BOUDVILLAIN Marc

email : marc.boudvillain[remplacer_par_at]cnrs-orleans.fr

Phone : +33 2.38.25.55.85

Research Director, Co-leader of the department “Molecular, Structural and Chemical Biology” and Leader of the team “RNA Remodeling Factors and Mechanisms”

CV and publications of Marc BOUDVILLAIN


68 documents

Article dans une revue45 documents

  • Emmanuel Saridakis, Rishi Vishwakarma, Josephine Lai-Kee-Him, Kevin Martin, Isabelle Simon, et al.. Cryo-EM structure of transcription termination factor Rho from Mycobacterium tuberculosis reveals bicyclomycin resistance mechanism. Communications Biology, 2022, 5 (1), pp.120. ⟨10.1038/s42003-022-03069-6⟩. ⟨hal-03563179⟩
  • Mildred Delaleau, Eric Eveno, Isabelle Simon, Annie Schwartz, Marc Boudvillain. A scalable framework for the discovery of functional helicase substrates and helicase-driven regulatory switches. Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (38), ⟨10.1073/pnas.2209608119⟩. ⟨hal-03800009⟩
  • Gauthier Roy, Antoine Rudy, Annie Schwartz, Stéphanie Slupek, Alex Rivera-Millot, et al.. Posttranscriptional Regulation by Copper with a New Upstream Open Reading Frame. mBio, 2022, ⟨10.1128/mbio.00912-22⟩. ⟨hal-03759142v2⟩
  • Isabelle Simon, Mildred Delaleau, Annie Schwartz, Marc Boudvillain. A large insertion domain in the Rho factor from a low G+C, Gram-negative bacterium is critical for RNA binding and transcription termination activity. Journal of Molecular Biology, 2021, 433 (15), pp.167060. ⟨10.1016/j.jmb.2021.167060⟩. ⟨hal-03248336⟩
  • Lionello Bossi, Nara Figueroa-Bossi, Philippe Bouloc, Marc Boudvillain. Regulatory interplay between small RNAs and transcription termination factor Rho. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms , 2020, pp.194546. ⟨10.1016/j.bbagrm.2020.194546⟩. ⟨hal-02533337⟩
  • Cédric Nadiras, Mildred Delaleau, Annie Schwartz, Emmanuel Margeat, Marc Boudvillain. A Fluorogenic Assay To Monitor Rho-Dependent Termination of Transcription. Biochemistry, 2019, 58 (7), pp.865-874. ⟨10.1021/acs.biochem.8b01216⟩. ⟨hal-02067416⟩
  • Lionello Bossi, Mathilde Ratel, Camille Laurent, Patricia Kerboriou, Andrew Camilli, et al.. NusG prevents transcriptional invasion of H-NS-silenced genes. PLoS Genetics, 2019, 15 (10), pp.e1008425. ⟨10.1371/journal.pgen.1008425⟩. ⟨hal-02308418⟩
  • Cédric Nadiras, Eric Eveno, Annie Schwartz, Nara Figueroa-Bossi, Marc Boudvillain. A multivariate prediction model for Rho-dependent termination of transcription. Nucleic Acids Research, 2018, 46 (16), pp.8245 - 8260. ⟨10.1093/nar/gky563⟩. ⟨hal-01880575⟩
  • Odil Porrua, Marc Boudvillain, Domenico Libri. Transcription Termination: Variations on Common Themes. Trends in Genetics, 2016, 32 (8), pp.508 - 522. ⟨10.1016/j.tig.2016.05.007⟩. ⟨hal-01407669⟩
  • F. d'Heygere, A. Schwartz, F. Coste, B. Castaing, M. Boudvillain. ATP-dependent motor activity of the transcription termination factor Rho from Mycobacterium tuberculosis. Nucleic Acids Research, 2015, 43 (12), pp.6099-60111. ⟨10.1093/nar/gkv505⟩. ⟨hal-01171219⟩
