SBM Team: Skin Biology and Microenvironment

The Skin Biology and Microenvironment team is interested in the role of the microenvironment in the regulation of physiological and pathological processes (skin ageing, cancer, inflammation, oxidative stress, etc.) through the development of original study models that respect the cellular microenvironment and that are closer to skin physiology.

Keywords :

Oxygen, physioxia, oxidative stress, skin aging, 3D models, reconstructed epidermis

Collaborations

Academic collaborations

• Dr Eric Robert, GREMI, UMR7344 CNRS/Université Orléans, France
• Dr Franck Bonnier – Dr Emilie Munnier, NMNS, EA 6295 Université de Tours, France
• Dr Michel Simon, INSERM - UMR 1291, Toulouse, France
• Pr Nadia Haddad, Pr Henri-Jean Boulouis, Dr Anne-Claire Lagrée, Ecole Nationale Vétérinaire d’Alfort, Maisons Alfort, France
• Dr Aleksandra Bielowska-Pohl, Dr Maria Paprocka, Dr Agnieska Krawczenko, Dr Aleksandra Klimczak, Polish Academy of Sciences, Wroclaw, Poland

Company collaborations

• Transderma, Tours, France
• Spincontrol, Tours, France
• Greentech, Saint Beauzire, France
• Eurofins Bio-EC, Longjumeau, France
• Garoma, Brouzet-lès-Alès, France

Partners, networks, fundings

Main publications

• Improvement of Antioxidant Defences in Keratinocytes Grown in Physioxia: Comparison of 2D and 3D Models. Chettouh-Hammas N, Fasani F, Boileau A, Gosset D, Busco G, Grillon C. Oxid Med Cell Longev. 2023 Jun 17;2023:6829931. doi: 10.1155/2023/6829931.
• Tumour angiogenesis normalized by myo-inositol trispyrophosphate alleviates hypoxia in the microenvironment and promotes antitumor immune response. El Hafny-Rahbi B, Brodaczewska K, Collet G, Majewska A, Klimkiewicz K, Delalande A, Grillon C, Kieda C. J Cell Mol Med. 2021 Apr;25(7):3284-3299. doi: 10.1111/jcmm.16399.
• The GTPase-activating protein-related domain of neurofibromin interacts with MC1R and regulates pigmentation-mediated signaling in human melanocytes. Deraredj Nadim W, Hassanaly S, Bénédetti H, Kieda C, Grillon C, Morisset-Lopez S. Biochem Biophys Res Commun. 2021 Jan 1;534:758-764. doi: 10.1016/j.bbrc.2020.11.003
• The emerging potential of cold atmospheric plasma in skin biology. Busco G, Robert E, Chettouh-Hammas N, Pouvesle JM, Grillon C. Free Radic Biol Med. 2020 Dec;161:290-304. doi: 10.1016/j.freeradbiomed.2020.10.004.
• Cold atmospheric single plasma jet for RONS delivery on large biological surfaces. AV Omran, G Busco, L Ridou, S Dozias, C Grillon, JM Pouvesle, E Robert. Plasma Sources Science and Technology 29 (10), 105002. Doi: 10.1088/1361-6595/abaffd.
• A 3D model of tumour angiogenic microenvironment to monitor hypoxia effects on cell interactions and cancer stem cell selection. Klimkiewicz K, Weglarczyk K, Collet G, Paprocka M, Guichard A, Sarna M, Jozkowicz A, Dulak J, Sarna T, Grillon C, Kieda C. Cancer Lett. 2017 Jun 28;396:10-20. doi: 10.1016/j.canlet.2017.03.006.

Techniques/ tools/expertise