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So far, the standard approach for analyzing molecule complexes in native mass spectrometry, ie by keeping the complexes intact in the instrument, used electrospray to produce the ions to be detected. MALDI ionization, however, has many advantages, such as reduced sample consumption and better tolerance to certain additives or contaminants, and its use opens new perspectives in native mass spectrometry.
CBM researchers, in collaboration with the team of Professor Vincent L. Pecoraro of the University of Michigan in the United States, have created a new generation of metal cryptates incorporating cations with a very particular architecture. The compounds belonging to this family combine original magnetic properties of slow relaxation with luminescence properties in the visible and in the near-infrared.
Great meeting of the National Nanomedicine Platforms organized by NOBEL during ETPN2018, May 29, in Berlin.
This method, based on multivariate statistical modeling of a large set of experimental data generated for the occasion, allows the prediction of potential sites of Rho-dependent transcription termination at the level of whole bacterial genomes.
MicroRNAs (miRNAs) are key regulatory elements encoded by the genome. A single miRNA can downregulate the expression of multiple genes involved in diverse functions. Because cancer is a disease with multiple gene aberrations, developing novel approaches to identify and modulate miRNA pathways may result in a breakthrough for cancer treatment. With a special focus on glioblastoma (GBM), this review provides an up-to-date summary of miRNA biogenesis, the role of miRNA in cancer resistance, and essential tools for modulating miRNA expression, as well as of clinically promising RNAi delivery systems and how they can be adapted for therapy.
Nucleotide analog interference mapping (NAIM) is a combinatorial approach that probes individual atoms and functional groups in an RNA molecule and identifies those that are important for a specific biochemical function. Here, we show how NAIM can be adapted to reveal functionally important atoms and groups on RNA substrates of helicases. We explain how NAIM can be used to investigate translocation and unwinding mechanisms of helicases and discuss the advantages and limitations of this powerful chemogenetic approach.