NMR of biomolecules

Group leaders: Céline LANDON & Karine LOTH

The research activities of the NMR group focus on the determination of the 3D solution structures of biomolecules from NMR data. While a wide range of biological questions are addressed, the constant objective in all these studies is to establish relationships between the biomolecules NMR 3D structures and their biological functions.
Most of the time structural studies involve studying the interactions with other biological molecules (DNA-protein, protein-peptide or protein-ligand complexes), and the dynamics in the free or bound form.
Up to now, NMR has been the main technique used to develop our research projects, combined with molecular modelling and docking techniques.

I. Small cystein-rich defense proteins

Our biological research theme concentrates on small cystein-rich defense proteins. The aim is to advance our understanding of the mechanism of action at the atomic level. It will lead us to study complex systems by liquid NMR and to closely associate a series of complementary biophysical or biological techniques.

Two families of small cystein-rich defense proteins are studied: Antimicrobial proteins and entomotoxins, adopting different 3D folds and different disulfide bridges arrays. Many of these molecules are now obtained by chemical synthesis in close collaboration with A. Delmas’ group.

3 levels are explored:
- Studying new molecules with therapeutic/agronomic interest
- Exploring other biological functions
- Understanding the mechanism of action at the atomic level

II. methodological expertise: nmr, modelling and docking

In order to respond to the variety of questions addressed by our biologist collaborators, we carry on a series of more methodological NMR projects. The defense proteins projects and these methodological expertises are mutually supportive, and are inseparable.

Ex1 : The folding dynamics of the dimeric
protein HU involved in the cold response.

rmn_structure_3d_dimere_proteine_hu_1_pour_internet.gif
Structure 3D du dimère de la protéine HU de E. Coli (Le Meur et al. En prep)

Ex2 : MC1 is a small architectural protein
from Methanosarcina which curves and
compacts the DNA of these Archaea.

rmn_modele_complexe_mc1_adn_courbe_pour_internet.gif
Modèle du complexe entre MC1 et l’ADN courbé (Paquet et al . 2014)

III.Métabolomic

A very recent development of our research concerns the metabolomic approach of various pathologies (phenylketonuria, Huntington's disease, glioma). We seek to identify characteristic metabolites to better understand their pathways of biosynthesis and degradation and possibly develop new therapeutic strategies.

NMR spectrometers
Techniques in few words
Software

significant publications:

  • Guyot N., Meudal H., Trapp , Iochmann S., Silvestre A ., Jousset G., Labas V., Reverdiau P., Loth K., Hervé V., Aucagne V., Delmas A.F., Rehault-Godbert S., Landon C. Structure, function and evolution of Gga-AvBD11, the archetype of a new structural avian-double-β-defensin family. Proc. Natl. Acad. Sci. USA (2020) 117, 337-345. doi : 10.1073/pnas.1912941117
  • Loth K., Vergnes A., Barreto C., Voisin S.N., Meudal H., Da Silva J., Bressan A., Belmadi N., Bachère E., Aucagne V., Cazevielle C., Marchandin H., Rosa R.D., Bulet P., Touqui L., Delmas A.F., Destoumieux-Garzon D. The ancestral N-terminal domain of big defensins drives bacteria-triggered assembly into antimicrobial nanonets. mBio (2019) 10(5). pii: e01821-19. doi : 10.1128/mBio.01821-19
  • Loth K., Largillière J., Coste F., Culard F., Landon C., Delmas A.F., Castaing B., Paquet F. New protein-DNA complexes in archaea: a small monomeric protein induces a sharp V turn DNA structure. Sci Rep 2019 9, 14253. doi : 10.1038/s41598-019-50211-2
  • Hervé-Grepinet, V., Meudal, H., Labas, V., Réhault-Godbert, S., Gautron, J., Berges, M., Guyot, N., Delmas, A. F., Nys, Y., and Landon, C.
    3D NMR structure of hen egg gallin (chicken ovo-defensin) reveals a new variation of the beta-defensin fold.
    J. Biol. Chem. (2014) 289, 7211-20
  • Senille, V., Lelievre, D., Paquet, F., Garnier, N., Lamb, N., Legrand, A., Delmas, A. F., and Landon, C.
    The addressing fragment of mitogaligin : first insights into functional and structural properties.
    Chembiochem : a European journal of chemical biology (2013) 14, 711-720. doi : 10.1074/jbc.M113.507046


