GOFFINONT Stéphane

email : stephane.goffinont[remplacer_par_at]cnrs-orleans.fr

Phone : +33 2.38.25.55.49

Engineer in biological techniques within the thematic group “DNA repair: structure, fonction and dynamic“

 


34 documents

Article dans une revue16 documents

  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection. Journal of Molecular Biology, 2024, 436 (22), pp.168768. ⟨10.1016/j.jmb.2024.168768⟩. ⟨hal-04771131⟩
  • Zahira Tber, Nicolas G. Biteau, Luigi Agrofoglio, Julien Cros, Stéphane Goffinont, et al.. Microwave-assisted Suzuki-Miyaura and Sonogashira coupling of 4-Chloro-2-(trifluoromethyl)pyrido[1,2-e]purine derivatives. European Journal of Organic Chemistry, 2019, 2019, pp.5756-5767. ⟨10.1002/ejoc.201900921⟩. ⟨hal-02347523⟩
  • R. Le Meur, Françoise Culard, V. Nadan, S. Goffinont, F. Coste, et al.. The nucleoid-associated protein HU enhances 8-oxoguanine base excision by the formamidopyrimidine-DNA glycosylase. Biochemical Journal, 2015, 471 (1), pp.13-23. ⟨10.1042/BJ20150387⟩. ⟨hal-01216639⟩
  • A. Biela, F. Coste, F. Culard, M. Guerin, S. Goffinont, et al.. Zinc finger oxidation of Fpg/Nei DNA glycosylases by 2-thioxanthine: biochemical and X-ray structural characterization. Nucleic Acids Research, 2014, 42 (16), pp.doi: 10.1093/nar/gku613. ⟨10.1093/nar/gku613⟩. ⟨hal-01175522⟩
  • Françoise Paquet, Olivier Delalande, Stephane Goffinont, Françoise Culard, Karine Loth, et al.. Model of a DNA-protein complex of the architectural monomeric protein MC1 from Euryarchaea. PLoS ONE, 2014, 9 (2), pp.e88809. ⟨10.1371/journal.pone.0088809⟩. ⟨hal-01063974⟩
  • Stephane Goffinont, Sandrine Villette, Melanie Spotheim-Maurizot. Alanine Screening Mutagenesis Establishes the Critical Inactivating Damage of Irradiated E. coli Lactose Repressor.. Radiation Research, 2012, 177 (6), pp.738-42. ⟨hal-00721863⟩
  • Viktorie Stisova, Stéphane Goffinont, Mélanie Spotheim-Maurizot, Marie Davidkova. Effects of gamma irradiation on the DNA-protein complex between the estrogen response element and the estrogen receptor. Radiation Physics and Chemistry, 2010, 79 (8), pp.880-889. ⟨10.1016/j.radphyschem.2010.03.009⟩. ⟨hal-00529465⟩
  • Samia Aci-Sèche, Norbert Garnier, Stéphane Goffinont, Daniel Genest, Spotheim-Maurizot Mélanie, et al.. Comparing native and irradiated E. coli lactose repressor-operator complex by molecular dynamics simulation. European Biophysics Journal, 2010, 39 (10), pp.1375-1384. ⟨10.1007/s00249-010-0591-1⟩. ⟨hal-00529210⟩
