Understanding the function of proteins requires knowing their structures.
To do this, scientists used artificial intelligence to predict the shape of a class of "PARP" type proteins that regulate DNA repair, gene transcription, and antiviral response, but are also potential targets for new cancer therapies. This approach, published in the journal Nucleic Acids Research, could be extended to many other families of proteins.
Voir l'actualité sur le site de l'Institut de Chimie du CNRS
Référence
Updated protein domain annotation of the PARP protein family sheds new light on biological function
Marcin J. Suskiewicz, Deeksha Munnur, Øyvind Strømland, Ji-Chun Yang, Laura E. Easton, Chatrin Chatri , Kang Zhu, Domagoj Baretić, Stéphane Goffinont, Marion Schuller, Wing-Fung Wu, Jonathan M Elkins, Dragana Ahel, Sumana Sanyal, David Neuhaus & Ivan Ahel
Journal Nucleic Acids Research
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad514/7199335?login=true