255 documents

Article dans une revue

  • Steve Reynaud, Justyna Ciolek, Michel Degueldre, Natalie Saez, Ana Filipa Sequeira, et al.. A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists. Journal of Medicinal Chemistry, American Chemical Society, 2020, 63 (15), pp.8250-8264. ⟨10.1021/acs.jmedchem.0c00485⟩. ⟨hal-02936788⟩
  • Nicolas Guyot, Hervé Meudal, Sascha Trapp, Sophie Iochmann, Anne Silvestre, et al.. Structure, function, and evolution of Gga -AvBD11, the archetype of the structural avian-double-β-defensin family. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2020, 117 (1), pp.337-345. ⟨10.1073/pnas.1912941117⟩. ⟨hal-02522250⟩
  • Marylène Bertrand, Martine Decoville, Herve Meudal, Serge Birman, Celine Landon. Metabolomic Nuclear Magnetic Resonance Studies at Presymptomatic and Symptomatic Stages of Huntington’s Disease on a Drosophila Model. Journal of Proteome Research, American Chemical Society, 2020, 19 (10), pp.4034-4045. ⟨10.1021/acs.jproteome.0c00335⟩. ⟨hal-02968233⟩
  • Thomas Aumer, Sébastien Voisin, Thomas Knobloch, Celine Landon, Philippe Bulet. Impact of an Antifungal Insect Defensin on the Proteome of the Phytopathogenic Fungus Botrytis cinerea. Journal of Proteome Research, American Chemical Society, 2020, 19 (3), pp.1131-1146. ⟨10.1021/acs.jproteome.9b00638⟩. ⟨hal-02974447⟩
  • Mylène Wartenberg, Ahlame Saidi, Mathieu Galibert, Alix Joulin-Giet, Julien Burlaud-Gaillard, et al.. Imaging of extracellular cathepsin S activity by a selective near infrared fluorescence substrate-based probe. Biochimie, Elsevier, 2019, ⟨10.1016/j.biochi.2019.03.013⟩. ⟨hal-02088627⟩
  • Monika Cieslikiewicz-Bouet, Svetlana Eliseeva, Vincent Aucagne, A.F. Delmas, Isabelle Gillaizeau, et al.. Near-infrared emitting lanthanide( iii ) complexes as prototypes of optical imaging agents with peptide targeting ability: a methodological approach. RSC Advances, Royal Society of Chemistry, 2019, 9 (3), pp.1747-1751. ⟨10.1039/c8ra09419e⟩. ⟨hal-02064990⟩
  • Karine Loth, Justine Largillière, Franck Coste, Françoise Culard, Céline Landon, et al.. New protein-DNA complexes in archaea: a small monomeric protein induces a sharp V-turn DNA structure. Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-50211-2⟩. ⟨hal-02306224⟩
  • Karine Loth, Agnès Vergnes, Cairé Barreto, Sébastien Voisin, Hervé Meudal, et al.. The Ancestral N-Terminal Domain of Big Defensins Drives Bacterially Triggered Assembly into Antimicrobial Nanonets. mBio, American Society for Microbiology, 2019, 10 (5), pii: e01821-19. ⟨10.1128/mBio.01821-19⟩. ⟨hal-02328576⟩
  • Claude Zoukimian, Hervé Meudal, Stephan de Waard, Karima Ait Ouares, Sébastien Nicolas, et al.. Synthesis by native chemical ligation and characterization of the scorpion toxin AmmTx3. Bioorganic & Medicinal Chemistry, 2019, 27 (1), pp.247-253. ⟨10.1016/j.bmc.2018.12.009⟩. ⟨hal-02522016⟩
  • Matthieu Galibert, Mylène Wartenberg, Fabien Lecaille, Ahlame Saidi, Sylvie Mavel, et al.. Substrate-derived triazolo- and azapeptides as inhibitors of cathepsins K and S. European Journal of Medicinal Chemistry, Elsevier, 2018, 144, pp.201 - 210. ⟨10.1016/j.ejmech.2017.12.012⟩. ⟨hal-01702303⟩
  • Victor Terrier, Agnès F. Delmas, Vincent Aucagne. Efficient synthesis of cysteine-rich cyclic peptides through intramolecular native chemical ligation of N-Hnb-Cys peptide crypto-thioesters. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2017, 15 (2), pp.316 - 319. ⟨10.1039/c6ob02546c⟩. ⟨hal-01618781⟩
  • H Blasco, C Veyrat-Durebex, M Bertrand, F Patin, F Labarthe, et al.. A Multiplatform Metabolomics Approach to Characterize Plasma Levels of Phenylalanine and Tyrosine in Phenylketonuria.. JIMD reports, 2017, pp.69-79. ⟨10.1007/8904_2016_568⟩. ⟨hal-01622559⟩
  • Fabien Kieken, Karine Loth, Nico van Nuland, Peter Tompa, Tom Lenaerts. Chemical shift assignments of the partially deuterated Fyn SH2–SH3 domain. Biomolecular NMR Assignments, Springer, 2017, ⟨10.1007/s12104-017-9792-1⟩. ⟨hal-01673443⟩
  • Vanessa Eyraud, Séverine Balmand, Lamis Karaki, Isabelle Rahioui, Catherine Sivignon, et al.. The interaction of the bioinsecticide PA1b (Pea Albumin 1 subunit b) with the insect V-ATPase triggers apoptosis. Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.4902. ⟨10.1038/s41598-017-05315-y⟩. ⟨hal-01558484⟩
  • Geoffrey Bailleul, Amanda Kravtzoff, Alix Joulin-Giet, Fabien Lecaille, Valérie Labas, et al.. The unusual resistance of avian defensin AvBD7 to proteolytic enzymes preserves its antibacterial activity. PLoS ONE, Public Library of Science, 2016, 11 (8), pp.1-20. ⟨10.1371/journal.pone.0161573⟩. ⟨hal-01594888⟩
  • Dominique Lelièvre, Victor P. Terrier, Agnès F. Delmas, Vincent Aucagne. Native Chemical Ligation Strategy to Overcome Side Reactions during Fmoc-Based Synthesis of C-Terminal Cysteine-Containing Peptides. Organic Letters, American Chemical Society, 2016, 18 (5), pp.920 - 923. ⟨10.1021/acs.orglett.5b03612⟩. ⟨hal-01407492⟩
  • Karine Loth, Soha Abou Ibrahim Alami, Chahrazed Habès, Solène Garrido, Vincent Aucagne, et al.. Complete 1H, 15N and 13C assignment of trappin-2 and 1H assignment of its two domains, elafin and cementoin. Biomolecular NMR Assignments, Springer, 2016, 10 (1), pp.223 - 226. ⟨10.1007/s12104-016-9671-1⟩. ⟨hal-01407495⟩
  • Victor P. Terrier, Hélène Adihou, Mathieu Arnould, Agnès F. Delmas, Vincent Aucagne. A straightforward method for automated Fmoc-based synthesis of bio-inspired peptide crypto-thioesters. Chemical Science , The Royal Society of Chemistry, 2016, 7 (1), pp.339 - 345. ⟨10.1039/C5SC02630J⟩. ⟨hal-01407765⟩
  • Caroline Decourt, Vincent Robert, Karine Anger, Mathieu Galibert, Jean-Baptiste Madinier, et al.. A synthetic kisspeptin analog that triggers ovulation and advances puberty. Scientific Reports, Nature Publishing Group, 2016, 6, pp.26908. ⟨10.1038/srep26908⟩. ⟨hal-01406943⟩
  • Julien Verdon, Pierre Coutos-Thevenot, Marie-Helene Rodier, Celine Landon, Segolene Depayras, et al.. Armadillidin H, a Glycine-Rich Peptide from the Terrestrial Crustacean Armadillidium vulgare, Displays an Unexpected Wide Antimicrobial Spectrum with Membranolytic Activity.. Frontiers in Microbiology, Frontiers Media, 2016, 7, pp.1484. ⟨hal-01427916⟩
  • Fatima Oukhatar, Hervé Meudal, Céline Landon, Nikos K Logothetis, Carlos Platas-Iglesias, et al.. Macrocyclic Gd(3+) Complexes with Pendant Crown Ethers Designed for Binding Zwitterionic Neurotransmitters.. Chemistry - A European Journal, Wiley-VCH Verlag, 2015, 21 (31), pp.11226-11237. ⟨hal-01196981⟩
  • R. Le Meur, Françoise Culard, V. Nadan, S. Goffinont, F. Coste, et al.. The nucleoid-associated protein HU enhances 8-oxoguanine base excision by the formamidopyrimidine-DNA glycosylase. Biochemical Journal, Portland Press, 2015, 471 (1), pp.13-23. ⟨10.1042/BJ20150387⟩. ⟨hal-01216639⟩
  • Karine Loth, Céline Landon, Françoise Paquet. Chemical shifts assignments of the archaeal MC1 protein and a strongly bent 15 base pairs DNA duplex in complex. Biomolecular NMR Assignments, Springer, 2015, 9 (1), pp.215-217. ⟨10.1007/s12104-014-9577-8⟩. ⟨hal-01171478⟩
  • Rémy Le Meur, Karine Loth, Françoise Culard, Bertrand Castaing, Céline Landon. Backbone assignment of the three dimers of HU from Escherichia coli at 293 K: EcHUα2, EcHUβ2 and EcHUαβ. Biomolecular NMR Assignments, Springer, 2015, 9 (2), pp.359-363. ⟨10.1007/s12104-015-9610-6⟩. ⟨hal-01171467⟩
  • Mathieu Galibert, Véronique Piller, Friedrich Piller, Vincent Aucagne, Agnès F. Delmas. Combining triazole ligation and enzymatic glycosylation on solid phase simplifies the synthesis of very long glycoprotein analogues. Chemical Science , The Royal Society of Chemistry, 2015, 6 (6), pp.3617-3623. ⟨10.1039/C5SC00773A⟩. ⟨hal-01178852⟩
  • Massimiliano Beltramo, Vincent Robert, Mathieu Galibert, Jean-Baptiste Madinier, Philippe Marceau, et al.. Rational Design of Triazololipopeptides Analogs of Kisspeptin Inducing a Long-Lasting Increase of Gonadotropins. Journal of Medicinal Chemistry, American Chemical Society, 2015, 58 (8), pp.3459-3470. ⟨10.1021/jm5019675⟩. ⟨hal-01170460⟩
  • Marylène Bertrand, Annie Chabin, Cyril Colas, Martine Cadène, Didier Chaput, et al.. The AMINO experiment: exposure of amino acids in the EXPOSE-R experiment on the International Space Station and in laboratory. International Journal of Astrobiology, Cambridge University Press (CUP), 2015, 14 (01), pp.89-97. ⟨10.1017/S1473550414000354⟩. ⟨hal-01170486⟩
  • Hervé Cottin, K. Saiagh, Y.Y. Guan, M. Cloix, D. Khalaf, et al.. The AMINO experiment: a laboratory for astrochemistry and astrobiology on the EXPOSE-R facility of the International Space Station. International Journal of Astrobiology, Cambridge University Press (CUP), 2015, 14 (01), pp.67-77. ⟨10.1017/S1473550414000500⟩. ⟨hal-01107510⟩
  • Karine Loth, Denis Costechareyre, Géraldine Effantin, Yvan Rahbé, Guy Condemine, et al.. New Cyt-like δ-endotoxins from Dickeya dadantii: structure and aphicidal activity.. Scientific Reports, Nature Publishing Group, 2015, 5, pp.8791. ⟨10.1038/srep08791⟩. ⟨hal-01124447⟩
  • Frances Westall, Frédéric Foucher, Nicolas Bost, Marylène Bertrand, Damien Loizeau, et al.. Biosignatures on Mars: What, Where, and How? Implications for the Search for Martian Life. Astrobiology, Mary Ann Liebert, 2015, 15 (11), pp.998-1029. ⟨10.1089/ast.2015.1374⟩. ⟨insu-01234353⟩
  • Hervé Cottin, Kafila Saiagh, D. Nguyen, Noël Grand, Yves Bénilan, et al.. Photochemical studies in low Earth orbit for organic compounds related to small bodies, Titan and Mars. Current and future facilities.. Bulletin de la Société Royale des Sciences de Liège, 2015, 84, pp.60 - 73. ⟨hal-01110518⟩
  • Isidore E. Decostaire, Dominique Lelièvre, Vincent Aucagne, Agnès F. Delmas. Solid phase oxime ligations for the iterative synthesis of polypeptide conjugates. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2014, 12 (29), pp.5536-5543. ⟨10.1039/c4ob00760c⟩. ⟨hal-01178857⟩
  • Françoise Paquet, Olivier Delalande, Stephane Goffinont, Françoise Culard, Karine Loth, et al.. Model of a DNA-protein complex of the architectural monomeric protein MC1 from Euryarchaea. PLoS ONE, Public Library of Science, 2014, 9 (2), pp.e88809. ⟨10.1371/journal.pone.0088809⟩. ⟨hal-01063974⟩
  • Fanny Meindre, Dominique Lelièvre, Karine Loth, Oriane Mith, Vincent Aucagne, et al.. The nuclear magnetic resonance solution structure of the synthetic AhPDF1.1b plant defensin evidences the structural feature within the γ-motif. Biochemistry, American Chemical Society, 2014, 53 (49), pp.7745-54. ⟨10.1021/bi501285k⟩. ⟨hal-01118914⟩
  • Virginie Hervé, Hervé Meudal, Valérie Labas, Sophie Réhault-Godbert, Joël Gautron, et al.. Three-dimensional NMR Structure of Hen Egg Gallin (Chicken Ovodefensin) Reveals a New Variation of the β-Defensin Fold. Journal of Biological Physics and Chemistry, Basel, Switzerland : Collegium Basilea (Institute of Advanced Study) ; Tbilisi : Association of Modern Scientific Investigation (AMSI), 2014, 289 (10), pp.7211-20. ⟨10.1074/jbc.M113.507046⟩. ⟨hal-01118312⟩
