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2024 May, 7 - El Hadji Cisse Defensis

"Synthesis of proteins by chemical ligation: methodological study to avoid aspartimide formation & application to SUMOylated peptides and proteins"

Watching enzymes work in vivo with rare-earth-based molecular probes

Scientists at the CNRS have developed rare-earth complexes as unique probes for the in vivo detection of enzyme activity by magnetic resonance imaging and near-infrared optical imaging. This study, published in the journal Angewandte Chemie International Edition, paves the way for new non-invasive diagnostic strategies.

New thesis offers at CBM

Enzymatic detection in near infrared optical imaging and MRI with a single ligand complexed to different lanthanide ions

Applying a single molecular probe to monitor biomarkers in multiple, complementary imaging modalities is highly desirable to ascertain detection and to avoid the complexity associated with the use of agents of different chemical entities. We demonstrate the versatility of lanthanide complexes with respect to their potential for enzymatic detection in NIR luminescence, CEST and T1 MR imaging, controlled by the nature of the Ln3+ ion.

Marie Curie Postdoctoral Fellowships

With two new "Marie Skłodowska-Curie postdoctoral fellowships" obtained, CBM chemists of the "Synthetic Proteins and Bioorthogonal Chemistry" and the vMetal Complexes and MRI" teams have a total of five of these prestigious European grants ongoing.

Congratulations to Lylia Azoug for her poster prize!

Her work “An efficient strategy to bioconjugate disulfide-containing peptides via thiol-maleimide chemistry while preserving their bridging pattern” was awarded at the “Chemical Biology Symposium 2024” conference organized by the Société Chimique de France.
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