Organisation: Dpt Molecular, Structural and Chemical Biology

VALLÉE-MÉHEUST Béatrice

 

email : beatrice.vallee[remplacer_par]cnrs-orleans.fr

Phone : +33 2.38.25.76.11

Researcher within the thematic group Cell signalling

 


75 documents

Article dans une revue32 documents

  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection. Journal of Molecular Biology, 2024, 436 (22), pp.168768. ⟨10.1016/j.jmb.2024.168768⟩. ⟨hal-04771131⟩
  • Anthony Champiré, Rayan Berabez, Abdennour Braka, Aurélie Cosson, Justine Corret, et al.. Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization. European Journal of Medicinal Chemistry, 2024, 271, pp.116391-116391. ⟨10.1016/j.ejmech.2024.116391⟩. ⟨hal-04575964⟩
  • Hélène Bénédetti, Béatrice Vallée. LIM Kinases: From Molecular to Pathological Features. Cells, 2023, 12 (12), pp.1649. ⟨10.3390/cells12121649⟩. ⟨hal-04208415⟩
  • Elodie Villalonga, Christine Mosrin, Thierry Normand, Caroline Girardin, Amandine Serrano, et al.. LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features. Cells, 2023, 12 (5), pp.805. ⟨10.3390/cells12050805⟩. ⟨hal-04208405⟩
  • Tea Martinić Cezar, Mateja Lozančić, Ana Novačić, Ana Matičević, Dominik Matijević, et al.. Streamlining N-terminally anchored yeast surface display via structural insights into S. cerevisiae Pir proteins. Microbial Cell Factories, 2023, 22 (1), pp.174. ⟨10.1186/s12934-023-02183-2⟩. ⟨hal-04208410⟩
  • Bojan Žunar, Taiga Ito, Christine Mosrin, Yoshiyuki Sugahara, Hélène Bénédetti, et al.. Confocal imaging of biomarkers at a single-cell resolution: quantifying 'living' in 3D-printable engineered living material based on Pluronic F-127 and yeast Saccharomyces cerevisiae. Biomaterials Research, 2022, 26, pp.85. ⟨10.1186/s40824-022-00337-8⟩. ⟨hal-03926884⟩
  • Bojan Žunar, Christine Mosrin-Huaman, Hélène Bénédetti, Béatrice Vallée. Re-engineering of CUP1 promoter and Cup2/Ace1 transactivator to convert Saccharomyces cerevisiae into a whole-cell eukaryotic biosensor capable of detecting 10 nM of bioavailable copper. Biosensors and Bioelectronics, 2022, 214, pp.114502. ⟨10.1016/j.bios.2022.114502⟩. ⟨hal-03820214⟩
  • Rayan Berabez, Sylvain Routier, Hélène Bénédetti, Karen Plé, Béatrice Vallée. LIM kinases, promising but reluctant therapeutic targets: chemistry and preclinical validation in vivo. Cells, 2022, 11 (13), pp.2090. ⟨10.3390/cells11132090⟩. ⟨hal-03721458⟩
  • Frédéric Buron, Nuno Rodrigues, Thibault Saurat, Marie-Aude Hiebel, Stéphane Bourg, et al.. Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-d]Pyrimidine Series as Novel PI3K/mTOR Inhibitors. Molecules, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩. ⟨hal-03348966⟩
  • Kossi Efouako Soklou, Hamid Marzag, Béatrice Vallée, Sylvain Routier, Karen Plé. Synthesis of Heterospirocycles through Gold‐(I) Catalysis, Useful Building Blocks for Medicinal Chemistry. Advanced Synthesis and Catalysis, 2021, ⟨10.1002/adsc.202101080⟩. ⟨hal-03411162⟩
  • Mohammed Bergoug, Michel Doudeau, Fabienne Godin, Christine Mosrin-Huaman, Béatrice Vallée, et al.. Neurofibromin Structure, Functions and Regulation. Cells, 2020, 9, ⟨10.3390/cells9112365⟩. ⟨hal-03070759v2⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Hélène Bénédetti. Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein. Journal of visualized experiments : JoVE, 2019, 148, pp.e59820. ⟨10.3791/59820⟩. ⟨hal-02282630⟩
  • Julie Tastet, Hélène Cuberos, Béatrice Vallée, Annick Toutain, Martine Raynaud, et al.. LIMK2-1 is a Hominidae-Specific Isoform of LIMK2 Expressed in Central Nervous System and Associated with Intellectual Disability. Neuroscience, 2019, 399, pp.199-210. ⟨10.1016/j.neuroscience.2018.12.017⟩. ⟨hal-02067472⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, David Gosset, et al.. LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b. Biochemical Journal, 2018, 475 (23), pp.3745-3761. ⟨hal-01966439⟩
  • A. de Cola, M. Franceschini, A. Di Matteo, G. Colotti, R. Celani, et al.. N6L pseudopeptide interferes with nucleophosmin protein-protein interactions and sensitizes leukemic cells to chemotherapy. Cancer Letters, 2018, 412, pp.272-282. ⟨10.1016/j.canlet.2017.10.038⟩. ⟨hal-02350445⟩
  • B. Vallée, L. Larrède, V. Willaume, A. Pascual, S. Meineri. Effets à long terme d’une stratégie engageante : augmenter le nombre d’adhésions de l’association sportive d’un collège mahorais. Pratiques Psychologiques, 2016, 22 (4), pp.353-362. ⟨10.1016/j.prps.2016.07.002⟩. ⟨hal-02493232⟩
  • H. Cuberos, B. Vallée, P. Vourc'H, J. Tastet, C.R. Andres, et al.. Roles of LIM kinases in central nervous system function and dysfunction. FEBS Letters, 2015, 589 (24PartB), pp.3795-3806. ⟨10.1016/j.febslet.2015.10.032⟩. ⟨hal-02072231⟩
  • Martine Beaufour, Fabienne Godin, Béatrice Vallée, Martine Cadene, Hélène Bénédetti. Interaction Proteomics Suggests a New Role for the Tfs1 Protein in Yeast.. Journal of Proteome Research, 2012, 11 (6), pp.3211-3218. ⟨10.1021/pr201239t⟩. ⟨hal-00721771⟩
  • Julie Tastet, Patrick Vourc'H, Frédéric Laumonnier, Béatrice Vallée, Carole Michelle, et al.. LIMK2d, a truncated isoform of Lim kinase 2 regulates neurite growth in absence of the LIM kinase domain. Biochemical and Biophysical Research Communications, 2012, 420 (2), pp.247-252. ⟨10.1016/j.bbrc.2012.02.134⟩. ⟨hal-01136281⟩
  • Fabienne Godin, Sandrine Villette, Béatrice Vallée, Michel Doudeau, Séverine Morisset-Lopez, et al.. A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.. Biochemical and Biophysical Research Communications, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩. ⟨hal-00721861⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Aurélie Gombault, Aurélie Tchalikian-Cosson, et al.. Nf1 RasGAP Inhibition of LIMK2 Mediates a New Cross-Talk between Ras and Rho Pathways. PLoS ONE, 2012, 7 (10), pp.e47283. ⟨10.1371/journal.pone.0047283⟩. ⟨hal-03054185⟩
  • A. Pascual, L. Dagot, B. Vallée, N. Gueguen. Soumission sans pression, médiatisation d’un tsunami et don d’argent : efficacité comparée de la porte-au-nez et du « vous êtes libre de… ». European Review of Applied Psychology / Revue Européenne de Psychologie Appliquée, 2009, 59 (1), pp.79-84. ⟨10.1016/j.erap.2006.07.003⟩. ⟨hal-02493142⟩
  • Aurélie Gombault, Jonas Warringer, Robert Caesar, Fabienne Godin, Béatrice Vallée, et al.. A phenotypic study of TFS1 mutants differentially altered in the inhibition of Ira2p or CPY. FEMS Yeast Research, 2009, 9 (6), pp.867-874. ⟨10.1111/j.1567-1364.2009.00535.x⟩. ⟨hal-00522432⟩
  • Aurélie Gombault, Fabienne Godin, Denise Sy, Baptiste Legrand, Hélène Chautard, et al.. Molecular Basis of the Tfs1/Ira2 Interaction: A Combined Protein Engineering and Molecular Modelling Study. Journal of Molecular Biology, 2007, 374 (3), pp.604-617. ⟨10.1016/j.jmb.2007.09.057⟩. ⟨hal-00181161⟩
  • Béatrice Vallée, H. Riezman. Lip 1p: a novel subunit of acyl-CoA ceramide synthase. EMBO Journal, 2005, 24, pp.730-741. ⟨hal-00088715⟩
  • Béatrice Vallée, G Coadou, H. Labbé, D. Sy, F. Vovelle, et al.. Peptides corresponding to the N- and C-terminal parts of PEBP are well-structured in solution: new insights into their possible interaction with partners in vivo.. Journal of Peptide Research, 2003, 61 (2), pp.47-57. ⟨hal-02118669⟩
  • Kouichi Funato, Ruben Lombardi, Béatrice Vallée, Howard Riezman. Lcb4p Is a Key Regulator of Ceramide Synthesis from Exogenous Long Chain Sphingoid Base in Saccharomyces cerevisiae. Journal of Biological Chemistry, 2003, 278 (9), pp.7325-7334. ⟨10.1074/jbc.M209925200⟩. ⟨hal-02118660⟩
  • Kouichi Funato, Béatrice Vallée, Howard Riezman. Biosynthesis and Trafficking of Sphingolipids in the Yeast Saccharomyces cerevisiae †. Biochemistry, 2002, 41 (51), pp.15105-15114. ⟨10.1021/bi026616d⟩. ⟨hal-02118664⟩
  • D Schorling, Béatrice Vallée, Wolfgang Barz, Howard Riezman, Dieter Oesterhelt. Lag1p and Lac1p Are Essential for the Acyl-CoA–dependent Ceramide Synthase Reaction in Saccharomyces cerevisae. Molecular Biology of the Cell, 2001, 12 (11), pp.3417-3427. ⟨10.1091/mbc.12.11.3417⟩. ⟨hal-02118674⟩
  • Béatrice Vallée, P Tauc, J Brochon, M Maget-Dana, D. Lelièvre, et al.. Behaviour of bovine phosphatidylethanolamine-binding protein with model membranes. Evidence of affinity for negatively charged membranes.. European Journal of Biochemistry, 2001, 268 (22), pp.5831-41. ⟨hal-02118681⟩
  • Béatrice Vallée, Caroline Teyssier, R. Maget-Dana, J. Ramstein, N. Bureaud, et al.. Stability and physicochemical properties of the bovine brain phosphatidylethanolamine-binding protein.. European Journal of Biochemistry, 1999, 266 (1), pp.40-52. ⟨hal-02118686⟩
  • C. Serre, Béatrice Vallée, N. Bureaud, F. Schoentgen, C. Zelwer. Crystal structure of the phosphatidylethanolamine-binding protein from bovine brain: a novel structural class of phospholipid-binding proteins.. Structure, 1998, 6 (10), pp.1255-65. ⟨hal-02118689⟩

