Creation of a predictive model of metabolic changes characteristic of neurodegenerative diseases

Drosophila flies are versatile animal models for the study of genetic mutations in neuronal pathologies. Their small size allows performing in vivo experiments to obtain high resolution nuclear magnetic resonance spectra. Dr. Martine Decoville of CBM, researchers from CEMHTIand ESPCI Paris used spatially-resolved ¹H high-resolution MAS NMR to investigate in vivo metabolite contents in different segments of the fly body. A comparative study of metabolic changes was performed for three neurodegenerative disorders: two cell-specific neuronal and glial models of Huntington disease and a model of glutamate excitotoxicity. These 3 pathologies are characterized by specific and sometimes anatomically localized variations in metabolite concentrations. In two cases, the modifications of ¹H MAS NMR spectra localized in fly heads were significant enough to allow the creation of a predictive model.

Spatially-resolved metabolic profiling of living Drosophila in neurodegenerative conditions using 1H magic angle spinning NMR - Scientific Reports (2020) https://doi.org/10.1038/s41598-020-66218-z

Disturbed expression of autophagy genes in blood of Parkinson’s disease patients

Parkinson's disease is a neurodegenerative pathology characterized by the presence of protein aggregates in the neurons of patients. This neurotoxic accumulation of misfolded proteins could be due to insufficient elimination by autophagic cellular mechanisms. Alain Legrand's group has just published a study highlighting an alteration in the expression of genes coding for autophagy proteins in the blood of patients with Parkinson's disease. This pilot study, carried out in collaboration with the Neurology Department of the Centre Hospitalier Régional d'Orléans (CHRO) and the Fundamental Informatics Laboratory of the University of Orléans (LIFO), shows that defects in autophagic systems that affect the brain of patients can also be detected in peripheral blood cells. These deregulated genes could thus constitute diagnostic markers of Parkinson's disease that can be measured non-invasively after a simple blood test.

El Haddad S. et al, Disturbed expression of autophagy genes in blood of Parkinson's disease patients.  Gene vol. 738 (2020): 144454

Claudine Kieda, Research Director Emeritus at the CBM, honored at the “Outstanding Poles in France” gala.

 

This action by the Polish Polskie Godlo Promocyjne Teraz Polska Foundation is awarded to Polish and Polish people permanently residing in France who have achieved great success in their work, who are recognized in their communities for initiatives and activities to promote a positive image of Poland and the Poles.

The aim is to make these people better known in France and also in Poland, where they often remain anonymous.

The title "Outstanding Polish" can be awarded in the following five categories: Business, Culture, Research / Science, Personality and "Young Poles".

 

symposium “Alzheimer’s disease”

This conference is organized and coordinated by the students who will speak on 4 major axes (sessions):

Session 1: Molecular basis of Alzheimer's pathology,

Session 2: Orthoptic and transgenic animal models,

Session 3: Markers and non-invasive diagnosis,

Session 4: Current and Future Therapeutic Approaches.

The symposium is organized with the presence of a Chairman and moderators for each session.