Impact of pesticides on biodiversity


Scientific works of Jean-Marc Bonmatin are at the interface of chemistry, biology and toxicology. His works mainly focus on:

1) measurements of exposures to xenobiotic molecules (especially pesticides acting on the central nervous system),

2) mechanisms of action of neuro-toxicants, and their effects on living systems.

Combination of these two approaches by using a new validated model of eco-toxicological risks, then allows him providing a fine risk assessment, this for both non-target invertebrates, and vertebrates.

Two main classes of insecticides have been extensively studied in the frame of European community research programs: neonicotinoids and phenylpyrazoles. By developing new analytical methods which are the most sensitive so far (LC/GC-MS-MS), JM Bonmatin and co-workers have demonstrated the contamination of pollen and nectar by these insecticides. They also shown that chronic exposure at very low doses induces a significant lethality and a set of sublethal effects, including effects on reproduction.

For a better understanding of these issues at the global level, JM Bonmatin has co-created an international expert group of independent researchers (22 countries): The Task Force on Systemic Pesticides (TFSP). The TFSP has published the first meta-analysis on this subject in 2015, with an update in 2017. The comprehensive meta-analysis revealed that systemic insecticides: a) contaminate significantly all compartments of the environment (soil, water, plants and air), and b) that these insecticides severely impact biodiversity (pollinators, terrestrial and aquatic invertebrates, and insectivorous vertebrates species).

In this context, Jean-Marc Bonmatin is involved in risk assessment of emerging issues, as a member of national expert committees (follow the links: Ministry of agriculture, Institute of bees and pollination, Agency of food safety and environment), as well as for international bodies (follow the links: IUCN, IPBES, OECD, and vice-Chair of the TFSP).

A few more at Washington Post, Cpac Canada, Euractiv,The Guardian, European Commission