Communication dans un congrès16 documents

  • Anthony Champiré, Margaux Sainjon, Abdennour Braka, Samia Aci-Seche, Pascal Bonnet, et al.. Synthesis and preclinical validation of LIMKs inhibitors: Promising drugs for osteosarcoma treatment?. XXVII EFMC International Symposium on Medicinal Chemistry, Sep 2022, NICE, France. ⟨hal-04823073⟩
  • Rayan Berabez, Anthony Champiré, Margaux Sainjon, Abdennour Braka, Samia Aci-Seche, et al.. Synthesis and preclinical validation of LIMKs inhibitors: Promising drugs for osteosarcoma treatment?. SCT 29th Young Research Fellow Meeting, Jul 2022, Nantes, France. ⟨hal-04822252⟩
  • Karen Plé, Franck Verrecchia, Béatrice Vallée, Régis Brion, Rayan Berabez, et al.. Un nouvel inhibiteur des LIMKs, l'AC429, bloque la croissance des tumeurs primaires d'ostéosarcome. Cancéropôle Grand Ouest, colloque du réseau Molécules marines, métabolisme et cancer, May 2022, Mansigné, France. ⟨hal-04820416⟩
  • Karen Plé, Béatrice Vallée. Les LIM kinases, des cibles thérapeutiques d’intérêt : de la conception de petites molécules inhibitrices aux premiers essais précliniques. Journée scientifique du réseau Cancers des Tissus Hormono-dépendants (CASTHOR), Cancéropôle Grand Ouest, Dec 2022, Nantes, France. ⟨hal-04823051⟩
  • N Laroui, C Delehedde, C Goncalves, F Godin, Federico Perche, et al.. High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells. SFNano 2021, Dec 2021, Angers, France. ⟨hal-03668422⟩
  • Béatrice Vallée, Christine Mosrin-Huaman, Hélène Bénédetti, Régis Guégan, Bojan Zunar. Life in the bioink: Physiology and energetics of Saccharomyces cerevisiae embedded in polymerized Pluronic F127-DMA, a “smart” thermoresponsive hydrogel. ICY15 meets 30ICYGMB, The spirit of Yeast, Aug 2021, Vienne, virtual, Austria. ⟨hal-03559939⟩
  • Béatrice Vallée, Hélène Bénédetti. Séminaire invité : Signalisation cellulaire et Neurofibromatose. Journées NF, Sep 2021, Orléans, France. ⟨hal-03560050⟩
  • Justine Corret, Sokaina Hammoud, Frédéric Buron, Pierre Daligaux, Christophe Chesné, et al.. Development of a bio­active fluorescent inhibitor probe targeting the Rho kinase ROCK for monitoring inhibition action. FEBS 2021, the 45th FEBS Congress, Jul 2021, Virtual, France. ⟨hal-03668584⟩
  • H. Bénédetti, Béatrice Vallée, A. Cosson, F. Godin, M. Doudeau. Les LIM kinases : nouvelles cibles thérapeutiques anti-cancer. Journée scientifique du réseau « Cancers hormonaux–dépendants » du Cancéropôle Grand-Ouest, Apr 2019, Nantes, France. ⟨hal-02928496⟩
  • M. Bergoug, A. Cosson, D. Casas, M. Doudeau, F. Godin, et al.. Neurofibromin, a new SUMO target involved in neurofibromatosis type 1 disease. 6th LIA Workshop on "Biomarkers and mediators of diseases and new approaches in repair/regenerative therapies, Jun 2019, Varsovie, Poland. ⟨hal-02928511⟩
  • Béatrice Vallée, K. Plé, A. Cosson, M. Doudeau, F. Godin, et al.. Détermination et mise en œuvre d’un modèle in vivo pour tester de nouveaux inhibiteurs originaux des LIM kinases, cibles thérapeutiques émergentes dans le cancer. Cancéropôle Grand Ouest, Colloque du Réseau Molécules marines, métabolisme et cancer, May 2019, Mansigné, France. ⟨hal-02928507⟩
  • M. Bergoug, A. Cosson, M. Doudeau, F. Godin, Béatrice Vallée, et al.. Study of the sumoylation of neurofibromin, the protein responsible for neurofibromatosis type 1. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France. ⟨hal-02928220⟩
  • Béatrice Vallée, Karen Plé, A. Cosson, M. Doudeau, F. Godin, et al.. Développement de petites molécules inhibitrices des LIM kinases, nouvelles cibles thérapeutiques pour lutter contre le cancer, les maladies neurologiques et la neurofibromatose. Journée Fédération CBM-ICOA, Jan 2018, Orléans, France. ⟨hal-02928530⟩
  • Béatrice Vallée, S. Routier, A. Cosson, M. Doudeau, F. Godin, et al.. Développement de modulateurs des LIM kinases. Cancéropôle Grand Ouest - 14e colloque du Réseau Produits de la mer en cancérologie - 5e colloque du Réseau Canaux ioniques et cancer, May 2018, Mansigné, France. ⟨hal-02928559⟩
  • Béatrice Vallée, A. Cosson, M. Doudeau, F Godin, A. Braka, et al.. Neurofibromatosis type I: from basic to applied research. 4th LIA Workshop, Jun 2017, Cracovie, Poland. ⟨hal-02928517⟩
  • Béatrice Vallée, Hélène Bénédetti, F. Godin, M. Doudeau. Study of new partners of neurofibromin: an approach to identify novel therapeutic targets for neurofibromatosis type 1. 17th European Neurofibromatosis meeting, Sep 2016, Albano-Terme, Italy. ⟨hal-02928226⟩

Poster24 documents

  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation. 2024 Global NF Conference, Jun 2024, Brussels, Belgium. ⟨hal-03679991⟩
  • Hélène Bénédetti, Christine Mosrin-Huaman, Mohammed Bergoug, Amandine Serrano, Fabienne Godin, et al.. Deciphering the Molecular Mechanism of Pathogenicity in Destabilized variants of Neurofibromin mutated in its SecPH domain. 2024 Global NF Conference, Jun 2024, Brussels (Belgium), Belgium. ⟨hal-04779581⟩
  • Elodie Villalonga, Célina Chalal, Déborah Cassas, Michel Doudeau, Fabienne Godin, et al.. New insights into the regulation of actin cytoskeleton dynamics via the Rho/ROCK/LIMK2/cofilin signalling pathway: a novel mechanism of regulation of cofilin by LIMK2. FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, virtual, Slovenia. ⟨hal-03680139⟩
  • N Laroui, C Delehedde, Cristine Gonçalves, F Godin, F Perche, et al.. High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells. 10th mRNA Health Conference, Nov 2021, Berlin, Germany. ⟨hal-03668434⟩
  • Christine Mosrin-Huaman, Mohammed Bergoug, Fabienne Godin, Michel Doudeau, Iva Sosic, et al.. Sumoylation of Neurofibromin and its SecPH Domain Plays a Role in Their Functions and Implies Unexpected Structural Requirements. 2021 NF1 virtual conference, Jun 2021, Virtual, France. ⟨hal-03680001⟩
  • Justine Corret, Sokaina Hammoud, Frédéric Buron, Pierre Daligaux, Christophe Chesné, et al.. Development of a bio­active fluorescent inhibitor probe targeting the Rho kinase ROCK for monitoring inhibition action. FEBS 2021, the 45th FEBS Congress, Jul 2021, Lnubljana, virtual, Slovenia. ⟨hal-03679980⟩
  • Mélissa Thomas, Lauren Blot, Kevin Lesage, Fabienne Godin, Michel Doudeau, et al.. New molecular insights into the crosstalk between Rho/ROCK/LIMK2/cofilin signalling pathway and Nf1. 2021 NF1 virtual conference, Jun 2021, Virtual, France. ⟨hal-03679999⟩
  • Bojan Zunar, Christine Mosrin-Huaman, Hélène Bénédetti, Régis Guégan, Béatrice Vallée. Stressed by hydrogel? Physiological response of yeast cells embedded in thermoresponsive Pluronic F127: a prerequisite for bioreactor development. FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, Slovenia. ⟨hal-03679975⟩
  • M. Bergoug, I. Sošic, M. Doudeau, F. Godin, Béatrice Vallée, et al.. Neurofibromin, a new SUMO target involved in neurofibromatosis type 1 disease. EMBO Workshop "The ubiquitin system: Biology, mechanisms and roles in disease", Sep 2019, Cavtat, Croatia. ⟨hal-02924095⟩
  • Béatrice Vallée, A. Cosson, M. Doudeau, F. Godin, A. Champiré, et al.. LIM kinases, new therapeutic targets to treat cancers, neurological disorders and Neurofibromatosis: development of small molecule inhibitors. FEBS Meeting 2019, Jul 2019, Cracovie, Poland. ⟨hal-02924140⟩
  • Christine Mosrin-Huaman, B. Handelaoui, H. Bénédetti, Béatrice Vallée. Yeast biosensors to detect environmental pollutants into effluent waters. ICYGMB XXIX International Congress on Yeast Genetics and Molecular Biology, Aug 2019, Göteborg, Sweden. ⟨hal-02924111⟩
  • H. Bénédetti, M. Bergoug, I. Sošic, M. Doudeau, F. Godin, et al.. Study of the different forms of sumoylation of the neurofibromin SecPH domain. EMBO Workshop "The ubiquitin system: Biology, mechanisms and roles in disease", Sep 2019, Cavtat, Croatia. ⟨hal-02924090⟩
  • H. Bénédetti, Béatrice Vallée, J. Tastet, H. Cubéros, A. Toutain, et al.. Molecular and functional characterization of LIMK2-1, a hominidae-specific isoform of LIMK2 associated with intellectual disability. NeuroFrance 2019, May 2019, Marseille, France. ⟨hal-02924881⟩
  • H. Bénédetti, M. Doudeau, F. Godin, Béatrice Vallée, A. Cosson, et al.. LARP6, a RNA−binding protein involved in translation and stability of collagen mRNA, is a new partner of Neurofibromin: Molecular studies and functional implications. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France. ⟨hal-02924084⟩
  • Béatrice Vallée, A. Cosson, M. Doudeau, F. Godin, A. Champiré, et al.. Development of small molecule inhibitors of LIM kinases, new therapeutic targets to treat Neurofibromatosis type I. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France. ⟨hal-02924077⟩
  • Béatrice Vallée, A. Cosson, M. Doudeau, F. Godin, Anthony Champiré, et al.. LIM Kinases: new anticancer therapeutic targets. Breast Cancer Symposium, Jun 2017, Nantes, France. ⟨hal-03680148⟩
  • M. Bergoug, A. Cosson, M. Doudeau, F. Godin, Béatrice Vallée, et al.. Study of the sumoylation of neurofibromin, the protein responsible for neurofibromatosis type 1. EMBO Conference "Ubiquitin and SUMO: from molecular mechanisms to system-wide responses, Sep 2017, Cavtat, Croatia. ⟨hal-02924070⟩
  • A. Champiré, A. Braka, Béatrice Vallée, M. Doudeau, F. Godin, et al.. Design, synthesis and biological evaluation of LIMK inhibitors. XXIVe Journées Jeunes Chercheurs (SCT), Feb 2017, Châtenay-Malabry, France. ⟨hal-02904837⟩
  • Béatrice Vallée, Michel Doudeau, F. Godin, H. Cubéros, A. Champiré, et al.. Projet Région LiCorNe: LIMK protein inhibitors, new therapeutic agents for treatment of cognitive disorders associated with type I Neurofibromatosis. Journée Fédération PCV FR2708, Jan 2016, Orléans, France. ⟨hal-02924056⟩
  • Hélène Bénédetti, Fabienne Godin, Michel Doudeau, Béatrice Vallée, Marie-Ludivine De Tauzia, et al.. LINGO-1, a protein involved in various neurodevelopmental processes, interacts with neurofibromin (Nf1), the protein responsible for neurofibromatosis type I: molecular studies and functional implications. 10 th FENS (Forum of Neuroscience), Jul 2016, Copenhague, Denmark. ⟨hal-02453487⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, Patrick Vourc’h, et al.. The three isoforms of human LIMK2 regulate actin cytoskeleton remodeling via different pathways. EMBL Symposium, Actin in action: From Molecules to Cellular Functions, Sep 2016, Heidelberg, Germany. . ⟨hal-02453489⟩
  • A. Champiré, A. Braka, Béatrice Vallée, M. Doudeau, F. Godin, et al.. Conception, synthèse et évaluation biologique d’inhibiteurs de LIM kinases. 29e colloque de Biotechnocentre, Oct 2016, Seillac, France. ⟨hal-02904847⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Anthony Champiré, Karen Plé, et al.. LIM kinases: new therapeutic targets to treat Neurofibromatosis type I. The 7th EMBO meeting, Sep 2016, Mannheim, Germany. . ⟨hal-02453490⟩
  • Béatrice Vallée, Hélène Cuberos, Julie Tastet, Michel Doudeau, Fabienne Godin, et al.. LIMK2-1, a new primate-specific isoform of LIMK2, is associated with intellectual disability. 10 th FENS (Forum of Neurosciences), Jul 2016, Copenhague, Denmark. . ⟨hal-02453486⟩

Brevet1 document

  • Sylvain Routier, Hélène Bénédetti, Béatrice Vallée, Pascal Bonnet, Karen Plé, et al.. 4-(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-3,6-dihydropyridine-(2H)-carboxamide derivatives as Limk and/or Rock kinases inhibitors for use in the treatment of cancer. France, Patent n° : WO2021239727 A1. AMV. 2021. ⟨hal-03555349⟩

Pré-publication, Document de travail1 document

  • Mohammed Bergoug, Christine Mosrin, Fabienne Godin, Michel Doudeau, Iva Sosic, et al.. Noncanonical structural requirements of neurofibromin SUMOylation reveal a folding-deficiency of several pathogenic mutants. 2022. ⟨hal-03668582⟩

HDR1 document

  • Béatrice Vallée. Etudes de différentes voies de transduction du signal afin de mettre à jour de nouveaux mécanismes moléculaires et de nouvelles cibles thérapeutiques. Biochimie, Biologie Moléculaire. Université d'Orléans, 2020. ⟨tel-03560017⟩

Documents récupérés de l'archive ouverte HAL logo









GAUDON Virginie

email : virginie.gaudon[remplacer_par_at]cnrs-orleans.fr

Phone : +33 2.38.25.55.64

biologist Engineer Assistant Team  “Post-translatonal modifications of proteins and DNA repair: structure, function and dynamic“

 


16 documents

Article dans une revue7 documents

  • Ostiane d'Augustin, Virginie Gaudon, Capucine Siberchicot, Rebecca Smith, Catherine Chapuis, et al.. Identification of key residues of the DNA glycosylase OGG1 controlling efficient DNA sampling and recruitment to oxidized bases in living cells. Nucleic Acids Research, 2023, 51 (10), pp.4942-4958. ⟨10.1093/nar/gkad243⟩. ⟨hal-04088267v2⟩
  • Kiyoto Kamagata, Nanako Iwaki, Saori Kanbayashi, Trishit Banerjee, Rika Chiba, et al.. Structure-dependent recruitment and diffusion of guest proteins in liquid droplets of FUS. Scientific Reports, 2022, 12 (1), pp.7101. ⟨10.1038/s41598-022-11177-w⟩. ⟨hal-03927893⟩
  • Alan Wacquiez, Franck Coste, Emmanuel Kut, Virginie Gaudon, Sascha Trapp, et al.. Structure and Sequence Determinants Governing the Interactions of RNAs with Influenza A Virus Non-Structural Protein NS1. Viruses, 2020, 12 (9), 25 p. ⟨10.3390/v12090947⟩. ⟨hal-03082436⟩
  • Charlotte Rieux, Stéphane Goffinont, Franck Coste, Zahira Tber, Julien Cros, et al.. Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights. International Journal of Molecular Sciences, 2020, 21 (6), pp.2058. ⟨10.3390/ijms21062058⟩. ⟨hal-03082414⟩
  • Sascha Trapp, Denis Soubieux, Alexandra Lidove, Evelyne Esnault, Adrien Lion, et al.. Major contribution of the RNA-binding domain of NS1 in the pathogenicity and replication potential of an avian H7N1 influenza virus in chickens. Virology Journal, 2018, 15, pp.1-12. ⟨10.1186/s12985-018-0960-4⟩. ⟨hal-02626011⟩
  • R. Le Meur, Françoise Culard, V. Nadan, S. Goffinont, F. Coste, et al.. The nucleoid-associated protein HU enhances 8-oxoguanine base excision by the formamidopyrimidine-DNA glycosylase. Biochemical Journal, 2015, 471 (1), pp.13-23. ⟨10.1042/BJ20150387⟩. ⟨hal-01216639⟩
  • Norbert Garnier, Karine Loth, Franck Coste, Rafal Augustyniak, Virginie Nadan, et al.. An alternative flexible conformation of the E. coli HU beta(2) protein: structural, dynamics, and functional aspects. European Biophysics Journal, 2011, 40 (2), pp.117-129. ⟨10.1007/s00249-010-0630-y⟩. ⟨hal-00602370⟩

