GARNIER Norbert

email : norbert.garnier[remplacer_par_at]cnrs-orleans.fr

Phone : +33 2.38.25.76.68

Lecturer within the thematic group “DNA repair: structure, fonction and dynamic“

 


59 documents

Article dans une revue30 documents

  • Charlotte Rieux, Stéphane Goffinont, Franck Coste, Zahira Tber, Julien Cros, et al.. Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights. International Journal of Molecular Sciences, 2020, 21 (6), pp.2058. ⟨10.3390/ijms21062058⟩. ⟨hal-03082414⟩
  • Abdennour Braka, Norbert Garnier, Pascal Bonnet, Samia Aci-Seche. Residence Time Prediction of Type 1 and 2 Kinase Inhibitors from Unbinding Simulations. Journal of Chemical Information and Modeling, 2019, 60 (1), pp.342-348. ⟨10.1021/acs.jcim.9b00497⟩. ⟨hal-02494409⟩
  • Laurent Jacob, Paul Sawma, Norbert Garnier, Lionel A.T. Meyer, Justine Fritz, et al.. Inhibition of PlexA1-mediated brain tumor growth and tumor-associated angiogenesis using a transmembrane domain targeting peptide. Oncotarget, 2016, 7 (36), pp.57851-57865. ⟨10.18632/oncotarget.11072⟩. ⟨hal-01407022⟩
  • Widade Ziani, Antoine P. Maillard, Isabelle Petit-Härtlein, Norbert Garnier, Serge Crouzy, et al.. The X-ray structure of NccX from Cupriavidus metallidurans 31A illustrates potential dangers of detergent solubilization when generating and interpreting crystal structures of membrane proteins.. Journal of Biological Chemistry, 2014, 289 (45), pp.31160-31172. ⟨10.1074/jbc.M114.586537⟩. ⟨hal-01109416⟩
  • Samia Aci-Sèche, Paul Sawma, Pierre Hubert, James N. Sturgis, Dominique Bagnard, et al.. Transmembrane Recognition of the Semaphorin Co-Receptors Neuropilin 1 and Plexin A1 : Coarse-Grained Simulations. PLoS ONE, 2014, 9 (5), pp.e97779. ⟨10.1371/journal.pone.0097779⟩. ⟨hal-01175479⟩
  • Alexia Arpel, Paul Sawma, Caroline Spenlé, Justine Fritz, Lionel Meyer, et al.. Transmembrane Domain Targeting Peptide Antagonizing ErbB2/Neu Inhibits Breast Tumor Growth and Metastasis.. Cell Reports, 2014, 8 (6), pp.1714-1721. ⟨10.1016/j.celrep.2014.07.044⟩. ⟨hal-01071710⟩
  • Violette Senille, Dominique Lelievre, Françoise Paquet, Norbert Garnier, Ned Lamb, et al.. The addressing fragment of mitogaligin: first insights into functional and structural properties.. ChemBioChem, 2013, 14 (6), pp.711-20. ⟨10.1002/cbic.201200715⟩. ⟨hal-00817503⟩
  • Norbert Garnier, Karine Loth, Franck Coste, Rafal Augustyniak, Virginie Nadan, et al.. An alternative flexible conformation of the E. coli HU beta(2) protein: structural, dynamics, and functional aspects. European Biophysics Journal, 2011, 40 (2), pp.117-129. ⟨10.1007/s00249-010-0630-y⟩. ⟨hal-00602370⟩
  • Samia Aci-Seche, Monique Genest, Norbert Garnier. Ligand entry pathways in the ligand binding domain of PPAR gamma receptor. FEBS Letters, 2011, 585 (16), pp.2599-2603. ⟨10.1016/j.febslet.2011.07.014⟩. ⟨hal-00624897⟩
