Organisation: Dpt Chemistry, Imaging and Exobiology

PERCHE Federico

email : federico.perche[remplacer_par_at]cnrs-orleans.fr

Phone : +33 2.38.25.56.29

Researcher, “Molecular Assemblies and Complex Systems” team co-leader


42 documents

Article dans une revue36 documents

  • Albert Ngalle Loth, Manon Maroquenne, Ayoub Medjmedj, Franck Coste, Thomas Bizien, et al.. Structural and functional characterization of a histidylated liposome for mRNA delivery. Journal of Controlled Release, 2025, 379, pp.164-176. ⟨10.1016/j.jconrel.2025.01.010⟩. ⟨hal-04984847⟩
  • Ayoub Medjmedj, Albert Ngalle-Loth, Rudy Clemençon, Josef Hamacek, Chantal Pichon, et al.. In Cellulo and In Vivo Comparison of Cholesterol, Beta-Sitosterol and Dioleylphosphatidylethanolamine for Lipid Nanoparticle Formulation of mRNA. Nanomaterials, 2022, 12 (14), pp.2446. ⟨10.3390/nano12142446⟩. ⟨hal-03727652⟩
  • Geoffrey Casas, Federico Perche, Patrick Midoux, Chantal Pichon, Jean-Marc Malinge. DNA minicircles as novel STAT3 decoy oligodeoxynucleotides endowed with anticancer activity in triple-negative breast cancer. Molecular Therapy - Nucleic Acids, 2022, 29, pp.162-175. ⟨10.1016/j.omtn.2022.06.012⟩. ⟨hal-03727647⟩
  • Fatma Elleuch, Patrick Baril, Mohamed Barkallah, Federico Perche, Slim Abdelkafi, et al.. Deciphering the Biological Activities of Dunaliella sp. Aqueous Extract from Stressed Conditions on Breast Cancer: from in Vitro to in Vivo Investigations. International Journal of Molecular Sciences, 2020, 21 (5), pp.1719. ⟨10.3390/ijms21051719⟩. ⟨hal-02553031⟩
  • Satoshi Uchida, Federico Perche, Chantal Pichon, Horacio Cabral. Nanomedicine-Based Approaches for mRNA Delivery. Molecular Pharmaceutics, 2020, 17 (10), pp.3654 - 3684. ⟨10.1021/acs.molpharmaceut.0c00618⟩. ⟨hal-02995814⟩
  • Pinpin Wang, Delphine Logeart-Avramoglou, Hervé Petite, Cristine Gonçalves, Patrick Midoux, et al.. Co-delivery of NS1 and BMP2 mRNAs to murine pluripotent stem cells leads to enhanced BMP-2 expression and osteogenic differentiation. Acta Biomaterialia, 2020, 108, pp.337-346. ⟨10.1016/j.actbio.2020.03.045⟩. ⟨hal-02553030⟩
  • Federico Perche, Tony Le Gall, Tristan Montier, Chantal Pichon, Jean-Marc Malinge. Cardiolipin-Based Lipopolyplex Platform for the Delivery of Diverse Nucleic Acids into Gram-Negative Bacteria. Pharmaceuticals, 2019, 12 (2), pp.81. ⟨10.3390/ph12020081⟩. ⟨hal-02172973⟩
  • Pinpin Wang, Federico Perche, Delphine Logeart-Avramoglou, Chantal Pichon. RNA-based therapy for osteogenesis. International Journal of Pharmaceutics, 2019, 569, pp.118594. ⟨10.1016/j.ijpharm.2019.118594⟩. ⟨hal-02995602⟩
  • Yu Yi, Hyun Jin Kim, Meng Zheng, Peng Mi, Mitsuru Naito, et al.. Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. Journal of Controlled Release, 2019, 295, pp.268 - 277. ⟨10.1016/j.jconrel.2019.01.006⟩. ⟨hal-02995629⟩
  • Federico Perche, Rudy Clemençon, Kai Schulze, Thomas Ebensen, Carlos Guzman, et al.. Neutral Lipopolyplexes for In Vivo Delivery of Conventional and Replicative RNA Vaccine. Molecular Therapy - Nucleic Acids, 2019, 17, pp.767-775. ⟨10.1016/j.omtn.2019.07.014⟩. ⟨hal-02321815⟩
  • Kevin van Der Jeught, Stefaan de Koker, Lukasz Bialkowski, Carlo Heirman, Patrick Tjok Joe, et al.. Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety. ACS Nano, 2018, 12 (10), pp.9815-9829. ⟨10.1021/acsnano.8b00966⟩. ⟨hal-01889829⟩