Communication dans un congrès3 documents

  • J. Cros, F. Coste, S. Goffinont, Virginie Nadan, V. Roy, et al.. Discovery and characterization of inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, pertinent therapeutic targets for cancer therapy. Laboratoire International Associé, Jun 2019, Varsovie, Poland. ⟨hal-02903108⟩
  • A. Wacquiez, F. Coste, V. Nadan, E. Kut, Norbert Garnier, et al.. Interaction de la protéine NS1 avec l’ARN : mécanismes impliqués dans la reconnaissance spécifique. Colloque annuel de ResaFlu, Réseau français sur les virus Influenza, Mar 2019, Lyon, France. ⟨hal-02903093⟩
  • J. Cros, F. Coste, Z. Tber, S. Goffinont, Virginie Nadan, et al.. Small molecule inhibitors of the human DNA glycosylases hOGG1 and NEIL1, pertinent therapeutic targets in cancer and neurodegenerative disease therapies. 25th Young Research Fellows Meeting, Mar 2018, Orléans, France. ⟨hal-02903084⟩

Poster6 documents

  • Julien Cros, Franck Coste, Stéphane Goffinont, Virginie Nadan, Norbert Garnier, et al.. Screening, characterization and structural studies of small molecules inhibitors of the DNA glycosylase hNEIL1 and hOGG1, potential therapeutic targets in cancer and neurodegenerative disease. 1st French congress on Integrative Structural Biology (BSI-2019), Oct 2019, Toulouse, France. ⟨hal-03385201⟩
  • Alan Wacquiez, Franck Coste, Caroline Blondeau, Emmanuel Kut, Virginie Nadan, et al.. NS1 des virus Influenza A : approches structurales et fonctionnelles pour de nouvelles stratégies anti-virales. 20. Journées Francophones de Virologie 2018, Mar 2018, Paris, France. John Libbey Eurotext, Virologie, 22, 148 p., 2018. ⟨hal-02736544⟩
  • J. Cros, F. Coste, Z. Tber, S. Goffinont, V. Nadan, et al.. Search for small molecule inhibitors of DNA glycosylases, pertinent therapeutic targets in cancer and neurodegenerative disease therapies. 5e Colloque annuel du Laboratoire International Associé (LIA) MiR-TANGo, May 2018, Orléans, France. ⟨hal-02904701⟩
  • A. Wacquiez, F. Coste, C. Blondeau, E. Kut, V. Nadan, et al.. NS1 des virus Influenza A : approches structurales et fonctionnelles pour de nouvelles stratégies anti-virales. Le Studium Conférence « Messenger RNA therapeutics : advances and perspectives », Mar 2017, Orléans, France. ⟨hal-02904828⟩
  • A. Wacquiez, S. Goffinont, V. Nadan, F. Coste, E. Kut, et al.. NS1 des virus influenza : relations structure-fonction pour la recherche de nouveaux anti-viraux. 30e colloque Biotechnocentre, Oct 2017, Seillac, France. ⟨hal-02904785⟩
  • A. Wacquiez, F. Coste, V. Nadan, E. Kut, S. Goffinont, et al.. NS1 of Influenza viruses: structural and functional approaches towards the discovery of novel anti-influenza drugs. Le Studium Conférence “Structural Biology and biophysics of RNA-protein complexes”, Nov 2017, Orléans, France. ⟨hal-02904778⟩

Documents récupérés de l'archive ouverte HAL logo

MALARD Virginie

email : virginie.malard[remplacer_par_at]cnrs-orleans.fr

Phone : +33 2.38.25.56.23

Engineer in chemical analysis within the team “Synthetic protein and bioorthogonal chemistry”

 


8 documents

Article dans une revue6 documents

  • Haifei Gao, Cristine Goncalves, Téo Gallego, Marc Francois-Heude, Virginie Malard, et al.. Comparative binding and uptake of liposomes decorated with mannose oligosaccharides by cells expressing the mannose receptor or DC-SIGN. Carbohydrate Research, 2020, 487, pp.107877. ⟨10.1016/j.carres.2019.107877⟩. ⟨hal-02522179⟩
  • Kevin van Der Jeught, Stefaan de Koker, Lukasz Bialkowski, Carlo Heirman, Patrick Tjok Joe, et al.. Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety. ACS Nano, 2018, 12 (10), pp.9815-9829. ⟨10.1021/acsnano.8b00966⟩. ⟨hal-01889829⟩
  • A. Le Moignic, V. Malard, T. Benvegnu, L. Lemiègre, Mathieu Berchel, et al.. Preclinical evaluation of mRNA trimannosylated lipopolyplexes as therapeutic cancer vaccines targeting dendritic cells. Journal of Controlled Release, 2018, 278, pp.110 - 121. ⟨10.1016/j.jconrel.2018.03.035⟩. ⟨hal-01774851⟩
  • Samuel Guillot, Fabienne Meducin, Kristina Poljak, Virginie Malard, Alexandra Foucault-Collet, et al.. Nanostructured monolinolein miniemulsions as delivery systems: Role of the internal mesophase on cytotoxicity and cell internalization. International Journal of Pharmaceutics, 2017, 523 (1), pp.142 - 150. ⟨10.1016/j.ijpharm.2017.03.012⟩. ⟨hal-01656547⟩
  • J. Barbeau, L. Lemiègre, A. Quelen, V. Malard, H. Gao, et al.. Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes. Carbohydrate Research, 2016, 435, pp.142--148. ⟨10.1016/j.carres.2016.10.003⟩. ⟨hal-01398046⟩
  • Cristine Gonçalves, Mathieu Berchel, Marie-Pierre Gosselin, Virginie Malard, Hervé Cheradame, et al.. Lipopolyplexes comprising imidazole/imidazolium lipophosphoramidate, histidinylated polyethyleneimine and siRNA as efficient formulation for siRNA transfection. International Journal of Pharmaceutics, 2014, 460 (1-2), pp.264-272. ⟨10.1016/j.ijpharm.2013.11.005⟩. ⟨hal-01179049⟩

Communication dans un congrès1 document

  • C Delehedde, G Haifei, C Gonçalves, Virginie Malard, N Rameix, et al.. Influence of the charge of mRNA mannosylated lipopolyplexes on the binding and uptake by dendritic cells. 33e colloque Biotechnocentre, Oct 2021, Seillac, France. ⟨hal-03668427⟩

Poster1 document

  • C Delehedde, G Haifei, Cristine Gonçalves, Virginie Malard, N Rameix, et al.. Influence of the charge of mRNA mannosylated lipopolyplexes on the binding and uptake by dendritic cells. 33e colloque Biotechnocentre, Oct 2021, Seillac, France. ⟨hal-03668442⟩

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LANDON Céline

 

email : celine.landon[remplacer_par_at]cnrs-orleans.fr

Phone : +33 2.38.25.55.74

Researcher, Co-leader of the department “Molecular, Structural and Chemical Biology” and Leader of the team “NMR of biomolecules”


