email : stephane.goffinont[remplacer_par_at]cnrs-orleans.fr
Phone : +33 2.38.25.55.49
Engineer in biological techniques within the thematic group “DNA repair: structure, fonction and dynamic“
- Filtres
Publications (Archives Hal)
Contact
isabelle.frapart@cnrs-orleans.fr
02.38.25.55.53
Disciplines
- Sciences du Vivant [q-bio]17
- Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire3
- Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Virologie3
- Sciences du Vivant [q-bio]/Cancer2
- Chimie/Catalyse1
- Chimie/Chimie organique1
- Chimie1
- Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biochimie [q-bio.BM]1
- Sciences du Vivant [q-bio]/Génétique1
Mots-clefs
ALPHA BINDING Base excision repair BER CIRCULAR-DICHROISM COMPLEXES DAMAGE DNA DNA-protein complex LAC REPRESSOR Mechanism of SUMOylation site selection Model of Nf1-SecPH/Ubc9 interaction Neurofibromin Nf1 and Nf1-SecPH domain SUMOylation OPERATOR OXIDATION PROTEIN Protein oxidation RADIOLYSIS SCM- and SIM-independent SUMOylation SUMOylation site selection dependent of 3D structure SYSTEM
- SYSTEM4
- DNA3
- LAC REPRESSOR3
- Mechanism of SUMOylation site selection3
- Model of Nf1-SecPH/Ubc9 interaction3
- Neurofibromin Nf1 and Nf1-SecPH domain SUMOylation3
- OPERATOR3
- PROTEIN3
- SCM- and SIM-independent SUMOylation3
- BINDING2
- Base excision repair BER2
- CIRCULAR-DICHROISM2
- COMPLEXES2
- DAMAGE2
- DNA-protein complex2
- OXIDATION2
- Protein oxidation2
- RADIOLYSIS2
- SUMOylation site selection dependent of 3D structure2
- ALPHA1
- ARNm1
- BETA1
- BINDING DOMAIN1
- BREAST-CANCER1
- C-C coupling1
- CELLS1
- Complexes NS1-ARN1
- Cross-coupling1
- DNA bending1
- DNA repair stimulation1
- DOMAIN1
- Dimer1
- Estrogen receptor1
- Estrogen response element1
- Fpg MutM1
- Fused-ring systems1
- GENE-EXPRESSION1
- Génétique inverse1
- HORMONE-BINDING1
- Influenza1
- Ionising radiation1
- Ionizing radiation1
- LAC REPRESSOR HEADPIECE1
- LACTOSE REPRESSOR1
- Lactose repressor1
- Life Sciences1
- MODELS1
- Mass spectrometry1
- Molecular dynamics1
- NS11
- Nitrogen Heterocycles1
- Nucleoid-associated protein NAP HU1
- Oxidation1
- Oxidative stress1
- Protein1
- Protein–DNA interaction1
- RADIATION-DAMAGE1
- RECOGNITION1
- Radiation1
- SIMULATION1
- Single-strand break SSB1
- TAMOXIFEN1
- TRANSCRIPTIONAL ACTIVATION1
- TYROSINE1
- Tetramer1
- Ubc9 fusion-directed SUMOylation1
- Virus influenza1
Auteurs
Goffinont Stéphane17
Castaing Bertrand17
Coste F.13
Goffinont S.13
Roy V.7
Garnier Norbert7
Agrofoglio L.7
Cros J.6
Nadan V.6
Kut E.4
Marc D.4
Wacquiez A.4
Coste Franck4
Goffinont Stephane4
Nadan Virginie4
Guerin Martine4
Cadene Martine4
Bernard P.3
Gaudon V.3
Sosic Iva3
Spotheim-Maurizot Mélanie3
Wacquiez Alan3
Kut Emmanuel3
Serrano Amandine3
Normand Thierry3
Bénédetti Hélène3
Mosrin-Huaman Christine3
Marc Daniel3
Spotheim-Maurizot Mélanie3
Davídková Marie3
Villette Sandrine3
Routier S.3
Culard F.2
Culard Françoise2
Davidkova Marie2
Genest Daniel2
Gillard Nathalie2
Maurizot Jean-Claude2
Mazier Sonia2
Nadan Virginie2
