MicroRNAs (miRNAs) are key regulatory elements encoded by the genome. A single miRNA can downregulate the expression of multiple genes involved in diverse functions. Because cancer is a disease with multiple gene aberrations, developing novel approaches to identify and modulate miRNA pathways may result in a breakthrough for cancer treatment. With a special focus on glioblastoma (GBM), this review provides an up-to-date summary of miRNA biogenesis, the role of miRNA in cancer resistance, and essential tools for modulating miRNA expression, as well as of clinically promising RNAi delivery systems and how they can be adapted for therapy.
A lire aussi
July 19, 2024 - Thibault Fillion's thesis defense
12 July 2024
par Laetitia Legoupil
Software is ubiquitous in science, yet overlooked
11 July 2024
par Laetitia Legoupil
Protein filaments in the regulation of gene expression
05 July 2024
par Laetitia Legoupil