115 documents

Article dans une revue57 documents

  • Yanis Achouba, Basile Peres, Steven Ascoët, Hervé Meudal, Cécile Caumes, et al.. Photoisomerization of Azobenzene‐Extended Charybdotoxin for the Optical Control of K v 1.2 Potassium Channel Activity. Angewandte Chemie International Edition, 2025, 64 (19), ⟨10.1002/anie.202423278⟩. ⟨hal-05101448⟩
  • Adryan F.L. Ferreira, Karen O Osiro, Kamila B.S. de Oliveira, Marlon H Cardoso, Lucas R de Lima, et al.. Defensins identified through molecular de-extinction. Cell Reports Physical Science, 2024, 5 (9), pp.102193. ⟨10.1016/j.xcrp.2024.102193⟩. ⟨hal-04790518⟩
  • Jérôme Montnach, Hugo Millet, Antoine Persello, Hervé Meudal, Stephan de Waard, et al.. Optical Control of Cardiac Rhythm by In Vivo Photoactivation of an ERG Channel Peptide Inhibitor. Circulation Research, 2023, 133 (6), pp.535-538. ⟨10.1161/CIRCRESAHA.123.322880⟩. ⟨hal-04225427⟩
  • Xavier Vuillemin, Maëlle da Silva, Maxime Bour, Céline Landon, Patrick Plésiat, et al.. Cefiderocol activity is compromised by acquired extended-spectrum oxacillinases in Pseudomonas aeruginosa. International Journal of Antimicrobial Agents, 2023, 62 (3), pp.106917. ⟨10.1016/j.ijantimicag.2023.106917⟩. ⟨hal-04225762⟩
  • Jérôme Montnach, Hugo Millet, Antoine Persello, Hervé Meudal, Stephan de Waard, et al.. Optical Control of Cardiac Rhythm by In Vivo Photoactivation of an ERG Channel Peptide Inhibitor. Circulation Research, 2023, 133 (6), pp.535-538. ⟨10.1161/CIRCRESAHA.123.322880⟩. ⟨hal-04634027⟩
  • Ludivine Lopez, Stephan de Waard, Hervé Meudal, Cécile Caumes, Kuldip Khakh, et al.. Structure-function relationship of new peptides activating human Nav1.1. Biomedicine and Pharmacotherapy, 2023, 165, pp.115173. ⟨10.1016/j.biopha.2023.115173⟩. ⟨hal-04224866⟩
  • Marylène Bertrand, Frédéric Szeremeta, Nadège Hervouet-Coste, Vincent Sarou-Kanian, Céline Landon, et al.. An adult Drosophila glioma model to highlight metabolic dysfunctions and evaluate the role of the serotonin 5‐HT 7 receptor as a potential therapeutic target. FASEB Journal, 2023, 37 (11), ⟨10.1096/fj.202300783RR⟩. ⟨hal-04301912⟩
  • Renato Bruno, Céline Boidin-Wichlacz, Oleg Melnyk, Daniela Zeppilli, Celine Landon, et al.. The diversification of the antimicrobial peptides from marine worms is driven by environmental conditions. Science of the Total Environment, 2023, 879, pp.162875. ⟨10.1016/j.scitotenv.2023.162875⟩. ⟨hal-04283278⟩
  • Jérôme Montnach, Laila Ananda Blömer, Ludivine Lopez, Luiza Filipis, Herve Meudal, et al.. In vivo spatiotemporal control of voltage-gated ion channels by using photoactivatable peptidic toxins. Nature Communications, 2022, 13 (1), pp.417. ⟨10.1038/s41467-022-27974-w⟩. ⟨hal-03578128⟩
  • Nicolas Guyot, Céline Landon, Philippe Monget. The Two Domains of the Avian Double-β-Defensin AvBD11 Have Different Ancestors, Common with Potential Monodomain Crocodile and Turtle Defensins. Biology, 2022, 11 (5), ⟨10.3390/biology11050690⟩. ⟨hal-03673045⟩
  • Céline Landon, Yanyu Zhu, Mainak Mustafi, Jean-Baptiste Madinier, Dominique Lelièvre, et al.. Real-Time Fluorescence Microscopy on Living E. coli Sheds New Light on the Antibacterial Effects of the King Penguin beta-Defensin AvBD103b. International Journal of Molecular Sciences, 2022, This article belongs to the Special Issue Antimicrobial Peptides: Structure and Mechanism of Biological Activity, 23 (2057), pp.2057. ⟨10.3390/ijms23042057⟩. ⟨hal-03860107⟩
  • Marion Maravat, Marylène Bertrand, Céline Landon, Franck Fayon, Séverine Morisset-Lopez, et al.. Complementary Nuclear Magnetic Resonance-Based Metabolomics Approaches for Glioma Biomarker Identification in a Drosophila melanogaster Model. Journal of Proteome Research, 2021, 20 (8), pp.3977-3991. ⟨10.1021/acs.jproteome.1c00304⟩. ⟨hal-03335927⟩
  • Marylène Bertrand, Martine Decoville, Herve Meudal, Serge Birman, Celine Landon. Metabolomic Nuclear Magnetic Resonance Studies at Presymptomatic and Symptomatic Stages of Huntington’s Disease on a Drosophila Model. Journal of Proteome Research, 2020, 19 (10), pp.4034-4045. ⟨10.1021/acs.jproteome.0c00335⟩. ⟨hal-02968233⟩
  • Celine Landon. Les bienfaits cachés des œufs…. Microscoop. Hors-série, 2020, HS20, pp.4-5. ⟨hal-03688691⟩
  • Thomas Aumer, Sébastien N Voisin, Thomas Knobloch, Celine Landon, Philippe Bulet. Impact of an Antifungal Insect Defensin on the Proteome of the Phytopathogenic Fungus Botrytis cinerea. Journal of Proteome Research, 2020, 19 (3), pp.1131-1146. ⟨10.1021/acs.jproteome.9b00638⟩. ⟨hal-02994657⟩
  • Nicolas Guyot, Herve Meudal, Sascha Trapp, Sophie Iochmann, Anne Silvestre, et al.. Structure, function, and evolution of Gga -AvBD11, the archetype of the structural avian-double-β-defensin family. Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (1), pp.337-345. ⟨10.1073/pnas.1912941117⟩. ⟨hal-02522250⟩
  • Steve Reynaud, Justyna Ciolek, Michel Degueldre, Natalie Saez, Ana Filipa Sequeira, et al.. A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists. Journal of Medicinal Chemistry, 2020, 63 (15), pp.8250-8264. ⟨10.1021/acs.jmedchem.0c00485⟩. ⟨hal-02936788⟩
  • Karine Loth, Justine Largillière, Franck Coste, Françoise Culard, Céline Landon, et al.. New protein-DNA complexes in archaea: a small monomeric protein induces a sharp V-turn DNA structure. Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-50211-2⟩. ⟨hal-02306224⟩
  • Claude Zoukimian, Hervé Meudal, Stephan de Waard, Karima Ait Ouares, Sébastien Nicolas, et al.. Synthesis by native chemical ligation and characterization of the scorpion toxin AmmTx3. Bioorganic and Medicinal Chemistry, 2019, 27 (1), pp.247-253. ⟨10.1016/j.bmc.2018.12.009⟩. ⟨hal-02522016⟩
  • H Blasco, C Veyrat-Durebex, M Bertrand, F Patin, F Labarthe, et al.. A Multiplatform Metabolomics Approach to Characterize Plasma Levels of Phenylalanine and Tyrosine in Phenylketonuria.. JIMD reports, 2017, pp.69-79. ⟨10.1007/8904_2016_568⟩. ⟨hal-01622559⟩
  • Geoffrey Bailleul, Amanda Kravtzoff, Alix Joulin-Giet, Fabien Lecaille, Valérie Labas, et al.. The unusual resistance of avian defensin AvBD7 to proteolytic enzymes preserves its antibacterial activity. PLoS ONE, 2016, 11 (8), pp.1-20. ⟨10.1371/journal.pone.0161573⟩. ⟨hal-01594888⟩
  • Karine Loth, Soha Abou Ibrahim Alami, Chahrazed Habès, Solène Garrido, Vincent Aucagne, et al.. Complete 1H, 15N and 13C assignment of trappin-2 and 1H assignment of its two domains, elafin and cementoin. Biomolecular NMR Assignments, 2016, 10 (1), pp.223 - 226. ⟨10.1007/s12104-016-9671-1⟩. ⟨hal-01407495⟩
  • Julien Verdon, Pierre Coutos-Thévenot, Marie-Hélène Rodier, Céline Landon, Segolene Depayras, et al.. Armadillidin H, a Glycine-Rich Peptide from the Terrestrial Crustacean Armadillidium vulgare, Displays an Unexpected Wide Antimicrobial Spectrum with Membranolytic Activity.. Frontiers in Microbiology, 2016, 7, pp.1484. ⟨10.3389/fmicb.2016.01484⟩. ⟨hal-01427916⟩
  • R. Le Meur, Françoise Culard, V. Nadan, S. Goffinont, F. Coste, et al.. The nucleoid-associated protein HU enhances 8-oxoguanine base excision by the formamidopyrimidine-DNA glycosylase. Biochemical Journal, 2015, 471 (1), pp.13-23. ⟨10.1042/BJ20150387⟩. ⟨hal-01216639⟩
  • Karine Loth, Denis Costechareyre, Géraldine Effantin, Yvan Rahbé, Guy Condemine, et al.. New Cyt-like δ-endotoxins from Dickeya dadantii: structure and aphicidal activity.. Scientific Reports, 2015, 5, pp.8791. ⟨10.1038/srep08791⟩. ⟨hal-01124447⟩
  • Karine Loth, Céline Landon, Françoise Paquet. Chemical shifts assignments of the archaeal MC1 protein and a strongly bent 15 base pairs DNA duplex in complex. Biomolecular NMR Assignments, 2015, 9 (1), pp.215-217. ⟨10.1007/s12104-014-9577-8⟩. ⟨hal-01171478⟩
  • Fatima Oukhatar, Hervé Meudal, Céline Landon, Nikos K Logothetis, Carlos Platas-Iglesias, et al.. Macrocyclic Gd(3+) Complexes with Pendant Crown Ethers Designed for Binding Zwitterionic Neurotransmitters.. Chemistry - A European Journal, 2015, 21 (31), pp.11226-11237. ⟨hal-01196981⟩
  • Rémy Le Meur, Karine Loth, Françoise Culard, Bertrand Castaing, Céline Landon. Backbone assignment of the three dimers of HU from Escherichia coli at 293 K: EcHUα2, EcHUβ2 and EcHUαβ. Biomolecular NMR Assignments, 2015, 9 (2), pp.359-363. ⟨10.1007/s12104-015-9610-6⟩. ⟨hal-01171467⟩
  • Françoise Paquet, Olivier Delalande, Stephane Goffinont, Françoise Culard, Karine Loth, et al.. Model of a DNA-protein complex of the architectural monomeric protein MC1 from Euryarchaea. PLoS ONE, 2014, 9 (2), pp.e88809. ⟨10.1371/journal.pone.0088809⟩. ⟨hal-01063974⟩
  • Virginie Hervé, Hervé Meudal, Valérie Labas, Sophie Réhault-Godbert, Joël Gautron, et al.. Three-dimensional NMR Structure of Hen Egg Gallin (Chicken Ovodefensin) Reveals a New Variation of the β-Defensin Fold. Journal of Biological Chemistry, 2014, 289 (10), pp.7211-20. ⟨10.1074/jbc.M113.507046⟩. ⟨hal-01118312⟩
  • Fanny Meindre, Dominique Lelièvre, Karine Loth, Oriane Mith, Vincent Aucagne, et al.. The nuclear magnetic resonance solution structure of the synthetic AhPDF1.1b plant defensin evidences the structural feature within the γ-motif. Biochemistry, 2014, 53 (49), pp.7745-54. ⟨10.1021/bi501285k⟩. ⟨hal-01118914⟩
  • Violette Senille, Dominique Lelievre, Françoise Paquet, Norbert Garnier, Ned Lamb, et al.. The addressing fragment of mitogaligin: first insights into functional and structural properties.. ChemBioChem, 2013, 14 (6), pp.711-20. ⟨10.1002/cbic.201200715⟩. ⟨hal-00817503⟩
  • Chrystelle Derache, Hervé Meudal, Vincent Aucagne, Kevin J Mark, Martine Cadène, et al.. Initial insights into structure-activity relationships of avian defensins.. Journal of Biological Chemistry, 2012, 287 (10), pp.7746-55. ⟨10.1074/jbc.M111.312108⟩. ⟨hal-00721842⟩
  • Chrystelle Derache, Valérie Labas, Vincent Aucagne, Hervé Meudal, Céline Landon, et al.. Primary Structure and Antibacterial Activity of Chicken Bone Marrow-Derived beta-Defensins. Antimicrobial Agents and Chemotherapy, 2009, 53 (11), pp.4647-4655. ⟨10.1128/AAC.00301-09⟩. ⟨hal-00522326⟩
  • Céline Landon, Florent Barbault, Michèle Legrain, Marc Guenneugues, Françoise Vovelle. Rational design of peptides active against the Gram positive bacteria Staphylococcus aureus. Proteins - Structure, Function and Bioinformatics, 2008, 72 (1), pp.229-239. ⟨10.1002/prot.21912⟩. ⟨hal-00283359⟩
  • Céline Landon, Hervé Meudal, Nathalie Boulanger, Philippe Bulet, Françoise Vovelle. Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an α-helical conformation. Biopolymers, 2006, 81 (2), pp.92-103. ⟨10.1002/bip.20370⟩. ⟨hal-03828817⟩
  • Céline Landon, H. Meudal, Nathalie Boulanger, Philippe Bulet, Françoise Vovelle. Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation. Biopolymers, 2006, 81 (2), pp.92-103. ⟨10.1002/bip.20370⟩. ⟨hal-00088871⟩
  • P. da Silva, C. Landon, R. Beltoise, M. Ponchet, F. Vovelle. Accessibility of tobacco lipid transfer protein cavity revealed by 15N NMR relaxation studies and molecular dynamics simulations. Proteins - Structure, Function and Bioinformatics, 2006, 64, pp.124-132. ⟨10.1002/prot.20971⟩. ⟨hal-00088840⟩
  • Pedro da Silva, Céline Landon, Benoit Industri, Antoine Marais, Didier D. Marion, et al.. Solution structure of a tobacco lipid transfer protein exhibiting new biophysical and biological features. Proteins - Structure, Function and Bioinformatics, 2005, 59 (2), pp.356-367. ⟨hal-02681302⟩
  • Loic Dubois, P. da Silva, C. Landon, J.G. Huber, M. Ponchet, et al.. Probing the hydrophobic cavity of lipid transfer protein from Nicotiana tabacum through xenon-based NMR spectroscopy. Journal of the American Chemical Society, 2004, 126 (48), pp.15738-15746. ⟨10.1021/ja046195i⟩. ⟨hal-00088366⟩
  • C. Landon, F. Barbault, M. Legrain, L. Menin, M. Guenneugues, et al.. Lead optimization of antifungal peptides with 3D NMR structures analysis. Protein science : a publication of the Protein Society., 2004, 13, pp.703-713. ⟨hal-00113063⟩
  • Céline Landon, Cécile Thouzeau, Henri Labbé, Philippe Bulet, Françoise Vovelle. Solution Structure of Spheniscin, a β-Defensin from the Penguin Stomach. Journal of Biological Chemistry, 2004, 279 (29), pp.30433-30439. ⟨10.1074/jbc.M401338200⟩. ⟨hal-03828241⟩
  • C. Landon, C. Thouzeau, H. Labbé, P. Bulet, F. Vovelle. Solution structure of spheniscin, a β-defensin from the penguin stomach. Journal of Biological Chemistry, 2004, 279, pp.30433-30439. ⟨hal-00113065⟩
  • A. Wélé, C. Landon, H. Labbé, F. Vovelle, Y. Zhang, et al.. Sequence and solution structure of cherimolacyclopeptides A and B, novel cyclooctapeptides from the seeds of Annona cherimola. Tetrahedron, 2004, 60 (2), pp.405-414. ⟨10.1016/j.tet.2003.11.026⟩. ⟨hal-00016015⟩
  • F. Barbault, C. Landon, M Guenneugues, J-P Meyer, V Schott, et al.. Solution Structure of Alo-3: A New Knottin-Type Antifungal Peptide from the Insect Acrocinus longimanus. Biochemistry, 2003, 42 (49), pp.14434 - 14442. ⟨10.1021/bi035400o⟩. ⟨hal-02422703⟩
  • Nadège Jamin, Yves-Marie Coïc, Céline Landon, Ludmila Ovtracht, Françoise Baleux, et al.. Most of the structural elements of the globular domain of murine prion protein form fibrils with predominant beta-sheet structure.. FEBS Letters, 2002, 529 (2-3), pp.256-60. ⟨10.1016/S0014-5793(02)03353-7⟩. ⟨pasteur-00166871⟩
  • F Lamberty, C. Caille, C. Landon, S Tassin-Moindrot, C Hetru, et al.. Solution structures of the antifungal heliomicin and a selected variant with both antibacterial and antifungal activities.. Biochemistry, 2001, 40 (40), pp.11995-2003. ⟨hal-02121162⟩
  • Céline Landon, Patrick Berthault, Francoise Vovelle, Hervé Desvaux. Magnetization transfer from laser-polarized xenon to protons located in the hydrophobic cavity of the wheat nonspecific lipid transfer protein. Protein Science, 2001, 10 (4), pp.762-770. ⟨10.1110/ps.47001⟩. ⟨hal-02121155⟩
  • Patrick Berthault, Céline Landon, Francoise Vovelle, Hervé Desvaux. Première détection d'un transfert d'aimantation entre du xénon polarisé par laser et des protons d'une protéine. Comptes Rendus de l'Académie des Sciences - Series IV - Physics, 2001, 2 (2), pp.327-332. ⟨10.1016/S1296-2147(01)01174-X⟩. ⟨hal-02121185⟩
  • Nicolas Mandard, Henri Labbé, Pedro da Silva, Charles Hetru, Céline Landon, et al.. Rôle des ponts disulfure dans le repliement en épingle à cheveux de l’androctonine. Relations structure–activité. Comptes rendus de l’Académie des sciences. Série IIc, Chimie, 2001, 4 (10), pp.735-738. ⟨10.1016/S1387-1609(01)01297-X⟩. ⟨hal-02120976⟩
  • Mireille Lamberty, Anita Caille, Céline Landon, Séverine Tassin-Moindrot, Charles Hetru, et al.. Solution Structures of the Antifungal Heliomicin and a Selected Variant with both Antibacterial and Antifungal Activities ,. Biochemistry, 2001, 40 (40), pp.11995-12003. ⟨10.1021/bi0103563⟩. ⟨hal-03828739⟩
  • C. Landon, A. Pajon, F. Vovelle, P. Sodano. The active site of drosomycin, a small insect antifungal protein, delineated by comparison with the modeled structure of Rs-AFP2, a plant antifungal protein.. Journal of Peptide Research, 2000, 56 (4), pp.231-8. ⟨hal-02121196⟩
  • P. Sodano, C. Landon, M. Ptak. A Novel Composite 90° Pulse Sequence Which Provides Distortionless NMR Spectra and Suppresses without Destroying the Water Magnetization. Journal of Magnetic Resonance, 1998, 133 (1), pp.194-199. ⟨10.1006/jmre.1998.1466⟩. ⟨hal-02121200⟩
  • M Goyffon, C. Landon. Toxines et défensines de scorpions. Comptes rendus des séances de la Société de biologie et de ses filiales, 1998, 192 (3), pp.445-462. ⟨hal-02121214⟩
  • Céline Landon, Patrick Sodano, C. Cornet, J.M. Bonmatin, Charles Kopeyan, et al.. Refined solution structure of the anti-mammal and anti-insect LqqIII scorpion toxin: Comparison with other scorpion toxins. Proteins: Structure, Function, and Genetics, 1997, 28 (3), pp.360-374. ⟨10.1002/(SICI)1097-0134(199707)28:3<360::AID-PROT6>3.0.CO;2-G⟩. ⟨hal-02082536⟩
  • Céline Landon, Patrick Sodano, Charles Hetru, Jules A. Hoffmann, Marius Ptak. Solution structure of drosomycin, the first inducible antifungal protein from insects. Protein Science, 1997, 6 (9), pp.1878-1884. ⟨10.1002/pro.5560060908⟩. ⟨hal-02121218⟩
  • C. Landon, C. Cornet, J.M. Bonmatin, C Kopeyan, H. Rochat, et al.. 1H-NMR-derived secondary structure and the overall fold of the potent anti-mammal and anti-insect toxin III from the scorpion Leiurus quinquestriatus quinquestriatus.. European Journal of Biochemistry, 1996, 236 (2), pp.395-404. ⟨hal-02082569⟩