  • Samia Aci-Sèche, Norbert Garnier, Stéphane Goffinont, Daniel Genest, Spotheim-Maurizot Mélanie, et al.. Comparing native and irradiated E. coli lactose repressor-operator complex by molecular dynamics simulation. European Biophysics Journal, 2010, 39 (10), pp.1375-1384. ⟨10.1007/s00249-010-0591-1⟩. ⟨hal-00529210⟩
  • Samia Aci-Seche, Norbert Garnier, Daniel Genest, Stéphane Bourg, Christophe Marot, et al.. A Restrained Molecular Dynamics Empirical Approach for Generating a Small Set of Structures Representative of the Internal Flexibility of a Receptor. QSAR & Combinatorial Science, 2009, 28 (9), pp.959-968. ⟨10.1002/qsar.200910031⟩. ⟨hal-02904717⟩
  • Samia Aci-Seche, Norbert Garnier, Daniel Genest, Stéphane Bourg, Christophe Marot, et al.. Molecular Dynamics Empirical Approach for Generating a Small Set of Structures Representative of the Internal Flexibility of a Receptor. QSAR & Combinatorial Science, 2009, 28 (9), pp.959-968. ⟨hal-00521647⟩
  • Oumarou Samna Soumana, Norbert Garnier, Monique Genest. Insight into the recognition patterns of the ErbB receptor family transmembrane domains: heterodimerization models through MD search. European Biophysics Journal, 2008, 37 (6), pp.851-864. ⟨10.1007/s00249-008-0293-0⟩. ⟨hal-00284330⟩
  • Daniel Genest, Norbert Garnier, Alban Arrault, Christophe Marot, Luc Morin-Allory, et al.. Ligand-escape pathways from the ligand-binding domain of PPAR gamma receptor as probed by molecular dynamics simulations. European Biophysics Journal, 2008, 37, pp.369-379. ⟨10.1007/s00249-007-0220-9⟩. ⟨hal-00512476⟩
  • Oumarou Samna Soumana, Norbert Garnier, Monique Genest. Molecular dynamics simulation approach for the prediction of transmembrane helix–helix heterodimers assembly. European Biophysics Journal, 2007, 36 (8), pp.1071-1082. ⟨10.1021/jm0702175S0022-2623(07)00217-8⟩. ⟨hal-00166544⟩
  • Pierre Aller, Norbert Garnier, Monique Genest. Transmembrane Helix Packing of ErbB/Neu Receptor in Membrane Environment: A Molecular Dynamics Study. Journal of Biomolecular Structure and Dynamics, 2006, 24 (3), pp.209-228. ⟨hal-00111939⟩
  • P. Aller, L. Voiry, Norbert Garnier, M. Genest. Molecular dynamics (MD) investigations of preformed structures of the transmembrane domain of the oncogenic Neu receptor dimer in a DMPC bilayer. Biopolymers, 2005, 77, pp.184-197. ⟨hal-00088475⟩
  • O. Samna Soumana, P. Aller, Norbert Garnier, M. Genest. Transmembrane peptides from tyrosine kinase receptor. Mutation-related behavior in a lipid bilayer investigated by molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics, 2005, 23, pp.91-100. ⟨hal-00088672⟩
  • Norbert Garnier, Serge Crouzy, Monique Genest. Molecular Dynamics Simulations of the Transmembrane Domain of the Oncogenic ErbB2 Receptor Dimer in a DMPC Bilayer. Journal of Biomolecular Structure and Dynamics, 2003, 21 (2), pp.179-200. ⟨10.1080/07391102.2003.10506916⟩. ⟨hal-02123803⟩