  • Stephen P. Muench, Shaun Rawson, Vanessa Eyraud, Agnès F. Delmas, Pedro da Silva, et al.. PA1b Inhibitor Binding to Subunits c and e of the Vacuolar ATPase Reveals its Insecticidal Mechanism. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2014, 289 (23), pp.16399-16408. ⟨10.1074/jbc.M113.541250⟩. ⟨hal-01179517⟩
  • Violette Senille, Dominique Lelievre, Françoise Paquet, Norbert Garnier, Ned Lamb, et al.. The addressing fragment of mitogaligin: first insights into functional and structural properties.. ChemBioChem, Wiley-VCH Verlag, 2013, 14 (6), pp.711-20. ⟨10.1002/cbic.201200715⟩. ⟨hal-00817503⟩
  • Laurent Raibaut, Hélène Adihou, Rémi Desmet, Agnès F. Delmas, Vincent Aucagne, et al.. Highly efficient solid phase synthesis of large polypeptides by iterative ligations of bis(2-sulfanylethyl)amido (SEA) peptide segments. Chemical Science , The Royal Society of Chemistry, 2013, 4, pp.4061-4066. ⟨10.1039/c3sc51824h⟩. ⟨hal-00944814v2⟩
  • Karine Loth, Manuel Gnida, Julija Romanuka, Robert Kaptein, Rolf Boelens. Sliding and target location of DNA-binding proteins:an NMR view of the lac repressor system.. Journal of Biomolecular NMR, Springer Verlag, 2013, epub ahead of print. ⟨10.1007/s10858-013-9723-0⟩. ⟨hal-00817496⟩
  • Francès Westall, D. Loizeau, Frédéric Foucher, Nicolas Bost, Marylène Bertrand, et al.. Habitability on Mars from a Microbial Point of View. Astrobiology, Mary Ann Liebert, 2013, 13 (9), pp.887-897. ⟨10.1089/ast.2013.1000⟩. ⟨insu-00866015⟩
  • Corinne Buré, Philippe Marceau, Hervé Meudal, Agnès F Delmas. Synthesis and analytical investigation of C-terminally modified peptide aldehydes and ketone: application to oxime ligation.. Journal of Peptide Science, Wiley, 2012, 18 (3), pp.147-54. ⟨10.1002/psc.1429⟩. ⟨hal-00721799⟩
  • Christelle Gaulier, Audrey Hospital, Bertrand Legeret, Delmas A.F., Vincent Aucagne, et al.. A water soluble Cu-I-NHC for CuAAC ligation of unprotected peptides under open air conditions.. Chemical Communications, Royal Society of Chemistry, 2012, 48, pp.4005-4007. ⟨hal-00711780⟩
  • Marylène Bertrand, Annie Chabin, André Brack, H. Cottin, D. Chaput, et al.. The PROCESS Experiment: Exposure of Amino Acids in the EXPOSE-E Experiment on the International Space Station and in Laboratory Simulations.. Astrobiology, Mary Ann Liebert, 2012, 12 (5), pp.426-35. ⟨10.1089/ast.2011.0755⟩. ⟨hal-00721777⟩
  • Hervé Cottin, Yuan Yong Guan, Audrey Noblet, Olivier Poch, Kafila Saiagh, et al.. The PROCESS Experiment: An Astrochemistry Laboratory for Solid and Gaseous Organic Samples in Low-Earth Orbit. Astrobiology, Mary Ann Liebert, 2012, 12 (5), pp.412-425. ⟨10.1089/ast.2011.0773⟩. ⟨hal-00710533⟩
  • Laurette Tavel, Lucie Jaquillard, Andreas I Karsisiotis, Fabienne Saab, Laurence Jouvensal, et al.. Ligand binding study of human PEBP1/RKIP: interaction with nucleotides and Raf-1 peptides evidenced by NMR and mass spectrometry.. PLoS ONE, Public Library of Science, 2012, 7 (4), pp.e36187. ⟨10.1371/journal.pone.0036187⟩. ⟨hal-00726284⟩
  • Ibai E Valverde, Fabien Lecaille, Gilles Lalmanach, Vincent Aucagne, Agnès F Delmas. Synthesis of a biologically active triazole-containing analogue of cystatin A through successive peptidomimetic alkyne-azide ligations.. Angewandte Chemie (English Edition), John Wiley & Sons, 2012, 51 (3), pp.718-22. ⟨10.1002/anie.201107222⟩. ⟨hal-00726293⟩
  • Chrystelle Derache, Hervé Meudal, Vincent Aucagne, Kevin J Mark, Martine Cadène, et al.. Initial insights into structure-activity relationships of avian defensins.. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (10), pp.7746-55. ⟨10.1074/jbc.M111.312108⟩. ⟨hal-00721842⟩
  • Vincent Aucagne, Ibai E Valverde, Philippe Marceau, Mathieu Galibert, Nabil Dendane, et al.. Towards the simplification of protein synthesis: iterative solid-supported ligations with concomitant purifications.. Angewandte Chemie (English Edition), John Wiley & Sons, 2012, 51 (45), pp.11320-4. ⟨10.1002/anie.201206428⟩. ⟨hal-00748170⟩
  • Pierre de Marcellus, Marylène Bertrand, Michel Nuevo, Frances Westall, Louis Le Sergeant d'Hendecourt. Prebiotic significance of extraterrestrial ice photochemistry: detection of hydantoin in organic residues.. Astrobiology, Mary Ann Liebert, 2011, 11 (9), pp.847-54. ⟨10.1089/ast.2011.0677⟩. ⟨hal-00720601⟩
  • Julie Hardouin, Anne-Gaelle Cremer, Agnes F. Delmas. Investigation of in-source decay of oxime-linked peptide by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry, Wiley, 2011, 25 (14), pp.2106-2112. ⟨10.1002/rcm.5071⟩. ⟨hal-00614901⟩
  • Norbert Garnier, Karine Loth, Franck Coste, Rafal Augustyniak, Virginie Nadan, et al.. An alternative flexible conformation of the E. coli HU beta(2) protein: structural, dynamics, and functional aspects. European Biophysics Journal, Springer Verlag (Germany), 2011, 40 (2), pp.117-129. ⟨10.1007/s00249-010-0630-y⟩. ⟨hal-00602370⟩
  • Mickaël Krzeminski, Karine Loth, Rolf Boelens, Alexandre Bonvin. SAMPLEX: automatic mapping of perturbed and unperturbed regions of proteins and complexes.. BMC Bioinformatics, BioMed Central, 2010, 11 (1), pp.51. ⟨10.1186/1471-2105-11-51⟩. ⟨inserm-00663535⟩
  • Gilles J. P. Rautureau, Françoise Vovelle, Françoise Schoentgen, Martine Decoville, Daniel Locker, et al.. NMR structure of a Phosphatidyl-ethanolamine Binding Protein from drosophila. Proteins - Structure, Function and Bioinformatics, Wiley, 2010, 78 (6), pp.1606-1610. ⟨10.1002/prot.22682⟩. ⟨hal-00453409⟩
  • Gilles J P Rautureau, Françoise Vovelle, Françoise Schoentgen, Martine Decoville, Daniel Locker, et al.. NMR structure of a phosphatidyl-ethanolamine binding protein from Drosophila.. Proteins - Structure, Function and Bioinformatics, Wiley, 2010, 78 (6), pp.1606-10. ⟨10.1002/prot.22682⟩. ⟨hal-00734254⟩
  • Françoise Paquet, Karine Loth, Hervé Meudal, Francoise Culard, Daniel Genest, et al.. Refined solution structure and backbone dynamics of the archaeal MC1 protein. FEBS Journal, Wiley, 2010, 277 (24), pp.5133-5145. ⟨10.1111/j.1742-4658.2010.07927.x⟩. ⟨hal-00602469⟩
  • Pedro da Silva, Isabelle Rahioui, Christian Laugier, Laurence Jouvensal, Hervé Meudal, et al.. Molecular requirements for the insecticidal activity of the plant peptide pea albumin 1 subunit b (PA1b).. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2010, 285 (43), pp.32689-94. ⟨10.1074/jbc.M110.147199⟩. ⟨hal-00591660⟩
  • Annie Chabin, Marylène Bertrand, André Brack, H. Cottin, Frances Westall. Exposure of Amino Acids on the International Space Station: EXPOSE-Eutef and EXPOSE-R. Origins of Life and Evolution of Biospheres, Springer Verlag, 2009, 39 (3-4 Sp. Iss. SI), pp.352-353. ⟨hal-00521873⟩
  • Marylène Bertrand, Sjerry van der Gaast, Faith Vilas, Friedrich Hörz, Gerald Haynes, et al.. Effect of impact shock simulation on amino acids. Origins of Life and Evolution of Biospheres, Springer Verlag, 2009, 393, pp.52-53. ⟨hal-00527525⟩
  • Gilles Rautureau, Laurence Jouvensal, Francoise Vovelle, Francoise Schoentgen, Daniel Locker, et al.. EXPRESSION AND CHARACTERIZATION OF THE PEBP HOMOLOG GENES FROM Drosophila. Archives of Insect Biochemistry and Physiology, Wiley, 2009, pp.1. ⟨hal-00490329⟩
  • P. da Silva, A. Strzepa, L. Jouvensal, I. Rahioui, F. Gressent, et al.. A folded and functional synthetic PA1b, an interlocked entomotoxic miniprotein. Biopolymers, Wiley, 2009, sous-presse (5), pp.1-1. ⟨10.1002/bip.21217⟩. ⟨hal-00391296⟩
  • Marylène Bertrand, Sjerry van der Gaast, Faith Vilas, Friedrich Hoerz, Gerald Haynes, et al.. The Fate of Amino Acids During Simulated Meteoritic Impact. Astrobiology, Mary Ann Liebert, 2009, 9 (10), pp.943-951. ⟨10.1089/ast.2008.0327⟩. ⟨hal-00521727⟩
  • Corinne Bure, Régine Maget, Agnès F. Delmas, Chantal Pichon, Patrick Midoux. Histidine-rich peptide: evidence for a single zinc-binding site on H5WYG peptide that promotes membrane fusion at neutral pH. Journal of Mass Spectrometry, Wiley-Blackwell, 2009, 44 (1), pp.81-89. ⟨10.1002/jms.1473⟩. ⟨hal-00521834⟩
  • Yves Aubert, Marcel Chassignol, Victoria Roig, Gladys Mbemba, Julien Weiss, et al.. Synthesis and anti-HIV-1 integrase activity of modified dinucleotides. European Journal of Medicinal Chemistry, Elsevier, 2009, 44 (12), pp.5029-5044. ⟨10.1016/j.ejmech.2009.09.007⟩. ⟨hal-00521651⟩
  • Ibai E. Valverde, Agnès F. Delmas, Vincent Aucagne. Click a la carte: robust semi-orthogonal alkyne protecting groups for multiple successive azide/alkyne cycloadditions. Tetrahedron, Elsevier, 2009, 65 (36), pp.7597-7602. ⟨10.1016/j.tet.2009.06.093⟩. ⟨hal-00525398⟩
  • Chrystelle Derache, Valérie Labas, Vincent Aucagne, Hervé Meudal, Céline Landon, et al.. Primary Structure and Antibacterial Activity of Chicken Bone Marrow-Derived beta-Defensins. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2009, 53 (11), pp.4647-4655. ⟨10.1128/AAC.00301-09⟩. ⟨hal-00522326⟩
  • Pedro da Silva, Anna Strzepa, Laurence Jouvensal, Isabelle Rahioui, Frédéric Gressent, et al.. A Folded and Functional Synthetic PA1b: An Interlocked Entomotoxic Miniprotein. Biopolymers / Biopolymers (Biospectroscopy); Biopolymers (Pept Sci ); Biopolymers (Peptide Sci ); Biopolymers (Pept Sci); Biopolymers, 2009, 62 (5), pp.436-444. ⟨10.1002/bip.21217⟩. ⟨hal-00521878⟩
  • Corinne Buré, Stéphane Goffinont, Agnès F. Delmas, Martine Cadene, Françoise Culard. Oxidation-sensitive residues mediate the DNA-bending activity of MC1 protein. Journal of Molecular Biology, Elsevier, 2008, 376 (1), pp.120-130. ⟨10.1016/j.jmb.2007.11.057⟩. ⟨hal-00283220⟩
  • Céline Landon, Florent Barbault, Michèle Legrain, Marc Guenneugues, Françoise Vovelle. Rational design of peptides active against the Gram positive bacteria Staphylococcus aureus. Proteins - Structure, Function and Bioinformatics, Wiley, 2008, 72 (1), pp.229-239. ⟨10.1002/prot.21912⟩. ⟨hal-00283359⟩
  • Marylène Bertrand, Annie Chabin, André Brack, Frances Westall. Separation of amino acid enantiomers via chiral derivatization and non chiral column by gas chromatography. Journal of Chromatography A, Elsevier, 2008, 1180 (1-2), pp.131-137. ⟨10.1016/j.chroma.2007.12.004⟩. ⟨hal-00282553⟩
  • Dominique Lelièvre, P. Barta, Vincent Aucagne, A.F. Delmas. Preparation of peptide thioesters using Fmoc strategy through hydroxyl side chain anchoring. Tetrahedron Letters, Elsevier, 2008, 49 (25), pp.4016-4019. ⟨10.1016/j.tetlet.2008.04.087⟩. ⟨hal-00518141⟩
  • Thomas Chauvin, Philippe Durand, Michèle Bernier, Hervé Meudal, Bich-Thuy Doan, et al.. Detection of enzymatic activity by PARACEST MRI: a general approach to target a large variety of enzymes. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2008, 47 (23), pp.4370-4372. ⟨10.1002/anie.200800809⟩. ⟨hal-00283242⟩
  • Gilles Rautureau, Laurence Jouvensal, Francoise Schoentgen, Francoise Vovelle. 1H, 15N and 13C resonance assignments of CG7054, a new PEBP from Drosophila melanogaster. J Biomol NMR, 2007, 38, pp.187. ⟨10.1007/s10858-006-9112-z⟩. ⟨hal-00646035⟩