60 documents

Article dans une revue

  • Go Ichikawa, Ryota Kuribayashi, Yoshinori Ikenaka, Takahiro Ichise, Shouta Nakayama, et al.. LC-ESI/MS/MS analysis of neonicotinoids in urine of very low birth weight infants at birth. PLoS ONE, Public Library of Science, 2019, 14 (7), pp.e0219208. ⟨10.1371/journal.pone.0219208⟩. ⟨hal-02321502⟩
  • Jean-Marc Bonmatin, Dominique Noome, Heron Moreno, Edward A.D. Mitchell, Gaétan Glauser, et al.. A survey and risk assessment of neonicotinoids in water, soil and sediments of Belize. Environmental Pollution, Elsevier, 2019, 249, pp.949-958. ⟨10.1016/j.envpol.2019.03.099⟩. ⟨hal-02107559⟩
  • Emilie Egea, Wilfried Sanchez, Philippe Garrigues, Gela Alemayehu Bayeta, Andres Arce, et al.. The Rovaltain Foundation Engages in Pollinator Health. Bee World, 2018, 95 (1), pp.20-21. ⟨10.1080/0005772X.2017.1408932⟩. ⟨hal-02082351⟩
  • Lorenzo Furlan, Alberto Pozzebon, Carlo Duso, Noa Simon-Delso, Francisco Sánchez-Bayo, et al.. An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 3: alternatives to systemic insecticides. Environmental Science and Pollution Research, Springer Verlag, 2018. ⟨hal-01966114⟩
  • Dave Goulson, Jennifer Sills, Hans Frey,, Sarah Tzinieris,, Edouard Colin, Marc, et al.. Call to restrict neonicotinoids. Science, American Association for the Advancement of Science, 2018, 360 (6392), pp.973.1-973. ⟨10.1126/science.aau0432⟩. ⟨hal-02107652⟩
  • Lennard Pisa, Dave Goulson, En-Cheng Yang, David Gibbons, Francisco Sánchez-Bayo, et al.. An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 2: impacts on organisms and ecosystems. Environmental Science and Pollution Research, Springer Verlag, 2017, ⟨10.1007/s11356-017-0341-3⟩. ⟨hal-02071713⟩
  • Chiara Giorio, Anton Safer, Francisco Sánchez-Bayo, Andrea Tapparo, Andrea Lentola, et al.. An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 1: new molecules, metabolism, fate, and transport. Environmental Science and Pollution Research, Springer Verlag, 2017, ⟨10.1007/s11356-017-0394-3⟩. ⟨hal-02068718⟩
  • Francisco Sánchez-Bayo, Luc Belzunces, Jean-Marc Bonmatin. Lethal and sublethal effects, and incomplete clearance of ingested imidacloprid in honey bees (Apis mellifera). Ecotoxicology, Springer Verlag, 2017, ⟨10.1007/s10646-017-1845-9⟩. ⟨hal-01606746⟩
  • Peter Paul Hoppe, Anton Safer, Vanessa Amaral-Rogers, Jean-Marc Bonmatin, Dave Goulson, et al.. Effects of a neonicotinoid pesticide on honey bee colonies: a response to the field study by Pilling et al. (2013). Environmental Sciences Europe, 2015, 27 (1), ⟨10.1186/s12302-015-0060-7⟩. ⟨hal-02072264⟩
  • J.-M. Bonmatin, C. Giorio, V. Girolami, D. Goulson, D. P. Kreutzweiser, et al.. Environmental fate and exposure; neonicotinoids and fipronil. Environmental Science and Pollution Research, Springer Verlag, 2015, 22 (1), pp.35-67. ⟨10.1007/s11356-014-3332-7⟩. ⟨hal-01170672⟩
  • N. Simon-Delso, V. Amaral-Rogers, L. P. Belzunces, Jean-Marc Bonmatin, M. Chagnon, et al.. Systemic insecticides (neonicotinoids and fipronil): trends, uses, mode of action and metabolites. Environmental Science and Pollution Research, Springer Verlag, 2015, 22 (1), pp.5-34. ⟨10.1007/s11356-014-3470-y⟩. ⟨hal-01171969⟩
  • J. P. van der Sluijs, V. Amaral-Rogers, L. P. Belzunces, M. F. I. J. Bijleveld van Lexmond, J-M. Bonmatin, et al.. Conclusions of the Worldwide Integrated Assessment on the risks of neonicotinoids and fipronil to biodiversity and ecosystem functioning. Environmental Science and Pollution Research, Springer Verlag, 2015, 22 (1), pp.148-154. ⟨10.1007/s11356-014-3229-5⟩. ⟨hal-01171970⟩
  • L. W. Pisa, V. Amaral-Rogers, L. P. Belzunces, J. M. Bonmatin, C. A. Downs, et al.. Effects of neonicotinoids and fipronil on non-target invertebrates. Environmental Science and Pollution Research, Springer Verlag, 2015, 22 (1), pp.68-102. ⟨10.1007/s11356-014-3471-x⟩. ⟨hal-01171771⟩