  • V. Gocheva, Antoine Le Gall, M. Boudvillain, E. Margeat, Marcelo Nollmann. Direct observation of the translocation mechanism of transcription termination factor Rho. Nucleic Acids Research, 2015, 43 (4), pp.2367-2377. ⟨10.1093/nar/gkv085⟩. ⟨hal-01171254⟩
  • N. Figueroa-Bossi, A. Schwartz, B. Guillemardet, F. d'Heygere, L. Bossi, et al.. RNA remodeling by bacterial global regulator CsrA promotes Rho-dependent transcription termination. Genes and Development, 2014, 28 (11), pp.1239-1251. ⟨10.1101/gad.240192.114⟩. ⟨hal-01178971⟩
  • Emilie Soares, Annie Schwartz, Marcelo Nollmann, Emmanuel Margeat, Marc Boudvillain. The RNA-mediated, asymmetric ring regulatory mechanism of the transcription termination Rho helicase decrypted by time-resolved nucleotide analog interference probing (trNAIP).. Nucleic Acids Research, 2014, 42 (14), pp.9270-9284. ⟨10.1093/nar/gku595⟩. ⟨hal-01180888⟩
  • Marc Boudvillain, Nara Figueroa-Bossi, Lionello Bossi. Terminator still moving forward: expanding roles for Rho factor.. Current Opinion in Microbiology, 2013, 16 (2), pp.118-24. ⟨10.1016/j.mib.2012.12.003⟩. ⟨hal-00840158⟩
  • François d'Heygère, Makhlouf Rabhi, Marc Boudvillain. Phyletic distribution and conservation of the bacterial transcription termination factor Rho.. Microbiology, 2013, epub ahead of print. ⟨10.1099/mic.0.067462-0⟩. ⟨hal-00840167⟩
  • Francesca Fiorini, Marc Boudvillain, Hervé Le Hir. Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains. Nucleic Acids Research, 2013, 41 (4), pp.2404-2415. ⟨10.1093/nar/gks1320⟩. ⟨hal-02358926⟩
  • Rachid Menouni, Stéphanie Champ, Leon Espinosa, Marc Boudvillain, Mireille Ansaldi. Transcription termination controls prophage maintenance in Escherichia coli genomes.. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (35), pp.14414-9. ⟨10.1073/pnas.1303400110⟩. ⟨hal-00874882⟩
  • Lionello Bossi, Annie Schwartz, Benoit Guillemardet, Marc Boudvillain, Nara Figueroa-Bossi. A role for Rho-dependent polarity in gene regulation by a noncoding small RNA.. Genes and Development, 2012, 26 (16), pp.1864-1873. ⟨10.1101/gad.195412.112⟩. ⟨hal-00727260⟩
  • Annie Schwartz, Makhlouf Rabhi, Emmanuel Margeat, Marc Boudvillain. Analysis of helicase-RNA interactions using nucleotide analog interference mapping.. Methods in Enzymology, 2012, 511, pp.149-69. ⟨10.1016/B978-0-12-396546-2.00007-3⟩. ⟨hal-00726256⟩
  • Makhlouf Rabhi, Veronika Gocheva, Frederique Jacquinot, Andrea Lee, Emmanuel Margeat, et al.. Mutagenesis-Based Evidence for an Asymmetric Configuration of the Ring-Shaped Transcription Termination Factor Rho. Journal of Molecular Biology, 2011, 405 (2), pp.497-518. ⟨10.1016/j.jmb.2010.11.006⟩. ⟨hal-00608241⟩
  • Makhlouf Rabhi, Olivier Espéli, Annie Schwartz, Bastien Cayrol, a Rachid Rahmouni, et al.. The Sm-like RNA chaperone Hfq mediates transcription antitermination at Rho-dependent terminators.. EMBO Journal, 2011, 30 (14), pp.2805-16. ⟨10.1038/emboj.2011.192⟩. ⟨hal-00720713⟩
  • Makhlouf Rabhi, Roman Tuma, Marc Boudvillain. RNA remodeling by hexameric RNA helicases. RNA Biology, 2010, 7 (6 - Sp. Iss. SI), pp.655-666. ⟨10.4161/rna.7.6.13570⟩. ⟨hal-00602496⟩
  • Marc Boudvillain, Marcelo Nollmann, Emmanuel Margeat. Keeping up to speed with the transcription termination factor Rho motor.. Transcription, 2010, 1 (2), pp.70-75. ⟨10.4161/trns.1.2.12232⟩. ⟨hal-00591655⟩
