email : severine.morisset-lopez[remplacer_par_at]cnrs-orleans.fr
Phone : +33 2.38.25.78.58
Senior Researcher, leader of the team “Neurobiology of receptors and and therapeutic innovations”
PERSONAL WEBSITE OF SEVERINE MORISSET-LOPEZ
- Métadonnées
Publications (Archives Hal)
Contact
isabelle.frapart@cnrs-orleans.fr 02.38.25.55.53
Disciplines
- Sciences du Vivant [q-bio]72
- Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Neurobiologie13
- Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Psychologie et comportements5
- Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Sciences cognitives5
- Chimie4
- Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]4
- Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Physiologie [q-bio.TO]3
- Chimie/Chimie organique2
- Chimie/Chimie thérapeutique2
- Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biologie moléculaire2
- Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire2
- Sciences du Vivant [q-bio]/Biologie cellulaire/Organisation et fonctions cellulaires [q-bio.SC]2
- Chimie/Chimie analytique1
- Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biochimie [q-bio.BM]1
- Sciences du Vivant [q-bio]/Biologie cellulaire/Interactions cellulaires [q-bio.CB]1
- Sciences du Vivant [q-bio]/Biologie cellulaire1
- Sciences du Vivant [q-bio]/Cancer1
- Sciences du Vivant [q-bio]/Immunologie1
- Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Anatomie, Histologie, Anatomopathologie [q-bio.TO]1
- Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Endocrinologie et métabolisme1
- Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Pédiatrie1
- Sciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacologie1
- Sciences du Vivant [q-bio]/Sciences pharmaceutiques1
Mots-clefs
5-HT7 receptor ADENYLYL-CYCLASE Animals Antagomirs/pharmacology/therapeutic use Antagonist/ inverse agonist Arrestin BF2649 Bibliographic/statistics & numerical data C-fos Cachexia Catalepsy Chemical biology Ciproxifan Drosophila Glioma Histamine H3 receptor Locomotor activity Metabolism NMR Serotonin
- 5-HT7 receptor3
- Drosophila3
- Glioma3
- Serotonin3
- Histamine H3 receptor2
- Locomotor activity2
- Metabolism2
- NMR2
- ADENYLYL-CYCLASE1
- Animals1
- Antagomirs/pharmacology/therapeutic use1
- Antagonist/ inverse agonist1
- Arrestin1
- BF26491
- Bibliographic/statistics & numerical data1
- C-fos1
- Cachexia1
- Catalepsy1
- Chemical biology1
- Ciproxifan1
- Cognition Disorders/drug therapy/genetics1
- DIFFERENTIATION1
- Databases1
- Dopamine D2 receptors1
- Drug discovery1
- Drug synergy1
- Enkephalin1
- Epigenetics1
- Food intake1
- G protein coupled receptor GPCR1
- G protein-coupled receptors1
- GAP-RELATED DOMAIN1
- GENE-PRODUCT1
- GPCR1
- GPCR signaling1
- GPCR-interacting proteins1
- Gene Expression Regulation/drug effects/physiology1
- Ghrelin receptor1
- Ghrelin/physiology1
- HETEROZYGOSITY1
- HR-MAS1
- HR-MAS NMR1
- Haloperidol1
- Histamine1
- Histamine neurons H3 receptor inverse agonists tele-methylhistamine cognition1
- Humans1
- INACTIVATION1
- Immunolocalization1
- In situ hybridization1
- Interleukin-10 IL-101
- Inverse agonist/antagonist1
- MRI1
- MicroRNAs/antagonists & inhibitors/genetics/metabolism1
- Multiple sclerosis1
- Mutation Analysis1
- NF1 TUMOR-SUPPRESSOR1
- Natalizumab treatment1
- Native chemical ligation1
- Neurodegenerative Diseases/drug therapy1
- Neuronal Plasticity/drug effects1
- Neurones à histamine récepteur H3 agonistes inverses tele-méthylhistamine cognition1
- Neurotensin1
- Nf11
- Nucleus1
- Obesity1
- PATHWAY1
- PBMCs peripheral blood mononuclear cells1
- PLA technique1
- PML bodies1
- PROTEIN1
- Peptide Protein-drug conjugate1
- Phosphorylation sites1
- Receptor-protein interactions1
- Schizophrenia1
- Screening1
- Signal Transduction/drug effects1
- Sleep/wake1
- Synthetic protein1
- T lymphocyte T-cell1
- TYPE-11
Auteurs
Morisset-Lopez Séverine68 Morisset Séverine13 Morisset-Lopez S12 Grillon Catherine12 Schwartz Jean-Charles10 Tardivel-Lacombe J.9 Morisset S.9 Decoville Martine9 Blot L.8 Rouleau A.8 Blot Lauren7 Gbahou F.7 Guillemain A.7 Schwartz J.7 Stark H.7 Traiffort Elisabeth7 Bénédetti Hélène7 Gbahou Florence6 Guillemain Anthony6 Ligneau X.6 Decoville M.6 Deraredj Nadim Wissem5 Reverchon Flora5 Schunack W.5 Tardivel-Lacombe Joël5 Maravat Marion5 Grillon C.5 Fasani Fabienne5 Ruat Martial5 Chen Wanyin4 Hassanaly Shalina4 Junier Marie-Pierre4 Bertrand Marylène4 Cobret Laetitia4 Marin Philippe4 Sarou-Kanian Vincent4 Kellenberger Esther4 Guillaumet G.4 Arrang J.3 Arrang J. M.3 Arrang J.M.3 Cobret L.3 Deau E.3 