  • Marcos A Fázio, Laurence Jouvensal, Françoise Vovelle, Philippe Bulet, M Terêsa M Miranda, et al.. Biological and structural characterization of new linear gomesin analogues with improved therapeutic indices.. Biopolymers / Biopolymers (Biospectroscopy); Biopolymers (Pept Sci ); Biopolymers (Peptide Sci ); Biopolymers (Pept Sci); Biopolymers, 2007, 88 (3), pp.386-400. ⟨10.1002/bip.20660⟩. ⟨hal-00286196⟩
  • Gilles Rautureau, Laurence Jouvensal, Francoise Schoentgen, Francoise Vovelle. 1H, 15N and 13C resonance assignments of CG7054, a new PEBP from Drosophila melanogaster. J Biomol NMR, 2007, 38, pp.187. ⟨10.1007/s10858-006-9112-z⟩. ⟨hal-00490353⟩
  • Gilles Rautureau, Laurence Jouvensal, Françoise Schoentgen, Françoise Vovelle. 1H, 15N and 13C resonance assignments of CG7054, a new PEBP from Drosophila melanogaste. Journal of Biomolecular NMR, Springer Verlag, 2007, 38 (2), pp.187. ⟨10.1007/s10858-006-9112-z⟩. ⟨hal-00159615⟩
  • Marcos A. Fázio, Laurence Jouvensal, Françoise Vovelle, Philippe Bulet, M. Terêsa M. Miranda, et al.. Biological and structural characterization of new linear gomesin analogues with improved therapeutic indices. Peptide Science, John Wiley & Sons, Ltd, 2007, 88 (3), pp.386-400. ⟨10.1002/bip.20660⟩. ⟨hal-00159531⟩
  • Anne-Laure Rollet, Patrice Porion, Michel Vaultier, Isabelle Billard, Michael Deschamps, et al.. Anomalous diffusion of water in [BMIM][TFSI] room-temperature ionic liquid.. Journal of Physical Chemistry B, American Chemical Society, 2007, 111 (41), pp.11888-91. ⟨10.1021/jp075378z⟩. ⟨hal-00181174⟩
  • Isidore P. Decostaire, Dominique Lelièvre, Vincent Aucagne, Agnès F. Delmas. Synergic effect of hydride and proton donors in the Pd(0)-mediated deprotection of Nα-Aloc proline derivatives. Tetrahedron Letters, Elsevier, 2007, 48, pp.6523-6526. ⟨10.1016/j.tetlet.2007.07.061⟩. ⟨hal-00166600⟩
  • G. Rautureau, L. Jouvensal, M. Decoville, D. Locker, F. Vovelle, et al.. Cloning, high yield over-expression, purification, and characterization of CG18594, a new PEBP/RKIP family member from Drosophila melanogaster. Protein Expression and Purification, Elsevier, 2006, 48, pp.90-97. ⟨10.1016/j.pep.2006.01.020⟩. ⟨hal-00088927⟩
  • Gaëlle-Anne Cremer, Hanane Tariq, Agnes F. Delmas. Combining a polar resin and a pseudo-proline to optimize the solid-phase synthesis of a 'difficult sequence'. Journal of Peptide Science, Wiley, 2006, 12 (6), pp.437-442. ⟨10.1002/psc.746⟩. ⟨hal-00168623⟩
  • Gaëlle-Anne Cremer, Nicole Bureaud, Véronique Piller, Horst Kunz, Friedrich Piller, et al.. Synthesis and biological evaluation of a multiantigenic Tn/TF-containing glycopeptide mimic of the tumor-related MUC1 glycoprotein. ChemMedChem, Wiley-VCH Verlag, 2006, 1 (9), pp.965-968. ⟨10.1002/cmdc.200600104⟩. ⟨hal-00168620⟩
  • Céline Landon, H. Meudal, Nathalie Boulanger, Philippe Bulet, Françoise Vovelle. Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation. Biopolymers, Wiley, 2006, 81 (2), pp.92-103. ⟨10.1002/bip.20370⟩. ⟨hal-00088871⟩
  • J. Hardouin, M. Hubert-Roux, A.F. Delmas, C. Lange. Identification of isoenzymes using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry, Wiley, 2006, 20, pp.725-732. ⟨10.1002/rcm.2355⟩. ⟨hal-00088855⟩
  • Nelly Morellet, Hervé Meudal, Serge Bouaziz, Bernard Pierre Roques. Structure of the zinc finger domain encompassing residues 13–51 of the nucleocapsid protein from simian immunodeficiency virus. Biochemical Journal, Portland Press, 2006, 393 (3), pp.725-732. ⟨10.1042/BJ20051203⟩. ⟨hal-02122534⟩
  • C. BurÉ, B. Castaing, C. Lange, A.F. Delmas. Location and base selectivity on fragmentation of brominated oligodeoxynucleotides. Journal of Mass Spectrometry, Wiley-Blackwell, 2006, 41 (1), pp.84-90. ⟨10.1002/jms.967⟩. ⟨hal-00088837⟩
  • Y. Bilbille, F. Paquet, H. Meudal, M.J. Giraud-Panis, G. Lancelot. NMR studies of telomeric nucleoprotein complexes involving the Myb-like domain of the human telomeric protein TRF2. Comptes Rendus Chimie, Elsevier Masson, 2006, 9 (3-4), pp.452-458. ⟨10.1016/j.crci.2005.06.019⟩. ⟨hal-00088835⟩
  • G.A. Cremer, H. Tariq, A.F. Delmas. Combining a polar resin and a pseudo-proline to optimize the solid-phase synthesis of a 'difficult sequence'. Journal of peptide science : an official publication of the European Peptide Society., 2006, 12, pp.437-442. ⟨hal-00088839⟩
  • Isidore P. Decostaire, Dominique Lelièvre, Zhang Haihui, Agnès F. Delmas. Controlling the outcome of overacylation of N-protected aminooxyacetic during the synthesis of aminooxy-peptide for chemical ligation. Tetrahedron Letters, Elsevier, 2006, 47 (39), pp.7057-7060. ⟨hal-00168750⟩
  • Decostaire I.P., D. Lelièvre, H. Zhang, Delmas A.F.. Controlling the outcome of overacylation of N-protected aminooxyacetic during the synthesis of aminooxy-peptide for chemical ligation. Tetrahedron Letters, Elsevier, 2006, 47, pp.7057-7060. ⟨10.1016/j.tetlet.2006.07.092⟩. ⟨hal-00110251⟩
  • P. da Silva, C. Landon, R. Beltoise, M. Ponchet, F. Vovelle. Accessibility of tobacco lipid transfer protein cavity revealed by 15N NMR relaxation studies and molecular dynamics simulations. Proteins - Structure, Function and Bioinformatics, Wiley, 2006, 64, pp.124-132. ⟨10.1002/prot.20971⟩. ⟨hal-00088840⟩
  • P. Marceau, C. BurÉ, A.F. Delmas. Efficient synthesis of C-terminal modified peptide ketones for chemical ligations. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2005, 15, pp.5442-5445. ⟨hal-00088623⟩
  • A. Antonopoulos, J. Hardouin, P. Favetta, W. Helbert, A.F. Delmas, et al.. Matrix-assisted laser desorption/ionisation mass spectrometry for the direct analysis of enzymatically digested kappa- iota- and hybrid iota/nu-carrageenans. Rapid Communications in Mass Spectrometry, Wiley, 2005, 19, pp.2217-2226. ⟨hal-00088480⟩
  • Aristotelis Antonopoulos, Julie Hardouin, Patrick Favetta, William Helbert, Agnès Delmas, et al.. Matrix-assisted laser desorption/ionisation mass spectrometry for the direct analysis of enzymatically digestedkappa-iota- and hybridiota/nu-carrageenans. Rapid Communications in Mass Spectrometry, Wiley, 2005, 19 (16), pp.2217-2226. ⟨10.1002/rcm.2051⟩. ⟨hal-02146666⟩
  • P. da Silva, C. Landon, B. Industri, A. Marais, D. Marion, et al.. Solution structure of a tobacco lipid transfer protein exhibiting new biophysical and biological features. Proteins - Structure, Function and Bioinformatics, Wiley, 2005, 59, pp.356-367. ⟨hal-00088539⟩
  • C. BurÉ, O. Boujard, M. Bertrand, C. Lange, A.F. Delmas. Letter: Collision-induced dissociation of peptide thioesters: influence of the peptide length on the fragmentation. European Journal of Mass Spectrometry, IM Publications, 2005, 11, pp.31-34. ⟨hal-00088531⟩
  • Pedro da Silva, Céline Landon, Benoit Industri, Antoine Marais, Didier Marion, et al.. Solution structure of a tobacco lipid transfer protein exhibiting new biophysical and biological features. Proteins - Structure, Function and Bioinformatics, Wiley, 2005, 59 (2), pp.356-367. ⟨hal-02681302⟩
  • G.A. Cremer, N. Bureaud, D. Lelièvre, V. Piller, F. Piller, et al.. Synthesis of branched oxime-linked peptide mimetics of the MUC1 containing a universal T-helper epitope. Chemistry - A European Journal, Wiley-VCH Verlag, 2004, 10 (24), pp.6353-6360. ⟨10.1002/chem.200400780⟩. ⟨hal-00112972⟩
  • C. Landon, F. Barbault, M. Legrain, L. Menin, M. Guenneugues, et al.. Lead optimization of antifungal peptides with 3D NMR structures analysis. Protein science : a publication of the Protein Society., 2004, 13, pp.703-713. ⟨hal-00113063⟩
  • C. Landon, C. Thouzeau, H. Labbé, P. Bulet, F. Vovelle. Solution structure of spheniscin, a β-defensin from the penguin stomach. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2004, 279, pp.30433-30439. ⟨hal-00113065⟩
  • L. Dubois, P. da Silva, C. Landon, J.G. Huber, M. Ponchet, et al.. Probing the hydrophobic cavity of lipid transfer protein from Nicotiana tabacum through xenon-based NMR spectroscopy. Journal of the American Chemical Society, American Chemical Society, 2004, 126 (48), pp.15738-15746. ⟨10.1021/ja046195i⟩. ⟨hal-00088366⟩
  • C. BurÉ, G. Le Falher, C. Lange, A.F. Delmas. Fragmentation study of peptide acetals and aldehydes using in-source collision-induced dissociation. International Journal of Mass Spectrometry, Elsevier, 2004, 39 (7), pp.817-823. ⟨10.1002/jms.661⟩. ⟨hal-00088354⟩
  • A. Wélé, C. Landon, H. Labbé, F. Vovelle, Y. Zhang, et al.. Sequence and solution structure of cherimolacyclopeptides A and B, novel cyclooctapeptides from the seeds of Annona cherimola. Tetrahedron, Elsevier, 2004, 60 (2), pp.405-414. ⟨10.1016/j.tet.2003.11.026⟩. ⟨hal-00016015⟩
  • Françoise Paquet, Françoise Culard, Florent Barbault, Jean-Claude Maurizot, Gérard Lancelot. NMR Solution Structure of the Archaebacterial Chromosomal Protein MC1 Reveals a New Protein Fold ‡. Biochemistry, American Chemical Society, 2004, 43 (47), pp.14971-14978. ⟨10.1021/bi048382z⟩. ⟨hal-02121481⟩
  • F. Barbault, C. Landon, M Guenneugues, J-P Meyer, V Schott, et al.. Solution Structure of Alo-3: A New Knottin-Type Antifungal Peptide from the Insect Acrocinus longimanus. Biochemistry, American Chemical Society, 2003, 42, pp.14434 - 14442. ⟨hal-02422703⟩
  • L. Jouvensal, L. Quillien, E. Ferrasson, Yvan Rahbé, F. Vovelle. PA1b, an insecticidal protein extracted from pea seeds (Pisum sativum): 1H﷓2-D NMR study and molecular modelling. Biochemistry, American Chemical Society, 2003, 42, pp.11915-11923. ⟨10.1021/bi034803l⟩. ⟨hal-00088180⟩
  • Florent Barbault, Céline Landon, Marc Guenneugues, Jean-Philippe Meyer, Valérie Schott, et al.. Solution Structure of Alo-3: A New Knottin-Type Antifungal Peptide from the Insect Acrocinus longimanus ‡. Biochemistry, American Chemical Society, 2003, 42 (49), pp.14434-14442. ⟨10.1021/bi035400o⟩. ⟨hal-02120951⟩
  • Nadège Jamin, Yves-Marie Coïc, Céline Landon, Ludmila Ovtracht, Françoise Baleux, et al.. Most of the structural elements of the globular domain of murine prion protein form fibrils with predominant beta-sheet structure.. FEBS Letters, Wiley, 2002, 529 (2-3), pp.256-60. ⟨10.1016/S0014-5793(02)03353-7⟩. ⟨pasteur-00166871⟩
  • Fabien Kieken, Eric Arnoult, Florent Barbault, Françoise Paquet, Tam Huynh-Dinh, et al.. HIV-1 Lai genomic RNA: combined used of NMR and molecular dynamics simulation for studying the structure and internal dynamics of a mutated SL1 hairpin. European Biophysics Journal, Springer Verlag (Germany), 2002, 31 (7), pp.521-531. ⟨10.1007/s00249-002-0251-1⟩. ⟨hal-02121476⟩
  • F. Boillot, A. Chabin, C. BurÉ, M. Venet, A. Belsky, et al.. The PERSEUS-Exobiology experiment on board MIR. Origins of Life and Evolution of the Biosphere, Springer-Verlag, 2002, 32 (4), pp.359-385. ⟨10.1023/A:1020501226958⟩. ⟨hal-02104813⟩
  • Dominique Lelièvre, Olivier Turpin, Said El Kazzouli, Agnès F. Delmas. Influence of polar support for the synthesis of large C-terminal peptide aldehyde: application to chemoselective ligation. Tetrahedron, Elsevier, 2002, 58 (27), pp.5525-5533. ⟨10.1016/S0040-4020(02)00486-6⟩. ⟨hal-02146693⟩