  • N. Garnier, C. Normand. Effects of curvature on hydrothermal waves instability of radial thermocapillary flows. Comptes Rendus. Physique, 2001, 2, pp.1227-1233. ⟨hal-00132425⟩
  • J-P Duneau, S. Crouzy, Norbert Garnier, Y. Chapron, M Genest. Molecular dynamics simulations of the ErbB-2 transmembrane domain within an explicit membrane environment: comparison with vacuum simulations.. Biophysical Chemistry, 1999, 76 (1), pp.35-53. ⟨hal-02123801⟩
  • Nicolas Sajot, Norbert Garnier, Monique Genest. Dimer models for ErbB-2/neu transmembrane domains from molecular dynamics simulations. Theoretical Chemistry Accounts: Theory, Computation, and Modeling, 1999, 101 (1-3), pp.67-72. ⟨10.1007/s002140050408⟩. ⟨hal-02123800⟩
  • J-P Duneau, Norbert Garnier, G Cremel, G Nullans, P. Hubert, et al.. Time resolved fluorescence properties of phenylalanine in different environments. Comparison with molecular dynamics simulation.. Biophysical Chemistry, 1998, 73 (1-2), pp.109-19. ⟨hal-02123796⟩
  • Jean-Pierre Duneau, Norbert Garnier, Monique Genest. Insight into Signal Transduction: Structural Alterations in Transmembrane Helices Probed by Multi-1 ns Molecular Dynamics Simulations. Journal of Biomolecular Structure and Dynamics, 1997, 15 (3), pp.555-572. ⟨10.1080/07391102.1997.10508966⟩. ⟨hal-02123789⟩
  • Norbert Garnier, Daniel Genest, Jean Pierre Duneau, Monique Genest. Molecular modeling of c-erbB2 receptor dimerization: Coiled-coil structure of wild and oncogenic transmembrane domains—Stabilization by interhelical hydrogen bonds in the oncogenic form. Biopolymers, 1997, 42 (2), pp.157-168. 3.0.CO;2-M">⟨10.1002/(SICI)1097-0282(199708)42:2<157::AID-BIP5>3.0.CO;2-M⟩. ⟨hal-02123792⟩
  • Norbert Garnier, D. Genest, M Genest. Correlated motions and propagation of the effect of a local conformational change in the transmembrane helix of the c-erb B2 encoded protein and its V659E mutant, studied by molecular dynamics simulations.. Biophysical Chemistry, 1996, 58 (3), pp.225-37. ⟨hal-02123788⟩
  • Norbert Garnier, Daniel Genest, Eric Hebert, Monique Genest. Influence of a Mutation in the Transmembrane Domain of the pl85 c- erb B2 Oncogene-Encoded Protein Studied by Molecular Dynamics Simulations. Journal of Biomolecular Structure and Dynamics, 1994, 11 (5), pp.983-1002. ⟨10.1080/07391102.1994.10508047⟩. ⟨hal-02123785⟩
  • Norbert Garnier, N. Ostrowsky. Brownian dynamics in a confined geometry. Experiments and numerical simulations. Journal de Physique II, 1991, 1 (10), pp.1221-1232. ⟨10.1051/jp2:1991129⟩. ⟨jpa-00247585⟩
  • N Ostrowsky, Norbert Garnier. Quasi-elastic light scattering from an evanescent wave to probe particle/wall interactions.. Biochemical Society Transactions, 1991, 19 (2), pp.500-1. ⟨hal-02123775⟩
  • Nicole Ostrowsky, Norbert Garnier, Didier Sornette. THE USE OF DYNAMIC LIGHT SCATTERING IN STUDIES OF VESICLES INTERACTIONS. Journal of Dispersion Science and Technology, 1989, 10 (3), pp.277-284. ⟨10.1080/01932698908943176⟩. ⟨hal-02123769⟩