Gbahou F3 Ligneau Xavier3 Menuet Arnaud3 Schwartz J. C.3 Héron Anne3 Pichon Chantal3 Kieda Claudine3 Suzenet Franck3 Epelbaum Jacques3 Arrang J2 Auzou Pascal2 Bogeas A2 Bogeas A.2 Bogeas Alexandra2 Bojarski A.2 Burban Aude2 Chen W.2 Cochois Véronique2 Crochet S.2 Davenas E.2 Decoville D.2 Deraredj Nadim W.2 Doudeau Michel2 Drutel Guillaume2 El Khamlichi C.2 Ganellin C2 Ganellin C.R.2 Ganellin R.2 Garbarg Monique2 Godin Fabienne2 Guillard Colleen2 Ligneau X2 Lin S.2 Madouri F.2 Madouri Fahima2 Makhloufi Y.2 Mollet Lucile2 Nivot Sylvie2 Pallix-Guyot Maud2 Parmentier R.2 Pillot Catherine2 Reverchon-Assadi Flora2 Robin Eric2 Sasse Astrid2 Schunack W2 Schwartz C.2 Traiffort E.2 Zahaf Amina2 Zajdel P.2 de Tauzia M.-L.2 Héron Anne2 Chen Wanyin2 Gosset David2 Valéry Antoine2 Ozsancak Canan2 Ardourel Maryvonne2 Pantel Jacques2
Revues
- Biochemical and Biophysical Research Communications5
- European Neuropsychopharmacology5
- Journal of Pharmacology and Experimental Therapeutics4
- International Journal of Molecular Sciences2
- Biochemical Pharmacology2
- British Journal of Pharmacology2
- Current Neuropharmacology2
- Biomedicines2
- Journal of Medicinal Chemistry2
- Journal of Neurochemistry2
- NeuroReport2
- FASEB Journal2
- Proceedings of the National Academy of Sciences of the United States of America2
- Cells1
- Brain Research1
- British Journal of Clinical Pharmacology1
- The Conversation France1
- European Journal of Medicinal Chemistry1
- Nature Chemical Biology1
- European Journal of Pharmacology1
- Journal of Clinical Investigation1
- Human Genetics1
- International Congress Series1
- Journal of Clinical Endocrinology and Metabolism1
- Journal of Proteome Research1
- Molecular Psychiatry1
- Molecules1
- Trends in Pharmacological Sciences1
- Thérapie1
- Journal of Neural Transmission Supplementum1
- Neuroscience1
- PLoS ONE1
- Annals of the New York Academy of Sciences1
- Science Signaling1
- Journal of Neuroscience1
- Nature1
- Physiological Reviews1
- Journal of Neural Transmission1
Année de production
Institutions
- Institut National de la Santé et de la Recherche Médicale92
- Université d'Orléans59
- Université de Tours58
- Institut de Chimie - CNRS Chimie58
- Université Paris Descartes - Paris 522
- Groupe hospitalier Broca20
- Université Louis Pasteur - Strasbourg I6
- Commissariat à l'énergie atomique et aux énergies alternatives5
- Université de Strasbourg4
- Université de Montpellier4
- Université Pierre et Marie Curie - Paris 64
- Université des Sciences et Technologies (Bordeaux 1)2
- Institut National de la Recherche Agronomique2
- Technologie Servier1
- Preclinical Research, Sandoz Pharma Ltd1
- Université Nice Sophia Antipolis (1965 - 2019)1
- Université Claude Bernard Lyon 11
- Institut Français du Cheval et de l'Equitation [Saumur]1
- The University of Queensland1
- Centre national du machinisme agricole, du génie rural, des eaux et forêts1
- Institut national des sciences de l'Univers1
- Service de Santé des Armées1
- Université de Technologie de Belfort-Montbeliard1
- La Rochelle Université1
- Ecole Nationale Supérieure de Mécanique et des Microtechniques1
- IFR931
- Centre Hospitalier Régional d'Orléans1
- Universität Wien = University of Vienna1
- Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]1
- Chinese Academy of Sciences [Beijing]1
- Uniwersytet Jagielloński w Krakowie = Jagiellonian University1
- INSTITUT SERVIER1
- Bioprojet-Biotech1
- Hôpial Sainte-Anne1
- Geneuro-Innovation1
- CHU Trousseau [APHP]1
- Université de Lorraine1
- Université Paris-Saclay1
- MEDALIS Drug Discovery Center1
- Université Montpellier 11
- Université de Franche-Comté1
- Vanderbilt University School of Medicine [Nashville]1
- Laboratoire Pharmaceutique Bioprojet Pharma [Paris]1
- Centre Hospitalier Victor Jousselin [Dreux]1
- Uppsala University1
- Université de Poitiers = University of Poitiers1
- Leipzig University | Universität Leipzig1
- Institut de Recherches SERVIER1
- Institut de Recherche pour le Développement1
- Muséum national d'Histoire naturelle1
- Université Montpellier 2 - Sciences et Techniques1
- Université Paris-Sud - Paris 111
Laboratoires
- Centre de biophysique moléculaire58
- Unité de Neurobiologie et Pharmacologie Moléculaire [Centre Paul Broca]20
- Unité de Neurobiologie et Pharmacologie Moléculaire15
- Centre de Psychiatrie et Neurosciences6
- Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique6
- Conditions Extrêmes et Matériaux : Haute Température et Irradiation6
- Immunologie et Neurogénétique Expérimentales et Moléculaires5