Spotheim-Maurizot Melanie2
Stísová Viktorie2
Tber Z.2
Bergoug Mohammed2
Doudeau Michel2
Godin Fabienne2
Suskiewicz Marcin J.2
Buré Corinne2
Vallée Béatrice2
Guerin M.2
Castaing B.2
Berteina-Raboin Sabine2
Berteina-Rabouin S.2
Culard Françoise2
Agrofoglio Luigi2
Asseline Ulysse1
Bergoug Mohammed1
Biela A.1
Biteau Nicolas G.1
Blondeau C.1
Blondeau Caroline1
Carell T.1
Castaing B.1
Ciesla Jaroslaw1
Courtois Gilles1
Cros Julien1
Davidkova M.1
Delalande Olivier1
Doudeau Michel1
Gasparutto D.1
Gasteiger K.1
Genest Dominique1
Godin Fabienne1
Kazimierczuk Z.1
Mélanie Spotheim-Maurizot1
Rieux C.1
Stisova Viktorie1
Tber Zahira1
Tudek B.1
Véron Michel1
Winczura A.1
Yamaoka Shoji1
Ye Fei1
Roy Vincent1
Cros Julien1
Suskiewicz Marcin1
Bourg S.1
Bure Corinne1
Paquet Françoise1
Loth K.1
Loth Karine1
Landon C.1
Landon Celine1
F. Delmas Agnès1
Aci-Sèche Samia1
Le Meur R.1
Nicolas Cyril1
Agou Fabrice1
Spotheim-Maurizot Melanie1
Israël Alain1
Revues
Institutions
- Université d'Orléans33
- Université de Tours33
- Institut National de la Santé et de la Recherche Médicale33
- Institut de Chimie - CNRS Chimie33
- Commissariat à l'énergie atomique et aux énergies alternatives10
- Nuclear Physics Institute of the AS CR5
- Institut National de la Recherche Agronomique3
- Université de Rennes1
- Institut Pasteur [Paris]1
- Department of Chemistry and Biochemistry1
- Institute of Biochemistry and Biophysics [Warsaw]1
- Rockefeller University [New York]1
- Faculty of Nuclear Sciences and Physical Engineering1
- Université Grenoble Alpes [2016-2019]1
- Structure Fédérative de Recherche en Biologie et Santé de Rennes1
- Warsaw University of Life Sciences1
- Université de la Méditerranée - Aix-Marseille 21
- Tokyo Medical and Dental University [Japan]1
- Uniwersytet Warszawski [Polska] = University of Warsaw [Poland] = Université de Varsovie [Pologne]1
Laboratoires
- Centre de biophysique moléculaire33
- Institut de Chimie Organique et Analytique9
- Department of Radiation Dosimetry5
- Infectiologie et Santé Publique3
- Ludwig-Maximilians-Universität München1
- Biologie Moléculaire de l'Expression Génique1
- Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University1
- Institut de Génétique et Développement de Rennes1
- Régulation Enzymatique des Activités Cellulaires1
- Institute of Biochemistry and Biophysics PAS, Ul. Pawinskiego 5A, 02-106 Warsaw1
Départements
Équipes de recherche
34 documents
Article dans une revue16 documents
- Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection. Journal of Molecular Biology, 2024, 436 (22), pp.168768. ⟨10.1016/j.jmb.2024.168768⟩. ⟨hal-04771131⟩
- Zahira Tber, Nicolas G. Biteau, Luigi Agrofoglio, Julien Cros, Stéphane Goffinont, et al.. Microwave-assisted Suzuki-Miyaura and Sonogashira coupling of 4-Chloro-2-(trifluoromethyl)pyrido[1,2-e]purine derivatives. European Journal of Organic Chemistry, 2019, 2019, pp.5756-5767. ⟨10.1002/ejoc.201900921⟩. ⟨hal-02347523⟩
