email : federico.perche[remplacer_par_at]cnrs-orleans.fr
Phone : +33 2.38.25.78.18
Researcher within the thematic group “Molecular Assemblies and Complex Systems”
- Métadonnées
Publications (Archives Hal)
Contact
isabelle.frapart@cnrs-orleans.fr 02.38.25.55.53
Disciplines
- Sciences du Vivant [q-bio]20
- Chimie/Chimie thérapeutique13
- Chimie/Chimie organique3
- Sciences du Vivant [q-bio]/Sciences pharmaceutiques3
- Chimie/Polymères1
- Chimie1
- Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire1
- Sciences du Vivant [q-bio]/Biologie cellulaire/Organisation et fonctions cellulaires [q-bio.SC]1
- Sciences du Vivant [q-bio]/Biotechnologies1
- Sciences du Vivant [q-bio]/Cancer1
- Sciences du Vivant [q-bio]/Immunologie/Vaccinologie1
- Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Rhumatologie et système ostéo-articulaire1
- Sciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacologie1
Mots-clefs
4T1 cells Alzheimer's disease Amyloid Amyloid beta Antitumor agents Azobenzene Bacterial delivery Bone morphogenetic protein 2 Breast cancer Cancer Cancer therapy Co-delivery DNA minicircle Gene therapy Liposomes MRNA Osteogenesis Polymeric micelles SiRNA delivery Tumor targeting
- MRNA3
- Polymeric micelles3
- SiRNA delivery3
- Tumor targeting3
- Cancer2
- Gene therapy2
- Liposomes2
- Osteogenesis2
- 4T1 cells1
- Alzheimer's disease1
- Amyloid1
- Amyloid beta1
- Antitumor agents1
- Azobenzene1
- Bacterial delivery1
- Bone morphogenetic protein 21
- Breast cancer1
- Cancer therapy1
- Co-delivery1
- DNA minicircle1
- Decoy1
- Doxorubicin1
- DsDNA1
- Dunaliella1
- Gene delivery1
- Gene delivery vehicles1
- Gold nanoparticles1
- Hydroxychloroquine1
- Hypoxia-triggered copolymer1
- Intracellular bioavailability1
- Intracellular trafficking1
- LN1
- Lipopolyplexes1
- Lung cancer1
- MRNA delivery1
- MRNA therapy1
- MRNA transfection1
- MRNA-based therapeutics1
- MT Oligonucleotides Therapies and Applications1
- Matrix metalloproteinase1
- Messenger RNA1
- Microalgae1
- Modified nucleosides1
- Multidrug resistance1
- Multifunctional1
- Nanomedicine1
- Nanoparticles1
- Non-small cell lung cancer1
- Non-structural protein 11
- Nonviral vectors1
- Octa-arginine1
- Oligonucleotide1
- Osteoporosis1
- PDNA1
- Paclitaxel1
- Passive immunotherapy1
- Plasmid1
- Polymer-drug conjugate1
- Polyplex nanomicelle1
- Protein replacement1
- RNA1
- RNA interference1
- RNA sensors1
- STAT31
- ScFv1
- Self-assembly1
- SiRNA and drug delivery1
- Smart copolymer1
- Spheroids1
- SsDNA1
- Stimuli-sensitive1
- Stimulus-sensitive1
- Survivin siRNA1
- T cell1
- Targeting1
- Therapeutic oligonucleotide1
- Transcription factor1
- Tumor1
- Tumor hypoxia1
- Tumor vaccine1
- Type I interferon1
Auteurs
Perche Federico41 Pichon Chantal13 Torchilin Vladimir9 Midoux Patrick6 Kataoka Kazunori5 Uchida Satoshi5 Ikegami Masaru4 Itaka Keiji4 Lin Chin-Yu4 Torchilin Vladimir P4 Jaffres Paul-Alain4 Biswas Swati4 Taigind Anton3 Torchilin V.3 Torchilin Vladimir P3 Wang Pinpin3 Zhu Lin3 Benvegnu Thierry3 Akiba Hiroki2 Biswas S.2 Cabral Horacio2 Clemençon Rudy2 Dirisala Anjaneyulu2 Nakashima Toshihiro2 Patel Niravkumar2 Pichon Chantal2 Riehle R.2 Salzano G.2 Sawant Rupa2 Tsumoto Kohei2 Zhu L.2 de Rosa G.2 Berchel Mathieu2 Logeart-Avramoglou Delphine2 Baril Patrick2 Gonçalves Cristine2 Wang Tao2 Petite Hervé2 Azevedo Ricardo1 Azevedo Ricardo B1 Barkallah Mohamed1 Bevers Sanne1 Bialkowski Lukasz1 Breckpot Karine1 Broos Katrijn1 Casas Geoffrey1 Clemençon R1 Delehedde C1 Deshpande Pranali1 Deshpande Pranali P1 Deswarte Kim1 Dirisala A1 Dodwadkar Namita1 Dodwadkar Namita S1 Ebensen Thomas1 Ebesen T1 Elleuch Fatma1 Fenway The1 Ferreira Lucas1 Ferreira Lucas a M1 Godin F1 Goncalves C1 Hamacek Josef1 Hammad Hamida1 Hayashi Kotaro1 Heirman Carlo1 Kataoka K1 Kim Beob Soo1 Kim Hyun Jin1 Kinoh Hiroaki1 Kooijmans Sander1 Laroui N1 Lebegue Loic1 Lienenklaus Stefan1 Logeart Delphine1 Maenhout Sarah1 Medjmedj Ayoub1 Mi P1 Mi Peng1 Midoux Patrick1 Min Hyun Su1 Miramon Marie-Laure1 Miyata K1 Miyata Kanjiro1 Mochida Yuki1 Mussi Samuel1 Mussi Samuel V1 Naito Mitsuru1 Navarro G.1 Navarro Gemma1 Ngalle-Loth Albert1 Oliveira Mônica1 Oliveira Mônica C1 Patel Nirav1 Rdrhielde Riehle1 Rosa De1 Sane Shailendra1 Sane Shailendra D1 Schiffelers Raymond1 Schulze K1