- Institut de Chimie Organique et Analytique5
- Laboratoire d'Innovation Thérapeutique4
- Institut de Génomique Fonctionnelle3
- Physiopathologie des maladies génétiques d'expression pédiatrique2
- Mécanismes Adaptatifs et Evolution1
- Neurobiologie des processus adaptatifs1
- Maladies et hormones du système nerveux1
- Department of neuropathology1
- Hydrosciences Montpellier1
- Élevages et territoires1
- Neurophysique et physiologie du système moteur1
- Cytokines, hématopoïèse et réponse immune1
- LIttoral ENvironnement et Sociétés1
- Génétique, immunothérapie, chimie et cancer (GICC), UMR 7292 CNRS [2012-2017]1
- Physiologie de la reproduction et des comportements [Nouzilly]1
- Institut de pharmacologie moléculaire et cellulaire1
- Centre de recherches sur la cognition et l'apprentissage [UMR 7295]1
- Institut de Génomique Fonctionnelle1
- Geneuro-Innovation1
- Institut de Recherches Cliniques de Montréal1
- Imagerie cellulaire des neurorécepteurs et physiopathologie neuroendocrinienne1
- Stéroides et système nerveux : physiopathologie moléculaire et clinique1
- Physiologie integrée du système d'éveil1
- Génétique cellulaire et moléculaire des leucémies1
- Bioprojet-Biotech1
- Laboratoire Sols et Environnement1
- Institut de recherches Servier1
- Récepteurs et protéines membranaires1
- Laboratoire de Neurobiologie1
- Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174)1
- Department of Medicinal Chemistry1
Départements
Équipes de recherche
94 documents
Article dans une revue59 documents
- Marylène Bertrand, Frédéric Szeremeta, Nadège Hervouet-Coste, Vincent Sarou-Kanian, Céline Landon, et al.. An adult Drosophila glioma model to highlight metabolic dysfunctions and evaluate the role of the serotonin 5‐HT 7 receptor as a potential therapeutic target. FASEB Journal, 2023, 37 (11), ⟨10.1096/fj.202300783RR⟩. ⟨hal-04301912⟩
- Ana Novak, Florian Kersaudy, Sylvie Berger, Séverine Morisset-Lopez, François Lefoulon, et al.. An efficient site-selective, dual bioconjugation approach exploiting N-terminal cysteines as minimalistic handles to engineer tailored anti-HER2 affibody conjugates. European Journal of Medicinal Chemistry, 2023, 260, pp.115747. ⟨10.1016/j.ejmech.2023.115747⟩. ⟨hal-04222710⟩
- Flora Reverchon, Colleen Guillard, Lucile Mollet, Pascal Auzou, David Gosset, et al.. T Lymphocyte Serotonin 5-HT7 Receptor Is Dysregulated in Natalizumab-Treated Multiple Sclerosis Patients. Biomedicines, 2022, 10 (10), pp.2418. ⟨10.3390/biomedicines10102418⟩. ⟨hal-03806213⟩
- Florestan Courant, Marion Maravat, Wanyin Chen, David Gosset, Lauren Blot, et al.. Expression of the Human Serotonin 5-HT7 Receptor Rescues Phenotype Profile and Restores Dysregulated Biomarkers in a Drosophila melanogaster Glioma Model. Cells, 2022, 11 (8), pp.1281. ⟨10.3390/cells11081281⟩. ⟨hal-03846028⟩
- Flora Reverchon, Colleen Guillard, Lucile Mollet, Pascal Auzou, David Gosset, et al.. T Lymphocyte Serotonin 5-HT7 Receptor Is Dysregulated in Natalizumab-Treated Multiple Sclerosis Patients. Biomedicines, 2022, 10 (10), pp.2418. ⟨10.3390/biomedicines10102418⟩. ⟨hal-03846032⟩
- Wissem Deraredj Nadim, Shalina Hassanaly, Hélène Bénédetti, Claudine Kieda, Catherine Grillon, et al.. The GTPase-activating protein-related domain of neurofibromin interacts with MC1R and regulates pigmentation-mediated signaling in human melanocytes. Biochemical and Biophysical Research Communications, 2021, 534, pp.758-764. ⟨10.1016/j.bbrc.2020.11.003⟩. ⟨hal-03007433⟩
- Elisabeth Traiffort, Séverine Morisset-Lopez, Mireille Moussaed, Amina Zahaf. Defective Oligodendroglial Lineage and Demyelination in Amyotrophic Lateral Sclerosis. International Journal of Molecular Sciences, 2021, 22 (7), pp.3426. ⟨10.3390/ijms22073426⟩. ⟨hal-03436366⟩
- Marion Maravat, Marylène Bertrand, Céline Landon, Franck Fayon, Séverine Morisset-Lopez, et al.. Complementary Nuclear Magnetic Resonance-Based Metabolomics Approaches for Glioma Biomarker Identification in a Drosophila melanogaster Model. Journal of Proteome Research, 2021, 20 (8), pp.3977-3991. ⟨10.1021/acs.jproteome.1c00304⟩. ⟨hal-03335927⟩
- Nayara Braga Emidio, Rajeshwari Meli, Hue Tran, Hayeon Baik, Séverine Morisset-Lopez, et al.. Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite. Journal of Medicinal Chemistry, 2021, 64 (13), pp.9484-9495. ⟨10.1021/acs.jmedchem.1c00767⟩. ⟨hal-03335490⟩
- Chayma El Khamlichi, Laetitia Cobret, Séverine Morisset-Lopez, Séverine Morisset-Lopez. BRET Analysis of GPCR Dimers in Neurons and Non-Neuronal Cells: Evidence for Inactive, Agonist, and Constitutive Conformations. International Journal of Molecular Sciences, 2021, 22 (19), pp.10638. ⟨10.3390/ijms221910638⟩. ⟨hal-03436322⟩