  • Céline Landon, Patrick Berthault, Francoise Vovelle, Hervé Desvaux. Magnetization transfer from laser-polarized xenon to protons located in the hydrophobic cavity of the wheat nonspecific lipid transfer protein. Protein Science, Wiley, 2001, 10 (4), pp.762-770. ⟨10.1110/ps.47001⟩. ⟨hal-02121155⟩
  • Corinne Bure, Wilfried Gobert, Dominique Lelièvre, Agnès F. Delmas. In-source fragmentation of peptide aldehydes and acetals: influence of peptide length and charge state. Journal of Mass Spectrometry, Wiley-Blackwell, 2001, 36 (10), pp.1149-1155. ⟨10.1002/jms.220⟩. ⟨hal-02146701⟩
  • Patrick Berthault, Céline Landon, Francoise Vovelle, Hervé Desvaux. Première détection d'un transfert d'aimantation entre du xénon polarisé par laser et des protons d'une protéine. Comptes Rendus de l'Académie des Sciences - Series IV - Physics, 2001, 2 (2), pp.327-332. ⟨10.1016/S1296-2147(01)01174-X⟩. ⟨hal-02121185⟩
  • Nicolas Mandard, Henri Labbé, Pedro da Silva, Charles Hetru, Céline Landon, et al.. Rôle des ponts disulfure dans le repliement en épingle à cheveux de l’androctonine. Relations structure–activité. Comptes Rendus de l'Académie des Sciences - Series IIC - Chemistry, 2001, 4 (10), pp.735-738. ⟨10.1016/S1387-1609(01)01297-X⟩. ⟨hal-02120976⟩
  • Dominique Lelièvre, Corinne Bure, Fabrice Laot, Agnès F. Delmas. Synthesis of peptide di-aldehyde precursor for stepwise chemoselective ligations via oxime bonds. Tetrahedron Letters, Elsevier, 2001, 42 (2), pp.235-238. ⟨10.1016/S0040-4039(00)01907-9⟩. ⟨hal-02146709⟩
  • F Lamberty, C. Caille, C. Landon, S Tassin-Moindrot, C Hetru, et al.. Solution structures of the antifungal heliomicin and a selected variant with both antibacterial and antifungal activities.. Biochemistry, American Chemical Society, 2001, 40 (40), pp.11995-2003. ⟨hal-02121162⟩
  • Marylène Bertrand, André Brack. Conformational Transition of Acidic Peptides Exposed to Minerals in Suspension. Chemistry - A European Journal, Wiley-VCH Verlag, 2000, 6 (18), pp.3452-3455. ⟨10.1002/1521-3765(20000915)6:18<3452::AID-CHEM3452>3.0.CO;2-T⟩. ⟨hal-02106710⟩
  • C. BurÉ, D. Lelièvre, Agnès F. Delmas. Identification of by-products from an orthogonal peptide ligation by oxime bonds using mass spectrometry and tandem mass spectrometry. Rapid Communications in Mass Spectrometry, Wiley, 2000, 14 (23), pp.2158-2164. ⟨10.1002/1097-0231(20001215)14:23<2158::AID-RCM147>3.0.CO;2-C⟩. ⟨hal-02146713⟩
  • Françoise Paquet, Jean-Claude Maurizot, Gérard Lancelot. Changes inlac Operator dynamics upon selective interaction withlac Repressor as revealed by heteronuclear relaxation rate measurements. Magnetic Resonance in Chemistry, Wiley, 2000, 38 (11), pp.946-950. ⟨10.1002/1097-458X(200011)38:11<946::AID-MRC763>3.0.CO;2-Q⟩. ⟨hal-02121469⟩
  • C. Landon, A. Pajon, F. Vovelle, P. Sodano. The active site of drosomycin, a small insect antifungal protein, delineated by comparison with the modeled structure of Rs-AFP2, a plant antifungal protein.. Journal of Peptide Research, Wiley-Blackwell, 2000, 56 (4), pp.231-8. ⟨hal-02121196⟩
  • Karine Lugardon, Roselyne Raffner, Yannick Goumon, Angelo Corti, Agnès F. Delmas, et al.. Antibacterial and Antifungal Activities of Vasostatin-1, the N-terminal Fragment of Chromogranin A. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2000, 275 (15), pp.10745-10753. ⟨10.1074/jbc.275.15.10745⟩. ⟨hal-02146721⟩
  • Françoise Paquet, Marc Boudvillain, Gérard Lancelot, Marc Leng. NMR solution structure of a DNA dodecamer containing a transplatin interstrand GN7-CN3 cross-link. Nucleic Acids Research, Oxford University Press, 1999, 27 (21), pp.4261-4268. ⟨10.1093/nar/27.21.4261⟩. ⟨hal-02075311⟩
  • C Delmotte, A. Delmas. Synthesis and fluorescence properties of Oregon Green 514 labeled peptides.. Bioorganic and Medicinal Chemistry Letters, Elsevier, 1999, 9 (20), pp.2989-94. ⟨hal-02146730⟩
  • C Delmotte, E Le Guern, Y. Trudelle, A. Delmas. Structural features of a chimeric peptide inducing cytotoxic T lymphocyte responses in saline.. European Journal of Biochemistry, Wiley, 1999, 265 (1), pp.336-45. ⟨hal-02146737⟩
  • Loïc Martin, Fabrice Cornille, Serge Turcaud, Hervé Meudal, Bernard Roques, et al.. Metallopeptidase Inhibitors of Tetanus Toxin: A Combinatorial Approach. Journal of Medicinal Chemistry, American Chemical Society, 1999, 42 (3), pp.515-525. ⟨10.1021/jm981066w⟩. ⟨hal-02528535⟩
  • M Goyffon, C. Landon. Scorpion toxins and defensins. Comptes rendus des séances de la Société de biologie et de ses filiales, Société de biologie, 1998, 192 (3), pp.445-62. ⟨hal-02121214⟩
  • Bernard Barbier, Marylène Bertrand, François Boillot, Annie Chabin, Didier Chaput, et al.. Delivery of extraterrestrial amino acids to the primitive Earth. Exposure experiments in Earth orbit.. Biological Sciences in Space, Japanese Society for Biological Sciences in Space, 1998, 12 (2), pp.92-95. ⟨10.2187/bss.12.92⟩. ⟨hal-02106435⟩
  • P. Sodano, C. Landon, M. Ptak. A Novel Composite 90° Pulse Sequence Which Provides Distortionless NMR Spectra and Suppresses without Destroying the Water Magnetization. Journal of Magnetic Resonance, Elsevier, 1998, 133 (1), pp.194-199. ⟨10.1006/jmre.1998.1466⟩. ⟨hal-02121200⟩
  • Dominique Lelièvre, Hadjila Chabane, Agnès F. Delmas. Simple and efficient solid-phase synthesis of unprotected peptide aldehyde for peptide segment ligation. Tetrahedron Letters, Elsevier, 1998, 39 (52), pp.9675-9678. ⟨10.1016/S0040-4039(98)02267-9⟩. ⟨hal-02146742⟩
  • Céline Landon, Patrick Sodano, Charles Hetru, Jules Hoffmann, Marius Ptak. Solution structure of drosomycin, the first inducible antifungal protein from insects. Protein Science, Wiley, 1997, 6 (9), pp.1878-1884. ⟨10.1002/pro.5560060908⟩. ⟨hal-02121218⟩
  • Marylène Bertrand, André Brack. Preferential beta-sheet structuration of multiconformational poly(Glu-Leu) by metallic ions. Letters in Peptide Science, Springer Verlag, 1997, 4 (4/6), pp.387-389. ⟨10.1023/A:1008877728409⟩. ⟨hal-02104833⟩
  • C.D Partidos, J Ripley, A. Delmas, O Obeid, A Denbury, et al.. Fine specificity of the antibody response to a synthetic peptide from the fusion protein and protection against measles virus-induced encephalitis in a mouse model.. Journal of General Virology, Microbiology Society, 1997, 78 (12), pp.3227-3232. ⟨10.1099/0022-1317-78-12-3227⟩. ⟨hal-02146813⟩
  • D. Lelièvre, S. C. Hsu, P. Daubos, C. Favard, P. Vigny, et al.. Structural properties of chimeric peptides containing a T-cell epitope linked to a fusion peptide and their importance for in vivo induction of cytotoxic T-cell responses.. European Journal of Biochemistry, Wiley, 1997, 249 (3), pp.895-904. ⟨hal-00455230⟩
  • Françoise Paquet, C. Perez, M. Leng, G. Lancelot, J-M Malinge. NMR Solution Structure of a DNA Decamer Containing an Interstrand Cross-link of the Antitumor Drug cis -diamminedichloroplatinum(II). Journal of Biomolecular Structure and Dynamics, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 1997, 14 (1), pp.67-77. ⟨10.1080/07391102.1996.10508930⟩. ⟨hal-02121444⟩
  • F Gaudin, Françoise Paquet, N.T Thuong, Daniel Genest, G. Lancelot. Selectively 13-C enriched DNA : Evidence of fast and slow internal motions. Journal of Biomolecular Structure and Dynamics, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 1997, 26 (1), pp.45. ⟨hal-02132728⟩
  • Céline Landon, Patrick Sodano, C. Cornet, J.M. Bonmatin, Charles Kopeyan, et al.. Refined solution structure of the anti-mammal and anti-insect LqqIII scorpion toxin: Comparison with other scorpion toxins. Proteins: Structure, Function, and Genetics, Wiley, 1997, 28 (3), pp.360-374. ⟨10.1002/(SICI)1097-0134(199707)28:3<360::AID-PROT6>3.0.CO;2-G⟩. ⟨hal-02082536⟩
  • Marylène Bertrand, Denise Sy, André Brack. Salt-dependent conformational diversity of alternating poly (Glu-Leu). The Journal of Peptide Research, 1996, 49 (3), pp.269-272. ⟨10.1111/j.1399-3011.1997.tb00886.x⟩. ⟨hal-02104850⟩
  • Marylène Bertrand, A. Brack. Conformational variety of polyanionic peptides at low salt concentrations.. Origins of Life and Evolution of Biospheres, Springer Verlag, 1996, 27 (5-6), pp.585-95. ⟨hal-02104860⟩
  • C.D Partidos, A. Delmas, M Steward. Structural requirements for synthetic immunogens to induce measles virus specific CTL responses.. Molecular Immunology, Elsevier, 1996, 33 (16), pp.1223-9. ⟨hal-02146823⟩
  • Anne Quesnel, Shiou-Chih Hsu, Agnès F. Delmas, Michael Steward, Yves Trudelle, et al.. Efficient binding to the MHC class I K d molecule of synthetic peptides in which the anchoring position 2 does not fit the consensus motif. FEBS Letters, Wiley, 1996, 387 (1), pp.42-46. ⟨10.1016/0014-5793(96)00446-2⟩. ⟨hal-02146830⟩
  • E Lacassie, A. Delmas, C. Meunier, D. Sy, Y. Trudelle. High thermal stability and cold-denaturation of an artificial polypeptide.. International Journal of Peptide and Protein Research, 1996, 48 (3), pp.249-58. ⟨10.1111/j.1399-3011.1996.tb00838.x⟩. ⟨hal-02146922⟩
  • Françoise Paquet, G. Gaudin, G. Lancelot. Selectively 13C-enriched DNA: evidence from 13C1' relaxation rate measurements of an internal dynamics sequence effect in the lac operator.. Journal of Biomolecular NMR, Springer Verlag, 1996, 8 (3), pp.252-60. ⟨hal-02121439⟩
  • C. Landon, C. Cornet, J.M. Bonmatin, C Kopeyan, H. Rochat, et al.. 1H-NMR-derived secondary structure and the overall fold of the potent anti-mammal and anti-insect toxin III from the scorpion Leiurus quinquestriatus quinquestriatus.. European Journal of Biochemistry, Wiley, 1996, 236 (2), pp.395-404. ⟨hal-02082569⟩
  • G. Gaudin, Françoise Paquet, L Chanteloup, J-M Beau, T. Nguyen, et al.. Selectively 13C-enriched DNA: dynamics of the C1'-H1' vector in d(CGCAAATTTGCG)2.. Journal of Biomolecular NMR, Springer Verlag, 1995, 5 (1), pp.49-58. ⟨hal-02121433⟩
  • A. Quesnel, A. Delmas, Y. Trudelle. Purification of Synthetic Peptide Libraries by Affinity Chromatography Using the Avidin-Biotin System. Analytical Biochemistry, Elsevier Masson, 1995, 231 (1), pp.182-187. ⟨10.1006/abio.1995.1519⟩. ⟨hal-02146927⟩
  • E Lacassie, A. Delmas, Y. Trudelle. Influence of the conformation of a macromolecule on the generation of T-cell proliferative response. A study with model polypeptides.. FEBS Letters, Wiley, 1994, 349 (3), pp.380-4. ⟨hal-02146930⟩
  • A. Delmas, A. Brack, Y. Trudelle. Studies of the influence of different cross-linking reagents on the immune response against a B-epitope.. Bioconjugate Chemistry, American Chemical Society, 1992, 3 (1), pp.80-4. ⟨10.1021/bc00013a013⟩. ⟨hal-02146933⟩
  • Josette Verhaeghe, Eric Lacassie, Marylène Bertrand, Yves Trudelle. A new route to sequential polypeptides combining solid phase synthesis and solution peptide synthesis. Tetrahedron Letters, Elsevier, 1992, 34 (3), pp.461-464. ⟨10.1016/0040-4039(93)85102-3⟩. ⟨hal-02104862⟩
  • Y Trudelle, A. Brack, A. Delmas, S Pedoussaut, P Rivaille. Synthesis of a new carrier for immunization: polytuftsin. Two examples of its use with peptides selected in the hepatitis B surface antigen.. International Journal of Peptide and Protein Research, 1987, 30 (1), pp.54-60. ⟨10.1111/j.1399-3011.1987.tb03312.x⟩. ⟨hal-02146960⟩

