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2024, May 15th - Seminar of Rebeca Lopez Adams
"Life on Earth can grow on extraterrestrial organic carbon: retaking the heterotrophic origin of life"
2024 May, 7 - El Hadji Cisse Defensis
"Synthesis of proteins by chemical ligation: methodological study to avoid aspartimide formation & application to SUMOylated peptides and proteins"
2024, April 25 - Ayyoub Rayyad Defensis
"Multiscale analysis of biopharmaceutical production using Raman spectroscopy"
2024, April 19 - Seminar of Dimitar Angelov
"Molecular mechanism of linker histone H1E-mediated chromatin folding and phase separations under normal and Rahman syndrome disease conditons"
2024, April 18 - "La plongée, un sport sous pression"
How pressure varies with depth in the aquatic environment and how it impacts dive management.
Breast cancer: towards early diagnosis by imaging
In vivo imaging of metastatic breast cancer tumors at very early stages will soon be possible.
2024, April 5 - Seminar of Carine Giovannangeli
"Precise genome editing with crispr: how to get it better?"
2024, March 29 - Seminar of Yu Kimura
"Versatile contrast agents width nanometer sizes to visualize diseases and treatment reagents"
Watching enzymes work in vivo with rare-earth-based molecular probes
Scientists at the CNRS have developed rare-earth complexes as unique probes for the in vivo detection of enzyme activity by magnetic resonance imaging and near-infrared optical imaging. This study, published in the journal Angewandte Chemie International Edition, paves the way for new non-invasive diagnostic strategies.
New thesis offers at CBM
La ligue contre le Cancer (The League Against Cancer) supports research carried out at the CBM
Each year, the Grand Ouest Committee of the League Against Cancer actively participates in research by financing a certain number of scientific projects.
2024, March 22 - Seminar of Marie Catherine Sforna
Metals as tracers of biological processes and metabolisms on the early Earth and Mars
The study of terrestrial fossils in ancient rocks: a crucial approach to identify potential signs of life on Mars
The identification of distinctive signatures indicating the presence of past life in terrestrial sediments dating back billions of years could serve as a model for the search for traces of life in Martian rocks to be brought back to Earth by 2035.
Enzymatic detection in near infrared optical imaging and MRI with a single ligand complexed to different lanthanide ions
Applying a single molecular probe to monitor biomarkers in multiple, complementary imaging modalities is highly desirable to ascertain detection and to avoid the complexity associated with the use of agents of different chemical entities. We demonstrate the versatility of lanthanide complexes with respect to their potential for enzymatic detection in NIR luminescence, CEST and T1 MR imaging, controlled by the nature of the Ln3+ ion.
2024, March 15 - Seminar of Timothée Lathion
"Functionalized Near-Infrared Emitting Lanthanide(III)/Gallium(III) Metallacrowns with Red-Shifted Excitation"
Marie Curie Postdoctoral Fellowships
With two new "Marie Skłodowska-Curie postdoctoral fellowships" obtained, CBM chemists of the "Synthetic Proteins and Bioorthogonal Chemistry" and the vMetal Complexes and MRI" teams have a total of five of these prestigious European grants ongoing.
New imaging probe enables MRI detection of early-stage breast cancer tumors
A novel imaging probe Gd-K enables successful MRI visualization of early stage 4T1 metastatic breast cancer tumors in mice, with 3-fold contrast enhancement compared to DOTAREM, the MRI clinical gold standard.
Congratulations to Lylia Azoug for her poster prize!
Her work “An efficient strategy to bioconjugate disulfide-containing peptides via thiol-maleimide chemistry while preserving their bridging pattern” was awarded at the “Chemical Biology Symposium 2024” conference organized by the Société Chimique de France.
2024, February 2 - Seminar of professor Michael ROWE
"Biogenicity and preservation of trace metals in hot spring deposits: preparing for a Mars sample return mission"
Comprehensive review about the “logic of protein modifications”
The CBM researcher Marcin Suskiewicz published a comprehensive review article that proposes a unifying narrative about protein post-translational modifications (PTMs), including the history of PTM research, chemical and mechanistic principles, and evolution.