Communication dans un congrès11 documents

  • Justine Largillière, Rémy Le Meur, David Ginguené, Norbert Garnier, Celine Landon, et al.. Architecture et dynamique de protéines histone-like de bactérie et d’archées. Journée BioRMN IdF, Sep 2020, Gif-sur-Yvette, France. ⟨hal-03053296⟩
  • Justine Largillière, Rémy Le Meur, David Ginguené, Norbert Garnier, Celine Landon, et al.. Vers une description cinétique et structurale complète du mécanisme d'échange de chaînes de la protéine HU d'Escherichia coli.. XXXIe congrès du GERM (Groupement d'Etudes de Résonance Magnétique), May 2019, Oléron, France. ⟨hal-02361645⟩
  • H. Meudal, Nicolas Guyot, K. Loth, G. Jousset, S. Trapp, et al.. Gga-AvBD11, the archetype of a new structural family of defensins. 21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France. ⟨hal-02892790⟩
  • Nicolas Guyot, Hervé Meudal, Karine Loth, Guillaume Jousset, Anne Silvestre, et al.. 1ère structure 3D d’une défensine à double motif β-défensine, Gga-AvBD11 du poulet Gallus gallus, et explorations fonctionnelles. 5es Journées GDR MuFoPAM, Centre National de la Recherche Scientifique (CNRS). FRA., Oct 2018, Paris, France. ⟨hal-02788993⟩
  • Marylène Bertrand, H. Meudal, S. Birman, M. Decoville, C. Landon. Metabolomic NMR studies & Huntington’s disease: models in transgenic drosophila. Conférence SMMAP 2017 - Conférence de Spectrométrie de Masse, Métabolomique et Fluxomique & Electrophorèse et Analyse Protéomique, Oct 2017, Marne-la-Vallée, France. ⟨hal-02919162⟩
  • Nicolas Guyot, Virginie Hervé, Hervé Meudal, Jean-Baptiste Madinier, Valérie Labas, et al.. Insights into the structure-function relationship of egg defensins. XIVth European Poultry Conference, World's Poultry Science Association (WPSA). INT., Jun 2014, Stavanger, Norway. ⟨hal-02743609⟩
  • Nicolas Guyot, Virginie Herve, Hervé Meudal, Jean-Baptiste Madinier, Valérie Labas, et al.. Functional and structural characterization of egg defensins. Banff Egg Forum, Jun 2014, Wroclaw, Poland. 12 diapositives. ⟨hal-02797356⟩
  • H. Meudal, Virginie Herve-Grepinet, Valérie Labas, A. Delmas, Yves Y. Nys, et al.. 1ère défensine d'oeuf : caractérisation, synthèse, structure. 22. Congrès de la Société Française de Biophysique, Sep 2010, La Colle-sur-Loup, France. ⟨hal-02757482⟩
  • Chrystelle Derache, Hervé Meudal, Vincent Aucagne, Martine Cadène, Agnès Delmas, et al.. First insights into the structure-activity relationships of avian beta-defensins.. 2nd International Symposium on Antimicrobial Peptides - Food Veterinary Medical and Novel Applications., 2009, Saint-Malo, France. ⟨hal-02753345⟩
  • C Derache, H Meudal, V Aucagne, Anne-Christine Lalmanach, C Landon, et al.. Cys-containing functional miniproteins: synthesis and oxidative folding.. 2nd International Symposium on Antimicrobial Peptides - Food Veterinary Medical and Novel Applications., 2009, Saint-Malo, France. ⟨hal-02751660⟩
  • C Derache, H Meudal, V Aucagne, M Cadène, A Delmas, et al.. 1ère structure 3D d'une défensine antibactérienne de poulet. 21e Colloque Biotechnocentre, 2008, Seillac, France. ⟨hal-02752777⟩

Poster44 documents

  • David Gosset, Julien Sobilo, Herve Meudal, Frederic Szeremeta, Marylène Bertrand, et al.. Plateforme MO2VING: from MOlecular Organization to in Vivo ImagiNG. 34ème Colloque Biotechnocentre, Oct 2022, Nouan Le Fuzelier, France. ⟨hal-03863246⟩
  • Françoise Paquet, Thomas Aumer, Ons Kharrat, Thomas Knoblock, Philippe Bulet, et al.. First insight into interactions of an antifungal insect defensin with mimetic membranes containing glycosylceramides, by NMR spectroscopy.. 8es journées annuelles du GDR MuFoPAM, Oct 2021, Marseille, France. ⟨hal-03519915⟩
  • Marylène Bertrand, Vidian De Concini, Rania Boussad, Céline Landon, Arnaud Menuet. NMR metabolomic analysis: an aid to understanding neuroinflammatory processes in nociceptive defects of Fmr1 KO mice, model of Fragile X syndrome. 14es journées scientifiques RFMF, Nov 2021, Aussois, France. ⟨hal-03616628⟩
  • Marion Maravat, Marylène Bertrand, M. Decoville, C. Landon, Séverine Morisset-Lopez, et al.. Biomarkers involved in glioma development in Drosophila melanogaster model. European RFMF Metabomeeting 2020, Jan 2020, Toulouse, France. ⟨hal-02919170⟩
  • Justine Largillière, Rémy Le Meur, David Ginguené, Norbert Garnier, Celine Landon, et al.. To a complete kinetics and structural description of the EcHU chain exchange system. NMR : a tool for biology XITh, Jan 2019, Paris, France. ⟨hal-02362588⟩
  • Marylène Bertrand, M. Decoville, H. Meudal, S. Birman, C. Landon. Metabolomic NMR studies at presymptomatic and symptomatic stages of Huntington’s disease, on drosophila model. 12es journées scientifiques du Réseau Francophone de Métabolomique et de Fluxomique, May 2019, Clermont-Ferrand, France. ⟨hal-02919883⟩
  • H. Meudal, K. Loth, G. Jousset, V. Aucagne, Nicolas Guyot, et al.. A new structural family for antimicrobial defensins. NMR : a tool for biology XIth, Jan 2019, Paris, France. ⟨hal-02919171⟩
  • Herve Meudal, Françoise Paquet, Laurence Jouvensal, V. Aucagne, A.F. Delmas, et al.. Chemical synthesis and natural abundance NMR: an efficient tandem to unravel 3D structures of unlabeled disulfide rich peptides. 21e congrès du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France. ⟨hal-02919180⟩
  • Marylène Bertrand, M. Decoville, H. Meudal, S. Birman, C. Landon. Metabolomic NMR studies at presymptomatic and symptomatic stages of Huntington’s disease, on drosophila model. 20th annual meeting of Invertebrate Neurobiology, May 2019, Orléans, France. ⟨hal-02919877⟩
  • Marion Maravat, Marylène Bertrand, M. Decoville, C. Landon, F. Fayon, et al.. Biomarkers involved in glioma development in Drosophila melanogaster model. 12es journées scientifiques du Réseau Francophone de Métabolomique et de Fluxomique, May 2019, Clermont-Ferrand, France. ⟨hal-02919890⟩
  • Marion Maravat, Martine Decoville, Marylène Bertrand, Celine Landon, Séverine Morisset-Lopez, et al.. NMR-based metabolomics for glioma biomarker discovery in a Drosophila melanogaster model. 3rd edition Metabolism & Cancer, Apr 2019, Marseille, France. ⟨hal-02986792⟩
  • Justine Largillière, Rémy Le Meur, David Ginguené, Norbert Garnier, Celine Landon, et al.. To a complete kinetics and structural description of the EcHU chain exchange system.. Journée Fédération de recherche “Physique et Chimie du Vivant”, Apr 2019, Orléans, France. ⟨hal-02362578⟩
  • Marion Maravat, Marylène Bertrand, S. Morisset-Lopez, F. Fayon, V. Sarou-Kanian, et al.. Identification de biomarqueurs impliqués dans le développement de gliomes dans un modèle développé chez la drosophile. 13es Journées Canceropôle Grand-Ouest, Jul 2019, Tours, France. ⟨hal-02919893⟩
  • H. Meudal, Laurence Jouvensal, K. Loth, Françoise Paquet, V. Aucagne, et al.. Chemical synthesis and natural abundance NMR: An efficient tandem to unravel 3D structures of Disulfide Rich Miniproteins. 35th European Peptide Symposium, Aug 2018, Dublin, Ireland. ⟨hal-02920483⟩
  • Marylène Bertrand, M. Decoville, H. Meudal, S. Birman, C. Landon. Huntington’s disease: metabolomic studies by NMR analyzes on Drosophila Model. 11es Journées du Réseau francophone de métabolomique et de fluxomique, May 2018, Liège, Belgium. ⟨hal-02919911⟩
  • Justine Largillière, Rémy Le Meur, David Ginguené, Celine Landon, A.F. Delmas, et al.. First kinetics description of the EcHU chain exchange system.. 28th ICMRBS - International Council on Magnetic Resonance in Biological Systems, Aug 2018, Dublin, Ireland. ⟨hal-02362586⟩
  • Karine Loth, Justine Largillière, Franck Coste, Françoise Culard, Celine Landon, et al.. New protein-DNA complexes in archaea: a small monomeric protein induces a sharp V-turn DNA structure.. EuroMar 2018, Jul 2018, Nantes, France. ⟨hal-02362581⟩
  • Justine Largillière, Rémy Le Meur, David Ginguené, Norbert Garnier, Celine Landon, et al.. To a complete kinetics and structural description of the EcHU chain exchange system.. 31e colloque Biotechnocentre, Oct 2018, Seillac, France. ⟨hal-02362818⟩
  • Justine Largillière, Rémy Le Meur, Martine Cadene, Bertrand Castaing, Karine Loth, et al.. Premières études cinétiques du mécanisme d’échange de chaînes de la protéine HU d’Escherischia coli.. 16e colloque scientifique de l’ADOC : Converger pour Renforcer, Apr 2018, Orléans, France. ⟨hal-02362579⟩
  • Justine Largillière, Rémy Le Meur, Norbert Garnier, Celine Landon, A.F. Delmas, et al.. Native and Intermediate conformations of the three HU dimers of E.coli.. 28th ICMRBS - International Council on Magnetic Resonance in Biological Systems, Aug 2018, Dublin, Ireland. ⟨hal-02362585⟩
  • Karine Loth, Françoise Culard, Justine Largillière, Celine Landon, Bertrand Castaing, et al.. New protein-DNA complexes in archaea: a monomeric protein induces a U-turn structure.. 5e séminaire scientifique du LIA MiR-TANGo, May 2018, Orléans, France. ⟨hal-02362804⟩
  • Justine Largillière, Rémy Le Meur, Martine Cadene, Bertrand Castaing, Karine Loth, et al.. Premières études cinétiques du mécanisme d’échange de chaînes de la protéine HU d’Escherischia coli.. Journée Fédération de recherche “Physique et Chimie du Vivant”, Jan 2018, Orléans, France. ⟨hal-02362577⟩
  • Françoise Paquet, H. Meudal, Laurence Jouvensal, K. Loth, V. Aucagne, et al.. Synthèse chimique et RMN en abondance naturelle : un tandem efficace pour résoudre les structures 3D de peptides/protéines riches en ponts disulfure. 5es journées annuelles du GDR MuFoPAM, Oct 2018, Paris, France. ⟨hal-02920025⟩
  • Karine Loth, Justine Largillière, Franck Coste, Françoise Culard, Bertrand Castaing, et al.. New protein-DNA complexes in archaea: a small monomeric protein induces a V-turn structure.. 28th ICMRBS - International Council on Magnetic Resonance in Biological Systems, Aug 2018, Dublin, Ireland. ⟨hal-02362584⟩
  • Marylène Bertrand, M. Decoville, H. Meudal, S. Birman, C. Landon. NMR metabolimics to detect Huntington’s disease at early stage. 28th ICMRBS - International Council on Magnetic Resonance in Biological Systems, Aug 2018, Dublin, Ireland. ⟨hal-02919924⟩
  • Karine Loth, Justine Largillière, Franck Coste, A.F. Delmas, Bertrand Castaing, et al.. New protein-DNA complexes in archaea: a monomeric protein induces a U-turn structure.. Le Studium Confenrence: Structural biology and biophysics of RNA-protein complexes, Nov 2017, Orléans, France. ⟨hal-02362576⟩
  • A.F. Delmas, K. Loth, Herve Meudal, V.P. Terrier, R.D. Rosa, et al.. NCL-based synthesis, 3D structure and first insight into antimicrobial properties of Cg-BigDef1, an oyster big defensin active at high salinity. 20e congrès annuel du Groupe Français des Peptides et Protéines (GFPP), Mar 2017, Arcachon, France. ⟨hal-02894301⟩
  • A. Delmas, K. Loth, Herve Meudal, V. Terrier, R.D. Rosa, et al.. NCL-based synthesis, 3D structure and first insight into antimicrobial properties of Cg-BigDef1, an oyster big defensin active at high salinity. NMR: a tool for Biology Xth, Jan 2017, Paris, France. ⟨hal-02453460⟩
  • Karine Loth, Françoise Culard, Justine Largillière, Celine Landon, Bertrand Castaing, et al.. The MC1-DNA complex solution structure reveals that a monomeric protein can induce a U-turn in archaea.. NMR: a tool for biology XTh, Jan 2017, Paris, France. ⟨hal-02361613⟩
  • Justine Largillière, Rémy Le Meur, Martine Cadene, Bertrand Castaing, Karine Loth, et al.. Première description cinétique du mécanisme d’échange de chaînes de la protéine HU d'Escherichia coli.. 30e colloque Biotechnocentre, Oct 2017, Seillac, France. ⟨hal-02361632⟩
  • Marylène Bertrand, H. Meudal, M. Decoville, C. Landon. Prediction of Huntingon's Disease by Metabolomic NMR Analyzes: Studies in Drosophila Model. NMR: a tool for biology Xth, Jan 2017, Paris, France. ⟨hal-02919990⟩
  • H. Meudal, Marylène Bertrand, Laurence Jouvensal, A.F. Delmas, Françoise Paquet, et al.. La résonance Magnétique Nucléaire pour la chimie et la biologie. 29e colloque Biotechnocentre, Oct 2016, Seillac, France. ⟨hal-02920143⟩
  • Marylène Bertrand, Hervé Meudal, Florence Bordères, Vincent Furstoss, Louis Wozniak, et al.. Etude de la fertilité chez le bouc : analyse métabolomique par RMN. 10. Journées scientifiques du Réseau Francophone de Métabolomique et Fluxomique RFMF 2016, May 2016, Montpellier, France. 155 p., 2016, 10 JS Réseau Francophone de Métabolique et Fluxomique. ⟨hal-01581541⟩
  • Marylène Bertrand, H. Meudal, M. Decoville, C. Landon. La RMN, un outil pour la métabolomique. 29e colloque Biotechnocentre, Oct 2016, Seillac, France. ⟨hal-02453360⟩
  • Karine Loth, Denis Costechareyre, Yvan Rahbé, Guy Condemine, Pedro da Silva, et al.. 3D NMR structure of a new Cyt-like delta-endotoxins from Dickeya dadantii. 26. International Conference on Magnetic Resonance in Biological Systems, Aug 2014, Dallas, United States. 1 p., 2014. ⟨hal-02795661⟩
  • Virginie Hervé, Nicolas Guyot, H. Meudal, Valérie Labas, Sophie Réhault-Godbert, et al.. Gallin is a chicken egg beta-defensin with a narrow antibacterial spectrum. 4. International Symposium on Antimicrobial Peptides, Jun 2014, Lorient, France. 1 p., 2014. ⟨hal-02793322⟩
  • H. Meudal, Chrystelle Derache, Virginie Herve-Grepinet, P. Bulet, Y. Le Maho, et al.. Avian defensins and ovo-defensins : a structural point of view. Antimicrobial Peptides. Discovery, Function and Application, Feb 2013, Ventura, CA, United States. 1 p., 2013. ⟨hal-02807466⟩
  • Mathieu Galibert, Chrystelle Derache, Franck Coste, Hervé Meudal, Anne-Christine Lalmanach, et al.. Improvement of the chemical production of β-defensins including straightforward attribution of disulfide bridges. 18. Réunion du GFPP, May 2013, Sète, France. 1 p., 2013. ⟨hal-02805308⟩
  • Hervé Meudal, Chrystelle Derache, Virginie Herve-Grepinet, Philippe Bulet, Yvon Le Maho, et al.. 3D structures of avian defensins. 3. International Symposium on Antimicrobial Peptides: Today knowledge and future applications. (AMP 2012), Jun 2012, Lille, France. , n.p., 2012. ⟨hal-02749392⟩
  • Chrystelle Derache, Emmanuel Kut, Hervé Meudal, Vincent Aucagne, Agnès Delmas, et al.. Antibacterial spectrum of avian defensin 2: peculiarities in relationship with structural features. 3. International Symposium on Antimicrobial Peptides: Today knowledge and future applications (AMP 2012), Jun 2012, Lille, France. , pp.D-97, 2012. ⟨hal-02807349⟩
  • M. Galibert, Chrystelle Derache, F. Coste, H. Meudal, Anne-Christine Lalmanach, et al.. Improvement of the chemical production of β-defensins including straighforward attribution of disulfide bridges. 3. International Symposium on Antimicrobial Peptides: Today knowledge and future applications, Jun 2012, Lille, France. , pp.C-43, 2012, AMP 2012 - Antimicrobial peptide symposium. ⟨hal-02748134⟩
  • Hervé Meudal, Chrystelle Derache, Virginie Herve-Grepinet, Philippe Bulet, Yvon Le Maho, et al.. Birds defensins: a structural point of view. 25. ICMRBS - International Conference on Magnetic Resonance in Biological Systems, Aug 2012, Lyon, France. 1 p., 2012. ⟨hal-02808400⟩
  • H. Meudal, Virginie Herve-Grepinet, Valérie Labas, A. Delmas, Yves Y. Nys, et al.. 1ère structure 3D d'une beta-défensine d'oeuf. GERM 2010 - Détection et Acquisition en Résonnance Magnétique, May 2010, Saint-Dié-des-Vosges, France. 1 p., 2010. ⟨hal-02816486⟩
  • Chrystelle Derache, Hervé Meudal, Vincent Aucagne, Anne-Christine Lalmanach, Céline Landon, et al.. Synthesis and oxidative folding of functional miniproteins containing three disulfide bridges. 21e Colloque Biotechnocentre, 2008, Seillac, France. 1 p, 2008. ⟨hal-02818274⟩