  • Federico Perche, Satoshi Uchida, Hiroki Akiba, Chin-Yu Lin, Masaru Ikegami, et al.. Improved brain expression of anti-amyloid β scFv by complexation of mRNA including a secretion sequence with PEG-based block catiomer. Current Alzheimer Research, 2017, 14 (3), pp.295-302. ⟨10.2174/1567205013666161108110031⟩. ⟨hal-02130712⟩
  • Chin-Yu Lin, Federico Perche, Masaru Ikegami, Satoshi Uchida, Kazunori Kataoka, et al.. Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles. Journal of Controlled Release, 2016, 235, pp.268-275. ⟨10.1016/j.jconrel.2016.06.001⟩. ⟨hal-02995717⟩
  • Chin-Yu Lin, Federico Perche, Masaru Ikegami, Satoshi Uchida, Kazunori Kataoka, et al.. Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles. Journal of Controlled Release, 2016, 235, pp.268-275. ⟨10.1016/j.jconrel.2016.06.001⟩. ⟨hal-02130718⟩
  • Federico Perche, Y. Yi, L. Hespel, P Mi, A Dirisala, et al.. Hydroxychloroquine-conjugated gold nanoparticles for improved siRNA activity. Biomaterials, 2016, 90, pp.62-71. ⟨10.1016/j.biomaterials.2016.02.027⟩. ⟨hal-02130728⟩
  • Federico Perche, Swati Biswas, Niravkumar Patel, Vladimir Torchilin. Hypoxia-Responsive Copolymer for siRNA Delivery. Methods in Molecular Biology, 2016, 1372 : RNA Imaging, pp.139-162. ⟨10.1007/978-1-4939-3148-4_12⟩. ⟨hal-02130872⟩
  • Federico Perche, Satoshi Uchida, Hiroki Akiba, Chin-Yu Lin, Masaru Ikegami, et al.. Improved brain expression of anti-amyloid β scFv by complexation of mRNA including a secretion sequence with PEG-based block catiomer. Current Alzheimer Research, 2015, 1 (999), pp.1-1. ⟨10.2174/1567205013666161108110031⟩. ⟨hal-02995714⟩
  • Tao Wang, Lin Zhu, Federico Perche, Anton Taigind, Vladimir P Torchilin. Matrix metalloproteinase 2-sensitive multifunctional polymeric micelles for tumor-specific co-delivery of siRNA and hydrophobic drugs. Biomaterials, 2014, 35 (13), pp.4213 - 4222. ⟨10.1016/j.biomaterials.2014.01.060⟩. ⟨hal-02995779⟩
  • Federico Perche, S. Biswas, T. Wang, L. Zhu, V. Torchilin. Hypoxia-Targeted siRNA Delivery. Angewandte Chemie International Edition, 2014, 53 (13), pp.3362-3366. ⟨10.1002/anie.201308368⟩. ⟨hal-02130753⟩
  • Samuel V Mussi, Rupa Sawant, Federico Perche, Mônica C Oliveira, Ricardo B Azevedo, et al.. Novel Nanostructured Lipid Carrier Co-Loaded with Doxorubicin and Docosahexaenoic Acid Demonstrates Enhanced in Vitro Activity and Overcomes Drug Resistance in MCF-7/Adr Cells. Pharmaceutical Research, 2014, 31 (8), pp.1882 - 1892. ⟨10.1007/s11095-013-1290-2⟩. ⟨hal-02995777⟩
  • Samuel Mussi, Rupa Sawant, Federico Perche, Mônica Oliveira, Ricardo Azevedo, et al.. Novel Nanostructured Lipid Carrier Co-Loaded with Doxorubicin and Docosahexaenoic Acid Demonstrates Enhanced in Vitro Activity and Overcomes Drug Resistance in MCF-7/Adr Cells. Pharmaceutical Research, 2014, 31 (8), pp.1882-1892. ⟨10.1007/s11095-013-1290-2⟩. ⟨hal-02130734⟩
  • G. Salzano, R. Riehle, G. Navarro, Federico Perche, G. de Rosa, et al.. Polymeric micelles containing reversibly phospholipid-modified anti-survivin siRNA: A promising strategy to overcome drug resistance in cancer. Cancer Letters, 2014, 343 (2), pp.224-231. ⟨10.1016/j.canlet.2013.09.037⟩. ⟨hal-02130786⟩
  • G. Salzano, R. Riehle, G. de Rosa, V.P. P Torchilin, Riehle Rdrhielde, et al.. Polymeric micelles containing reversibly phospholipid-modified anti-survivin siRNA: A promising strategy to overcome drug resistance in cancer. Cancer Letters, 2014, 343 (2), pp.224 - 231. ⟨10.1016/j.canlet.2013.09.037⟩. ⟨hal-02995789⟩
