access both epimers of a C-D-mannopyranoside. Tetrahedron Letters, Elsevier, 2008, 49, pp.4750-4753. ⟨10.1016/j.tetlet.2008.05.117⟩. ⟨hal-00512453⟩
  • Isidore P. Decostaire, Dominique Lelièvre, Vincent Aucagne, Agnès F. Delmas. Synergic effect of hydride and proton donors in the Pd(0)-mediated deprotection of Nα-Aloc proline derivatives. Tetrahedron Letters, Elsevier, 2007, 48, pp.6523-6526. ⟨10.1016/j.tetlet.2007.07.061⟩. ⟨hal-00166600⟩
  • Vincent Aucagne, J. Berna, Jd Crowley, Sm Goldup, Kd Haenni, et al.. Catalytic "Active-Metal" template synthesis of [2]rotaxanes, [3]rotaxanes, and molecular shuttles, and some observations on the mechanism of the Cu(I)-catalyzed azide-alkyne 1,3-cycloaddition. Journal of the American Chemical Society, American Chemical Society, 2007, 129, pp.11950-11963. ⟨hal-00275210⟩
  • J. Broggi, N. Joubert, Vincent Aucagne, T. Zevaco, S. Berteina-Raboin, et al.. Study of different copper(I) catalysts for the "click chemistry" approach to carbanucleosides. Nucleosides, Nucleotides and Nucleic Acids, Taylor & Francis, 2007, 26, pp.779-783. ⟨hal-00275217⟩
  • Julie Broggi, Nicolas Joubert, Vincent Aucagne, Sabine Berteina-Raboin, S. Diez-Gonzalez, et al.. Alkyne-Azide Click Chemistry Mediated Carbanucleosides Synthesis. Nucleosides, Nucleotides and Nucleic Acids, Taylor & Francis, 2007, 26 (10-12), pp.1391-1394. ⟨10.1080/15257770701534139⟩. ⟨hal-02086003⟩
  • Vincent Aucagne, Kevin Hänni, David Leigh, Paul Lusby, D Barney Walker. Catalytic “Click” Rotaxanes: A Substoichiometric Metal-Template Pathway to Mechanically Interlocked Architectures. Journal of the American Chemical Society, American Chemical Society, 2006, 128 (7), pp.2186-2187. ⟨10.1021/ja056903f⟩. ⟨hal-02086010⟩
  • Vincent Aucagne, David Leigh, Julia Lock, Andrew Thomson. Rotaxanes of Cyclic Peptides. Journal of the American Chemical Society, American Chemical Society, 2006, 128 (6), pp.1784-1785. ⟨10.1021/ja057206q⟩. ⟨hal-02086005⟩
  • Vincent Aucagne, David A. Leigh. Chemoselective formation of successive triazole linkages in one pot: "click-click" chemistry. Organic Letters, American Chemical Society, 2006, 8 (20), pp.4505-4507. ⟨10.1021/ol061657d⟩. ⟨hal-00387909⟩
  • Vanessa Escuret, Vincent Aucagne, Nicolas Joubert, David Durantel, Kimberly Rapp, et al.. Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: Antiviral activity and cellular toxicity. Bioorganic & Medicinal Chemistry, 2005, 13 (21), pp.6015-6024. ⟨10.1016/j.bmc.2005.06.021⟩. ⟨hal-02086013⟩
  • Franck Amblard, Vincent Aucagne, Pierre Guenot, Raymond Schinazi, Luigi Agrofoglio. Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series. Bioorganic & Medicinal Chemistry, 2005, 13 (4), pp.1239-1248. ⟨10.1016/j.bmc.2004.11.057⟩. ⟨hal-02086014⟩
  • V. Aucagne, C. Lorin, A. Tatibouët, P. Rollin. Regioselective Michael-induced cyclisation of γ- and δ-hydroxy vinyl sulfides and vinyl dithiocarbamates. Tetrahedron Letters, Elsevier, 2005, 46 (25), pp.4349-4352. ⟨10.1016/j.tetlet.2005.04.112⟩. ⟨hal-02086017⟩
  • Vincent Aucagne, Franck Amblard, Luigi Agrofoglio. Highly Efficient AgNO3-Catalyzed Preparation of Substituted Furanopyrimidine Nucleosides [cf. (III)].. ChemInform, Wiley-VCH Verlag, 2005, 36 (18), ⟨10.1002/chin.200518181⟩. ⟨hal-02086027⟩
  • Vincent Aucagne, Arnaud Tatibouët, Patrick Rollin. Wittig approach to carbohydrate-derived vinyl sulfides, new substrates for regiocontrolled ring-closure reactions. Tetrahedron, Elsevier, 2004, 60 (8), pp.1817-1826. ⟨10.1016/j.tet.2003.12.040⟩. ⟨hal-02086021⟩
  • Vincent Aucagne, Sabine Berteina-Raboin, Pierre Guenot, Luigi Agrofoglio. Palladium-Catalyzed Synthesis of Uridines on Polystyrene-Based Solid Supports. Journal of Combinatorial Chemistry, American Chemical Society, 2004, 6 (5), pp.717-723. ⟨10.1021/cc049976o⟩. ⟨hal-02086022⟩
  • Isabelle Gillaizeau, Irene m. Lagoja, Steve p. Nolan, Vincent Aucagne, Jef Rozenski, et al.. Straightforward Synthesis of Labeled and Unlabeled Pyrimidine d4Ns via 2′,3′-Diyne seco Analogues through Olefin Metathesis Reactions. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2003, 2003 (4), pp.666-671. ⟨10.1002/ejoc.200390107⟩. ⟨hal-02086029⟩
  • Vincent Aucagne, Maria Aversa, Anna Barattucci, Paola Bonaccorsi, Placido Giannetto, et al.. Sulfenic acids in the carbohydrate field. Synthesis of transient glycosulfenic acids and their addition to unsaturated acceptors.. Journal of Organic Chemistry, American Chemical Society, 2002, 67 (20), pp.6925-30. ⟨hal-02086034⟩
  • Vincent Aucagne, David Gueyrard, Arnaud Tatibouët, Alain Quinsac, Patrick Rollin. Synthetic Approaches to C-Glucosinolates. Tetrahedron, Elsevier, 2000, 56 (17), pp.2647-2654. ⟨10.1016/S0040-4020(00)00153-8⟩. ⟨hal-02086037⟩
  • V. Aucagne, D. Gueyrard, A. Tatibout, S. Cottaz, H. Driguez, et al.. the first synthesis of c-glucotropeolin. Tetrahedron Letters, Elsevier, 1999, pp.7319-7321. ⟨hal-00309763⟩

