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Article in "Methods in Enzymology" by the team "Hélicases et ARN : mécanismes, ciblage et bio-mimétisme"

Nucleotide analog interference mapping (NAIM) is a combinatorial approach that probes individual atoms and functional groups in an RNA molecule and identifies those that are important for a specific biochemical function. Here, we show how NAIM can be adapted to reveal functionally important atoms and groups on RNA substrates of helicases. We explain how NAIM can be used to investigate translocation and unwinding mechanisms of helicases and discuss the advantages and limitations of this powerful chemogenetic approach.

News june 2009

In the second tender of the Regional Center in 2008, a collaborative project between the CBM and ICOA was selected for regional funding.

Molecular traps for DNA repair enzymes, a way for cancers and aging diseases therapies

The challenge for DNA glycosylases, enzymes involved in the base excision repair pathway, such Fpg and hOgg1, is to identify and remove one lesion among millions of undamaged bases by not only identifying small lesions that didn’t cause large disruptions of local DNA structures, but also by accommodating and processing bulky lesions using the same active site.
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