Typologie d'actualités: Group Pharmacological targets and Biomarkers

Targeting the LINGO-1 receptor and its hetero-complexes: new therapeutic perspectives for the treatment of demyelinating and neurodegenerative diseases

LINGO-1 is a transmembrane protein mainly expressed in neurons and oligodendrocytes where it negatively regulates regeneration, neuronal survival, oligodendrocyte differentiation and myelination. Its expression was shown to be dysregulated in several brain disorders, in particular, Parkinson's disease and multiple sclerosis, which makes LINGO-1 a particular interesting therapeutic target. Three homologs LINGO-2, LINGO-3 and LINGO-4 have been described in human but until now their functions remain largely unknown. In this article published in the FASEB Journal, the researchers evaluated the expression, the cerebral distribution and the colocalization of these different homologs in several brain areas. They also showed the formation of hetero-complexes of LINGO-1 with its homologs in the brain, revealing a new level of complexity in the regulation of the activity of these receptors. The demonstration of this LINGO-1 signaling opens the way to new strategies to modulate its activity for the treatment of brain disorders.

Guillemain, A., Y. Laouarem, L. Cobret, D. Stefok, W. Chen, S. Boch, A. Zahaf, L. Blot, F. Reverchon, T. Normand, M. Decoville, C. Grillon, E. Traiffort and S. Morisset (2020). "LINGO family receptors are differentially expressed in mouse brain and forms native multimeric complexes " FASEB J (2020) doi : 10.1096/fj.202000826R

Creation of a predictive model of metabolic changes characteristic of neurodegenerative diseases

Drosophila flies are versatile animal models for the study of genetic mutations in neuronal pathologies. Their small size allows performing in vivo experiments to obtain high resolution nuclear magnetic resonance spectra. Dr. Martine Decoville of CBM, researchers from CEMHTIand ESPCI Paris used spatially-resolved ¹H high-resolution MAS NMR to investigate in vivo metabolite contents in different segments of the fly body. A comparative study of metabolic changes was performed for three neurodegenerative disorders: two cell-specific neuronal and glial models of Huntington disease and a model of glutamate excitotoxicity. These 3 pathologies are characterized by specific and sometimes anatomically localized variations in metabolite concentrations. In two cases, the modifications of ¹H MAS NMR spectra localized in fly heads were significant enough to allow the creation of a predictive model.

Spatially-resolved metabolic profiling of living Drosophila in neurodegenerative conditions using 1H magic angle spinning NMR - Scientific Reports (2020) https://doi.org/10.1038/s41598-020-66218-z

Claudine Kieda, Research Director Emeritus at the CBM, honored at the “Outstanding Poles in France” gala.

 

This action by the Polish Polskie Godlo Promocyjne Teraz Polska Foundation is awarded to Polish and Polish people permanently residing in France who have achieved great success in their work, who are recognized in their communities for initiatives and activities to promote a positive image of Poland and the Poles.

The aim is to make these people better known in France and also in Poland, where they often remain anonymous.

The title "Outstanding Polish" can be awarded in the following five categories: Business, Culture, Research / Science, Personality and "Young Poles".

 

New models to predict and study the effects of cosmetic compounds

Evaluating the activity of compounds on the skin and understanding their mechanisms of action have become unavoidable steps to select and develop a dermocosmetic product. Since the ban on the use of animals in the cosmetic field, many "models" have been  developed, especially with recent advances in research in skin biology and computer science.

The book "Modèles pour l'évaluation des produits cosmétiques, de la molécule à l'humain", coordinated by Catherine Grillon, Leader of the Skin Biology Group at CBM, and Marek Haftek of the Laboratory of Tissue Biology and Therapeutic Engineering de Lyon, gives an overview of all the models used to evaluate the activity of dermocosmetic compounds, with their advantages, disadvantages and limitations. This book, edited by Cosmetic Valley Editions, brings together academic and industrial researchers, all specialists in their field, ranging from in silico prediction to in vivo evaluations, to all in vitro cell models, from the simplest to the most complex.

 

Escape Game – Week of the brain – 11 to 15th of march 2019

During the week of the brain 2019, come and take part to an escape game  which has been designed by researchers of the group "Cibles pharmacologiques et biomarqueurs" of the CBM and of the team "Neurotoxicité et développement" of the INEM laboratory !

The participation is free but the registration is mandatory.

The game is designed for a group of 4 to 6 people. Two possibilities: either you register with your already formed team or , if you are less than four, you can join another team !

Game accessible from 8 years old, accompanied by an adult.

from 11 to 15 march at:  Maison pour la Science en Centre-Val de Loire, 5 rue du carbone, 45100 Orleans.

Partners of th event :
Collégium Sciences et techniques de l’Université d’Orleans, Université d’Orléans, Laboratoire INEM et CBM du CNRS d’Orléans, Maison pour la science, SFR FED4226, Centre Sciences.