PERCHE Federico

email :

Phone : +33

Office A212

Researcher within the thematic group “RNA biology and RNA therapeutics


25 documents

Article dans une revue

  • Pinpin Wang, Federico Perche, Delphine Logeart-Avramoglou, Chantal Pichon. RNA-based therapy for osteogenesis. International Journal of Pharmaceutics, Elsevier, 2019, 569, pp.118594. ⟨10.1016/j.ijpharm.2019.118594⟩. ⟨hal-02321838⟩
  • Yu Yi, Hyun Jin Kim, Meng Zheng, Peng Mi, Mitsuru Mi, et al.. Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. Journal of Controlled Release, Elsevier, 2019, 295, pp.268-277. ⟨10.1016/j.jconrel.2019.01.006⟩. ⟨hal-02067488⟩
  • Federico Perche, Rudy Clemençon, Kai Schulze, Thomas Ebensen, Carlos Guzman, et al.. Neutral Lipopolyplexes for In Vivo Delivery of Conventional and Replicative RNA Vaccine. Molecular Therapy - Nucleic Acids, Nature Publishing Group, 2019, 17, pp.767-775. ⟨10.1016/j.omtn.2019.07.014⟩. ⟨hal-02321815⟩
  • Federico Perche, Tony Le Gall, Tristan Montier, Chantal Pichon, Jean-Marc Malinge. Cardiolipin-Based Lipopolyplex Platform for the Delivery of Diverse Nucleic Acids into Gram-Negative Bacteria. Pharmaceuticals, MDPI, 2019, 12 (2), pp.81. ⟨10.3390/ph12020081⟩. ⟨hal-02172973⟩
  • Kevin van der Jeught, Stefaan de Koker, Lukasz Bialkowski, Carlo Heirman, Patrick Tjok Joe, et al.. Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety. ACS Nano, American Chemical Society, 2018, 12 (10), pp.9815-9829. ⟨10.1021/acsnano.8b00966⟩. ⟨hal-01889829⟩
  • Federico Perche, Satoshi Uchida, Hiroki Akiba, Chin-Yu Lin, Masaru Ikegami, et al.. Improved brain expression of anti-amyloid β scFv by complexation of mRNA including a secretion sequence with PEG-based block catiomer. Current Alzheimer Research, Bentham Science Publishers, 2017, 14 (3), pp.295-302. ⟨10.2174/1567205013666161108110031⟩. ⟨hal-02130712⟩
  • Federico Perche, Y. Yi, L. Hespel, P Mi, A Dirisala, et al.. Hydroxychloroquine-conjugated gold nanoparticles for improved siRNA activity. Biomaterials, Elsevier, 2016, 90, pp.62-71. ⟨10.1016/j.biomaterials.2016.02.027⟩. ⟨hal-02130728⟩
  • Chin-Yu Lin, Federico Perche, Masaru Ikegami, Satoshi Uchida, Kazunori Kataoka, et al.. Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles. Journal of Controlled Release, Elsevier, 2016, 235, pp.268-275. ⟨10.1016/j.jconrel.2016.06.001⟩. ⟨hal-02130718⟩
  • Federico Perche, Vladimir Torchilin. Cancer cell spheroids as a model to evaluate chemotherapy protocols. Cancer Biology and Therapy, Taylor & Francis, 2014, 13 (12), pp.1205-1213. ⟨10.4161/cbt.21353⟩. ⟨hal-02130815⟩
  • Federico Perche, S. Biswas, T. Wang, L. Zhu, V. Torchilin. Hypoxia-Targeted siRNA Delivery. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2014, 53 (13), pp.3362-3366. ⟨10.1002/anie.201308368⟩. ⟨hal-02130753⟩
  • Lin Zhu, Federico Perche, Tao Wang, Vladimir Torchilin. Matrix metalloproteinase 2-sensitive multifunctional polymeric micelles for tumor-specific co-delivery of siRNA and hydrophobic drugs. Biomaterials, Elsevier, 2014, 35 (13), pp.4213-4222. ⟨10.1016/j.biomaterials.2014.01.060⟩. ⟨hal-02130742⟩
  • Samuel Mussi, Rupa Sawant, Federico Perche, Mônica Oliveira, Ricardo Azevedo, et al.. Novel Nanostructured Lipid Carrier Co-Loaded with Doxorubicin and Docosahexaenoic Acid Demonstrates Enhanced in Vitro Activity and Overcomes Drug Resistance in MCF-7/Adr Cells. Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2014, 31 (8), pp.1882-1892. ⟨10.1007/s11095-013-1290-2⟩. ⟨hal-02130734⟩
  • G. Salzano, R. Riehle, G. Navarro, Federico Perche, G. de Rosa, et al.. Polymeric micelles containing reversibly phospholipid-modified anti-survivin siRNA: A promising strategy to overcome drug resistance in cancer. Cancer Letters, Elsevier, 2014, 343 (2), pp.224-231. ⟨10.1016/j.canlet.2013.09.037⟩. ⟨hal-02130786⟩
  • Lin Zhu, Tao Wang, Federico Perche, Anton Taigind, Vladimir Torchilin. Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2013, 110 (42), pp.17047-17052. ⟨10.1073/pnas.1304987110⟩. ⟨hal-02130803⟩
  • Swati Biswas, Pranali Deshpande, Federico Perche, Namita Dodwadkar, Shailendra Sane, et al.. Octa-arginine-modified pegylated liposomal doxorubicin: An effective treatment strategy for non-small cell lung cancer. Cancer Letters, Elsevier, 2013, 335 (1), pp.191-200. ⟨10.1016/j.canlet.2013.02.020⟩. ⟨hal-02130808⟩
  • Federico Perche, Vladimir Torchilin. Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting. Journal of Drug Delivery, Hindawi Publishing Corporation, 2013, 2013, pp.1-32. ⟨10.1155/2013/705265⟩. ⟨hal-02130868⟩
  • Federico Perche, Olivier Lambert, Mathieu Berchel, Paul-Alain Jaffres, Chantal Pichon, et al.. Gene transfer by histidylated lipopolyplexes: A dehydration method allowing preservation of their physicochemical parameters and transfection efficiency.. International Journal of Pharmaceutics, Elsevier, 2012, 423 (1), pp.144-50. ⟨10.1016/j.ijpharm.2011.04.009⟩. ⟨hal-00726238⟩
  • Federico Perche, Niravkumar Patel, Vladimir Torchilin. Accumulation and toxicity of antibody-targeted doxorubicin-loaded PEG–PE micelles in ovarian cancer cell spheroid model. Journal of Controlled Release, Elsevier, 2012, 164 (1), pp.95-102. ⟨10.1016/j.jconrel.2012.09.003⟩. ⟨hal-02130810⟩
  • Federico Perche, Thierry Benvegnu, Mathieu Berchel, Loic Lebegue, Chantal Pichon, et al.. Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA.. Nanomedicine: Nanotechnology, Biology and Medicine, Elsevier, 2011, 7 (4), pp.445-53. ⟨10.1016/j.nano.2010.12.010⟩. ⟨hal-00754373⟩
  • Federico Perche, David Gosset, Mathieu Mével, Marie-Laure Miramon, Jean-Jacques Yaouanc, et al.. Selective gene delivery in dendritic cells with mannosylated and histidylated lipopolyplexes.. Journal of Drug Targeting, Informa Healthcare, 2011, 19 (5), pp.315-25. ⟨10.3109/1061186X.2010.504262⟩. ⟨hal-00753554⟩