- Anthony Guillemain, Yousra Laouarem, Laetitia Cobret, Dora Štefok, Wanyin Chen, et al.. LINGO family receptors are differentially expressed in the mouse brain and form native multimeric complexes. FASEB Journal, 2020, pp.1-13. ⟨10.1096/fj.202000826R⟩. ⟨hal-02943248⟩
- Chayma El Khamlichi, Flora Reverchon-Assadi, Nadège Hervouet-Coste, Lauren Blot, Eric Reiter, et al.. Bioluminescence Resonance Energy Transfer as a Method to Study Protein-Protein Interactions: Application to G Protein Coupled Receptor Biology. Molecules, 2019, 24 (3), pp.537. ⟨10.3390/molecules24030537⟩. ⟨hal-02067271⟩
- Céline Dubourg, Flora Reverchon-Assadi, Maryvonne Ardourel, Olivier Richard, Séverine Morisset-Lopez, et al.. Votre cerveau est-il grignoté par les neuromythes ?. The Conversation France, 2018, https://bit.ly/2CBaykM. ⟨hal-02972757⟩
- Wissem Deraredj Nadim, Simion Viorel, Hélène Bénédetti, Chantal Pichon, Patrick Baril, et al.. MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?. Current Neuropharmacology, 2017, 15 (2), pp.260 - 275. ⟨10.2174/1570159X14666160709001441⟩. ⟨hal-01618199⟩
- Viorel Simion, Wissem Deraredj Nadim, Hélène Bénédetti, Chantal Pichon, Séverine Morisset-Lopez, et al.. Pharmacomodulation of microRNA Expression in Neurocognitive Diseases: Obstacles and Future Opportunities. Current Neuropharmacology, 2017, 15 (2), pp.276 - 290. ⟨10.2174/1570159X14666160630210422⟩. ⟨hal-01618771⟩
- Wissem Deraredj Nadim, Séverine Chaumont-Dubel, Fahima Madouri, Laetitia Cobret, Marie-Ludivine de Tauzia, et al.. Physical interaction between neurofibromin and serotonin 5-HT 6 receptor promotes receptor constitutive activity. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (43), pp.12310 - 12315. ⟨10.1073/pnas.1600914113⟩. ⟨hal-01407899⟩
- Yacine Chebani, Candice Marion, Philippe Zizzari, Khadidja Chettab, Marie Pastor, et al.. Enhanced responsiveness of Ghsr Q343X rats to ghrelin results in enhanced adiposity without increased appetite. Science Signaling, 2016, 9 (424), pp.ra39. ⟨10.1126/scisignal.aae0374⟩. ⟨inserm-01463897⟩
- L Cobret, M L de Tauzia, J Ferent, E Traiffort, I Hénaoui, et al.. Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling. British Journal of Clinical Pharmacology, 2015, 172 (3), pp.841-856. ⟨10.1111/bph.12945⟩. ⟨hal-01170735⟩
- Emmanuel Deau, Elodie Robin, Raluca Voinea, Nathalie Percina, Grzegorz Satała, et al.. Rational Design, Pharmacomodulation, and Synthesis of Dual 5-Hydroxytryptamine 7 (5-HT 7 )/5-Hydroxytryptamine 2A (5-HT 2A ) Receptor Antagonists and Evaluation by [ 18 F]-PET Imaging in a Primate Brain. Journal of Medicinal Chemistry, 2015, 58 (20), pp.8066-8096. ⟨10.1021/acs.jmedchem.5b00874⟩. ⟨hal-03082898⟩
- Fanny Duhr, Paul Déléris, F. Raynaud, Martial Séveno, Séverine Morisset-Lopez, et al.. Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth. Nature Chemical Biology, 2014, 10 (7), pp.590-597. ⟨10.1038/nchembio.1547⟩. ⟨hal-01178901⟩
- Fabienne Godin, Sandrine Villette, Béatrice Vallée, Michel Doudeau, Séverine Morisset-Lopez, et al.. A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.. Biochemical and Biophysical Research Communications, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩. ⟨hal-00721861⟩
- F. Gbahou, E. Davenas, S. Morisset, J.- Arrang. Effects of Betahistine at Histamine H3 Receptors: Mixed Inverse Agonism/Agonism In Vitro and Partial Inverse Agonism In Vivo. Journal of Pharmacology and Experimental Therapeutics, 2010, 334 (3), pp.945-954. ⟨10.1124/jpet.110.168633⟩. ⟨hal-02071192⟩
- M. Picard, S. Morisset, J.F. Cloix, J.C. Bizot, M. Guerin, et al.. Pharmacological, neurochemical, and behavioral profile of JB-788, a new 5-HT1A agonist. Neuroscience, 2010, 169 (3), pp.1337-1346. ⟨10.1016/j.neuroscience.2010.05.040⟩. ⟨hal-02071835⟩
- Mouhammad Motawaj, Aude Burban, Elisabeth Davenas, Florence Gbahou, Raphaël Faucard, et al.. Le système histaminergique : une cible pour de nouveaux traitements des deficits cognitifs. Thérapie, 2010, 65 (5), pp.415-422. ⟨10.2515/therapie/2010058⟩. ⟨hal-02071208⟩
- Jacques Pantel, Marie Legendre, Sylvie Nivot, Séverine Morisset, Marie Vie-Luton, et al.. Recessive Isolated Growth Hormone Deficiency and Mutations in the Ghrelin Receptor. Journal of Clinical Endocrinology and Metabolism, 2009, 94 (11), pp.4334-4341. ⟨10.1210/jc.2009-1327⟩. ⟨hal-02081574⟩
- W. Beghdadi, A. Porcherie, Schneider B.S., S. Morisset, D. Dubayle, et al.. Histamine H3 receptor-mediated signaling protects mice from cerebral malaria.. PLoS ONE, 2009, 4, pp.e6004. ⟨hal-00397938⟩