Communication dans un congrès

  • Justine Largillière, Rémy Le Meur, David Guiguène, Norbert Garnier, Celine Landon, et al.. Vers une description cinétique et structurale complète du mécanisme d'échange de chaînes de la protéine HU d'Escherichia coli.. XXXIe congrès du GERM (Groupement d'Etudes de Résonance Magnétique), May 2019, Oléron, France. ⟨hal-02361645⟩
  • Maxime Roger, Yassine Maanane, Mathieu Galtier, Frédéric André, Agnès Delmas. SYMBOLIC MONTE CARLO METHOD BASED ON ORTHOGONAL POLYNOMIALS SERIES: APPLICATION TO PHASE FUNCTION. Proceedings of the 9th International Symposium on Radiative Transfer, RAD-19, Jun 2019, Athens, France. pp.295-302, ⟨10.1615/RAD-19.360⟩. ⟨hal-02350441⟩
  • G. Lalmanach, M. Wartenberg, M. Galibert, A. Saidi, F. Lecaille, et al.. Design of both pseudopeptide inhibitors and imaging probes derived from a unique substrate sequence: a versatile molecular toolbox for studying proteases. 21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France. ⟨hal-02892793⟩
  • H. Meudal, N. Guyot, K. Loth, G. Jousset, S. Trapp, et al.. Gga-AvBD11, the archetype of a new structural family of defensins. 21eme réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France. ⟨hal-02892790⟩
  • S. Abboud, M. Amoura, V. P. Terrier, A. F. Delmas, V. Aucagne. An improved synthesis of N-Hnb-Cys peptide crypto-thioesters ‒studies on the epimerization of cysteine during solid-phase reductive amination. 21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France. ⟨hal-02892784⟩
  • Nicolas Guyot, Hervé Meudal, Karine Loth, Guillaume Jousset, Anne Silvestre, et al.. 1ère structure 3D d’une défensine à double motif β-défensine, Gga-AvBD11 du poulet Gallus gallus, et explorations fonctionnelles. 5. Journées GDR MuFoPAM, Centre National de la Recherche Scientifique (CNRS). FRA., Oct 2018, Paris, France. ⟨hal-02788993⟩
  • T.M. Vishwanatha, C. Decourt, V.P. Terrier, V. Robert, M. Galibert, et al.. Rational design of kisspeptin analogs for the control of reproduction. 4th Belgian Peptide Group Meeting, Feb 2018, Bruxelles, Belgium. ⟨hal-02892809⟩
  • A.F. Delmas, Vincent Aucagne. Synthesis and structural characterization of naturally-occuring disulfide rich antimicrobial peptides Gyros Protein Technologies. European peptide symposium, Aug 2018, Dublin, Ireland. ⟨hal-02919154⟩
  • N. Guyot, H. Meudal, K. Loth, G. Jousset, A. Silvestre, et al.. 1ère structure 3D d’une défensine à double motif β défensine, Gga-AvBD11 du poulet Gallus gallus, et explorations fonctionnelles. Ves journées annuelles du GDR MuFoPAM, Oct 2018, Paris, France. ⟨hal-02919165⟩
  • M. Amoura, D. Sarraf, L. Nauton, V.P. Terrier, D. Lelièvre, et al.. N-2-hydroxybenzyl-cysteine peptide crypto-thioesters for native chemical ligation. 35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland. ⟨hal-02892802⟩
  • Marylène Bertrand, H. Meudal, S. Birman, M. Decoville, C. Landon. Metabolomic NMR studies & Huntington’s disease: models in transgenic drosophila. Conférence SMMAP 2017 - Conférence de Spectrométrie de Masse, Métabolomique et Fluxomique & Electrophorèse et Analyse Protéomique, Oct 2017, Marne-la-Vallée, France. ⟨hal-02919162⟩
  • A.F. Delmas. Naturally-occuring disulfide rich antimicrobial peptides: Their chemical production for structural and functionnal studies. AntiMIC 2017 (Symposium Franco-canadien sur les antimicrobiens naturels : applications alimentaires, médicales et vétérinaires), Jun 2017, Québec, Canada. ⟨hal-02919153⟩
  • A.F. Delmas. Methodological developments for the chemical synthesis of proteins and analogs. Journées de la Section Régionale Centre-Ouest de la Société Chimique de France, Feb 2017, Tours, France. ⟨hal-02919158⟩
  • A. Casas-Mora, M. Galibert, A.F. Delmas, V. Aucagne. A non-chromatographic catch-and-release purification method to simplify the synthesis of cysteine-rich peptides. 20e réunion du Groupe Français des Peptides et des Protéines (GFPP 20), Mar 2017, Arcachon, France. ⟨hal-02893392⟩
  • A.F. Delmas, V.P. Terrier, R.D. Rosa, A. Bressan, P. Marceau, et al.. Native Chemical ligation simplifies the access of multidomain antimicrobial peptides: application to the study of big-defensins. International symposium on AntiMicrobial Peptides (AMP2016), Jun 2016, Montpellier, France. ⟨hal-02892834⟩
  • Nicolas Guyot, Virginie Herve, Hervé Meudal, Jean-Baptiste Madinier, Valérie Labas, et al.. Functional and structural characterization of egg defensins. Banff Egg Forum, Jun 2014, Wroclaw, Poland. 12 diapositives. ⟨hal-02797356⟩
  • Nicolas Guyot, Virginie Hervé, Hervé Meudal, Jean-Baptiste Madinier, Valérie Labas, et al.. Insights into the structure-function relationship of egg defensins. XIVth European Poultry Conference, World's Poultry Science Association (WPSA). INT., Jun 2014, Stavanger, Norway. ⟨hal-02743609⟩
  • Massimiliano Beltramo, Vincent Aucagne, Vincent Robert, Mathieu Galibert, Jean-Baptiste Madinier, et al.. Design and profiling of new selective KISS1R agonists that stimulate the reproductive system. 8. International Congress of Neuroendocrinology, Society for Behavioral Neuroendocrinology (SBN). USA., Aug 2014, Sydney, Australia. ⟨hal-02738894⟩
  • H. Meudal, Virginie Herve-Grepinet, Valérie Labas, A. Delmas, Yves Nys, et al.. 1ère défensine d'oeuf : caractérisation, synthèse, structure. 22. Congrès de la Société Française de Biophysique, Sep 2010, La Colle-sur-Loup, France. ⟨hal-02757482⟩
  • Anne-Christine Lalmanach, Chrystelle Derache, Evelyne Esnault, Valérie Labas, V. Aucagne, et al.. Avian beta-defensins in the control of bacterial pathogens of chicken digestive tract. 2. International Symposium on Antimicrobial Peptides. Food Veterinary Medical and Novel Applications, Jun 2009, Saint-Malo, France. ⟨hal-02751627⟩
  • L. Robin, A. Delmas, F. Oeldhoffen. Calcul des propriétés radiatives d'un matériau projeté plasma. Congrés Français de Thermique, May 2007, France. ⟨hal-00456026⟩