  • Robert Paxton, Mark Brown, Michael Kuhlmann, Dave Goulson, Axel Decourtye, et al.. Entomology: The bee-all and end-all. Nature, Nature Publishing Group, 2015, 521 (7552), pp.S57-S59. ⟨10.1038/521S57a⟩. ⟨hal-02082386⟩
  • Maarten Bijleveld van Lexmond, Jean-Marc Bonmatin, Dave Goulson, Dominique A. Noome. Worldwide integrated assessment on systemic pesticides. Environmental Science and Pollution Research, Springer Verlag, 2015, 22 (1), pp.1-4. ⟨10.1007/s11356-014-3220-1⟩. ⟨hal-01182130⟩
  • Delphine Paradis, Géraldine Bérail, Jean-Marc Bonmatin, Luc P Belzunces. Sensitive analytical methods for 22 relevant insecticides of 3 chemical families in honey by GC-MS/MS and LC-MS/MS.. Analytical and Bioanalytical Chemistry, Springer Verlag, 2014, 406 (2), pp.621-633. ⟨hal-01180808⟩
  • Gaël Charpentier, Fanny Louat, Jean-Marc Bonmatin, Patrice A. Marchand, Fanny Vanier, et al.. Lethal and sublethal effects of imidacloprid, after chronic exposure, on the insect model Drosophila melanogaster. Environmental Science and Technology, American Chemical Society, 2014, 48 (7), pp.4096-4102. ⟨10.1021/es405331c⟩. ⟨hal-01178479⟩
  • Jeroen P van der Sluijs, Noa Simon-Delso, Dave Goulson, Laura Maxim, Jean-Marc Bonmatin, et al.. Neonicotinoids, bee disorders and the sustainability of pollinator services. Current Opinion in Environmental Sustainability, Elsevier, 2013, 5 (3-4), pp.293-305. ⟨10.1016/j.cosust.2013.05.007⟩. ⟨hal-00874897⟩
  • Marc-Edouard Colin, Patrice Marchand, Jean-Marc Bonmatin. L'apiculture écologique. L'Ecologiste, 2007, 21, pp.41-43. ⟨hal-00170381⟩
  • Qiasong Zhang, Juliette R. Ongus, Willem Jan Boot, Johan Calis, Jean-Marc Bonmatin, et al.. Detection and localisation of picorna-like virus particles in tissues of Varroa destructor, an ectoparasite of the honey bee, Apis mellifera. Journal of Invertebrate Pathology, Elsevier, 2007, 96 (2), pp.97-105. ⟨10.1016/j.jip.2007.03.019⟩. ⟨hal-00159630⟩
  • J.M. Bonmatin, P.A. Marchand, R. Charvet, I. Moineau, E.R. Bengsch, et al.. Quantification of imidacloprid uptake in maize crops. Journal of Agricultural and Food Chemistry, American Chemical Society, 2005, 53, pp.5336-5341. ⟨hal-00088508⟩
  • R. Charvet, M. Katouzian-Safadi, M. Colin, P.-A. Marchand, J.M. Bonmatin. Insecticides systémiques : de nouveaux risques pour les insectes pollinisateurs. Annales Pharmaceutiques Françaises, Elsevier Masson, 2004, 62 (1), pp.29-35. ⟨10.1016/S0003-4509(04)94278-2⟩. ⟨hal-02082454⟩
  • R. Charvet, M. Katouzian-Safadi, Colin M.E., Marchand P.A., Bonmatin J.M.. (Systemic insecticides: new risks for pollinator insects) Insecticides systémiques : de nouveaux risques pour les insectes pollinisateurs. Annales Pharmaceutiques Françaises, Elsevier Masson, 2004, 62 (1), pp.29-35. ⟨hal-00112964⟩
  • M.E. Colin, J.M. Bonmatin, I. Moineau, C. Gaimon, S. Brun, et al.. A method to quantify and analyze the foraging activity of honey bees: relevance to the sublethal effects induced by systemic insecticides. Archives of Environmental Contamination and Toxicology, Springer Verlag, 2004, 47 (3), pp.387-395. ⟨10.1007/s00244-004-3052-y⟩. ⟨hal-00112970⟩
  • J.R. Ongus, D. Peters, J.M. Bonmatin, E. Bengsch, J.M. Vlak, et al.. Complete sequence of a picorna-like virus of the genus Iflavirus replicating in the mite varroa destructor. Journal of General Virology, Microbiology Society, 2004, 85, pp.3747-3755. ⟨hal-00113080⟩
  • J.M. Bonmatin, O. Laprévote, F. Peypoux. Diversity among microbial cyclic lipopeptides: iturins and surfactins. Activity-structure relationships to design new bioactives agents. Combinatorial chemistry & high throughput screening., 2003, 6, pp.541-556. ⟨hal-00087693⟩