- E. Davenas, A. Rouleau, S. Morisset, J. Arrang. Autoregulation of McA-RH7777 Hepatoma Cell Proliferation by Histamine H3 Receptors. Journal of Pharmacology and Experimental Therapeutics, 2008, 326 (2), pp.406-413. ⟨10.1124/jpet.107.135368⟩. ⟨hal-02081595⟩
- Xavier Ligneau, Laurent Landais, David Perrin, Johanne Piriou, Marilyne Uguen, et al.. Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649.. Biochemical Pharmacology, 2007, 73 (8), pp.1215-24. ⟨10.1016/j.bcp.2007.01.023⟩. ⟨inserm-00150117⟩
- Marie Humbert-Claude, Séverine Morisset, Florence Gbahou, Séverine Morisset-Lopez. Histamine H3 and dopamine D2 receptor-mediated [35S]GTPγ[S] binding in rat striatum: Evidence for additive effects but lack of interactions. Biochemical Pharmacology, 2007, 73 (8), pp.1172-1181. ⟨10.1016/j.bcp.2007.01.006⟩. ⟨hal-02081605⟩
- Séverine Morisset-Lopez, Séverine Morisset, Florence Gbahou. Constitutive activity of the histamine H3 receptor. Trends in Pharmacological Sciences, 2007, 28 (7), pp.350-357. ⟨10.1016/j.tips.2007.05.002⟩. ⟨hal-02081603⟩
- M. Humbert-Claude, S Morisset-Lopez, F. Gbahou, M. Arrang. Potential molecular interactions between the histamine H3 receptor and the dopamine D2 receptor in the rat striatum. European Neuropsychopharmacology, 2006, 16, pp.S16-S17. ⟨10.1016/s0924-977x(06)80021-0⟩. ⟨hal-02082149⟩
- J. Pantel, Marie Legendre, Sylvie Cabrol, Latifa Hilal, Yassir Hajaji, et al.. Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature. Journal of Clinical Investigation, 2006, 116 (3), pp.760-768. ⟨10.1172/JCI25303⟩. ⟨hal-02082146⟩
- S Morisset-Lopez, C. Chabret, J.M. Arrang. P.1.31 Constitutive dimerization of the histamineH3 receptor in living cells. European Neuropsychopharmacology, 2005, 15, pp.S25-S26. ⟨10.1016/s0924-977x(05)80136-1⟩. ⟨hal-02082151⟩
- F. Gbahou, A. Rouleau, S Morisset-Lopez, X. Ligneau, J. Tardivel-Lacombe, et al.. P.1.03 Constitutive activity of the recombinant and native histamine H3 receptor: effects of inverse agonists and protean agonists. European Neuropsychopharmacology, 2004, 14, pp.S4-S5. ⟨10.1016/s0924-977x(04)90004-1⟩. ⟨hal-02081569⟩
- F. Gbahou, A. Rouleau, S Morisset-Lopez, R. Parmentier, S. Crochet, et al.. Protean agonism at histamine H3 receptors in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America, 2003, 100 (19), pp.11086-11091. ⟨10.1073/pnas.1932276100⟩. ⟨hal-02081588⟩
- J. C. Schwartz, S Morisset-Lopez, A. Rouleau, X. Ligneau, F. Gbahou, et al.. Therapeutic implications of constitutive activity of receptors: the example of the histamine H3 receptor.. Journal of Neural Transmission Supplementum, 2003, 64, pp.1-16. ⟨hal-02081590⟩
- J.M. Arrang, S. Morisset, A. Rouleau, F. Gbahou, X. Ligneau, et al.. Constitutive activity of the recombinant and native histamine H3 receptor. International Congress Series, 2003, 1249, pp.139-151. ⟨10.1016/S0531-5131(03)00617-4⟩. ⟨hal-02081573⟩
- Brigitte Ilien, Christelle Franchet, Philippe Bernard, Séverine Morisset, Claire Odile Weill, et al.. Fluorescence resonance energy transfer to probe human M1 muscarinic receptor structure and drug binding properties.. Journal of Neurochemistry, 2003, 85 (3), pp.768-78. ⟨hal-02081577⟩
- J.M. Arrang, S Morisset-Lopez, A. Rouleau, F. Gbahou, X. Ligneau, et al.. S.16.04 Histamine H3-receptor ligands: Effects of inverse agonists and protean ligands. European Neuropsychopharmacology, 2003, 13, pp.S141. ⟨10.1016/s0924-977x(03)91663-4⟩. ⟨hal-02081585⟩
- C. Chotard, T. Ouimet, S. Morisset, U. Sahm, C. Schwartz, et al.. Effects of histamine H 3 receptor agonist and antagonist on histamine co-transmitter expression in rat brain. Journal of Neural Transmission, 2002, 109 (3), pp.293-306. ⟨10.1007/s007020200024⟩. ⟨hal-02081594⟩
- Catherine Pillot, Jordi Ortiz, Anne Héron, Sophie Ridray, Jean-Charles Schwartz, et al.. Ciproxifan, a Histamine H 3 -Receptor Antagonist/Inverse Agonist, Potentiates Neurochemical and Behavioral Effects of Haloperidol in the Rat. Journal of Neuroscience, 2002, 22 (16), pp.7272-7280. ⟨hal-01490023⟩
- Séverine Morisset-Lopez, Catherine Pilon, Joël Tardivel-Lacombe, D Weinstein, William Rostene, et al.. Acute and chronic effects of methamphetamine on tele-methylhistamine levels in mouse brain: selective involvement of the D(2) and not D(3) receptor.. Journal of Pharmacology and Experimental Therapeutics, 2002, 300 (2), pp.621-8. ⟨10.1124/jpet.300.2.621⟩. ⟨hal-02082246⟩