  • Annie Schwartz, Makhlouf Rabhi, Frederique Jacquinot, Emmanuel Margeat, A. Rachid Rahmouni, et al.. A stepwise 2 '-hydroxyl activation mechanism for the bacterial transcription termination factor Rho helicase. Nature Structural and Molecular Biology, 2009, 16 (12), pp.1309-1316. ⟨10.1038/nsmb.1711⟩. ⟨hal-00525325⟩
  • Annie Schwartz, Emmanuel Margeat, A. Rachid Rahmouni, Marc Boudvillain. Transcription termination factor Rho can displace streptavidin from biotinylated RNA. Journal of Biological Chemistry, 2007, 282 (43), pp.31469-31476. ⟨10.1074/jbc.M706935200⟩. ⟨hal-00176284⟩
  • Annie Schwartz, Céline Walmacq, A. Rachid Rahmouni, Marc Boudvillain. Noncanonical Interactions in the Management of RNA Structural Blocks by the Transcription Termination Rho Helicase. Biochemistry, 2007, 46 (33), pp.9366 - 9379. ⟨10.1021/bi700493m⟩. ⟨hal-00166551⟩
  • C. Walmacq, A.R. Rahmouni, M. Boudvillain. Testing the steric exclusion model for hexameric helicases: substrate features that alter RNA-DNA unwinding by the transcription termination factor Rho. Biochemistry, 2006, 45, pp.5885-5895. ⟨10.1021/bi0600648⟩. ⟨hal-00088941⟩
  • C. Walmacq, A.R. Rahmouni, M. Boudvillain. Influence of substrate composition on the helicase activity of transcription termination factor Rho: reduced processivity of Rho hexamers during unwinding of RNA-DNA hybrid regions. Journal of Molecular Biology, 2004, 342 (2), pp.403-420. ⟨10.1016/j.jmb.2004.07.026⟩. ⟨hal-00113090⟩
  • A. Schwartz, A. Rachid Rahmouni, Marc Boudvillain. The functional anatomy of an intrinsic transcription terminator. EMBO Journal, 2003, 22 (13), pp.3385 - 3394. ⟨10.1093/emboj/cdg310⟩. ⟨hal-01880611⟩
  • Kathrin Schmidt, Marc Boudvillain, Annie Schwartz, Gijs van Der Marel, Jacques van Boom, et al.. Monofunctionallytrans-Diammine Platinum(II)-Modified Peptide Nucleic Acid Oligomers: A New Generation of Potential Antisense Drugs. Chemistry - A European Journal, 2002, 8 (24), pp.5566 - 5570. 3.0.CO;2-#">⟨10.1002/1521-3765(20021216)8:24<5566::AID-CHEM5566>3.0.CO;2-#⟩. ⟨hal-01880614⟩
  • Marc Boudvillain, Annie Schwartz, A. Rachid Rahmouni. Limited Topological Alteration of the T7 RNA Polymerase Active Center at Intrinsic Termination Sites †. Biochemistry, 2002, 41 (9), pp.3137-3146. ⟨10.1021/bi011358q⟩. ⟨hal-02075291⟩
  • Boudvillain Marc, Rozenn Dalbies-Tran, Marc Leng, Marc Boudvillain. Oligonucleotides Modified With Transplatin Derivatives: Fast and Efficient Metalloribozymes. Metal-Based Drugs, 2001, 8 (1), pp.39 - 45. ⟨10.1155/MBD.2001.39⟩. ⟨hal-01880601⟩
  • Marc Boudvillain, Alexandre de Lencastre, Anna Marie Pyle. A tertiary interaction that links active-site domains to the 5′ splice site of a group II intron. Nature, 2000, 406 (6793), pp.315 - 318. ⟨10.1038/35018589⟩. ⟨hal-01880615⟩
  • Jens Müller, Markus Drumm, Marc Boudvillain, Marc Leng, Einar Sletten, et al.. Parallel-stranded DNA with Hoogsteen base pairing stabilized by a trans-[Pt(NH3)2]2+ cross-link: characterization and conversion into a homodimer and a triplex. Journal of Biological Inorganic Chemistry, 2000, 5 (5), pp.603-611. ⟨10.1007/s007750000143⟩. ⟨hal-02075297⟩