Poster

  • S. Abboud, A.F. Delmas, V. Aucagne. Synthesis of N-Hnb-Cys peptide crypto-thioesters: identification of imadozolidinone and epimerized side products, and development of an optimized protocol. 4th GFPP Chemical Ligation Meeting (Ligation2020), Jan 2020, Orléans, France. ⟨hal-02893398⟩
  • M. Maravat, Marylène Bertrand, M. Decoville, C. Landon, Séverine Morisset-Lopez, et al.. Biomarkers involved in glioma development in Drosophila melanogaster model. European RFMF Metabomeeting 2020, Jan 2020, Toulouse, France. ⟨hal-02919170⟩
  • Marylène Bertrand, M. Decoville, H. Meudal, S. Birman, C. Landon. Metabolomic NMR studies at presymptomatic and symptomatic stages of Huntington’s disease, on drosophila model. 12es journées scientifiques du Réseau Francophone de Métabolomique et de Fluxomique, May 2019, Clermont-Ferrand, France. ⟨hal-02919883⟩
  • Marylène Bertrand, M. Decoville, H. Meudal, S. Birman, C. Landon. Metabolomic NMR studies at presymptomatic and symptomatic stages of Huntington’s disease, on drosophila model. 20th annual meeting of Invertebrate Neurobiology, May 2019, Orléans, France. ⟨hal-02919877⟩
  • M. Maravat, Marylène Bertrand, M. Decoville, C. Landon, F. Fayon, et al.. Biomarkers involved in glioma development in Drosophila melanogaster model. 12es journées scientifiques du Réseau Francophone de Métabolomique et de Fluxomique, May 2019, Clermont-Ferrand, France. ⟨hal-02919890⟩
  • Justine Largillière, Rémy Le Meur, David Guinguène, Norbert Garnier, Celine Landon, et al.. To a complete kinetics and structural description of the EcHU chain exchange system.. Journée Fédération de recherche “Physique et Chimie du Vivant”, Apr 2019, Orléans, France. ⟨hal-02362578⟩
  • Justine Largillière, Rémy Le Meur, David Guinguène, Norbert Garnier, Celine Landon, et al.. To a complete kinetics and structural description of the EcHU chain exchange system. NMR : a tool for biology XITh, Jan 2019, Paris, France. ⟨hal-02362588⟩
  • S. Abboud, M. Amoura, P. Terrier V., A.F. Delmas, V. Aucagne. N-Hnb-Cys peptide crypto-thioesters: optimized synthetic protocol and second generation device. Noncanonical amino acids (ncAAs): Tools for biological and biophysical investigations, Oct 2019, Paris, France. ⟨hal-02893409⟩
  • Laurence Jouvensal, K. Loth, A.F. Delmas, I. Rahioui, P. Sivignon, et al.. A new legume bio-insecticide peptide. VIes journées annuelles du GDR MuFoPAM, Oct 2019, Besançon, France. ⟨hal-02919908⟩
  • S. Abboud, M. Amoura, V.P. Terrier, A.F. Delmas, V. Aucagne. An improved synthesis of N-Hnb-Cys peptide crypto-thioesters - studies on the epimerization of cysteine during solid-phase reductive amination. 8th Chemical Protein Synthesis meeting (CPS2019), Jun 2019, Berlin, Germany. ⟨hal-02893426⟩
  • L. Jouvensal, K. Loth, A.F. Delmas, J. Orlans, C. Sivignon, et al.. Legume AG41 peptide: a promising bio-insecticide. 21e congrès du Groupe Français des Peptides et des Protéines (GFPP), May 2019, Amboise, France. ⟨hal-02919178⟩
  • Françoise Paquet, K. Loth, C. Arnoult, V. Aucagne, A.F. Delmas. Spermaurin, a scorpion venom disulfide-rich miniprotein that improves sperm motility and fertilization in mammals.. 21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France. ⟨hal-02893462⟩
  • F. Coste, G. Chaume, J.-B. Madinier, I. Rahioui, B. Castaing, et al.. Incorporation of trifluoromethylated pseudoproline in an entomotoxic knottin: effects on oxidative folding, 3D structure and biological activity. 21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France. ⟨hal-02893471⟩
  • H. Meudal, N. Guyot, K. Loth, G. Jousset, S. Trapp, et al.. Gga-AvBD11, the archetype of a new structural family of defensins. 21e congrès du Groupe Français des Peptides et des Protéines (GFPP), May 2019, Amboise, France. ⟨hal-02923098⟩
  • H. Meudal, Françoise Paquet, Laurence Jouvensal, V. Aucagne, A.F. Delmas, et al.. Chemical synthesis and natural abundance NMR: an efficient tandem to unravel 3D structures of unlabeled disulfide rich peptides. 21e congrès du Groupe Français des Peptides et des Protéines (GFPP), May 2019, Amboise, France. ⟨hal-02919180⟩
  • H. Meudal, K. Loth, G. Jousset, V. Aucagne, N. Guyot, et al.. A new structural family for antimicrobial defensins. NMR : a tool for biology XIth, Jan 2019, Paris, France. ⟨hal-02919171⟩
  • M. Maravat, Marylène Bertrand, S. Morisset-Lopez, F. Fayon, V. Sarou-Kanian, et al.. Identification de biomarqueurs impliqués dans le développement de gliomes dans un modèle développé chez la drosophile. 13es Journées scientifiques Canceropôle Grand-Ouest, Jul 2019, Tours, France. ⟨hal-02919893⟩
  • Marylène Bertrand, M. Decoville, H. Meudal, S. Birman, C. Landon. NMR metabolimics to detect Huntington’s disease at early stage. 28th ICMRBS - International Council on Magnetic Resonance in Biological Systems, Aug 2018, Dublin, Ireland. ⟨hal-02919924⟩
  • Marylène Bertrand, M. Decoville, H. Meudal, S. Birman, C. Landon. Huntington’s disease: metabolomic studies by NMR analyzes on Drosophila Model. 11es Journées du Réseau francophone de métabolomique et de fluxomique, May 2018, Liège, Belgium. ⟨hal-02919911⟩
  • Justine Largillière, Rémy Le Meur, David Guinguène, Celine Landon, A.F. Delmas, et al.. First kinetics description of the EcHU chain exchange system.. 28th ICMRBS - International Council on Magnetic Resonance in Biological Systems, Aug 2018, Dublin, Ireland. ⟨hal-02362586⟩
  • Karine Loth, Justine Largillière, Franck Coste, Françoise Culard, Bertrand Castaing, et al.. New protein-DNA complexes in archaea: a small monomeric protein induces a V-turn structure.. 28th ICMRBS - International Council on Magnetic Resonance in Biological Systems, Aug 2018, Dublin, Ireland. ⟨hal-02362584⟩
  • Justine Largillière, Rémy Le Meur, Norbert Garnier, Celine Landon, A.F. Delmas, et al.. Native and Intermediate conformations of the three HU dimers of E.coli.. 28th ICMRBS - International Council on Magnetic Resonance in Biological Systems, Aug 2018, Dublin, Ireland. ⟨hal-02362585⟩
  • Karine Loth, Françoise Culard, Justine Largillière, Celine Landon, Bertrand Castaing, et al.. New protein-DNA complexes in archaea: a monomeric protein induces a U-turn structure.. 5e séminaire scientifique du LIA MiR-TANGo, May 2018, Orléans, France. ⟨hal-02362804⟩
  • Justine Largillière, Rémy Le Meur, Martine Cadene, Bertrand Castaing, Karine Loth, et al.. Premières études cinétiques du mécanisme d’échange de chaînes de la protéine HU d’Escherischia coli.. Journée Fédération de recherche “Physique et Chimie du Vivant”, Jan 2018, Orléans, France. ⟨hal-02362577⟩
  • Justine Largillière, Rémy Le Meur, Martine Cadene, Bertrand Castaing, Karine Loth, et al.. Premières études cinétiques du mécanisme d’échange de chaînes de la protéine HU d’Escherischia coli.. 16e colloque scientifique de l’ADOC : Converger pour Renforcer, Apr 2018, Orléans, France. ⟨hal-02362579⟩
  • Justine Largillière, Rémy Le Meur, David Guinguène, Norbert Garnier, Celine Landon, et al.. To a complete kinetics and structural description of the EcHU chain exchange system.. 31e colloque Biotechnocentre, Oct 2018, Seillac, France. ⟨hal-02362818⟩
  • Karine Loth, Justine Largillière, Franck Coste, Françoise Culard, Celine Landon, et al.. New protein-DNA complexes in archaea: a small monomeric protein induces a sharp V-turn DNA structure.. EuroMar 2018, Jul 2018, Nantes, France. ⟨hal-02362581⟩
  • M. Amoura, V.P. Terrier, A.F. Delmas, V. Aucagne. Second generation N-2-hydroxybenzyl-cysteine peptide crypto-thioesters for native chemical ligation. 35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland. ⟨hal-02894157⟩
  • S. Abboud, V. Piller, S. Papot, A.F. Delmas, V. Aucagne. Development of chemo-enzymatic methodologies for the total synthesis of proteins through solid-supported chemical ligation. 31e Colloque Biotechnocentre, Oct 2018, Seillac, France. ⟨hal-02894152⟩
  • T.M. Vishwanatha, C. Decourt C, V. Robert, M. Galibert, J.-B. Madinier, et al.. Long-lasting increase of gonadotropins by rational design of lipophilic kisspeptin analogs. 2018 International Symposium on Chemical Biology, Jan 2018, Genève, Switzerland. ⟨hal-02894282⟩
  • M. Amoura, V.P. Terrier, A.F. Delmas, V. Aucagne. N-2-Hydroxybenzyl-Cysteine Peptides as Efficient Thioester Surrogates for Native Chemical Ligation. 4th Belgian Peptide Group Meeting, Feb 2018, Bruxelles, Belgium. ⟨hal-02894279⟩
  • T.M. Vishwanatha, C. Decourt, V.P. Terrier, V. Robert, J.-B. Madinier, et al.. Rational design of kisspeptin analogs for the control of the reproductive system. 25th SCT Young Research Fellows meeting, Mar 2018, Orléans, France. ⟨hal-02894277⟩
  • F. Coste, G. Chaume, J.-B. Madinier, I. Rahioui, B. Castaing, et al.. Incorporation of trifluoromethylated pseudoproline in an entomotoxic knottin: effects on oxidative folding, 3D structure and biological activity. 35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland. ⟨hal-02894161⟩
  • M. Amoura, V.P. Terrier, A.F. Delmas, V. Aucagne. Design and optimization of alternative thioester precursors to simplify protein synthesis by native chemical ligation. 25th SCT Young Research Fellows meeting, Mar 2018, Orléans, France. ⟨hal-02894273⟩
  • H. Meudal, Laurence Jouvensal, K. Loth, Françoise Paquet, V. Aucagne, et al.. Chemical synthesis and natural abundance NMR: An efficient tandem to unravel 3D structures of Disulfide Rich Miniproteins. 35th European Peptide Symposium, Aug 2018, Dublin, Ireland. ⟨hal-02920483⟩
  • A.F. Delmas, H. Meudal, Laurence Jouvensal, K. Loth, Françoise Paquet, et al.. Chemical synthesis and natural abundance NMR: An efficient tandem to unravel 3D structures of Disulfide Rich Miniproteins. 35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland. ⟨hal-02920471⟩
  • H. Meudal, Laurence Jouvensal, Françoise Paquet, K. Loth, V. Aucagne, et al.. Chemical synthesis and natural abundance NMR: An efficient tandem to unravel 3D structures of Disulfide Rich Miniproteins. 35th European Peptide Symposium, Aug 2018, Dublin, Ireland. ⟨hal-02919932⟩
  • Françoise Paquet, H. Meudal, Laurence Jouvensal, K. Loth, V. Aucagne, et al.. Synthèse chimique et RMN en abondance naturelle : un tandem efficace pour résoudre les structures 3D de peptides/protéines riches en ponts disulfure. 5es journées annuelles du GDR MuFoPAM, Oct 2018, Paris, France. ⟨hal-02920025⟩
  • Marylène Bertrand, H. Meudal, M. Decoville, C. Landon. Prediction of Huntingon's Disease by Metabolomic NMR Analyzes: Studies in Drosophila Model. NMR: a tool for biology Xth, Jan 2017, Paris, France. ⟨hal-02919990⟩
  • Justine Largillière, Rémy Le Meur, Martine Cadene, Bertrand Castaing, Karine Loth, et al.. Première description cinétique du mécanisme d’échange de chaînes de la protéine HU d'Escherichia coli.. 30ème colloque Biotechnocentre, Oct 2017, Seillac, France. ⟨hal-02361632⟩
  • Karine Loth, Françoise Culard, Justine Largillière, Celine Landon, Bertrand Castaing, et al.. The MC1-DNA complex solution structure reveals that a monomeric protein can induce a U-turn in archaea.. NMR: a tool for biology XTh, Jan 2017, Paris, France. ⟨hal-02361613⟩
  • M. Amoura, V.P. Terrier, D. Lelièvre, A.F. Delmas, V. Aucagne. N-2-Hydroxybenzyl-Cysteine Peptides as Efficient Thioester Surrogates for Native Chemical Ligation. 25th American Peptide Symposium (APS 25), Jun 2017, Whistler, Canada. ⟨hal-02894293⟩
  • Karine Loth, Justine Largillière, Franck Coste, A.F. Delmas, Bertrand Castaing, et al.. New protein-DNA complexes in archaea: a monomeric protein induces a U-turn structure.. Le Studium Confenrence: Structural biology and biophysics of RNA-protein complexes, Nov 2017, Orléans, France. ⟨hal-02362576⟩
  • A.F. Delmas, K. Loth, H. Meudal, V.P. Terrier, R.D. Rosa, et al.. NCL-based synthesis, 3D structure and first insight into antimicrobial properties of Cg-BigDef1, an oyster big defensin active at high salinity. 20e congrès annuel du Groupe Français des Peptides et des Protéines (GFPP), Mar 2017, Arcachon, France. ⟨hal-02894301⟩
  • M. Amoura, V. P. Terrier, A.F. Delmas, Vincent Aucagne. Second generation N-2-hydroxybenzyl-cysteine peptide crypto-thioesters: achieving very fast NCL kinetics at neutral pH. 20e congrès annuel du Groupe Français des Peptides et Protéines (GFPP), Mar 2017, Arcachon, France. ⟨hal-02453275⟩
  • A. Delmas, K. Loth, H. Meudal, V. Terrier, R.D. Rosa, et al.. NCL-based synthesis, 3D structure and first insight into antimicrobial properties of Cg-BigDef1, an oyster big defensin active at high salinity. NMR: a tool for Biology Xth, Jan 2017, Paris, France. ⟨hal-02453460⟩
  • A. Casas-Mora, M. Galibert, A.F. Delmas, V. Aucagne. Design of a New N-Terminal Linker for the Capture-and-Release Purification of Biologically-Relevant Disulfide-Rich Peptides. 25th American Peptide Symposium (APS 25), Jun 2017, Whistler, Canada. ⟨hal-02894295⟩
  • N. J. Stanley, D. Lelièvre, A.F. Delmas, Vincent Aucagne. Development of highly base-labile linkers for the catch-and-release purification of difficult peptides. Application to Avian beta-defensin 2. 20e congrès annuel du Groupe Français des Peptides et Protéines (GFPP), Mar 2017, Arcachon, France. ⟨hal-02453245⟩
  • M. Amoura, V.P. Terrier, D. Lelièvre, A.F. Delmas, V. Aucagne. N-2-Hydroxybenzyl-Cysteine Peptides as Efficient Thioester Surrogates for Native Chemical Ligation. 7th Chemical Protein Synthesis meeting (CPS 2017), Sep 2017, Haifa, Israel. ⟨hal-02894290⟩
  • Caroline Decourt, Vincent Robert, Didier Lomet, Karine Anger, A. Delmas, et al.. Investigation of tachyphylaxis of LH response following repeated injections of the kisspeptin analog C6. Colloque International NeuroFrance 2017, May 2017, Bordeaux, France. 2017, Colloque International NeuroFrance 2017. ⟨hal-01605114⟩
  • Marylène Bertrand, H. Meudal, M. Decoville, C. Landon. La RMN, un outil pour la métabolomique. 29e colloque Biotechnocentre, Oct 2016, Seillac, France. ⟨hal-02453360⟩
  • Caroline Decourt, Vincent Robert, Didier Lomet, Karine Anger, M. Galibert, et al.. Induction of fertile ovulation and puberty advancement by a new kisspeptin analog. 18th International Congress on Animal Reproduction (ICAR), Jun 2016, Tours, France. 676 p., 2016, 18th International Congress on Animal Reproduction (ICAR). ⟨hal-01604087⟩
  • H. Meudal, Marylène Bertrand, Laurence Jouvensal, A.F. Delmas, Françoise Paquet, et al.. La résonance Magnétique Nucléaire pour la chimie et la biologie. 29e colloque Biotechnocentre, Oct 2016, Seillac, France. ⟨hal-02920143⟩
  • Agnes Vergnes, Victor P. Terrier, Bressan Albert, Rafael Diego Rosa, Vincent Aucagne, et al.. Laligation native simplifie l’étude de l’activité etdu mécanismed’action des peptides antimicrobiens à multiples domaines :cas des Big défensines d’huître.. IIIèmes journées annuelles MuFoPAM « MultiFonction des Peptides AntiMicrobiens », Oct 2016, Tours, France. ⟨hal-02128427⟩
  • Marylène Bertrand, H. Meudal, F. Borderes, V. Furstoss, L. Wozniak, et al.. Etude de la fertilité chez le bouc : analyse métabolique par RMN. 10e Journées du Réseau francophone de métabolomique et de fluxomique, May 2016, Montpellier, France. ⟨hal-02453355⟩
  • V. P. Terrier, H. Adihou, D. Lelièvre, M. Amoura, A.F. Delmas, et al.. A straightforward strategy for automated Fmoc-based synthesis of peptide “crypto-thioesters”. Application to the total synthesis of biologically-relevant disulfide-rich peptides. Journées de Chimie Organique de la Société Chimique de France (JCO2016), Dec 2016, Palaiseau, France. ⟨hal-02453318⟩
  • A. Casas-Mora, M. Galibert, A.F. Delmas, V. Aucagne. A capture-and-release purification strategy to simplify the synthesis of disulfide-rich peptides. 1st PSL Chemical Biology Meeting, Dec 2016, Paris, France. ⟨hal-02453303⟩
  • A.F. Delmas, V.P. Terrier, R.D. Rosa, A. Bressan, P. Marceau, et al.. Native Chemical ligation simplifies the access of multi-domain antimicrobial peptides: application to the study of big-defensins. 34th European Peptide Symposium 2016 (EPS2016), Sep 2016, Leipzig, Germany. ⟨hal-02895296⟩
  • M. Beltramo, V. Robert, D. Lomet, K. Anger, M. Galibert, et al.. A new selective kisspeptin analog, C6, that advance puberty in mice and stimulate fertile ovulation in ewe. British Society for Neuroendocrinology Annual Meeting, Sep 2016, Glasgow, United Kingdom. ⟨hal-02453336⟩
  • H. Meudal, F. Borderes, Marylène Bertrand, V. Furstoss, L. Wozniak, et al.. Etude de la fertilité chez le bouc : analyse métabolique par RMN. 10e Journées du Réseau francophone de métabolomique et de fluxomique, May 2016, Montpellier, France. ⟨hal-02920007⟩
  • Marylène Bertrand, Hervé Meudal, Florence Bordères, Vincent Furstoss, Louis Wozniak, et al.. Etude de la fertilité chez le bouc : analyse métabolomique par RMN. 10. Journées scientifiques du Réseau Francophone de Métabolomique et Fluxomique RFMF 2016, May 2016, Montpellier, France. 155 p., 2016, 10 JS Réseau Francophone de Métabolique et Fluxomique. ⟨hal-01581541⟩
  • Vincent Aucagne, Vincent Robert, Mathieu Galibert, Jean-Baptiste Madinier, P. Marceau, et al.. Rational design of triazolo-lipopeptides analogs of kisspeptin inducing a long-lasting increase of gonadotropins. 24. Meeting of the American Peptide Society, Jun 2015, Orlando, United States. 2015, 24th Meeting of the American Peptide Society. ⟨hal-02741835⟩
  • Caroline Decourt, Vincent Robert, Didier Lomet, Karine Anger, Mathieu Galibert, et al.. Induction of synchronized fertile ovulation by a new selective agonist of kisspeptin receptor. 1 Journées du GdR 3606 Repro, Apr 2015, Rennes, France. 105 p., 2015, 1ères Journées Scientifiques du GdR Repro. ⟨hal-02742326⟩
  • Vincent Aucagne, Vincent Robert, Mathieu Galibert, Jean-Baptiste Madinier, P. Marceau, et al.. Rational design of triazolo-lipopeptides analogs of kisspeptin inducing a long-lasting increase of gonadotrophins. 19. Congrès du Groupe Français des Peptides et des Protéines, May 2015, Port-Bail, United States. 2015. ⟨hal-02793091⟩
  • Virginie Hervé, Nicolas Guyot, H. Meudal, Valérie Labas, Sophie Rehault Godbert, et al.. Gallin is a chicken egg beta-defensin with a narrow antibacterial spectrum. 4. International Symposium on Antimicrobial Peptides, Jun 2014, Lorient, France. 1 p., 2014. ⟨hal-02793322⟩
  • Karine Loth, Denis Costechareyre, Yvan Rahbé, Guy Condemine, Pedro da Silva, et al.. 3D NMR structure of a new Cyt-like delta-endotoxins from Dickeya dadantii. 26. International Conference on Magnetic Resonance in Biological Systems, Aug 2014, Dallas, United States. 1 p., 2014. ⟨hal-02795661⟩
  • Caroline Decourt, Karine Anger, Vincent Robert, Vincent Aucagne, Mathieu Galibert, et al.. Development of new kisspeptin analogs to stimulate the reproductive system. International Conference on Gonadotropins & Receptors, Sep 2014, Tours, France. 2014, ICGRIII International Conference on Gonadotropins & Receptors. ⟨hal-02744014⟩
  • Massimiliano Beltramo, V. Aucagne, Vincent Robert, M. Galibert, J.B. Madinier, et al.. Design and functional profiling of new KISS1R agonists. 2. Annual Meeting of the GDR RCPG-PhysioMed, Oct 2013, Illkirch, France. 2013, 2nd Annual Meeting of the GDR RCPG-PhysioMed. ⟨hal-02745908⟩
  • H. Meudal, Chrystelle Derache, Virginie Herve-Grepinet, P. Bulet, Y. Le Maho, et al.. Avian defensins and ovo-defensins : a structural point of view. Antimicrobial Peptides. Discovery, Function and Application, Feb 2013, Ventura, CA, United States. 1 p., 2013. ⟨hal-02807466⟩
  • Mathieu Galibert, Chrystelle Derache, Franck Coste, Hervé Meudal, Anne-Christine Lalmanach, et al.. Improvement of the chemical production of β-defensins including straightforward attribution of disulfide bridges. 18. Réunion du GFPP, May 2013, Sète, France. 1 p., 2013. ⟨hal-02805308⟩
  • Massimiliano Beltramo, V. Aucagne, R. Vincent, M. Galibert, J.B. Madinier, et al.. La kisspeptine : une nouvelle voie pour maitriser l’ovulation chez les petits ruminants ?. 5. Journées d'Animation Scientifique du département Phase (JAS Phase 2013), Oct 2013, Paris, France. 2013. ⟨hal-02805330⟩
  • M. Galibert, Chrystelle Derache, F. Coste, H. Meudal, Anne-Christine Lalmanach, et al.. Improvement of the chemical production of β-defensins including straighforward attribution of disulfide bridges. 3. International Symposium on Antimicrobial Peptides: Today knowledge and future applications, Jun 2012, Lille, France. pp.C-43, 2012, AMP 2012 - Antimicrobial peptide symposium. ⟨hal-02748134⟩
  • Hervé Meudal, Chrystelle Derache, Virginie Herve-Grepinet, Philippe Bulet, Yvon Le Maho, et al.. Birds defensins: a structural point of view. 25. ICMRBS - International Conference on Magnetic Resonance in Biological Systems, Aug 2012, Lyon, France. 1 p., 2012. ⟨hal-02808400⟩
  • Chrystelle Derache, Emmanuel Kut, Hervé Meudal, Vincent Aucagne, Agnès Delmas, et al.. Antibacterial spectrum of avian defensin 2: peculiarities in relationship with structural features. 3. International Symposium on Antimicrobial Peptides: Today knowledge and future applications (AMP 2012), Jun 2012, Lille, France. pp.D-97, 2012. ⟨hal-02807349⟩
  • Hervé Meudal, Chrystelle Derache, Virginie Herve-Grepinet, Philippe Bulet, Yvon Le Maho, et al.. 3D structures of avian defensins. 3. International Symposium on Antimicrobial Peptides: Today knowledge and future applications. (AMP 2012), Jun 2012, Lille, France. n.p., 2012. ⟨hal-02749392⟩
  • H. Meudal, Virginie Herve-Grepinet, Valérie Labas, A. Delmas, Yves Nys, et al.. 1ère structure 3D d'une beta-défensine d'oeuf. GERM 2010 - Détection et Acquisition en Résonnance Magnétique, May 2010, Saint-Dié-des-Vosges, France. 1 p., 2010. ⟨hal-02816486⟩
  • Chrystelle Derache, Hervé Meudal, Vincent Aucagne, Anne-Christine Lalmanach, Céline Landon, et al.. Synthesis and oxidative folding of functional miniproteins containing three disulfide bridges. 21e Colloque Biotechnocentre, 2008, Seillac, France. 1 p, 2008. ⟨hal-02818274⟩