Revues
- Journal of Controlled Release5
- Cancer Letters4
- Biomaterials3
- Molecular Therapy - Nucleic Acids2
- Current Alzheimer Research2
- International Journal of Pharmaceutics2
- Pharmaceutical Research2
- Journal of Drug Delivery2
- Proceedings of the National Academy of Sciences of the United States of America2
- Nanomaterials1
Institutions
- Northeastern University [Boston]21
- Université d'Orléans18
- Université de Tours18
- Institut National de la Santé et de la Recherche Médicale18
- Institut de Chimie - CNRS Chimie18
- Université de Brest5
- Université de Rennes3
- Institut National des Sciences Appliquées - Rennes3
- Ecole Nationale Supérieure de Chimie de Rennes3
- The University of Tokyo3
- Universität Kassel [Kassel]1
- Université de Bordeaux1
- EFS1
- Université Paris Diderot - Paris 71
- École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux1
- SIGMA Clermont1
- Helmholtz Centre for Infection Research1
- Université Clermont Auvergne [2017-2020]1
- École Nationale d'Ingénieurs de Sfax | National School of Engineers of Sfax1
- VIB Inflammation Research Center [Ghent, Belgium]1
- Medizinische Hochschule Hannover = Hannover Medical School1
- Laboratory of Molecular and Cellular Therapy, Vrije Universiteit Brussel, Brussels, Belgium1
- eTheRNA Immunotherapies NV1
- University of Naples Federico II = Università degli studi di Napoli Federico II1
- Université Paris Cité1
- University Medical Center [Utrecht]1
Laboratoires
- Centre de biophysique moléculaire18
- Chimie, Electrochimie Moléculaires et Chimie Analytique4
- Graduate School of Medecine3
- Institut des Sciences Chimiques de Rennes3
- Biologie, Bioingénierie et Bioimagerie Ostéo-articulaires1
- Institut de Biologie et Chimie des Protéines1
- Center for Environmental Systems Research [Kassel]1
- Bioingénierie et Bioimagerie Ostéo-articulaires ; Biomécanique et Biomatériaux Ostéo-Articulaires1
- Génétique, génomique fonctionnelle et biotechnologies (UMR 1078)1
- Chimie et Biologie des Membranes et des Nanoobjets1
Départements
Équipes de recherche
41 documents
Article dans une revue35 documents
- Ayoub Medjmedj, Albert Ngalle-Loth, Rudy Clemençon, Josef Hamacek, Chantal Pichon, et al.. In Cellulo and In Vivo Comparison of Cholesterol, Beta-Sitosterol and Dioleylphosphatidylethanolamine for Lipid Nanoparticle Formulation of mRNA. Nanomaterials, 2022, 12 (14), pp.2446. ⟨10.3390/nano12142446⟩. ⟨hal-03727652⟩
- Geoffrey Casas, Federico Perche, Patrick Midoux, Chantal Pichon, Jean-Marc Malinge. DNA minicircles as novel STAT3 decoy oligodeoxynucleotides endowed with anticancer activity in triple-negative breast cancer. Molecular Therapy - Nucleic Acids, 2022, 29, pp.162-175. ⟨10.1016/j.omtn.2022.06.012⟩. ⟨hal-03727647⟩
- Pinpin Wang, Delphine Logeart-Avramoglou, Hervé Petite, Cristine Gonçalves, Patrick Midoux, et al.. Co-delivery of NS1 and BMP2 mRNAs to murine pluripotent stem cells leads to enhanced BMP-2 expression and osteogenic differentiation. Acta Biomaterialia, 2020, 108, pp.337-346. ⟨10.1016/j.actbio.2020.03.045⟩. ⟨hal-02553030⟩
- Satoshi Uchida, Federico Perche, Chantal Pichon, Horacio Cabral. Nanomedicine-Based Approaches for mRNA Delivery. Molecular Pharmaceutics, 2020, 17 (10), pp.3654 - 3684. ⟨10.1021/acs.molpharmaceut.0c00618⟩. ⟨hal-02995814⟩