Chapitre d'ouvrage1 document

  • N. Mandard, P. Bulet, C. Hétru, C. Landon, F. Vovelle. Solution structure of antimicrobial peptides with a β-hairpin fold. Structure-activity relationship. Membrane interacting peptides and proteins, Research Signpost, Trivandrum, pp.155-171, 2002. ⟨hal-00115803⟩

Brevet1 document

  • Nicolas Guyot, Sophie Réhault-Godbert, Anne Silvestre, Sascha Trapp, Sophie Iochmann, et al.. Peptides dérivés d'une beta-défensine 11 aviaire et leurs utilisations. France, N° de brevet: WO 2020/030773 A1. AMV; SA, 3IMo, AIM. 2020. ⟨hal-02595638⟩

Autre publication1 document

  • Sophie Réhault-Godbert, Nicolas Guyot, Celine Landon. AvBD11, une protéine naturelle de l’œuf au potentiel thérapeutique prometteur. 2020. ⟨hal-03556897⟩

Documents récupérés de l'archive ouverte HAL logo

KEITA-PAQUET Françoise

 

email : francoise.paquet[remplacer_par_at]cnrs-orleans.fr

Phone : +33 2.38.25.76.92

Researcher within the thematic group “NMR of biomolecules“

 


58 documents

Article dans une revue31 documents

  • Valentine Barassé, Laurence Jouvensal, Guillaume Boy, Arnaud Billet, Steven Ascoët, et al.. Discovery of an Insect Neuroactive Helix Ring Peptide from Ant Venom. Toxins, 2023, 15 (10), pp.600. ⟨10.3390/toxins15100600⟩. ⟨hal-04390519⟩
  • Steven Ascoët, Axel Touchard, Nathan Téné, Benjamin Lefranc, Jérôme Leprince, et al.. The mechanism underlying toxicity of a venom peptide against insects reveals how ants are master at disrupting membranes. iScience, 2023, 26 (3), pp.106157. ⟨10.1016/j.isci.2023.106157⟩. ⟨hal-04071274⟩
  • Karine Loth, Nicolas Parisot, Françoise Paquet, Hugo Terrasson, Catherine Sivignon, et al.. Aphid BCR4 Structure and Activity Uncover a New Defensin Peptide Superfamily. International Journal of Molecular Sciences, 2022, 23 (20), pp.12480. ⟨10.3390/ijms232012480⟩. ⟨hal-03862651⟩
  • Darielys Santana, Rocmira Perez Nicado, Yanet Climent, Laura Marta Marta Rodríguez Noda, Belinda Sánchez Ramírez, et al.. A COVID-19 vaccine candidate composed of SARS-CoV-2 RBD dimer and Neisseria meningitidis outer membrane vesicles. RSC Chemical Biology, 2022, 3 (2), pp.242-249. ⟨10.1039/D1CB00200G⟩. ⟨hal-03519898v2⟩
  • Valentine Barassé, Nathan Téné, Christophe Klopp, Françoise Paquet, Niklas Tysklind, et al.. Venomics survey of six myrmicine ants provides insights into the molecular and structural diversity of their peptide toxins. Insect Biochemistry and Molecular Biology, 2022, 151, pp. 103876. ⟨10.1016/j.ibmb.2022.103876⟩. ⟨hal-04446316⟩
  • Yury Valdes-Balbin, Darielys Santana-Mederos, Françoise Paquet, Sonsire Fernandez, Yanet Climent, et al.. Molecular Aspects Concerning the Use of the SARS-CoV-2 Receptor Binding Domain as a Target for Preventive Vaccines. ACS Central Science, 2021, 7, pp.757 - 767. ⟨10.1021/acscentsci.1c00216⟩. ⟨hal-04446345⟩
  • Yury Valdes-Balbin, Darielys Santana-Mederos, Lauren Quintero, Sonsire Fernández, Laura Rodriguez, et al.. SARS-CoV-2 RBD-Tetanus Toxoid Conjugate Vaccine Induces a Strong Neutralizing Immunity in Preclinical Studies. ACS Chemical Biology, 2021, 16 (7), pp.1223-1233. ⟨10.1021/acschembio.1c00272⟩. ⟨hal-03443835⟩
  • Yury Valdes-Balbin, Darielys Santana-Mederos, Françoise Paquet, Sonsire Fernandez, Yanet Climent, et al.. Molecular Aspects Concerning the Use of the SARS-CoV-2 Receptor Binding Domain as a Target for Preventive Vaccines. ACS Central Science, 2021, 7 (5), pp.757-767. ⟨10.1021/acscentsci.1c00216⟩. ⟨hal-03327027⟩
  • Blanca I Tolón Murguía, Yuleidys de Las Mercedes Iglesias Morales, Miriam Mesa Hernández, Yaneisy Yu Pérez, Claudia Labrada Regalado, et al.. An efficient synthetic route to O-(2-O-benzyl-3,4-di-O-acetyl-α/β-l-fucopyranosyl)-trichloroacetimidate. Carbohydrate Research, 2020, 499, ⟨10.1016/j.carres.2020.108221⟩. ⟨hal-03432512⟩
  • Karine Loth, Justine Largillière, Franck Coste, Françoise Culard, Céline Landon, et al.. New protein-DNA complexes in archaea: a small monomeric protein induces a sharp V-turn DNA structure. Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-50211-2⟩. ⟨hal-02306224⟩
  • Karine Loth, Céline Landon, Françoise Paquet. Chemical shifts assignments of the archaeal MC1 protein and a strongly bent 15 base pairs DNA duplex in complex. Biomolecular NMR Assignments, 2015, 9 (1), pp.215-217. ⟨10.1007/s12104-014-9577-8⟩. ⟨hal-01171478⟩
  • Fanny Meindre, Dominique Lelièvre, Karine Loth, Oriane Mith, Vincent Aucagne, et al.. The nuclear magnetic resonance solution structure of the synthetic AhPDF1.1b plant defensin evidences the structural feature within the γ-motif. Biochemistry, 2014, 53 (49), pp.7745-54. ⟨10.1021/bi501285k⟩. ⟨hal-01118914⟩
  • Françoise Paquet, Olivier Delalande, Stephane Goffinont, Françoise Culard, Karine Loth, et al.. Model of a DNA-protein complex of the architectural monomeric protein MC1 from Euryarchaea. PLoS ONE, 2014, 9 (2), pp.e88809. ⟨10.1371/journal.pone.0088809⟩. ⟨hal-01063974⟩
  • Violette Senille, Dominique Lelievre, Françoise Paquet, Norbert Garnier, Ned Lamb, et al.. The addressing fragment of mitogaligin: first insights into functional and structural properties.. ChemBioChem, 2013, 14 (6), pp.711-20. ⟨10.1002/cbic.201200715⟩. ⟨hal-00817503⟩
  • Françoise Paquet, Karine Loth, Hervé Meudal, Francoise Culard, Daniel Genest, et al.. Refined solution structure and backbone dynamics of the archaeal MC1 protein. FEBS Journal, 2010, 277 (24), pp.5133-5145. ⟨10.1111/j.1742-4658.2010.07927.x⟩. ⟨hal-00602469⟩
  • F. Kieken, F. Paquet, Fabienne Brulé, J. Paoletti, G. Lancelot. A new NMR solution structure of the SL1 HIV-1Lai loop-loop dimmer. Nucleic Acids Research, 2006, 34, pp.343-352. ⟨10.1093/nar/gkj427⟩. ⟨hal-00088868⟩
  • Y. Bilbille, F. Paquet, H. Meudal, M.J. Giraud-Panis, G. Lancelot. NMR studies of telomeric nucleoprotein complexes involving the Myb-like domain of the human telomeric protein TRF2. Comptes Rendus. Chimie, 2006, 9 (3-4), pp.452-458. ⟨10.1016/j.crci.2005.06.019⟩. ⟨hal-00088835⟩
  • Françoise Paquet, Françoise Culard, Florent Barbault, Jean-Claude Maurizot, Gérard Lancelot. NMR Solution Structure of the Archaebacterial Chromosomal Protein MC1 Reveals a New Protein Fold ‡. Biochemistry, 2004, 43 (47), pp.14971-14978. ⟨10.1021/bi048382z⟩. ⟨hal-02121481⟩
  • Françoise Paquet, Jean-Claude Maurizot, Gérard Lancelot. Changes inlac Operator dynamics upon selective interaction withlac Repressor as revealed by heteronuclear relaxation rate measurements. Magnetic Resonance in Chemistry, 2000, 38 (11), pp.946-950. ⟨10.1002/1097-458X(200011)38:11<946::AID-MRC763>3.0.CO;2-Q⟩. ⟨hal-02121469⟩
  • Françoise Paquet, Marc Boudvillain, Gérard Lancelot, Marc Leng. NMR solution structure of a DNA dodecamer containing a transplatin interstrand GN7-CN3 cross-link. Nucleic Acids Research, 1999, 27 (21), pp.4261-4268. ⟨10.1093/nar/27.21.4261⟩. ⟨hal-02075311⟩
  • F Gaudin, Françoise Paquet, N.T Thuong, Daniel Genest, G. Lancelot. Selectively 13-C enriched DNA : Evidence of fast and slow internal motions. Journal of Biomolecular Structure and Dynamics, 1997, 26 (1), pp.45. ⟨hal-02132728⟩
  • Françoise Paquet, C. Perez, M. Leng, G. Lancelot, J-M Malinge. NMR Solution Structure of a DNA Decamer Containing an Interstrand Cross-link of the Antitumor Drug cis -diamminedichloroplatinum(II). Journal of Biomolecular Structure and Dynamics, 1997, 14 (1), pp.67-77. ⟨10.1080/07391102.1996.10508930⟩. ⟨hal-02121444⟩
  • Françoise Paquet, G. Gaudin, G. Lancelot. Selectively 13C-enriched DNA: evidence from 13C1' relaxation rate measurements of an internal dynamics sequence effect in the lac operator.. Journal of Biomolecular NMR, 1996, 8 (3), pp.252-60. ⟨hal-02121439⟩
  • G. Gaudin, Françoise Paquet, L Chanteloup, J-M Beau, T. Nguyen, et al.. Selectively 13C-enriched DNA: dynamics of the C1'-H1' vector in d(CGCAAATTTGCG)2.. Journal of Biomolecular NMR, 1995, 5 (1), pp.49-58. ⟨hal-02121433⟩
  • Jean-Michel Petit, Françoise Paquet, Jean-Marie Beau. Syntheses of β-2-deoxy-D-glycosides assisted by glycosidases. Tetrahedron Letters, 1991, 32 (43), pp.6125-6128. ⟨10.1016/0040-4039(91)80769-3⟩. ⟨hal-02121425⟩
  • Jean-Michel Petit, Françoise Paquet, Jean-Marie Beau. Syntheses of β-2-deoxy-D-glycosides assisted by glycosidases. Tetrahedron Letters, 1991, 32 (43), pp.6125-6128. ⟨10.1016/0040-4039(91)80769-3⟩. ⟨hal-03519976⟩
  • Jean-Marc Lancelin, Françoise Paquet, Jean-Marie Beau. Stereochemical studies on the polyene macrolide nystatin A1: the hydroxyl groups in the C-1—C-10 fragment are all-syn. Tetrahedron Letters, 1988, 29 (23), pp.2827-2830. ⟨10.1016/0040-4039(88)85222-5⟩. ⟨hal-02121419⟩
  • G. Catelani, A. Marra, Françoise Paquet, P Sinaÿ. Chemical synthesis of the desialylated human Cad-anti-genic determinant.. Carbohydrate Research, 1986, 155, pp.131-40. ⟨hal-02121411⟩
  • Giorgio Catelani, Alberto Marra, Françoise Paquet, Pierre Sinaÿ. Synthesis of trisaccharide derivatives with the sequence of the desialylated Cad blood groop determinant.. Gazetta Chimica Italiana, 1985, 115, pp.565-567. ⟨hal-02132694⟩
  • Françoise Paquet, Pierre Sinaÿ. A new stereocontrolled approach to KDO containing disaccharides. Journal of the American Chemical Society, 1984, 106 (26), pp.8313-8315. ⟨10.1021/ja00338a062⟩. ⟨hal-02121396⟩
  • Françoise Paquet, Pierre Sinaÿ. Intramolecular oximercuration-demercuration reaction: a new stereocontrolled approach to sialic acid containing disaccharides. Tetrahedron Letters, 1984, 25 (29), pp.3071-3074. ⟨10.1016/0040-4039(84)80010-6⟩. ⟨hal-02121392⟩