Chapitre d'ouvrage

  • S. Abboud, A.F. Delmas, V. Aucagne. Solid phase chemical ligation. Brik A., Dawson P., Liu L. Chemical Protein Synthesis, Wiley, In press. ⟨hal-02974365⟩
  • A. Miranda, L. Jouvensal, F. Vovelle, P. Bulet, S. Daffre. Gomesin: a powerful antimicrobial peptide isolated from the Brazilian tarantula spider Acanthoscurria gomesiana. Lima, M.E., Pimenta, A.M.C., Martin-Eauclaire, M.F., Zingali, R. & Rochat, H. Animal toxins: state of the art. Perspectives in halth and biotechnology, Belo Horizonte: Editora UFMG, pp.323-343, 2009. ⟨hal-00283559⟩
  • A. Miranda, L. Jouvensal, F. Vovelle, P. Bulet, S. Daffre. Gomesin: a powerful antimicrobial peptide isolated from the Brazilian tarantula spider Acanthoscurria gomasiana. Lima, M.E., Pimenta, A.M.C., Martin-Eauclaire, M.F., Zingali, R., Rochat, H. Animal toxins: state of the art. Perspectives in halth and biotechnology, Belo Horizonte: Editora UFMG, pp.323-343, 2008. ⟨hal-00623591⟩
  • D. Lelièvre, C. Favard, B. Antonny, M. Chabre, A. Delmas. Design and synthesis of a peptide construct mimicking the p23 protein using oxime ligation. Flegel M., Fridkin M., Gilon C., Slaninova J. Peptides 2004: Proceedings of the 3rd International and 28th European Peptide Symposium, Kenes International, Tel Aviv, pp.389-390, 2005. ⟨hal-00115173⟩
  • Gérard Lancelot, Françoise Paquet. NMR Studies of lac Operator and lac Repressor. Annual Reports on NMR Spectroscopy, pp.169-211, 2003. ⟨hal-02121524⟩
  • N. Mandard, P. Bulet, C. Hétru, C. Landon, F. Vovelle. Solution structure of antimicrobial peptides with a β-hairpin fold. Structure-activity relationship. Membrane interacting peptides and proteins, Research Signpost, Trivandrum, pp.155-171, 2002. ⟨hal-00115803⟩
  • Le Falher G., C. BurÉ, A. Delmas. Peptide aldehyde reactivity in aqueous solution: influence of the hydrated form studied by electrospray mass spectrometry. Benedetti E., Pedone C. Peptide 2002: Proceedings of the 27th European Peptide Symposium, Edizioni Ziino, Naples, pp.82-83, 2002. ⟨hal-00115801⟩

Brevet

  • Nicolas Guyot, Sophie Réhault-Godbert, Anne Silvestre, Sascha Trapp, Sophie Iochmann, et al.. Peptides dérivés d'une beta-défensine 11 aviaire et leurs utilisations. France, N° de brevet: WO 2020/030773 A1. AMV. 2020. ⟨hal-02595638⟩