  • Lin Zhu, Federico Perche, Tao Wang, Vladimir Torchilin. Matrix metalloproteinase 2-sensitive multifunctional polymeric micelles for tumor-specific co-delivery of siRNA and hydrophobic drugs. Biomaterials, 2014, 35 (13), pp.4213-4222. ⟨10.1016/j.biomaterials.2014.01.060⟩. ⟨hal-02130742⟩
  • Swati Biswas, Pranali P Deshpande, Federico Perche, Namita S Dodwadkar, Shailendra D Sane, et al.. Octa-arginine-modified pegylated liposomal doxorubicin: An effective treatment strategy for non-small cell lung cancer. Cancer Letters, 2013, 335 (1), pp.191 - 200. ⟨10.1016/j.canlet.2013.02.020⟩. ⟨hal-02995795⟩
  • Lin Zhu, Federico Perche, Tao Wang, Anton Taigind, Vladimir P Torchilin, et al.. Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (42), pp.17047 - 17052. ⟨10.1073/pnas.1304987110⟩. ⟨hal-02995791⟩
  • Swati Biswas, Pranali Deshpande, Federico Perche, Namita Dodwadkar, Shailendra Sane, et al.. Octa-arginine-modified pegylated liposomal doxorubicin: An effective treatment strategy for non-small cell lung cancer. Cancer Letters, 2013, 335 (1), pp.191-200. ⟨10.1016/j.canlet.2013.02.020⟩. ⟨hal-02130808⟩
  • Federico Perche, Vladimir Torchilin. Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting. Journal of Drug Delivery, 2013, 2013, pp.1-32. ⟨10.1155/2013/705265⟩. ⟨hal-02130868⟩
  • Lin Zhu, Tao Wang, Federico Perche, Anton Taigind, Vladimir Torchilin. Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (42), pp.17047-17052. ⟨10.1073/pnas.1304987110⟩. ⟨hal-02130803⟩
  • Federico Perche, Vladimir P Torchilin. Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting. Journal of Drug Delivery, 2013, 2013, pp.1 - 32. ⟨10.1155/2013/705265⟩. ⟨hal-02995820⟩
  • Federico Perche, Vladimir P Torchilin. Cancer cell spheroids as a model to evaluate chemotherapy protocols. Cancer Biology and Therapy, 2012, 13 (12), pp.1205 - 1213. ⟨10.4161/cbt.21353⟩. ⟨hal-02995802⟩
  • Federico Perche, Nirav Patel, Vladimir P Torchilin. Accumulation and toxicity of antibody-targeted doxorubicin-loaded PEG–PE micelles in ovarian cancer cell spheroid model. Journal of Controlled Release, 2012, 164 (1), pp.95 - 102. ⟨10.1016/j.jconrel.2012.09.003⟩. ⟨hal-02995799⟩
  • Federico Perche, Olivier Lambert, Mathieu Berchel, Paul-Alain Jaffres, Chantal Pichon, et al.. Gene transfer by histidylated lipopolyplexes: A dehydration method allowing preservation of their physicochemical parameters and transfection efficiency. International Journal of Pharmaceutics, 2012, 423 (1), pp.144 - 150. ⟨10.1016/j.ijpharm.2011.04.009⟩. ⟨hal-02995807⟩
  • Federico Perche, Niravkumar Patel, Vladimir Torchilin. Accumulation and toxicity of antibody-targeted doxorubicin-loaded PEG–PE micelles in ovarian cancer cell spheroid model. Journal of Controlled Release, 2012, 164 (1), pp.95-102. ⟨10.1016/j.jconrel.2012.09.003⟩. ⟨hal-02130810⟩
  • Federico Perche, Thierry Benvegnu, Mathieu Berchel, Loic Lebegue, Chantal Pichon, et al.. Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA.. Nanomedicine: Nanotechnology, Biology and Medicine, 2011, 7 (4), pp.445-53. ⟨10.1016/j.nano.2010.12.010⟩. ⟨hal-00754373⟩
  • Federico Perche, David Gosset, Mathieu Mével, Marie-Laure Miramon, Jean-Jacques Yaouanc, et al.. Selective gene delivery in dendritic cells with mannosylated and histidylated lipopolyplexes.. Journal of Drug Targeting, 2011, 19 (5), pp.315-25. ⟨10.3109/1061186X.2010.504262⟩. ⟨hal-00753554⟩