  • Stéphane Goffinont, Marie Davídková, Mélanie Spotheim-Maurizot. Radiation-induced tetramer-to-dimer transition of Escherichia coli lactose repressor. Biochemical and Biophysical Research Communications, 2009, 386 (2), pp.300-304. ⟨10.1016/j.bbrc.2009.06.012⟩. ⟨hal-00522426⟩
  • Mélanie Spotheim-Maurizot, Sonia Mazier, Sandrine Villette, Stéphane Goffinont, Dominique Genest, et al.. Radiationinduced oxidation of proteins in DNA-protein complexes. Radioprotection, 2008, 43 (5), pp.131-132. ⟨10.1051/radiopro:2008526⟩. ⟨hal-00527448⟩
  • Corinne Buré, Stéphane Goffinont, Agnès F. Delmas, Martine Cadene, Françoise Culard. Oxidation-sensitive residues mediate the DNA-bending activity of MC1 protein. Journal of Molecular Biology, 2008, 376 (1), pp.120-130. ⟨10.1016/j.jmb.2007.11.057⟩. ⟨hal-00283220⟩
  • Sonia Mazier, Sandrine Villette, Stéphane Goffinont, Stéphane Renouard, Jean-Claude Maurizot, et al.. Radiation Damage to a DNA-Binding Protein. Combined Circular Dichroism and Molecular Dynamics Simulation Analysis. Radiation Research, 2008, 170 (5), pp.604-612. ⟨hal-00518177⟩
  • Nathalie Gillard, Stephane Goffinont, Corinne Buré, Marie Davidkova, Jean-Claude Maurizot, et al.. Radiation-induced oxidative damage to the DNA-binding domain of the lactose repressor. Biochemical Journal, 2007, 403 (3), pp.463-472. ⟨10.1042/BJ20061466⟩. ⟨hal-00478672⟩
  • Marie Davídková, Viktorie Stísová, Stéphane Goffinont, Nathalie Gillard, Bertrand Castaing, et al.. Modification of DNA radiolysis by DNA-binding proteins: structural aspects. Radiation Protection Dosimetry, 2006, 122 (1-4), pp.100-105. ⟨10.1093/rpd/ncl442⟩. ⟨hal-00168743⟩
  • Viktorie Stísová, Stephane Goffinont, Melanie Spotheim-Maurizot, Marie Davídková. Radiation damage to DNA–protein specific complexes: estrogen response element–estrogen receptor complex. Radiation Protection Dosimetry, 2006, 122 (1-4), pp.106-109. ⟨10.1093/rpd/ncl443⟩. ⟨hal-00159626⟩
  • Fabrice Agou, Fei Ye, Stéphane Goffinont, Gilles Courtois, Shoji Yamaoka, et al.. NEMO Trimerizes through Its Coiled-coil C-terminal Domain. Journal of Biological Chemistry, 2002, 277 (20), pp.17464-17475. ⟨10.1074/jbc.M201964200⟩. ⟨hal-02112165⟩