  • Mehrnaz Katouzian-Safadi, Jean-Marc Bonmatin. The use of honey in the simple and composed drugs at Rhazés. Revue d'histoire de la pharmacie, Société d'histoire de la pharmacie, A paraître, 51 (337), pp.29-36. ⟨hal-02082483⟩
  • Joëlle Ricordel, Jean-Marc Bonmatin. Honey's virtues in theriacs. Revue d'histoire de la pharmacie, Société d'histoire de la pharmacie, 2003, 51 (337), pp.21-8. ⟨hal-02082486⟩
  • J.M. Bonmatin, I. Moineau, R. Charvet, C. FlÉchÉ, M.E. Colin, et al.. A LC/APCI-MS/MS method for analysis of imidacloprid in soils, in plants and in pollens. Analytical Chemistry, American Chemical Society, 2003, 75, pp.2027-2033. ⟨hal-00087695⟩
  • Jean-Marc Bonmatin, Olivier Laprévote, Françoise Peypoux. Diversity among microbial cyclic lipopeptides: iturins and surfactins. Activity-structure relationships to design new bioactive agents.. Combinatorial Chemistry and High Throughput Screening, Bentham Science Publishers, 2003, 6 (6), pp.541-56. ⟨hal-02082474⟩
  • Marc Colin, Marc Tchamitchian, Jean-Marc Bonmatin, Sylvie Di Pasquale. Presence of chitinase in adult Varroa destructor, an ectoparasitic mite of Apis mellifera. Experimental and Applied Acarology, Springer Verlag, 2001, 25 (12), pp.947-955. ⟨10.1023/A:1020657906024⟩. ⟨hal-02082513⟩
  • F Peypoux, J Bonmatin, J. Wallach. Recent trends in the biochemistry of surfactin.. Applied Microbiology and Biotechnology, Springer Verlag, 1999, 51 (5), pp.553-63. ⟨hal-02082527⟩
  • F Grangemard, J.M. Bonmatin, B. Bernillon, B Das, F Peypoux. Lichenysins G, a novel family of lipopeptide biosurfactants from Bacillus licheniformis IM 1307: production, isolation and structural evaluation by NMR and mass spectrometry.. Journal of Antibiotics, Nature Publishing Group: Open Access Hybrid Model Option B, 1999, 52 (4), pp.363-73. ⟨hal-02082523⟩
  • Nicolas Mandard, Denise Sy, Corinne Maufrais, Jean-Marc Bonmatin, Philippe Bulet, et al.. Androctonin, a Novel Antimicrobial Peptide from Scorpion Androctonus Australis : Solution Structure and Molecular Dynamics Simulations in the Presence of a Lipid Monolayer. Journal of Biomolecular Structure and Dynamics, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 1999, 17 (2), pp.367-380. ⟨10.1080/07391102.1999.10508368⟩. ⟨hal-02082519⟩
  • F Mandard, P. Sodano, H Labbe, J.M. Bonmatin, P. Bulet, et al.. Solution structure of thanatin, a potent bactericidal and fungicidal insect peptide, determined from proton two-dimensional nuclear magnetic resonance data.. European Journal of Biochemistry, Wiley, 1998, 256 (2), pp.404-10. ⟨hal-02082530⟩
  • Céline Landon, Patrick Sodano, C. Cornet, J.M. Bonmatin, Charles Kopeyan, et al.. Refined solution structure of the anti-mammal and anti-insect LqqIII scorpion toxin: Comparison with other scorpion toxins. Proteins: Structure, Function, and Genetics, Wiley, 1997, 28 (3), pp.360-374. ⟨10.1002/(SICI)1097-0134(199707)28:3<360::AID-PROT6>3.0.CO;2-G⟩. ⟨hal-02082536⟩
  • A Grangemard, F Peypoux, J. Wallach, B Das, H Labbé, et al.. Lipopeptides with improved properties: structure by NMR, purification by HPLC and structure-activity relationships of new isoleucyl-rich surfactins.. Journal of Peptide Science, Wiley, 1997, 3 (2), pp.145-54. ⟨10.1002/(SICI)1099-1387(199703)3:2%3C145::AID-PSC96%3E3.0.CO;2-Y⟩. ⟨hal-02082565⟩
  • C. Landon, C. Cornet, J.M. Bonmatin, C Kopeyan, H. Rochat, et al.. 1H-NMR-derived secondary structure and the overall fold of the potent anti-mammal and anti-insect toxin III from the scorpion Leiurus quinquestriatus quinquestriatus.. European Journal of Biochemistry, Wiley, 1996, 236 (2), pp.395-404. ⟨hal-02082569⟩