Communication dans un congrès7 documents

  • Françoise Paquet, Sonsire Fernandez, Dagmar Garcia Rivera, Yury Valdes Balbin, Vicente Verez Bencomo. RSV F protein as target for vaccines. VACCIPHARMA 2023, Jun 2023, Varadero, Cuba. ⟨hal-04406393⟩
  • Hugo Terrasson, Karine Loth, Nicolas Parisot, Françoise Paquet, Isabelle Rahioui, et al.. Bacteriocyte-specific Cysteine-Rich (BCR) peptides form a new aphid-specific defensin-like family and are promising regulators of aphid symbiosis. Rencontres du Réseau Ecologie des Interactions Durables (REID), May 2023, Poitiers, France. ⟨hal-04633283⟩
  • Hugo Terrasson, Karine Loth, Nicolas Parisot, Françoise Paquet, Isabelle Rahioui, et al.. Peptides « Bacteriocyte-specific Cysteine Rich » (BCR) : un rôle dans le contrôle de la symbiose ? Focus sur BCR4 chez le puceron du pois.. 12èmes rencontres du réseau français de Biologie Adaptative des Pucerons et Organismes Associés (BAPOA), May 2022, Nice, France. ⟨hal-04771966⟩
  • Hugo Terrasson, Karine Loth, Nicolas Parisot, Françoise Paquet, Isabelle Rahioui, et al.. Les peptides « Bacteriocyte-specific Cystein-Rich » : une nouvelle famille de défensine. Régulateurs de la symbiose chez les pucerons ?. 9ème Journées du GDR "MultiFonction des Peptides AntiMicrobiens" (MuFoPAM), Oct 2022, Amboise, France. ⟨hal-04633233⟩
  • Françoise Paquet, Darielys Santana Mederos, Raine Garrido Arteaga, Daniel García Rivera, Yury Valdés Balbín, et al.. Structural biology for vaccine development : the example of SOBERANA vaccines. BIOHABANA 2022, Apr 2022, La Havane (Cuba), Cuba. ⟨hal-04406363⟩
  • Steven Ascoët, Nathan Téné, Axel Touchard, Jérôme Leprince, Françoise Paquet, et al.. Comparative Investigation of the Mechanisms of Two Cytotoxic Venom Peptides from the Ant Tetramorium Bicarinatum. 27th Meeting of the French Society of Toxinology, Dec 2021, On line, France. ⟨hal-05158078⟩
  • Françoise Paquet. Séminaire invité : Unraveling the interaction between the capsular polysaccharide of Streptococcus pneumoniae type 6B and the anti-6B Monoclonal Antibody using an NMR approach. Finlay Institute of Vaccines, Sep 2018, La Havane, Cuba. ⟨hal-03604330⟩

Poster19 documents

  • Axel Touchard, Valentine Barassé, Laurence Jouvensal, Guillaume Boy, Arnaud Billet, et al.. Venin de la fourmi Tetramorium bicarinatum : découverte d'un peptide original neuroactif chez les insectes. 52ème Congrès du Groupe Français de Recherches sur les Pesticides, May 2024, Lyon, France. 2024. ⟨hal-05169446⟩
  • Hugo Terrasson, Karine Loth, Nicolas Parisot, Françoise Paquet, Isabelle Rahioui, et al.. The aphid BCR4 structure and activity uncover a new defensin peptide superfamily. XXVII International Congress of Entomology, Aug 2024, Kyoto, Japan. ⟨hal-04702878⟩
  • Hugo Terrasson, Karine Loth, Françoise Paquet, Nicolas Parisot, Isabelle Rahioui, et al.. The Bacteriocyte-specific Cysteine-Rich (BCR) proteins: a role in the control of aphid symbiosis ?. Journée scientifique enjeu « santé globale et bio‐ingénierie » de l'INSA Lyon, Apr 2023, Villeurbanne, France. ⟨hal-04633269⟩
  • Laurence Jouvensal, Karine Loth, Axel Touchard, Arnaud Billet, Michel Treilhou, et al.. Diversity of host defense peptides in the venom of the ant T. bicarinatum. MuFoPAM 2023, Oct 2023, Lille, France. ⟨hal-04406429⟩
  • Steven Ascoët, Nathan Téné, Axel Touchard, Benjamin Lefranc, Françoise Paquet, et al.. Investigation of the U9-MYRTX-Tb1a Mechanism, a Cytotoxic Peptide from the Ant Tetramorium Bicarinatum Venom. 22ème Congrès Du Groupe Français Des Peptides et Des Protéines et BPGMS5, French-Belgian Joint Meeting, May 2022, Port-Leucate, France. ⟨hal-05167772⟩
  • Hugo Terrasson, Karine Loth, Nicolas Parisot, Françoise Paquet, Isabelle Rahioui, et al.. Bacteriocyte specific Cystein Rich peptides, a new defensin like protein family , are promising regulators of aphid symbiosis. 10th congress of the International Symbiosis Society (ISS) - 3rd International Conference on Holobionts (joint meeting), Jul 2022, Lyon, France. ⟨hal-04771990⟩
  • Steven Ascoët, Nathan Téné, Axel Touchard, Benjamin Lefranc, Jérôme Leprince, et al.. Between Apoptosis and Necrosis: Study of U9-MYRTX-Tb1a Mechanism, a Cytotoxic Venom Peptide from the Tetramorium Bicarinatum Ant. Venoms and Toxins, Aug 2022, Oxford, United Kingdom. 2022. ⟨hal-05166727⟩
  • Steven Ascoët, Nathan Téné, Axel Touchard, Jérôme Leprince, Françoise Paquet, et al.. Comparative investigation of the mechanisms of two cytotoxic venom peptides from the ant Tetramorium bicarinatum.. e-RT27 – 27th Meeting of the French Society of Toxinology, Dec 2021, virtual, France. ⟨hal-03519944⟩
  • Françoise Paquet, Thomas Aumer, Ons Kharrat, Thomas Knoblock, Philippe Bulet, et al.. First insight into interactions of an antifungal insect defensin with mimetic membranes containing glycosylceramides, by NMR spectroscopy.. 8es journées annuelles du GDR MuFoPAM, Oct 2021, Marseille, France. ⟨hal-03519915⟩
  • Françoise Paquet, K. Loth, C. Arnoult, V. Aucagne, A.F. Delmas. Spermaurin, a scorpion venom disulfide-rich miniprotein that improves sperm motility and fertilization in mammals.. 21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France. ⟨hal-02893462⟩
  • Herve Meudal, Françoise Paquet, Laurence Jouvensal, V. Aucagne, A.F. Delmas, et al.. Chemical synthesis and natural abundance NMR: an efficient tandem to unravel 3D structures of unlabeled disulfide rich peptides. 21e congrès du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France. ⟨hal-02919180⟩
  • Karine Loth, Justine Largillière, Franck Coste, Françoise Culard, Bertrand Castaing, et al.. New protein-DNA complexes in archaea: a small monomeric protein induces a V-turn structure.. 28th ICMRBS - International Council on Magnetic Resonance in Biological Systems, Aug 2018, Dublin, Ireland. ⟨hal-02362584⟩
  • Karine Loth, Françoise Culard, Justine Largillière, Celine Landon, Bertrand Castaing, et al.. New protein-DNA complexes in archaea: a monomeric protein induces a U-turn structure.. 5e séminaire scientifique du LIA MiR-TANGo, May 2018, Orléans, France. ⟨hal-02362804⟩
  • Françoise Paquet, H. Meudal, Laurence Jouvensal, K. Loth, V. Aucagne, et al.. Synthèse chimique et RMN en abondance naturelle : un tandem efficace pour résoudre les structures 3D de peptides/protéines riches en ponts disulfure. 5es journées annuelles du GDR MuFoPAM, Oct 2018, Paris, France. ⟨hal-02920025⟩
  • Karine Loth, Justine Largillière, Franck Coste, Françoise Culard, Celine Landon, et al.. New protein-DNA complexes in archaea: a small monomeric protein induces a sharp V-turn DNA structure.. EuroMar 2018, Jul 2018, Nantes, France. ⟨hal-02362581⟩
  • H. Meudal, Laurence Jouvensal, K. Loth, Françoise Paquet, V. Aucagne, et al.. Chemical synthesis and natural abundance NMR: An efficient tandem to unravel 3D structures of Disulfide Rich Miniproteins. 35th European Peptide Symposium, Aug 2018, Dublin, Ireland. ⟨hal-02920483⟩
  • Karine Loth, Françoise Culard, Justine Largillière, Celine Landon, Bertrand Castaing, et al.. The MC1-DNA complex solution structure reveals that a monomeric protein can induce a U-turn in archaea.. NMR: a tool for biology XTh, Jan 2017, Paris, France. ⟨hal-02361613⟩
  • Karine Loth, Justine Largillière, Franck Coste, A.F. Delmas, Bertrand Castaing, et al.. New protein-DNA complexes in archaea: a monomeric protein induces a U-turn structure.. Le Studium Confenrence: Structural biology and biophysics of RNA-protein complexes, Nov 2017, Orléans, France. ⟨hal-02362576⟩
  • H. Meudal, Marylène Bertrand, Laurence Jouvensal, A.F. Delmas, Françoise Paquet, et al.. La résonance Magnétique Nucléaire pour la chimie et la biologie. 29e colloque Biotechnocentre, Oct 2016, Seillac, France. ⟨hal-02920143⟩