Communication dans un congrès8 documents

  • Justine Largillière, Rémy Le Meur, David Ginguené, Norbert Garnier, Celine Landon, et al.. Architecture et dynamique de protéines histone-like de bactérie et d’archées. Journée BioRMN IdF, Sep 2020, Gif-sur-Yvette, France. ⟨hal-03053296⟩
  • A. Wacquiez, F. Coste, V. Nadan, E. Kut, Norbert Garnier, et al.. Interaction de la protéine NS1 avec l’ARN : mécanismes impliqués dans la reconnaissance spécifique. Colloque annuel de ResaFlu, Réseau français sur les virus Influenza, Mar 2019, Lyon, France. ⟨hal-02903093⟩
  • Justine Largillière, Rémy Le Meur, David Ginguené, Norbert Garnier, Celine Landon, et al.. Vers une description cinétique et structurale complète du mécanisme d'échange de chaînes de la protéine HU d'Escherichia coli.. XXXIe congrès du GERM (Groupement d'Etudes de Résonance Magnétique), May 2019, Oléron, France. ⟨hal-02361645⟩
  • J. Cros, F. Coste, S. Goffinont, Virginie Nadan, V. Roy, et al.. Discovery and characterization of inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, pertinent therapeutic targets for cancer therapy. Laboratoire International Associé, Jun 2019, Varsovie, Poland. ⟨hal-02903108⟩
  • Béatrice Vallée, Karen Plé, A. Cosson, M. Doudeau, F. Godin, et al.. Développement de petites molécules inhibitrices des LIM kinases, nouvelles cibles thérapeutiques pour lutter contre le cancer, les maladies neurologiques et la neurofibromatose. Journée Fédération CBM-ICOA, Jan 2018, Orléans, France. ⟨hal-02928530⟩
  • Béatrice Vallée, S. Routier, A. Cosson, M. Doudeau, F. Godin, et al.. Développement de modulateurs des LIM kinases. Cancéropôle Grand Ouest - 14e colloque du Réseau Produits de la mer en cancérologie - 5e colloque du Réseau Canaux ioniques et cancer, May 2018, Mansigné, France. ⟨hal-02928559⟩
  • A. Braka, S. Aci-Sèche, Bourg Stéphane, Norbert Garnier, P. Bonnet. Impact and prediction of binding kinetics on in vivo drug efficacy. 5th EFMC Young Medical Chemist Symposium, Sep 2018, Ljubljana, Slovenia. ⟨hal-02903060⟩
  • N. Garnier, A. Casner. Sur la nature de la transition convectif/absolu de l'instabilité d'Eckhaus d'une onde non-linéaire. 2001, pp.18-20. ⟨hal-00124009⟩