Communication dans un congrès3 documents

  • J. Cros, F. Coste, S. Goffinont, Virginie Nadan, V. Roy, et al.. Discovery and characterization of inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, pertinent therapeutic targets for cancer therapy. Laboratoire International Associé, Jun 2019, Varsovie, Poland. ⟨hal-02903108⟩
  • A. Wacquiez, F. Coste, V. Nadan, E. Kut, Norbert Garnier, et al.. Interaction de la protéine NS1 avec l’ARN : mécanismes impliqués dans la reconnaissance spécifique. Colloque annuel de ResaFlu, Réseau français sur les virus Influenza, Mar 2019, Lyon, France. ⟨hal-02903093⟩
  • J. Cros, F. Coste, Z. Tber, S. Goffinont, Virginie Nadan, et al.. Small molecule inhibitors of the human DNA glycosylases hOGG1 and NEIL1, pertinent therapeutic targets in cancer and neurodegenerative disease therapies. 25th Young Research Fellows Meeting, Mar 2018, Orléans, France. ⟨hal-02903084⟩

Poster14 documents

  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation. 2024 Global NF Conference, Jun 2024, Brussels, Belgium. ⟨hal-03679991⟩
  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation. 2024 Global NF Conference, Jun 2024, Brussels, Belgium. ⟨hal-04778711⟩
  • Julien Cros, Franck Coste, Stéphane Goffinont, Virginie Nadan, Norbert Garnier, et al.. Screening, characterization and structural studies of small molecules inhibitors of the DNA glycosylase hNEIL1 and hOGG1, potential therapeutic targets in cancer and neurodegenerative disease. 1st French congress on Integrative Structural Biology (BSI-2019), Oct 2019, Toulouse, France. ⟨hal-03385201⟩
  • J. Cros, F. Coste, S. Goffinont, V. Gaudon, V. Roy, et al.. Search for small molecule inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, potential therapeutic targets in cancer. Journée Fédération de recherche “Physique et Chimie du Vivant” FR2708 (CBM/ICOA), Apr 2019, Orléans, France. ⟨hal-02903223⟩
  • J. Cros, F. Coste, S. Goffinont, V. Gaudon, V. Roy, et al.. Search for small molecule inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, potential therapeutic targets in cancer. 13th French 3R meeting, May 2019, Presqu’île de Giens, France. ⟨hal-02903219⟩
  • Daniel Marc, Alan Wacquiez, Stéphane Goffinont, Virginie Nadan, Franck Coste, et al.. Interaction de la protéine NS1 des virus influenza A avec l’ARN : mécanismes impliqués dans la reconnaissance spécifique. XIIes Journées Francophones de Virologie, Mar 2019, Lyon, France. Virologie, 23, 2019. ⟨hal-02737761⟩
  • Alan Wacquiez, Franck Coste, Caroline Blondeau, Emmanuel Kut, Virginie Nadan, et al.. NS1 des virus Influenza A : approches structurales et fonctionnelles pour de nouvelles stratégies anti-virales. 20. Journées Francophones de Virologie 2018, Mar 2018, Paris, France. John Libbey Eurotext, Virologie, 22, 148 p., 2018. ⟨hal-02736544⟩
  • J. Cros, F. Coste, S. Goffinont, V. Gaudon, V. Roy, et al.. Recherche d’inhibiteurs des enzymes de réparation de l’ADN hNeil1 et hOGG1, de nouvelles cibles pertinentes pour le développement de thérapies anticancéreuses. 31e colloque Biotechnocentre, Oct 2018, Seillac, France. ⟨hal-02904682⟩
  • J. Cros, F. Coste, Z. Tber, S. Goffinont, V. Nadan, et al.. Search for small molecule inhibitors of DNA glycosylases, pertinent therapeutic targets in cancer and neurodegenerative disease therapies. 5e Colloque annuel du Laboratoire International Associé (LIA) MiR-TANGo, May 2018, Orléans, France. ⟨hal-02904701⟩
  • Alan Wacquiez, Stéphane Goffinont, Virginie Nadan, Franck Coste, Emmanuel Kut, et al.. Structures et fonctions de la protéine NS1 des virus influenza pour la recherche de nouvelles cibles thérapeutiques. 31e Colloque Biotechnocentre, Oct 2018, Seillac, France. , 2018. ⟨hal-02736195⟩
  • A. Wacquiez, F. Coste, C. Blondeau, E. Kut, V. Nadan, et al.. NS1 des virus Influenza A : approches structurales et fonctionnelles pour de nouvelles stratégies anti-virales. Le Studium Conférence « Messenger RNA therapeutics : advances and perspectives », Mar 2017, Orléans, France. ⟨hal-02904828⟩
  • A. Wacquiez, F. Coste, V. Nadan, E. Kut, S. Goffinont, et al.. NS1 of Influenza viruses: structural and functional approaches towards the discovery of novel anti-influenza drugs. Le Studium Conférence “Structural Biology and biophysics of RNA-protein complexes”, Nov 2017, Orléans, France. ⟨hal-02904778⟩
  • A. Wacquiez, S. Goffinont, V. Nadan, F. Coste, E. Kut, et al.. NS1 des virus influenza : relations structure-fonction pour la recherche de nouveaux anti-viraux. 30e colloque Biotechnocentre, Oct 2017, Seillac, France. ⟨hal-02904785⟩
  • C. Rieux, F. Coste, F. Culard, S. Goffinont, S. Bourg, et al.. Small-molecule inhibitors of Fpg/Nei DNA glycosylases, enzymes initiating the base excision repair pathway, new targets for cancer therapy. XXII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids, Jul 2016, Paris, France. ⟨hal-02919151⟩

Chapitre d'ouvrage1 document

  • Françoise Culard, Mélanie Spotheim-Maurizot, Corinne Bure, Stéphane Goffinont, Martine Cadene. A mass spectrometry approach for the identification of oxidation-sensitive residues in DNA-binding proteins: correlation with protein function. Pandey, A., Banerjee, R. Horizons in Biotechnology, Asiatech Publishers, New Delhi, pp.123-134, 2008. ⟨hal-00623581⟩

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