  • Anna M. Pyle, V Chu, E Jankowsky, Marc Boudvillain. Using DNAzymes to cut, process, and map RNA molecules for structural studies or modification.. Methods in Enzymology, 1999, 317, pp.140-6. ⟨hal-02096724⟩
  • Françoise Paquet, Marc Boudvillain, Gérard Lancelot, Marc Leng. NMR solution structure of a DNA dodecamer containing a transplatin interstrand GN7-CN3 cross-link. Nucleic Acids Research, 1999, 27 (21), pp.4261-4268. ⟨10.1093/nar/27.21.4261⟩. ⟨hal-02075311⟩
  • Marc Boudvillain, Anna M. Pyle. Defining functional groups, core structural features and inter-domain tertiary contacts essential for group II intron self-splicing: a NAIM analysis. EMBO Journal, 1998, 17 (23), pp.7091-7104. ⟨10.1093/emboj/17.23.7091⟩. ⟨hal-02096717⟩
  • Caroline Colombier, Marc Boudvillain, Marc Leng. Interstrand Crosslinking Reaction in Transplatin-Modified Oligo-2‵-O-Methyl Ribonucleotide-RNA Hybrids. Antisense and Nucleic Acid Drug Development, 1997, 7 (4), pp.397-402. ⟨10.1089/oli.1.1997.7.397⟩. ⟨hal-02322135⟩
  • Marc Boudvillain, Martine Guerin, Rozenn Dalbies, Tula Saison-Behmoaras, Marc Leng. Transplatin-Modified Oligo(2‘- O -methyl ribonucleotide)s: A New Tool for Selective Modulation of Gene Expression †. Biochemistry, 1997, 36 (10), pp.2925 - 2931. ⟨10.1021/bi962695f⟩. ⟨hal-01880625⟩
  • Marc Boudvillain, C. Prevost, P. Beudaert, M. Leng, R. Lavery, et al.. Distortions of the DNA Double Helix Induced by 1,3-trans-Diamminedichloroplatinum(II)-intrastrand Cross-link: An Internal Coordinate Molecular Modeling Study. Journal of Biomolecular Structure and Dynamics, 1997, 14 (6), pp.703 - 714. ⟨10.1080/07391102.1997.10508173⟩. ⟨hal-01880624⟩
  • Eloy Bernal-Méndez, Marc Boudvillain, Francisco González-Vílchez, Marc Leng. Chemical Versatility of Transplatin Monofunctional Adducts within Multiple Site-Specifically Platinated DNA †. Biochemistry, 1997, 36 (24), pp.7281 - 7287. ⟨10.1021/bi9703148⟩. ⟨hal-01880622⟩
  • C. Prevost, M. Boudvillain, P. Beudaert, M. Leng, R. Lavery, et al.. Distortions of the DNA double helix induced by 1,3-trans-diamminedichloroplatinum(II)-intrastrand cross-link: an internal coordinate molecular modeling study.. Journal of Biomolecular Structure and Dynamics, 1997, 14, pp.703-714. ⟨hal-00313421⟩
  • Marc Boudvillain, Rozenn Dalbies, M. Leng. Evidences for a catalytic activity of the DNA double helix in the reaction between DNA, platinum(II), and intercalators.. Metal Ions in Biological Systems, 1996, 33, pp.87-104. ⟨hal-02322086⟩
  • Marc Boudvillain, Rozenn Dalbies, Christophe Aussourd, Marc Leng. Intrastrand cross-links are not formed in the reaction between transplatin and native DNA: relation with the clinical inefficency of transplatin. Nucleic Acids Research, 1995, 23 (13), pp.2381-2388. ⟨10.1093/nar/23.13.2381⟩. ⟨hal-02075318⟩
  • Rozenn Dalbies, Marc Boudvillain, Marc Leng. Linkage isomerization reaction of intrastrand cross-links in trans -diamminedichloroplatinum(II)-modified single-stranded oligonucleotides. Nucleic Acids Research, 1995, 23 (6), pp.949-953. ⟨10.1093/nar/23.6.949⟩. ⟨hal-02075321⟩