Poster19 documents

  • Justine Largillière, Rémy Le Meur, David Ginguené, Norbert Garnier, Celine Landon, et al.. To a complete kinetics and structural description of the EcHU chain exchange system.. Journée Fédération de recherche “Physique et Chimie du Vivant”, Apr 2019, Orléans, France. ⟨hal-02362578⟩
  • Béatrice Vallée, A. Cosson, M. Doudeau, F. Godin, A. Champiré, et al.. LIM kinases, new therapeutic targets to treat cancers, neurological disorders and Neurofibromatosis: development of small molecule inhibitors. FEBS Meeting 2019, Jul 2019, Cracovie, Poland. ⟨hal-02924140⟩
  • Justine Largillière, Rémy Le Meur, David Ginguené, Norbert Garnier, Celine Landon, et al.. To a complete kinetics and structural description of the EcHU chain exchange system. NMR : a tool for biology XITh, Jan 2019, Paris, France. ⟨hal-02362588⟩
  • Julien Cros, Franck Coste, Stéphane Goffinont, Virginie Nadan, Norbert Garnier, et al.. Screening, characterization and structural studies of small molecules inhibitors of the DNA glycosylase hNEIL1 and hOGG1, potential therapeutic targets in cancer and neurodegenerative disease. 1st French congress on Integrative Structural Biology (BSI-2019), Oct 2019, Toulouse, France. ⟨hal-03385201⟩
  • J. Cros, F. Coste, S. Goffinont, V. Gaudon, V. Roy, et al.. Search for small molecule inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, potential therapeutic targets in cancer. 13th French 3R meeting, May 2019, Presqu’île de Giens, France. ⟨hal-02903219⟩
  • J. Cros, F. Coste, S. Goffinont, V. Gaudon, V. Roy, et al.. Search for small molecule inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, potential therapeutic targets in cancer. Journée Fédération de recherche “Physique et Chimie du Vivant” FR2708 (CBM/ICOA), Apr 2019, Orléans, France. ⟨hal-02903223⟩
  • Justine Largillière, Rémy Le Meur, Norbert Garnier, Celine Landon, A.F. Delmas, et al.. Native and Intermediate conformations of the three HU dimers of E.coli.. 28th ICMRBS - International Council on Magnetic Resonance in Biological Systems, Aug 2018, Dublin, Ireland. ⟨hal-02362585⟩
  • Béatrice Vallée, A. Cosson, M. Doudeau, F. Godin, A. Champiré, et al.. Development of small molecule inhibitors of LIM kinases, new therapeutic targets to treat Neurofibromatosis type I. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France. ⟨hal-02924077⟩
  • Justine Largillière, Rémy Le Meur, David Ginguené, Norbert Garnier, Celine Landon, et al.. To a complete kinetics and structural description of the EcHU chain exchange system.. 31e colloque Biotechnocentre, Oct 2018, Seillac, France. ⟨hal-02362818⟩
  • A. Braka, S. Aci-Sèche, S. Bourg, Norbert Garnier, P. Bonnet. LIM kinase inhibitors discovery by flexible protein high-throughput virtual screening. Structure-based design of LIM kinase inhibitors. Journée Fédération de recherche “Physique et Chimie du Vivant” FR2708 (CBM/ICOA), Jan 2018, Orléans, France. ⟨hal-02904708⟩
  • A. Braka, S. Aci-Sèche, Norbert Garnier, S. Bourg, P. Bonnet. Kinetic rates prediction of protein kinase inhibitors by enhanced molecular dynamics. K4 DD Meeting - Binding kinetics: Time is of the essence, Nov 2017, Berlin, Germany. ⟨hal-02904780⟩
  • A. Braka, S. Aci-Sèche, S. Bourg, Norbert Garnier, P. Bonnet. Simulation of the protein-ligand association process for kinetics prediction. 20e congrès du Groupe de Graphisme et Modélisation Moléculaire (GGMM), May 2017, Reims, France. ⟨hal-02904825⟩
  • A. Braka, S. Aci-Sèche, S. Bourg, Norbert Garnier, P. Bonnet. Path-based simulation of ligand-receptor binding process for binding kinetics prediction. XXIVe Journées Jeunes Chercheurs (SCT), Feb 2017, Châtenay-Malabry, France. ⟨hal-02904830⟩
  • A. Champiré, A. Braka, B. Vallée, M. Doudeau, F. Godin, et al.. LIM kinases as new therapeutic targets for the treatment of neurofibromatosis type 1. VII International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC) –, Aug 2017, Vienne, Austria. ⟨hal-02904794⟩
  • A. Champiré, A. Braka, Béatrice Vallée, M. Doudeau, F. Godin, et al.. Design, synthesis and biological evaluation of LIMK inhibitors. XXIVe Journées Jeunes Chercheurs (SCT), Feb 2017, Châtenay-Malabry, France. ⟨hal-02904837⟩
  • A. Braka, S. Aci-Sèche, S. Bourg, Norbert Garnier, P. Bonnet. Etude par simulations de dynamique moléculaire de la cinétique du processus d’association récepteur-ligand. 29e colloque de Biotechnocentre, Oct 2016, Seillac, France. ⟨hal-02904842⟩
  • A. Champiré, A. Braka, Béatrice Vallée, M. Doudeau, F. Godin, et al.. Conception, synthèse et évaluation biologique d’inhibiteurs de LIM kinases. 29e colloque de Biotechnocentre, Oct 2016, Seillac, France. ⟨hal-02904847⟩
  • C. Rieux, F. Coste, F. Culard, S. Goffinont, S. Bourg, et al.. Small-molecule inhibitors of Fpg/Nei DNA glycosylases, enzymes initiating the base excision repair pathway, new targets for cancer therapy. XXII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids, Jul 2016, Paris, France. ⟨hal-02919151⟩
  • A. Braka, Samia Aci-Seche, S. Bourg, Norbert Garnier, Pascal Bonnet. Computational study of ligand-receptor binding process using enhanced molecular dynamics simulations. 21st European Symposium on Quantitative Structure-Activity Relationship, Sep 2016, Vérone, Italy. ⟨hal-02919149⟩

Chapitre d'ouvrage2 documents

  • Norbert Garnier, D. Genest, M. Genest. Motions and correlations of the transmembrane domain of a protein receptor studied by molecular dynamics simulation. Nonlinear excitations in biomolecules, Springer Berlin Heidelberg, pp.241-246, 1994. ⟨hal-02123780⟩
  • N. Ostrowsky, Norbert Garnier. Brownian dynamics close to a wall, measured by quasi-elastic light scattering from an evanescent wave. Progress in colloid and polymer science, 84, Steinkopff, Heildberg, pp.371-376, 1991, Progress in Colloid & Polymer Science. ⟨hal-02123777⟩

Documents récupérés de l'archive ouverte HAL logo