- A. Rouleau, X Ligneau, J. Tardivel-Lacombe, S Morisset-Lopez, F Gbahou, et al.. Histamine H 3 -receptor-mediated [ 35 S]GTPγ[S] binding: evidence for constitutive activity of the recombinant and native rat and human H 3 receptors. British Journal of Pharmacology, 2002, 135 (2), pp.383-392. ⟨10.1038/sj.bjp.0704490⟩. ⟨hal-02082155⟩
- Joël Tardivel-Lacombe, Séverine Morisset, Florence Gbahou, Jean-Charles Schwartz, Séverine Morisset-Lopez. Chromosomal mapping and organization of the human histamine H3 receptor gene. NeuroReport, 2001, 12 (2), pp.321-324. ⟨10.1097/00001756-200102120-00028⟩. ⟨hal-02082162⟩
- Séverine Morisset, Astrid Sasse, Florence Gbahou, Anne Héron, Xavier Ligneau, et al.. The Rat H3 Receptor: Gene Organization and Multiple Isoforms. Biochemical and Biophysical Research Communications, 2001, 280 (1), pp.75-80. ⟨10.1006/bbrc.2000.4073⟩. ⟨hal-02082164⟩
- Jean-Charles Schwartz, Séverine Morisset, Agnès Rouleau, Joël Tardivel-Lacombe, Florence Gbahou, et al.. Application of genomics to drug design: the example of the histamine H3 receptor. European Neuropsychopharmacology, 2001, 11 (6), pp.441-448. ⟨10.1016/s0924-977x(01)00121-3⟩. ⟨hal-02129745⟩
- S. Morisset, E. Traiffort, J. M. Arrang, J. C. Schwartz. Changes in histamine H3 receptor responsiveness in mouse brain.. Journal of Neurochemistry, 2000, 74 (1), pp.339-46. ⟨hal-00347608⟩
- X. Ligneau, S Morisset-Lopez, J. Tardivel-Lacombe, F Gbahou, C Ganellin, et al.. Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain.. British Journal of Pharmacology, 2000, 131 (7), pp.1247-50. ⟨10.1038/sj.bjp.0703712⟩. ⟨hal-02081534⟩
- S Morisset-Lopez, Agnés Rouleau, Anne Héron, Joël Tardivel-Lacombe, Séverine Morisset, et al.. Cloning and cerebral expression of the guinea pig histamine H3 receptor. NeuroReport, 2000, 11 (4), pp.755-759. ⟨10.1097/00001756-200003200-00020⟩. ⟨hal-02082171⟩
- C Ito, S Morisset-Lopez, J-P Olié, H Lôo, M-F Poirier, et al.. Histamine H2 receptor gene variants: lack of association with schizophrenia. Molecular Psychiatry, 2000, 5 (2), pp.159-164. ⟨10.1038/sj.mp.4000664⟩. ⟨hal-02082207⟩
- S. Morisset, A. Rouleau, X Ligneau, F Gbahou, J. Tardivel-Lacombe, et al.. High constitutive activity of native H3 receptors regulates histamine neurons in brain.. Nature, 2000, 408 (6814), pp.860-4. ⟨10.1038/35048583⟩. ⟨hal-02081523⟩
- S. Morisset, U. G. Sahm, E. Traiffort, J. Tardivel-Lacombe, J. M. Arrang, et al.. Atypical neuroleptics enhance histamine turnover in brain via 5-Hydroxytryptamine2A receptor blockade.. Journal of Pharmacology and Experimental Therapeutics, 1999, 288 (2), pp.590-6. ⟨hal-00347619⟩
- Séverine Morisset, Elisabeth Traiffort, Jean-Charles Schwartz. Inhibition of histamine versus acetylcholine metabolism as a mechanism of tacrine activity. European Journal of Pharmacology, 1996, 315 (1), pp.R1-R2. ⟨10.1016/s0014-2999(96)00738-8⟩. ⟨hal-02081407⟩
- Guillaume Drutel, Markus Kathmann, Anne Héron, Jean-Charles Schwartz, Séverine Morisset-Lopez. Cloning and Selective Expression in Brain and Kidney of ARNT2 Homologous to the Ah Receptor Nuclear Translocator (ARNT). Biochemical and Biophysical Research Communications, 1996, 225, pp.333-339. ⟨10.1006/bbrc.1996.1176⟩. ⟨hal-01560437⟩
- Séverine Morisset-Lopez, Guillaume Drutel, Monique Garbarg, Martial Ruat, Elisabeth Traiffort, et al.. Molecular and Functional Diversity of Histamine Receptor Subtypes. Annals of the New York Academy of Sciences, 1995, 757 (1), pp.314-323. ⟨10.1111/j.1749-6632.1995.tb17489.x⟩. ⟨hal-03534121⟩
- Maryvonne Le Coniat, Elisabeth Traiffort, Martial Ruat, Séverine Morisset-Lopez, Roland Berger. Chromosomal localization of the human histamine H1-receptor gene. Human Genetics, 1994, 94 (2), pp.186-188. ⟨10.1007/BF00202867⟩. ⟨hal-03535137⟩
- Martial Ruat, Elisabeth Traiffort, Séverine Morisset-Lopez, Rob Leurs, Jean-Charles Schwartz. Cloning and tissue expression of a rat histamine H2-receptor gene. Biochemical and Biophysical Research Communications, 1991, 179 (3), pp.1470-1478. ⟨10.1016/0006-291x(91)91738-x⟩. ⟨hal-03536798⟩
- Jean-Charles Schwartz, Séverine Morisset-Lopez, Monique Garbarg, Hélène Pollard, Martial Ruat. Histaminergic transmission in the mammalian brain. Physiological Reviews, 1991, 71 (1), pp.1-51. ⟨10.1152/physrev.1991.71.1.1⟩. ⟨hal-03536845⟩
- M.I. Martinez-Mir, H. Pollard, J. Moreau, Séverine Morisset-Lopez, Martial Ruat, et al.. Three histamine receptors (H1, H2 and H3) visualized in the brain of human and non-human primates. Brain Research, In press, 526 (2), pp.322-327. ⟨10.1016/0006-8993(90)91240-h⟩. ⟨hal-03536911⟩
Communication dans un congrès10 documents