Communication dans un congrès1 document

  • N Laroui, C Delehedde, C Goncalves, F Godin, Federico Perche, et al.. High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells. SFNano 2021, Dec 2021, Angers, France. ⟨hal-03668422⟩

Poster2 documents

  • Pinpin Wang, Delphine Logeart, Lucie Pigeon, Cristine Gonçalves, Hervé Petite, et al.. Improved osteogenic commitment of BMP2 mRNA-transfected MSCs using NS1 mRNA. ASGCT 2019, Apr 2020, Washington, United States. ⟨hal-03668438⟩
  • Federico Perche, R Clemençon, K Schulze, T Ebesen, Chantal Pichon. Neutral lipopolyplexes for in Vivo delivery of Conventional and replicative RNA vaccine. mRNA Health Conference 2020, Nov 2020, Boston (virtual), United States. ⟨hal-03668439⟩

Chapitre d'ouvrage1 document

  • Federico Perche, S. Biswas, V. Torchilin. Stimuli-Sensitive Polymeric Nanomedicines for Cancer Imaging and Therapy. Handbook of polymers for pharmaceutical technologies, John Wiley & Sons, Inc., pp.311-344, 2015. ⟨hal-02130886⟩

Brevet2 documents

  • Vladimir Torchilin, Swati Biswas, Federico Perche. HYPOXIA-TARGETED DELIVERY SYSTEM FOR PHARMACEUTICAL AGENTS. France, Patent n° : WO2015061321. 2015. ⟨hal-02130900⟩
  • L. Zhu, Federico Perche, Vladimir Torchilin. COPOLYMERS FOR THE DELIVERY OF DRUGS INTO CELLS. France, Patent n° : WO2014085579. 2014. ⟨hal-02130892⟩

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