Communication dans un congrès3 documents

  • Mildred Delaleau, Eric Eveno, Annie Schwartz, Isabelle Simon, Marc Boudvillain. Helicase-SELEX: A versatile new approach to seek constitutive or conditional helicase substrates at global scale. 12th SifrARN: Structure, integration, function & reactivity of RNA, Oct 2022, Bordeaux, France. ⟨hal-04148466⟩
  • Marc Boudvillain. Régulation des gènes par un moteur moléculaire unique aux bactéries. 34e Colloque de Biotechnocentre, Oct 2022, Nouan-le-Fuzelier, France. ⟨hal-04148476⟩
  • Emmanuel Saridakis, Rishi Vishwakarma, Joséphine Lai Kee Him, Kevin Martin, Isabelle Simon, et al.. Structural basis for resistance of Mycobacterium tuberculosis Rho to bicyclomycin. Helicases & Nucleic Acid-Based Machines: Structure, Mechanism & Regulation, and Roles in HumanDisease, Jul 2021, Paris, France. ⟨hal-03419029⟩

Poster10 documents

  • Isabelle Simon, Mildred Delaleau, Annie Schwartz, Marc Boudvillain. Variation on a theme - the unusual features of the essential transcription termination Rho factor from a low G+C, Gram-negative bacterium. 45th FEBS congress, Jul 2021, Lubjana, Slovenia. ⟨hal-03419044⟩
  • E. Eveno, C. Nadiras, N. Figueroa-Bossi, A. Schwartz, M. Boudvillain. Predicting Rho-dependent termination of transcription at genome scale. 24th Annual Meeting of the RNA Society, Jun 2019, Cracovie, Poland. ⟨hal-02902104⟩
  • I. Simon, A. Schwartz, M. Delaleau, L. Bossi, N. Figueroa-Bossi, et al.. Exploring Rho helicase activity for the purpose of synthetic regulation. 32e Colloque Biotechnocentre, Oct 2019, Seillac, France. ⟨hal-02902096⟩
  • E. Eveno, C. Nadiras, A. Schwartz, N. Figueroa-Bossi, M. Boudvillain. Genome-scale prediction of Rho-dependent termination of transcription. 11e Rencontre SifrARN (SFBBM), Nov 2018, Nancy, France. ⟨hal-02902107⟩
  • C. Nadiras, E. Eveno, M. Boudvillain. Towards a model for predicting Rho-dependent transcription termination sites. Le Studium conference “Structural biology and biophysics of RNA-protein complexes”, Nov 2017, Orléans, France. ⟨hal-02902112⟩
  • C. Clerte, O. Manier, J-B. Fiche, M. Boudvillain, L. Bossi, et al.. Relationships between Rho and RNA polymerase in living bacteria. Le Studium conference “Structural biology and biophysics of RNA-protein complexes”, Nov 2017, Orléans, France. ⟨hal-02902111⟩
  • R. Vishwakarma, A. Nord, F. Pedaci, M. Boudvillain, E. Margeat. Single-molecule analysis of E. coli Rho translocase, Helicase, transcription termination activities, and its interactions with RNA polymerase. Le Studium conference “Structural biology and biophysics of RNA-protein complexes”, Nov 2017, Orléans, France. ⟨hal-02902115⟩
  • C. Nadiras, E. Eveno, M. Boudvillain. Identification des sites de terminaison de transcription Rho-dépendantes dans les génomes bactériens. 30e Colloque Biotechnocentre, Oct 2017, Seillac, France. ⟨hal-02902116⟩
  • C. Nadiras, E. Eveno, M. Boudvillain. Seeking Rho-dependent transcription termination sites within bacterial genomes. EMBO & Harden conference - Helicases and Nucleic Acid Translocases, Jul 2017, Kloster Banz-Bamberg, Germany. ⟨hal-02902120⟩
  • C. Nadiras, Eric Eveno, A. Schwartz, M. Boudvillain. Analyse des terminateurs Rho-dépendants bactériens. 29e colloque Biotechnocentre, Oct 2016, Seillac, France. ⟨hal-02453368⟩

