Catégorie d'actualités: Events

Collaboration with Béatrice Vallée, co-leader of the Team Cell Signaling and Neurofibromatosis

Bojan Žunar, assistant professor at the University of Zagreb Faculty of Food Technology and Biotechnology in the Laboratory for Biochemistry is visiting the team Cell Signaling and Neurofibromatosis for 2 months.

Bojan is well known at the CBM as he used to be a post-doc fellow in 2020-2021 in the same team.

Now, he is a group leader, and he was awarded a European Grant (https://croestro.eu/, NextGenerationUE), allowing him and members of his group to come to the CBM to perform experiments and to take advantage of Mo2Ving imaging facilities.

His fields of interest concern synthetic biology and yeast engineering in order to design humanized biosensors and innovative microbial factories for research, environmental and manufacturing purposes.

J.-M. Bonmatin co-organiser of the HOLIMITOX feedback day. Holimitox a network of 16 laboratories working on impacts of SDHI fungicides.

The report day of the Holimitox network (https://holimitox.fr/) was held on 7 November 2024 in Paris. The Holimitox interdisciplinary scientific network involves 16 national research laboratories, including the CBM, and has been working for four years on the impact of SDHI pesticides on the environment, biodiversity and health. Holimitox is financed solely by public funds or charitable foundations (>€2M).

The Institut d'Etudes Avancées de Paris hosted the event at the prestigious Hôtel de Lauzun on the Île Saint Louis. J.-M. Bonmatin, a member of the Holimitox Steering Committee, co-organised the two half-day events. The programme is available here. The morning was devoted to presenting the scientific results. The afternoon was devoted to putting these results into perspective within the broader issue of pesticides, this through three round-table discussions. All the stakeholders (parliamentarians, universities and research bodies, ministries (health, agriculture, ecology), ANSES, ANR, manufacturers, journalists, manufactures, NGOs, lawyers, charitable foundations, etc.) played to a full house.

 

 

Welcome to Nikola Baslerova !

Doctoral student Nikola Baslerova is joining the “Molecular Assemblies and Complex Systems” team for a 3-month Erasmus stay, as part of a collaboration with the University of Pardubice in the Czech Republic.

Currently in her third year of doctoral studies, she carries out her research in the field of microbiology, but collaborates with chemists. The title of her thesis is “Determination of the biological activity of boranes and heteroboranes”.

At CBM, she studies the cytotoxicity of certain synthetic molecules, in particular complex, polyhedral boranes and heteroboranes. These compounds are of potential interest for certain biomedical applications, which are currently being explored.

A new anticancer therapeutic strategy targeting the protein kinases LIMKs via new innovative chemical compounds

These last years, significant advances have been obtained in oncology leading to an increase of patients’ lifespan and improved life conditions. However, several cancers remain difficult to treat with mitigated results, and more and more resistances are observed. It is then vital to go on developing new therapies.

LIM kinase proteins are overproduced in many cancers and constitute interesting therapeutic targets. All over the world, small chemical molecules targeting their kinase activity have been developed these 15 last years, but failed to reach clinical trial stage. In collaboration with chemists from ICOA Institute, we developed a new category of innovative small molecules, called PROTACs, which aims to decrease or even to totally shut down the production of LIM kinase proteins. Our first results are really promising as 2 of the molecules synthesized by the chemists are very active: they totally shut down LIMK production and exhibit drastic effects on cells. We have to go on with the characterization of these molecules especially their cellular effect to open the path towards a new innovative efficient therapeutic strategy targeting the LIM kinase proteins for cancer treatment.

Call for application “Arts-Sciences Residency 2024”

Arts-Sciences Residency 2024 - The CBM welcomes an artist

The École supérieure d'art et de design d'Orléans (ESAD Orléans), the CBM research institute (Centre for Molecular Biophysics) and LE STUDIUM Loire Valley Institute for Advanced Studies are offering an ARTS-SCIENCES Artist Residency.

The artistic project will echo the research carried out by the CBM. The residency will result in the creation of a work or prototype produced in collaboration with one of the ESAD Orleans' research programmes and the CBM.

Know more and apply.  Deadline for applications: October 6, 2024.