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The CNRS Institute of Chemistry reports on its website the work of CBM researchers
The CNRS Institute of Chemistry reports on its website a publication by CBM researchers published in the journal Nucleic Acids Research. The researchers used "AlphaFold 2", an artificial intelligence tool, to predict and describe the structure of PARP proteins in order to better understand their functionalities. PARP proteins are potential targets for new cancer treatments.
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Discover some experiences
35th Biotechnocentre symposium - October 19 and 20, 2023
Meetings in the fields of Life Sciences, Health and Well-being in the Centre - Val de Loire region
Friday, September 1, 2023 - Seminar of Professor Jérôme LAMARTINE
"The microRNA miR-30a plays a key role in human chronological skin aging by regulating cell differentiation, cell death and autophagy".
Oxygen impact on our skin antioxidant defences: a new epidermis 3D model that is closer to physiology
The development of a new epidermis model that respects the skin oxygen physiological level of oxygen by CBM researchers has highlighted the role of oxygen in the expression and activity of antioxidant enzymes, which are essential for slowing skin ageing.
Structural insights into the SUMOylation reaction
The new study focussed on the process known as SUMOylation, an essential biological regulatory mechanism, inaugurates the "SUMOwriteNread" project funded by the European Research Council, which aims to crack secrets of SUMOylation.
Valentin BEAUVAIS thesis defense
"mRNPs biogenesis perturbation by the bacterial Rho factor : genomic analysis of the recrutment of the THO complex and its subunits".
Edison ZHAMUNGUI thesis defense
"Direct structural/functional characterization of therapeutically relevant membrane protein complexes and soluble oligomers by NALIM (Native Liquid MALDI) - TOF MS, an original Mass Spectrometry approach".
Combining computers and experiments to study the domain composition and function of the PARP protein family
A collaborative study co-led by the CBM researcher, Marcin J. Suskiewicz, combines structural prediction with the AI-powered tool AlphaFold2 with experiments to gain deeper understanding of an important group of proteins, the PARP family.
Friday, June 30, 2023 - Seminar of Prof. Sébastien HUET
Contribution of HPF1 to cellular response to cancer-relevant PARP inhibitors via the modulation of PARP1 trapping at DNA lesions
Seminars by doctors Katel Hervé-Aubert, Stéphanie David and Emilie Allard-Vannier - Monday, June 12, 2023
3 researchers from the NMNS "NanoMedicines and NanoProbes" laboratory in Tours will present their research work.
Conference by Prof. Ken LAU and Dr Andrea ROLONG - June 5, 2023
Le Studium Experts Days "Cell state transitions and plasticity at the interface of inflammation and pre-neoplasia in mouse, human, and organoids"
Truly life materials?
How is life in 3D-printable Engineered Living Materials? CBM researchers answered this question by confocal imaging at single cell resolution of several biomarkers on engineered eukaryotic cell Saccharomyces cerevisiae associated with Pluronic F-127 hydrogel.
Milk thistle, a plant extract with promising –green- medicinal properties against psoriasis
Cell-based screening of medicinal plants placed under the control of the TGFβ/miRNA-21 pathway in epidermal cells identified the milk thistle plant extract as regenerative and anti-inflammatory natural product against psoriasis.
Seminar of Dr Marc LE BERT - 2023, May 5
"Ethique et réglementation de l’utilisation d’animaux à des fins scientifiques"