  • M Maget-Dana, J.M Bonmatin, C Hetru, M. Ptak, J Maurizot. The secondary structure of the insect defensin A depends on its environment. A circular dichroism study.. Biochimie, Elsevier, 1995, 77 (4), pp.240-4. ⟨hal-02082593⟩
  • J Faucon, J.M Bonmatin, J Dufourcq, E Dufourc. Acyl chain length dependence in the stability of melittin-phosphatidylcholine complexes. A light scattering and 31P-NMR study.. BBA - Biochimica et Biophysica Acta, Elsevier, 1995, 1234 (2), pp.235-43. ⟨hal-02082588⟩
  • Jean-Marc Bonmatin, Henri Labbé, Isabelle Grangemard, Françoise Peypoux, Régine Maget-Dana, et al.. Production, isolation and characterization of [Leu4]- and [Ile4]surfactins from Bacillus subtilis. Letters in Peptide Science, Springer Verlag, 1995, 2 (1), pp.41-47. ⟨10.1007/BF00122922⟩. ⟨hal-02082582⟩
  • F. Cornet, J.M. Bonmatin, C Hetru, J. Hoffmann, M. Ptak, et al.. Refined three-dimensional solution structure of insect defensin A.. Structure, Elsevier (Cell Press), 1995, 3 (5), pp.435-48. ⟨hal-02082576⟩
  • Jean-Marc Bonmatin, Monique Genest, Henri Labbé, Marius Ptak. Solution three-dimensional structure of surfactin: A cyclic lipopeptide studied by 1 H-nmr, distance geometry, and molecular dynamics. Biopolymers, Wiley, 1994, 34 (7), pp.975-986. ⟨10.1002/bip.360340716⟩. ⟨hal-02082601⟩
  • M Peypoux, J.M Bonmatin, H Labbe, G Grangemard, B Das, et al.. [Ala4]surfactin, a novel isoform from Bacillus subtilis studied by mass and NMR spectroscopies.. European Journal of Biochemistry, Wiley, 1994, 224 (1), pp.89-96. ⟨hal-02082597⟩
  • J. Dufourcq, E. Dufourc, J.C Maillet, I Cornut, E. Thiaudiere, et al.. Peptide-Induced Changes in Structure, Dynamic and Barrier Properties of Liposomes and Membranes. Phosphorus, Sulfur, and Silicon and the Related Elements, Taylor & Francis, 1993, 77 (1-4), pp.113-116. ⟨10.1080/10426509308045632⟩. ⟨hal-02082605⟩
  • J. M. Bonmatin, M. Genest, M. C. Petit, E. Gincel, Jean-Pierre Simorre, et al.. Progress in multidimensional NMR investigations of peptide and protein 3-D structures in solution. From structure to functional aspects.. Biochimie, Elsevier, 1992, 74 (9-10), pp.825-36. ⟨hal-00433186⟩
  • J.M. Bonmatin, J Bonnat, X. Gallet, F. Vovelle, M. Ptak, et al.. Two-dimensional 1H NMR study of recombinant insect defensin A in water: resonance assignments, secondary structure and global folding.. Journal of Biomolecular NMR, Springer Verlag, 1992, 2 (3), pp.235-56. ⟨hal-02082611⟩
  • Pascale Malon, Jean-Marc Bonmatin, André Brack. Synthesis and characterization of cyclic peptides with hydrolytic activity. Tetrahedron Letters, Elsevier, 1991, 32 (39), pp.5337-5340. ⟨10.1016/S0040-4039(00)92379-7⟩. ⟨hal-02082617⟩
  • M Peypoux, J.M Bonmatin, H Labbé, B Das, M. Ptak, et al.. Isolation and characterization of a new variant of surfactin, the [Val7]surfactin.. European Journal of Biochemistry, Wiley, 1991, 202 (1), pp.101-6. ⟨hal-02082613⟩
  • Jean Marc Bonmatin, Ian Smith, Harold Jarrell, David Siminovitch. Use of a comprehensive approach to molecular dynamics in ordered lipid systems: cholesterol reorientation in oriented lipid bilayers. A deuterium NMR relaxation case study. Journal of the American Chemical Society, American Chemical Society, 1990, 112 (5), pp.1697-1704. ⟨10.1021/ja00161a007⟩. ⟨hal-02082619⟩
  • E.J Dufourc, J.M Bonmatin, J Dufourcq. Membrane structure and dynamics by 2H- and 31P-NMR. Effects of amphipatic peptidic toxins on phospholipid and biological membranes.. Biochimie, Elsevier, 1989, 71 (1), pp.117-23. ⟨hal-02082623⟩
  • Jean Marc. Bonmatin, Ian Smith, Harold Jarrell, David Siminovitch. Orientation dependence of 2H NMR spin-lattice relaxation rates for cholesterol in macroscopically oriented multibilayers. Journal of the American Chemical Society, American Chemical Society, 1988, 110 (26), pp.8693-8695. ⟨10.1021/ja00234a019⟩. ⟨hal-02082626⟩

