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Cover page of a volume of the journal "Chemistry-A European Journal"

CBM researchers make the cover page of a volume of the journal "Chemistry-A European Journal" during a work dedicated to the creation and rationalization of the behavior of Erbium complexes, formed with a new generation of ligands, to generate the luminescence of Er which is rarely observed in the visible range for a molecular compound. The results of this work, carried out in close collaboration with researchers from the Chemistry Section of the University of Geneva in Switzerland, open up major new perspectives in the field of higher molecular energy converters.

CBM researchers have created the first method for detecting non-covalent complexes of biomolecules by MALDI mass spectrometry based on liquid deposits

So far, the standard approach for analyzing molecule complexes in native mass spectrometry, ie by keeping the complexes intact in the instrument, used electrospray to produce the ions to be detected. MALDI ionization, however, has many advantages, such as reduced sample consumption and better tolerance to certain additives or contaminants, and its use opens new perspectives in native mass spectrometry.

CBM researchers have worked out a new generation of metallacryptates

CBM researchers, in collaboration with the team of Professor Vincent L. Pecoraro of the University of Michigan in the United States, have created a new generation of metal cryptates incorporating cations with a very particular architecture. The compounds belonging to this family combine original magnetic properties of slow relaxation with luminescence properties in the visible and in the near-infrared.

MicroRNA-Based Drugs for Brain Tumors

MicroRNAs (miRNAs) are key regulatory elements encoded by the genome. A single miRNA can downregulate the expression of multiple genes involved in diverse functions. Because cancer is a disease with multiple gene aberrations, developing novel approaches to identify and modulate miRNA pathways may result in a breakthrough for cancer treatment. With a special focus on glioblastoma (GBM), this review provides an up-to-date summary of miRNA biogenesis, the role of miRNA in cancer resistance, and essential tools for modulating miRNA expression, as well as of clinically promising RNAi delivery systems and how they can be adapted for therapy.

Article in "Methods in Enzymology" by the team "Hélicases et ARN : mécanismes, ciblage et bio-mimétisme"

Nucleotide analog interference mapping (NAIM) is a combinatorial approach that probes individual atoms and functional groups in an RNA molecule and identifies those that are important for a specific biochemical function. Here, we show how NAIM can be adapted to reveal functionally important atoms and groups on RNA substrates of helicases. We explain how NAIM can be used to investigate translocation and unwinding mechanisms of helicases and discuss the advantages and limitations of this powerful chemogenetic approach.

News june 2009

In the second tender of the Regional Center in 2008, a collaborative project between the CBM and ICOA was selected for regional funding.

Molecular traps for DNA repair enzymes, a way for cancers and aging diseases therapies

The challenge for DNA glycosylases, enzymes involved in the base excision repair pathway, such Fpg and hOgg1, is to identify and remove one lesion among millions of undamaged bases by not only identifying small lesions that didn’t cause large disruptions of local DNA structures, but also by accommodating and processing bulky lesions using the same active site.
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