- Wanyin Chen, Anthony Guillemain, Lauren Blot, Fabienne Fasani, Esther Kellenberger, et al.. Anti-tumor activity of new ligands targeting LINGO1- a protein primarily expressed in CNS for the treatment of glioblastomas. Colloque Niche et épigénétique des tumeurs, Jul 2020, Online, France. ⟨hal-03686680⟩
- Séverine Morisset-Lopez. Innovations pharmacologiques pour l'étude des neurorécepteurs : intérêt du BRET et de la technologie AlphaScreen. Journée scientifique de l’axe protéomique des plateformes de Biogenouest, Feb 2020, Roscoff, France. ⟨hal-02973392⟩
- Séverine Morisset-Lopez. Utilisation de la technologie Alpha Screen pour étudier les neurorécepteurs : du binding à la signalisation. Séminaire technologique organisé par Perkin Elmer, Sep 2019, Paris, France. ⟨hal-02973431⟩
- W. Chen, A. Guillemain, L. Blot, Fabienne Fasani, E. Kellenberger, et al.. The research of new therapeutic targets and small chemical molecules for glioblastoma therapies. Central South University in HuNan, Dec 2019, Changsha, China. ⟨hal-03686683⟩
- Séverine Morisset-Lopez. Séminaire invité : Ligands biaisés du récepteur 5-HT7: outils pharmacologiques, d'imagerie et applications thérapeutiques. PRC INRA, Nouzilly, Apr 2019, Nouzilly, France. ⟨hal-02974178⟩
- Séverine Morisset-Lopez. Le récepteur 5-HT7 de la sérotonine : de la pharmacologie moléculaire vers la physiopathologie. ESBS, Apr 2018, Strasbourg, France. ⟨hal-02974183⟩
- Séverine Morisset-Lopez. Les neurorécepteurs : Bases moléculaires de leur activation et intérêts physiopathologiques,. Journée de la SFR Neuroimagerie, May 2018, La Riche, France. ⟨hal-02973456⟩
- Séverine Morisset-Lopez. Le récepteur 5-HT7 de la sérotonine : de la pharmacologie moléculaire vers la physiopathologie. ESBS, Apr 2018, Strasbourg, France. ⟨hal-03331436⟩
- Séverine Morisset-Lopez. Le récepteur 5-HT7 de la sérotonine, un acteur dans les neuropathologies: signalisation cellulaire et modèles animaux. INEM, Jul 2017, Orléans, France. ⟨hal-03331443⟩
- Shalina Hassanaly, Alexia Perrin, Séverine Morisset-Lopez, Catherine Grillon. Modèles pour l’étude de la pigmentation. 1er atelier thématique du GDR Cosm’actifs Quel modèle pour tester l’activité d’un composé : de la molécule à l’homme, Mar 2016, Lyon, France. ⟨hal-03668561⟩
Poster22 documents
- Khadidja Sidelarbi, Fabienne Fasani, Séverine Morisset-Lopez, Catherine Grillon. Rôle différentiel de Lingo1 et Lingo3 dans la prolifération et la migration des cellules de glioblastome. 16èmes journées du Cancéropôle Grand Ouest, Jun 2021, Angers, France. ⟨hal-03838122⟩
- Marion Maravat, Marylène Bertrand, M. Decoville, C. Landon, Séverine Morisset-Lopez, et al.. Biomarkers involved in glioma development in Drosophila melanogaster model. European RFMF Metabomeeting 2020, Jan 2020, Toulouse, France. ⟨hal-02919170⟩
- Wanyin Chen, Anthony Guillemain, Lauren Blot, Fabienne Fasani, Esther Kellenberger, et al.. Anti-tumor activity of new ligands targeting LINGO1- a protein primarily expressed in CNS for the treatment of glioblastomas. Colloque Niche et épigénétique des tumeurs, Jul 2020, Online, France. . ⟨hal-03686675⟩
- W. Chen, A. Guillemain, L. Blot, F. Fasani, E. Kellenberger, et al.. Nouvelles molécules chimiques anti-tumorales pour le traitement du glioblastomes. 13es journées du Cancéropôle Grand Ouest, Jul 2019, Tours, France. ⟨hal-02973622⟩
- Wanyin Chen, Anthony Guillemain, Lauren Blot, Fabienne Fasani, Esther Kellenberger, et al.. Etude de l’activité anti-tumorale de nouveaux ligands ciblant LINGO-1 pour le traitement des glioblastomes. Colloque de l’ADOC, Jul 2019, Orléans, France. ⟨hal-03686230⟩
- F. Courant, Marion Maravat, L. Blot, David Gosset, Séverine Morisset-Lopez, et al.. Etude d’une nouvelle cible thérapeutique dans un modèle de gliome chez Drosophila melanogaster. 13es journées du cancéropôle Grand Ouest, Jul 2019, Tours, France. ⟨hal-02973627⟩
- Marion Maravat, Martine Decoville, Marylène Bertrand, Celine Landon, Séverine Morisset-Lopez, et al.. NMR-based metabolomics for glioma biomarker discovery in a Drosophila melanogaster model. 3rd edition Metabolism & Cancer, Apr 2019, Marseille, France. ⟨hal-02986792⟩
- Wanyin Chen, Anthony Guillemain, Lauren Blot, Fabienne Fasani, Esther Kellenberger, et al.. Etude de l’activité anti-tumorale de nouveaux ligands ciblant LINGO-1 pour le traitement des glioblastomes. Journée Fédération FR2708 Physique et Chimie du Vivant, Apr 2019, Orléans, France. ⟨hal-03625295⟩
- C. El Khamlichi, Flora Reverchon, Eric Robin, N. Chopin, E. Deau, et al.. Identification of biased ligands of 5-HT7 receptor: Molecular bases of their action. 7th Annual meeting GDR 3545, Oct 2018, Strasbourg, France. ⟨hal-02973734⟩