Chapitre d'ouvrage1 document

  • Gérard Lancelot, Françoise Paquet. NMR Studies of lac Operator and lac Repressor. Annual Reports on NMR Spectroscopy, pp.169-211, 2003. ⟨hal-02121524⟩

Documents récupérés de l'archive ouverte HAL logo

GOFFINONT Stéphane

email : stephane.goffinont[remplacer_par_at]cnrs-orleans.fr

Phone : +33 2.38.25.55.49

Engineer in biological techniques within the thematic group “DNA repair: structure, fonction and dynamic“

 


34 documents

Article dans une revue16 documents

  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection. Journal of Molecular Biology, 2024, 436 (22), pp.168768. ⟨10.1016/j.jmb.2024.168768⟩. ⟨hal-04771131⟩
  • Zahira Tber, Nicolas G. Biteau, Luigi Agrofoglio, Julien Cros, Stéphane Goffinont, et al.. Microwave-assisted Suzuki-Miyaura and Sonogashira coupling of 4-Chloro-2-(trifluoromethyl)pyrido[1,2-e]purine derivatives. European Journal of Organic Chemistry, 2019, 2019, pp.5756-5767. ⟨10.1002/ejoc.201900921⟩. ⟨hal-02347523⟩
  • R. Le Meur, Françoise Culard, V. Nadan, S. Goffinont, F. Coste, et al.. The nucleoid-associated protein HU enhances 8-oxoguanine base excision by the formamidopyrimidine-DNA glycosylase. Biochemical Journal, 2015, 471 (1), pp.13-23. ⟨10.1042/BJ20150387⟩. ⟨hal-01216639⟩
  • Françoise Paquet, Olivier Delalande, Stephane Goffinont, Françoise Culard, Karine Loth, et al.. Model of a DNA-protein complex of the architectural monomeric protein MC1 from Euryarchaea. PLoS ONE, 2014, 9 (2), pp.e88809. ⟨10.1371/journal.pone.0088809⟩. ⟨hal-01063974⟩
  • A. Biela, F. Coste, F. Culard, M. Guerin, S. Goffinont, et al.. Zinc finger oxidation of Fpg/Nei DNA glycosylases by 2-thioxanthine: biochemical and X-ray structural characterization. Nucleic Acids Research, 2014, 42 (16), pp.doi: 10.1093/nar/gku613. ⟨10.1093/nar/gku613⟩. ⟨hal-01175522⟩
  • Stephane Goffinont, Sandrine Villette, Melanie Spotheim-Maurizot. Alanine Screening Mutagenesis Establishes the Critical Inactivating Damage of Irradiated E. coli Lactose Repressor.. Radiation Research, 2012, 177 (6), pp.738-42. ⟨hal-00721863⟩
  • Samia Aci-Sèche, Norbert Garnier, Stéphane Goffinont, Daniel Genest, Spotheim-Maurizot Mélanie, et al.. Comparing native and irradiated E. coli lactose repressor-operator complex by molecular dynamics simulation. European Biophysics Journal, 2010, 39 (10), pp.1375-1384. ⟨10.1007/s00249-010-0591-1⟩. ⟨hal-00529210⟩
  • Viktorie Stisova, Stéphane Goffinont, Mélanie Spotheim-Maurizot, Marie Davidkova. Effects of gamma irradiation on the DNA-protein complex between the estrogen response element and the estrogen receptor. Radiation Physics and Chemistry, 2010, 79 (8), pp.880-889. ⟨10.1016/j.radphyschem.2010.03.009⟩. ⟨hal-00529465⟩
  • Stéphane Goffinont, Marie Davídková, Mélanie Spotheim-Maurizot. Radiation-induced tetramer-to-dimer transition of Escherichia coli lactose repressor. Biochemical and Biophysical Research Communications, 2009, 386 (2), pp.300-304. ⟨10.1016/j.bbrc.2009.06.012⟩. ⟨hal-00522426⟩
  • Mélanie Spotheim-Maurizot, Sonia Mazier, Sandrine Villette, Stéphane Goffinont, Dominique Genest, et al.. Radiationinduced oxidation of proteins in DNA-protein complexes. Radioprotection, 2008, 43 (5), pp.131-132. ⟨10.1051/radiopro:2008526⟩. ⟨hal-00527448⟩
  • Sonia Mazier, Sandrine Villette, Stéphane Goffinont, Stéphane Renouard, Jean-Claude Maurizot, et al.. Radiation Damage to a DNA-Binding Protein. Combined Circular Dichroism and Molecular Dynamics Simulation Analysis. Radiation Research, 2008, 170 (5), pp.604-612. ⟨hal-00518177⟩
  • Corinne Buré, Stéphane Goffinont, Agnès F. Delmas, Martine Cadene, Françoise Culard. Oxidation-sensitive residues mediate the DNA-bending activity of MC1 protein. Journal of Molecular Biology, 2008, 376 (1), pp.120-130. ⟨10.1016/j.jmb.2007.11.057⟩. ⟨hal-00283220⟩
  • Nathalie Gillard, Stephane Goffinont, Corinne Buré, Marie Davidkova, Jean-Claude Maurizot, et al.. Radiation-induced oxidative damage to the DNA-binding domain of the lactose repressor. Biochemical Journal, 2007, 403 (3), pp.463-472. ⟨10.1042/BJ20061466⟩. ⟨hal-00478672⟩
  • Viktorie Stísová, Stephane Goffinont, Melanie Spotheim-Maurizot, Marie Davídková. Radiation damage to DNA–protein specific complexes: estrogen response element–estrogen receptor complex. Radiation Protection Dosimetry, 2006, 122 (1-4), pp.106-109. ⟨10.1093/rpd/ncl443⟩. ⟨hal-00159626⟩
  • Marie Davídková, Viktorie Stísová, Stéphane Goffinont, Nathalie Gillard, Bertrand Castaing, et al.. Modification of DNA radiolysis by DNA-binding proteins: structural aspects. Radiation Protection Dosimetry, 2006, 122 (1-4), pp.100-105. ⟨10.1093/rpd/ncl442⟩. ⟨hal-00168743⟩
  • Fabrice Agou, Fei Ye, Stéphane Goffinont, Gilles Courtois, Shoji Yamaoka, et al.. NEMO Trimerizes through Its Coiled-coil C-terminal Domain. Journal of Biological Chemistry, 2002, 277 (20), pp.17464-17475. ⟨10.1074/jbc.M201964200⟩. ⟨hal-02112165⟩

Communication dans un congrès3 documents

  • J. Cros, F. Coste, S. Goffinont, Virginie Nadan, V. Roy, et al.. Discovery and characterization of inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, pertinent therapeutic targets for cancer therapy. Laboratoire International Associé, Jun 2019, Varsovie, Poland. ⟨hal-02903108⟩
  • A. Wacquiez, F. Coste, V. Nadan, E. Kut, Norbert Garnier, et al.. Interaction de la protéine NS1 avec l’ARN : mécanismes impliqués dans la reconnaissance spécifique. Colloque annuel de ResaFlu, Réseau français sur les virus Influenza, Mar 2019, Lyon, France. ⟨hal-02903093⟩
  • J. Cros, F. Coste, Z. Tber, S. Goffinont, Virginie Nadan, et al.. Small molecule inhibitors of the human DNA glycosylases hOGG1 and NEIL1, pertinent therapeutic targets in cancer and neurodegenerative disease therapies. 25th Young Research Fellows Meeting, Mar 2018, Orléans, France. ⟨hal-02903084⟩

Poster14 documents

  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation. 2024 Global NF Conference, Jun 2024, Brussels, Belgium. ⟨hal-03679991⟩
  • Mohammed Bergoug, Christine Mosrin-Huaman, Amandine Serrano, Fabienne Godin, Michel Doudeau, et al.. Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation. 2024 Global NF Conference, Jun 2024, Brussels, Belgium. ⟨hal-04778711⟩
  • Daniel Marc, Alan Wacquiez, Stéphane Goffinont, Virginie Nadan, Franck Coste, et al.. Interaction de la protéine NS1 des virus influenza A avec l’ARN : mécanismes impliqués dans la reconnaissance spécifique. XIIes Journées Francophones de Virologie, Mar 2019, Lyon, France. Virologie, 23, 2019. ⟨hal-02737761⟩
  • J. Cros, F. Coste, S. Goffinont, V. Gaudon, V. Roy, et al.. Search for small molecule inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, potential therapeutic targets in cancer. Journée Fédération de recherche “Physique et Chimie du Vivant” FR2708 (CBM/ICOA), Apr 2019, Orléans, France. ⟨hal-02903223⟩
  • J. Cros, F. Coste, S. Goffinont, V. Gaudon, V. Roy, et al.. Search for small molecule inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, potential therapeutic targets in cancer. 13th French 3R meeting, May 2019, Presqu’île de Giens, France. ⟨hal-02903219⟩
  • Julien Cros, Franck Coste, Stéphane Goffinont, Virginie Nadan, Norbert Garnier, et al.. Screening, characterization and structural studies of small molecules inhibitors of the DNA glycosylase hNEIL1 and hOGG1, potential therapeutic targets in cancer and neurodegenerative disease. 1st French congress on Integrative Structural Biology (BSI-2019), Oct 2019, Toulouse, France. ⟨hal-03385201⟩
  • Alan Wacquiez, Stéphane Goffinont, Virginie Nadan, Franck Coste, Emmanuel Kut, et al.. Structures et fonctions de la protéine NS1 des virus influenza pour la recherche de nouvelles cibles thérapeutiques. 31e Colloque Biotechnocentre, Oct 2018, Seillac, France. , 2018. ⟨hal-02736195⟩
  • J. Cros, F. Coste, Z. Tber, S. Goffinont, V. Nadan, et al.. Search for small molecule inhibitors of DNA glycosylases, pertinent therapeutic targets in cancer and neurodegenerative disease therapies. 5e Colloque annuel du Laboratoire International Associé (LIA) MiR-TANGo, May 2018, Orléans, France. ⟨hal-02904701⟩
  • J. Cros, F. Coste, S. Goffinont, V. Gaudon, V. Roy, et al.. Recherche d’inhibiteurs des enzymes de réparation de l’ADN hNeil1 et hOGG1, de nouvelles cibles pertinentes pour le développement de thérapies anticancéreuses. 31e colloque Biotechnocentre, Oct 2018, Seillac, France. ⟨hal-02904682⟩
  • Alan Wacquiez, Franck Coste, Caroline Blondeau, Emmanuel Kut, Virginie Nadan, et al.. NS1 des virus Influenza A : approches structurales et fonctionnelles pour de nouvelles stratégies anti-virales. 20. Journées Francophones de Virologie 2018, Mar 2018, Paris, France. John Libbey Eurotext, Virologie, 22, 148 p., 2018. ⟨hal-02736544⟩
  • A. Wacquiez, S. Goffinont, V. Nadan, F. Coste, E. Kut, et al.. NS1 des virus influenza : relations structure-fonction pour la recherche de nouveaux anti-viraux. 30e colloque Biotechnocentre, Oct 2017, Seillac, France. ⟨hal-02904785⟩
  • A. Wacquiez, F. Coste, V. Nadan, E. Kut, S. Goffinont, et al.. NS1 of Influenza viruses: structural and functional approaches towards the discovery of novel anti-influenza drugs. Le Studium Conférence “Structural Biology and biophysics of RNA-protein complexes”, Nov 2017, Orléans, France. ⟨hal-02904778⟩
  • A. Wacquiez, F. Coste, C. Blondeau, E. Kut, V. Nadan, et al.. NS1 des virus Influenza A : approches structurales et fonctionnelles pour de nouvelles stratégies anti-virales. Le Studium Conférence « Messenger RNA therapeutics : advances and perspectives », Mar 2017, Orléans, France. ⟨hal-02904828⟩
  • C. Rieux, F. Coste, F. Culard, S. Goffinont, S. Bourg, et al.. Small-molecule inhibitors of Fpg/Nei DNA glycosylases, enzymes initiating the base excision repair pathway, new targets for cancer therapy. XXII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids, Jul 2016, Paris, France. ⟨hal-02919151⟩

Chapitre d'ouvrage1 document

  • Françoise Culard, Mélanie Spotheim-Maurizot, Corinne Bure, Stéphane Goffinont, Martine Cadene. A mass spectrometry approach for the identification of oxidation-sensitive residues in DNA-binding proteins: correlation with protein function. Pandey, A., Banerjee, R. Horizons in Biotechnology, Asiatech Publishers, New Delhi, pp.123-134, 2008. ⟨hal-00623581⟩

Documents récupérés de l'archive ouverte HAL logo