Ouvrage (y compris édition critique et traduction)1 document


Chapitre d'ouvrage8 documents

  • Isabelle Simon, Marc Boudvillain. A simple fluorescence microplate assay to monitor RNA-DNA hybrid unwinding by the bacterial transcription termination factor Rho. Marc Boudvillain. RNA remodeling proteins : Methods and Protocols, 2209, Humana press, pp.143-161, 2021, Methods in Molecular Biology, 978-1-0716-0937-8. ⟨10.1007/978-1-0716-0935-4_10⟩. ⟨hal-03036494⟩
  • Cédric Nadiras, Annie Schwartz, Mildred Delaleau, Marc Boudvillain. Evaluating the Effect of Small RNAs and Associated Chaperones on Rho-Dependent Termination of Transcription In Vitro.. Methods in Mecular Biology, 1737, humana press, Totowa, NJ-USA, pp.99-118, 2018, Bacterial regulatory RNA (Arluison & Valverde, eds), ⟨10.1007/978-1-4939-7634-8_7⟩. ⟨hal-01880631⟩
  • F. d'Heygère, A. Schwartz, F. Coste, B. Castaing, M. Boudvillain. Monitoring RNA Unwinding by the Transcription Termination Factor Rho from Mycobacterium tuberculosis. Methods in Mecular Biology, 1259, Springer, pp.293-311, 2015, RNA remodelling proteins (Boudvillain, ed), 978-1-4939-2213-0. ⟨10.1007/978-1-4939-2214-7_18⟩. ⟨hal-01174055⟩
  • Olga Fedorova, Marc Boudvillain, Christina Waldsich. Nucleotide Analog Interference Mapping and Suppression (NAIM/NAIS): a Combinatorial Approach to Study RNA Structure, Folding, and Interaction with Proteins. Handbook of RNA Biochemistry, 2nd edition (Westhof, Bindereif, Schon & Hartmann, eds), Wiley-VCH Verlag GmbH & Co. KGaA, pp.329-368, 2014, ⟨10.1002/9783527647064.ch17⟩. ⟨hal-02097735⟩
  • Makhlouf Rabhi, Rahmouni Rachid A., Marc Boudvillain. Transcription termination factor Rho: a ring-shaped RNA helicase from bacteria. Eckhard Jankowsky. RNA helicases, Royal Society of Chemistry Publishing, pp.243-271, 2010, ⟨10.1039/9781849732215-00243⟩. ⟨hal-00610004⟩
  • Marc Boudvillain, Céline Walmacq, Annie Schwartz, Frédérique Jacquinot. Simple enzymatic assays for the in vitro motor activity of transcription termination factor Rho from Escherichia coli. Mohamed M. M. Abdelhaleem. Methods in Mecular Biology, Humana Press, pp.137-154, 2009, Helicases (Abdelhaleem, ed), ⟨10.1007/978-1-60327-355-8_10⟩. ⟨hal-00623571⟩
  • O. Fedorova, M. Boudvillain, J. Kawaola, A.M. Pyle. Nucleotide analog interference mapping and suppression (NAIM/NAIS): specific applications in studies of RNA tertiary structure, dynamic helicase mechanism, and RNA-protrein interactions. E. Westhof, A. Bindereif, A. Schon, R.I. Hartmann. Handbook of RNA biochemistry, Wiley-VCH, pp.259-293, 2005. ⟨hal-00088591⟩
  • Marc Boudvillain, Rozenn Dalbies-Tran, Leng M.. Trans-Diamminedichloroplatinum (II) Is Not an Antitumor Drug: Why?. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy, 2, Plenum Press, New'Tork, USA, pp.17-25, 1996. ⟨hal-02097755⟩

Brevet1 document

  • Marc Leng, Rozenn Dalbies, Marc Boudvillain. Procédé de pontage sélectif et irréversible d'oligonucléotides platinés sur de l'ARN et ses applications. France, Patent n° : WO1998018915A2. 1996. ⟨hal-02097839⟩

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