- R. Le Meur, Françoise Culard, V. Nadan, S. Goffinont, F. Coste, et al.. The nucleoid-associated protein HU enhances 8-oxoguanine base excision by the formamidopyrimidine-DNA glycosylase. Biochemical Journal, 2015, 471 (1), pp.13-23. ⟨10.1042/BJ20150387⟩. ⟨hal-01216639⟩
- Françoise Paquet, Olivier Delalande, Stephane Goffinont, Françoise Culard, Karine Loth, et al.. Model of a DNA-protein complex of the architectural monomeric protein MC1 from Euryarchaea. PLoS ONE, 2014, 9 (2), pp.e88809. ⟨10.1371/journal.pone.0088809⟩. ⟨hal-01063974⟩
- A. Biela, F. Coste, F. Culard, M. Guerin, S. Goffinont, et al.. Zinc finger oxidation of Fpg/Nei DNA glycosylases by 2-thioxanthine: biochemical and X-ray structural characterization. Nucleic Acids Research, 2014, 42 (16), pp.doi: 10.1093/nar/gku613. ⟨10.1093/nar/gku613⟩. ⟨hal-01175522⟩
- Stephane Goffinont, Sandrine Villette, Melanie Spotheim-Maurizot. Alanine Screening Mutagenesis Establishes the Critical Inactivating Damage of Irradiated E. coli Lactose Repressor.. Radiation Research, 2012, 177 (6), pp.738-42. ⟨hal-00721863⟩
- Samia Aci-Sèche, Norbert Garnier, Stéphane Goffinont, Daniel Genest, Spotheim-Maurizot Mélanie, et al.. Comparing native and irradiated E. coli lactose repressor-operator complex by molecular dynamics simulation. European Biophysics Journal, 2010, 39 (10), pp.1375-1384. ⟨10.1007/s00249-010-0591-1⟩. ⟨hal-00529210⟩
- Viktorie Stisova, Stéphane Goffinont, Mélanie Spotheim-Maurizot, Marie Davidkova. Effects of gamma irradiation on the DNA-protein complex between the estrogen response element and the estrogen receptor. Radiation Physics and Chemistry, 2010, 79 (8), pp.880-889. ⟨10.1016/j.radphyschem.2010.03.009⟩. ⟨hal-00529465⟩
- Stéphane Goffinont, Marie Davídková, Mélanie Spotheim-Maurizot. Radiation-induced tetramer-to-dimer transition of Escherichia coli lactose repressor. Biochemical and Biophysical Research Communications, 2009, 386 (2), pp.300-304. ⟨10.1016/j.bbrc.2009.06.012⟩. ⟨hal-00522426⟩
- Mélanie Spotheim-Maurizot, Sonia Mazier, Sandrine Villette, Stéphane Goffinont, Dominique Genest, et al.. Radiationinduced oxidation of proteins in DNA-protein complexes. Radioprotection, 2008, 43 (5), pp.131-132. ⟨10.1051/radiopro:2008526⟩. ⟨hal-00527448⟩
- Corinne Buré, Stéphane Goffinont, Agnès F. Delmas, Martine Cadene, Françoise Culard. Oxidation-sensitive residues mediate the DNA-bending activity of MC1 protein. Journal of Molecular Biology, 2008, 376 (1), pp.120-130. ⟨10.1016/j.jmb.2007.11.057⟩. ⟨hal-00283220⟩
- Sonia Mazier, Sandrine Villette, Stéphane Goffinont, Stéphane Renouard, Jean-Claude Maurizot, et al.. Radiation Damage to a DNA-Binding Protein. Combined Circular Dichroism and Molecular Dynamics Simulation Analysis. Radiation Research, 2008, 170 (5), pp.604-612. ⟨hal-00518177⟩
- Nathalie Gillard, Stephane Goffinont, Corinne Buré, Marie Davidkova, Jean-Claude Maurizot, et al.. Radiation-induced oxidative damage to the DNA-binding domain of the lactose repressor. Biochemical Journal, 2007, 403 (3), pp.463-472. ⟨10.1042/BJ20061466⟩. ⟨hal-00478672⟩
