Typologie d'actualités: CBM

Marcin Suskiewicz, research fellow at the CBM, obtained an ERC Starting 2022 grant

SUMOylation is a natural reaction that changes the structure of proteins in cells. Thanks to his ERC SUMOwriteNread project, Marcin Suskiewicz of the CBM wants to characterize the mechanism by which it occurs, as well as its effects on the properties of proteins. This reaction remains poorly understood even though it probably plays an essential role in our cells.

Find out more on the CNRS Institute of Chemistry website

CBM PhD students have talent!

Ons Kharrat, from the "NMR of Biomolecules" group, received one of the 3 prizes for the best oral communication at the GDR MuFoPAM days which took place from October 19 to 21, 2022.
This prize was awarded to him by the company Genepep (https://www.genepep.com/accueil/).

Elodie Villalonga, from the "Cell signaling and neurofibromatosis" group, won one of the 2 prizes for the best oral communication
and
Valentin Beauvais, from the group “Dysregulation of autophagy during inflammation due to HIV”, received one of the poster prizes at the 34th Biotechnocentre conference which took place on October 20 and 21, 2022.

A major advance in the understanding of DNA damage repair

The "DNA repair: structure, function and dynamics" team has just revealed, in the prestigious journal Nucleic Acid Research, how archaeal DNA glycosylases are able to recognize and repair, at the molecular level, certain lesions in their DNA.

To know more :
Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing
Coste Franck, Goffinont Stéphane, Cros Julien, Gaudon Virginie, Guérin Martine, Garnier Norbert, Confalonieri Fabrice, Flament Didier, Suskiewicz Marcin Josef, Castaing Bertrand https://doi.org/10.1093/nar/gkac932

Welcome to the 9 PhD students of the 2022-2023 class!

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

From top to bottom and left to right:
Adrien Uguen, Sebastien Gfellner, Lucija Mance, Sara Ben Jemaa, Pamela Guerillot, Lylia Azzoug, Giuliano Migliorini, Ivan Ciganek, Thuy-Duong Do (not present in the photo).

2022, October, 14: Seminar of Manon Isaac

Séminaire de Manon Isaac, post-doctorante dans le groupe thématique "Complexes métalliques et IRM".

Abstract:

Zinc cations play a key role as a cofactor in gene transcription and metalloenzyme functions, but also in signaling pathways in the immune system, or during fertilization. To understand its underlying function, on top of the quantification of the total amount of zinc, the detection of the labile pool and its evolution is crucial. Whatever the technique is, probes are required to visualize labile zinc. The probes have to be optimized for a given technique but also for the biological context (e.g. extracellular vs intracellular).

Manon Isaac will present several tools to detect labile zinc developed during her PhD and postdocs: design and characterization of peptidic luminescent probes, the first steps towards a device to detect zinc released by the egg after in vitro fertilization, and MRI zinc probes.