- Séverine Morisset-Lopez, L. Blot, A. Guillemain, C. Grillon, D. Decoville. Identification of new partner of EGF receptor: functional interaction and interest for the treatment of glioma. Studium conference Stem cells and cancer stem cells, Jun 2018, Orléans, France. ⟨hal-02973700⟩
- L. Blot, Y. Makhloufi, V. Sarou-Kainian, A. Guillemain, C. Grillon, et al.. Développement des gliomes chez Drosophila Melanogaster: rôle du récepteur 5-HT7 de la sérotonine. Journée Scientifique de la fédération de Recherche FR 2708, Jan 2018, Orléans, France. ⟨hal-02973683⟩
- C. El Khamlichi, Flora Reverchon, Eric Robin, Arnaud Menuet, N. Chopin, et al.. Serotonin 5-HT7 receptor: characterization of new potent ligands with therapeutical properties. 31e colloque Biotechnocentre, Oct 2018, Seillac, France. ⟨hal-02973722⟩
- L. Blot, A. Guillemain, C. Grillon, D. Decoville, Séverine Morisset-Lopez. Identification d’un nouveau partenaire de l’EGFR : interaction fonctionnelle et intérêt pour le traitement des tumeurs cérébrales. 12es journées du cancéropôle Grand Ouest, Jul 2018, Vannes, France. ⟨hal-02973707⟩
- Séverine Morisset-Lopez, W. Deraredj Nadim, S. Chaumont−dubel, F. Madouri, L. Cobret, et al.. Neurofibromin 1 promotes constitutive activity of native 5−HT6 receptors expressed in mouse prefrontal cortex. Neurofrance, May 2017, Bordeaux, France. ⟨hal-02973767⟩
- L. Blot, Y. Makhloufi, A. Guillemain, C. Grillon, Séverine Morisset-Lopez, et al.. Rôle du récepteur 5-HT7 de la sérotonine dans le développement des gliomes chez Drosophila Melanogaster. 11es journées du Cancéropôle Grand Ouest, Jun 2017, Vannes, France. ⟨hal-02973773⟩
- Martine Decoville, Anthony Guillemain, Catherine Grillon, Séverine Morisset. Effect of the serotonin 5-HT7 recepteur on cellular proliferation in Drosophila melanogaster. 5th annual meeting of the GDR 3545 RCPG-PhysioMed 2016, Nov 2016, Tours, France. ⟨hal-02453412⟩
- Hélène Bénédetti, Fabienne Godin, Michel Doudeau, Béatrice Vallée, Marie-Ludivine De Tauzia, et al.. LINGO-1, a protein involved in various neurodevelopmental processes, interacts with neurofibromin (Nf1), the protein responsible for neurofibromatosis type I: molecular studies and functional implications. 10 th FENS (Forum of Neuroscience), Jul 2016, Copenhague, Denmark. ⟨hal-02453487⟩
- A. Guillemain, L. Blot, L. Cobret, M. Decoville, Séverine Morisset-Lopez. Etude d’une nouvelle cible thérapeutique LINGO-1 pour le traitement des tumeurs cérébrales. 10es Journées du Cancéropôle Grand Ouest, Jun 2016, Les-Sables-d'Olonne, France. ⟨hal-02973806⟩
- W. Deraredj Nadim, S. Chaumont-Dubel, F. Madouri, L. Cobret, M.-L. de Tauzia, et al.. A Physical Interaction between Neurofibromin and Serotonin 5-HT6 Receptor Promotes Receptor Constitutive Activity. 5th annual meeting of the GDR 3545 RCPG-PhysioMed 2016, Nov 2016, Tours, France. ⟨hal-02973912⟩
- Shalina Hassanaly, Wissem Deraredj Nadim, Claudine Kieda, Séverine Morisset, Catherine Grillon. Regulation of MC1R-mediated pigmentation by the GRD domain of neurofibromin in human melanocytes. 20th ESPCR Meeting, Sep 2016, Milan, Italy. ⟨hal-02453404⟩
- Shalina Hassanaly, Wissem Deraredj Nadim, Claudine Kieda, Séverine Morisset, Catherine Grillon. Regulation of MC1R-mediated pigmentation in human melanocytes by the GRD domain of neurofibromin. 5th annual meeting of the GDR 3545 RCPG-PhysioMed 2016, Nov 2016, Tours, France. ⟨hal-02453410⟩
- Anne Héron, Véronique Cochois, Valérie Biran, Séverine Morisset-Lopez, Christiane Charriaut-Marlangue. Etude de l'histamine au cours du développement des lesions consecutives à une ischémie cérébrale néonatale. 7e colloque de la Société des neurosciences, 2005, Lille, France. ⟨hal-01610437⟩
Ouvrage (y compris édition critique et traduction)1 document
- Séverine Morisset-Lopez. Voyage au centre du cerveau avec le Professeur Ciboulot. édité dans le cadre du Labo Tour’80. 100 p., 2019. ⟨hal-02973919⟩
Brevet2 documents
- Séverine Morisset-Lopez, F. Suzenet, G. Guillaumet, E. Deau, E. Robin, et al.. Applications of biased ligands of the serotonin 5-HT7 receptor for the treatment of pain, multiple sclerosis and the control of thermoregulation. France, Patent n° : Patent BET 20P3848 (STL-SED) - EUROPE 21315045.1. BIOBRAT. 2021. ⟨hal-03668557⟩
- Séverine Morisset-Lopez, Hélène Bénédetti. Tools for the identification od LINGO-1, LINGO-2, LINGO-3 and LINGO-4, ligands, and uses thereof. France, Patent n° : WO2011121257. BCT. 2011. ⟨hal-02130935⟩