Chapitre d'ouvrage

  • Federico Perche, Swati Biswas, Niravkumar Patel, Vladimir Torchilin. Hypoxia-Responsive Copolymer for siRNA Delivery. Methods Molecular Biology, 1372, pp.139-162, 2016, ⟨10.1007/978-1-4939-3148-4_12⟩. ⟨hal-02130872⟩
  • Federico Perche, S. Biswas, V. Torchilin. Stimuli-Sensitive Polymeric Nanomedicines for Cancer Imaging and Therapy. Handbook of polymers for pharmaceutical technologies, John Wiley & Sons, Inc., pp.311-344, 2015. ⟨hal-02130886⟩


  • Vladimir Torchilin, Swati Biswas, Federico Perche. HYPOXIA-TARGETED DELIVERY SYSTEM FOR PHARMACEUTICAL AGENTS. France, Patent n° : WO2015061321. 2015. ⟨hal-02130900⟩
  • L. Zhu, Federico Perche, Vladimir Torchilin. COPOLYMERS FOR THE DELIVERY OF DRUGS INTO CELLS. France, Patent n° : WO2014085579. 2014. ⟨hal-02130892⟩


  • Federico Perche. Transfert d'ARNm par des lipopolyplexes et vaccination antimélanome : ciblage des cellules dendritiques à l'aide de lipopolyplexes mannosylés. Médecine humaine et pathologie. Université d'Orléans, 2010. Français. ⟨NNT : 2010ORLE2068⟩. ⟨tel-00665118⟩