- Marie Davídková, Viktorie Stísová, Stéphane Goffinont, Nathalie Gillard, Bertrand Castaing, et al.. Modification of DNA radiolysis by DNA-binding proteins: structural aspects. Radiation Protection Dosimetry, 2006, 122 (1-4), pp.100-105. ⟨10.1093/rpd/ncl442⟩. ⟨hal-00168743⟩
- Viktorie Stísová, Stephane Goffinont, Melanie Spotheim-Maurizot, Marie Davídková. Radiation damage to DNA–protein specific complexes: estrogen response element–estrogen receptor complex. Radiation Protection Dosimetry, 2006, 122 (1-4), pp.106-109. ⟨10.1093/rpd/ncl443⟩. ⟨hal-00159626⟩
- Fabrice Agou, Fei Ye, Stéphane Goffinont, Gilles Courtois, Shoji Yamaoka, et al.. NEMO Trimerizes through Its Coiled-coil C-terminal Domain. Journal of Biological Chemistry, 2002, 277 (20), pp.17464-17475. ⟨10.1074/jbc.M201964200⟩. ⟨hal-02112165⟩
Communication dans un congrès3 documents
- J. Cros, F. Coste, S. Goffinont, Virginie Nadan, V. Roy, et al.. Discovery and characterization of inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, pertinent therapeutic targets for cancer therapy. Laboratoire International Associé, Jun 2019, Varsovie, Poland. ⟨hal-02903108⟩
- A. Wacquiez, F. Coste, V. Nadan, E. Kut, Norbert Garnier, et al.. Interaction de la protéine NS1 avec l’ARN : mécanismes impliqués dans la reconnaissance spécifique. Colloque annuel de ResaFlu, Réseau français sur les virus Influenza, Mar 2019, Lyon, France. ⟨hal-02903093⟩
- J. Cros, F. Coste, Z. Tber, S. Goffinont, Virginie Nadan, et al.. Small molecule inhibitors of the human DNA glycosylases hOGG1 and NEIL1, pertinent therapeutic targets in cancer and neurodegenerative disease therapies. 25th Young Research Fellows Meeting, Mar 2018, Orléans, France. ⟨hal-02903084⟩
Poster14 documents
- Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation. 2024 Global NF Conference, Jun 2024, Brussels, Belgium. ⟨hal-03679991⟩
- Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation. 2024 Global NF Conference, Jun 2024, Brussels, Belgium. ⟨hal-04778711⟩
- Daniel Marc, Alan Wacquiez, Stéphane Goffinont, Virginie Nadan, Franck Coste, et al.. Interaction de la protéine NS1 des virus influenza A avec l’ARN : mécanismes impliqués dans la reconnaissance spécifique. XIIes Journées Francophones de Virologie, Mar 2019, Lyon, France. Virologie, 23, 2019. ⟨hal-02737761⟩
- J. Cros, F. Coste, S. Goffinont, V. Gaudon, V. Roy, et al.. Search for small molecule inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, potential therapeutic targets in cancer. 13th French 3R meeting, May 2019, Presqu’île de Giens, France. ⟨hal-02903219⟩
- J. Cros, F. Coste, S. Goffinont, V. Gaudon, V. Roy, et al.. Search for small molecule inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, potential therapeutic targets in cancer. Journée Fédération de recherche “Physique et Chimie du Vivant” FR2708 (CBM/ICOA), Apr 2019, Orléans, France. ⟨hal-02903223⟩