Communication dans un congrès

  • P. Da Silva, I. Rahioui, C. Laugier, Y. Rahbé, A. Delmas, et al.. PA1b, un peptide à activité insecticide : relations structure/fonction. XVème Colloque de Physiologie de l'Insecte, 2007, Rennes (France), juillet 2007, France. pp.1-1. ⟨hal-00391295⟩


  • Caroline Decourt, Vincent Robert, Didier Lomet, Karine Anger, A. Delmas, et al.. Investigation of tachyphylaxis of LH response following repeated injections of the kisspeptin analog C6. Colloque International NeuroFrance 2017, May 2017, Bordeaux, France. 2017. ⟨hal-01605114⟩
  • Caroline Decourt, Vincent Robert, Didier Lomet, Vincent Aucagne, Greg Anderson, et al.. Investigation of a kisspeptin analog effects both on synchronization of ovulation and puberty onset in domestic mammals and in rodents. 2. Journées du GdR 3606 Repro , Apr 2017, Tours, France. 75 p., 2017. ⟨hal-01603310⟩
  • Agnes Vergnes, Victor P. Terrier, Bressan Albert, Rafael Diego Rosa, Vincent Aucagne, et al.. Laligation native simplifie l’étude de l’activité etdu mécanismed’action des peptides antimicrobiens à multiples domaines :cas des Big défensines d’huître.. IIIèmes journées annuelles MuFoPAM « MultiFonction des Peptides AntiMicrobiens », Oct 2016, Tours, France. ⟨hal-02128427⟩
  • Caroline Decourt, Vincent Robert, Didier Lomet, Karine Anger, M. Galibert, et al.. Induction of fertile ovulation and puberty advancement by a new kisspeptin analog. 18th International Congress on Animal Reproduction (ICAR) , Jun 2016, Tours, France. 676 p., 2016. ⟨hal-01604087⟩

Chapitre d'ouvrage