Communication dans un congrès

  • J.M. Bonmatin, P.A. Marchand, S. Sobanska, M.E. Colin, L.P. Belzunces. Colony Collapse Disorder (CCD): Detection of systemic insecticides and interactions with pollinators. 7th international conference "Aegean Analytical Chemistry Days", Sep 2010, Lesvos, Greece. ⟨hal-00831542⟩
  • Jean-Marc Bonmatin, P.A. Marchand, Gaëlle Danièle, Hervé Casabianca, Marc-Edouard Colin, et al.. Impact of environmental toxins: bioavailability of systemic insecticides il pollen and interactions with bee colonies. International Conference on Pollinator Biology, Health and Policy, Jul 2010, State College, Pennsylvania, United States. ⟨hal-00639757⟩
  • Gaëlle Danièle, Hervé Casabianca, Marion Courtiade, Jean-Marc Bonmatin, Patrice Marchand. Nano-détection du fipronil et de ses principaux métabolites dans diverses matrices apicoles. 1ere journée scientifique apicole, Feb 2009, Saint-Avold, France. ⟨hal-00742669⟩


  • S. Sobanska, N. Dupuy, J.M. Bonmatin. Raman characterization of pollen pellets collected by honey bees. Euroanalysis 2015, Sep 2015, Bordeaux, France. ⟨hal-01263522⟩

Ouvrage (y compris édition critique et traduction)

  • Jean-Marc Bonmatin, Francisco Sánchez-Bayo. Systemic Pesticides: A Worldwide Assessment. Francisco Sanchez-Bayo, Jose Isagani B. Janairo, Jean-Marc Bonmatin. De La Salle Universyt Publishing House, 2017, 978-9715556484. ⟨hal-02071583⟩

Chapitre d'ouvrage

  • Mehrnaz Katouzian-Safadi, Jean-Marc Bonmatin. Du Diagnostic Differential aux Therapies Prudentes : Le traité de la rougeole et de la variole de Râzi. Medicine and Healing in the Ancient Mediterranean World, D. Michaelides (Dir.),, Oxford & Philadelphia, Oxbow Books, pp.334-349, 2014. ⟨hal-01533047⟩
  • Jm. Bonmatin, Pa. Marchand, Jf. Cotte, A. Aajoud, H. Casabianca, et al.. Bees and systemic insecticides (imidacloprid, fipronil) in pollen: subnano-quantification by HPLC/MS/MS and GC/MS. A.A.M. Del Re, E. Capri, G. Fragoulis and M. Trevisan. Environmental Fate and Ecological Effects of Pesticides, Ed. La Goliardica Pavese, Pavia, Italy, pp.837-845, 2007. ⟨hal-00282377⟩
  • J.M. Bonmatin, I. Moineau, R. Charvet, M.E. Colin, C. FlÉchÉ, et al.. Behaviour of imidacloprid in fields. Toxicity for honey bees. E. Lichtfouse, J. Schwarzbauer, D. Robert. Environmental Chemistry. Green chemistry and pollutants in ecosystems, Springer, pp.483-494, 2005. ⟨hal-00088509⟩