- Julien Cros, Franck Coste, Stéphane Goffinont, Virginie Nadan, Norbert Garnier, et al.. Screening, characterization and structural studies of small molecules inhibitors of the DNA glycosylase hNEIL1 and hOGG1, potential therapeutic targets in cancer and neurodegenerative disease. 1st French congress on Integrative Structural Biology (BSI-2019), Oct 2019, Toulouse, France. ⟨hal-03385201⟩
- J. Cros, F. Coste, Z. Tber, S. Goffinont, V. Nadan, et al.. Search for small molecule inhibitors of DNA glycosylases, pertinent therapeutic targets in cancer and neurodegenerative disease therapies. 5e Colloque annuel du Laboratoire International Associé (LIA) MiR-TANGo, May 2018, Orléans, France. ⟨hal-02904701⟩
- Alan Wacquiez, Stéphane Goffinont, Virginie Nadan, Franck Coste, Emmanuel Kut, et al.. Structures et fonctions de la protéine NS1 des virus influenza pour la recherche de nouvelles cibles thérapeutiques. 31e Colloque Biotechnocentre, Oct 2018, Seillac, France. , 2018. ⟨hal-02736195⟩
- J. Cros, F. Coste, S. Goffinont, V. Gaudon, V. Roy, et al.. Recherche d’inhibiteurs des enzymes de réparation de l’ADN hNeil1 et hOGG1, de nouvelles cibles pertinentes pour le développement de thérapies anticancéreuses. 31e colloque Biotechnocentre, Oct 2018, Seillac, France. ⟨hal-02904682⟩
- Alan Wacquiez, Franck Coste, Caroline Blondeau, Emmanuel Kut, Virginie Nadan, et al.. NS1 des virus Influenza A : approches structurales et fonctionnelles pour de nouvelles stratégies anti-virales. 20. Journées Francophones de Virologie 2018, Mar 2018, Paris, France. John Libbey Eurotext, Virologie, 22, 148 p., 2018. ⟨hal-02736544⟩
- A. Wacquiez, S. Goffinont, V. Nadan, F. Coste, E. Kut, et al.. NS1 des virus influenza : relations structure-fonction pour la recherche de nouveaux anti-viraux. 30e colloque Biotechnocentre, Oct 2017, Seillac, France. ⟨hal-02904785⟩
- A. Wacquiez, F. Coste, V. Nadan, E. Kut, S. Goffinont, et al.. NS1 of Influenza viruses: structural and functional approaches towards the discovery of novel anti-influenza drugs. Le Studium Conférence “Structural Biology and biophysics of RNA-protein complexes”, Nov 2017, Orléans, France. ⟨hal-02904778⟩
- A. Wacquiez, F. Coste, C. Blondeau, E. Kut, V. Nadan, et al.. NS1 des virus Influenza A : approches structurales et fonctionnelles pour de nouvelles stratégies anti-virales. Le Studium Conférence « Messenger RNA therapeutics : advances and perspectives », Mar 2017, Orléans, France. ⟨hal-02904828⟩
- C. Rieux, F. Coste, F. Culard, S. Goffinont, S. Bourg, et al.. Small-molecule inhibitors of Fpg/Nei DNA glycosylases, enzymes initiating the base excision repair pathway, new targets for cancer therapy. XXII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids, Jul 2016, Paris, France. ⟨hal-02919151⟩
Chapitre d'ouvrage1 document
- Françoise Culard, Mélanie Spotheim-Maurizot, Corinne Bure, Stéphane Goffinont, Martine Cadene. A mass spectrometry approach for the identification of oxidation-sensitive residues in DNA-binding proteins: correlation with protein function. Pandey, A., Banerjee, R. Horizons in Biotechnology, Asiatech Publishers, New Delhi, pp.123-134, 2008. ⟨hal-00623581⟩