- Fatma Elleuch, Patrick Baril, Mohamed Barkallah, Federico Perche, Slim Abdelkafi, et al.. Deciphering the Biological Activities of Dunaliella sp. Aqueous Extract from Stressed Conditions on Breast Cancer: from in Vitro to in Vivo Investigations. International Journal of Molecular Sciences, 2020, 21 (5), pp.1719. ⟨10.3390/ijms21051719⟩. ⟨hal-02553031⟩
- Yu Yi, Hyun Jin Kim, Meng Zheng, Peng Mi, Mitsuru Naito, et al.. Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. Journal of Controlled Release, 2019, 295, pp.268 - 277. ⟨10.1016/j.jconrel.2019.01.006⟩. ⟨hal-02995629⟩
- Pinpin Wang, Federico Perche, Delphine Logeart-Avramoglou, Chantal Pichon. RNA-based therapy for osteogenesis. International Journal of Pharmaceutics, 2019, 569, pp.118594. ⟨10.1016/j.ijpharm.2019.118594⟩. ⟨hal-02995602⟩
- Federico Perche, Tony Le Gall, Tristan Montier, Chantal Pichon, Jean-Marc Malinge. Cardiolipin-Based Lipopolyplex Platform for the Delivery of Diverse Nucleic Acids into Gram-Negative Bacteria. Pharmaceuticals, 2019, 12 (2), pp.81. ⟨10.3390/ph12020081⟩. ⟨hal-02172973⟩
- Federico Perche, Rudy Clemençon, Kai Schulze, Thomas Ebensen, Carlos Guzman, et al.. Neutral Lipopolyplexes for In Vivo Delivery of Conventional and Replicative RNA Vaccine. Molecular Therapy - Nucleic Acids, 2019, 17, pp.767-775. ⟨10.1016/j.omtn.2019.07.014⟩. ⟨hal-02321815⟩
- Kevin van Der Jeught, Stefaan de Koker, Lukasz Bialkowski, Carlo Heirman, Patrick Tjok Joe, et al.. Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety. ACS Nano, 2018, 12 (10), pp.9815-9829. ⟨10.1021/acsnano.8b00966⟩. ⟨hal-01889829⟩
- Federico Perche, Satoshi Uchida, Hiroki Akiba, Chin-Yu Lin, Masaru Ikegami, et al.. Improved brain expression of anti-amyloid β scFv by complexation of mRNA including a secretion sequence with PEG-based block catiomer. Current Alzheimer Research, 2017, 14 (3), pp.295-302. ⟨10.2174/1567205013666161108110031⟩. ⟨hal-02130712⟩
- Chin-Yu Lin, Federico Perche, Masaru Ikegami, Satoshi Uchida, Kazunori Kataoka, et al.. Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles. Journal of Controlled Release, 2016, 235, pp.268-275. ⟨10.1016/j.jconrel.2016.06.001⟩. ⟨hal-02130718⟩
- Federico Perche, Swati Biswas, Niravkumar Patel, Vladimir Torchilin. Hypoxia-Responsive Copolymer for siRNA Delivery. Methods in Molecular Biology, 2016, 1372 : RNA Imaging, pp.139-162. ⟨10.1007/978-1-4939-3148-4_12⟩. ⟨hal-02130872⟩
- Federico Perche, Y. Yi, L. Hespel, P Mi, A Dirisala, et al.. Hydroxychloroquine-conjugated gold nanoparticles for improved siRNA activity. Biomaterials, 2016, 90, pp.62-71. ⟨10.1016/j.biomaterials.2016.02.027⟩. ⟨hal-02130728⟩
- Chin-Yu Lin, Federico Perche, Masaru Ikegami, Satoshi Uchida, Kazunori Kataoka, et al.. Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles. Journal of Controlled Release, 2016, 235, pp.268-275. ⟨10.1016/j.jconrel.2016.06.001⟩. ⟨hal-02995717⟩
- Federico Perche, Satoshi Uchida, Hiroki Akiba, Chin-Yu Lin, Masaru Ikegami, et al.. Improved brain expression of anti-amyloid β scFv by complexation of mRNA including a secretion sequence with PEG-based block catiomer. Current Alzheimer Research, 2015, 1 (999), pp.1-1. ⟨10.2174/1567205013666161108110031⟩. ⟨hal-02995714⟩
- Samuel V Mussi, Rupa Sawant, Federico Perche, Mônica C Oliveira, Ricardo B Azevedo, et al.. Novel Nanostructured Lipid Carrier Co-Loaded with Doxorubicin and Docosahexaenoic Acid Demonstrates Enhanced in Vitro Activity and Overcomes Drug Resistance in MCF-7/Adr Cells. Pharmaceutical Research, 2014, 31 (8), pp.1882 - 1892. ⟨10.1007/s11095-013-1290-2⟩. ⟨hal-02995777⟩
- G. Salzano, R. Riehle, G. Navarro, Federico Perche, G. de Rosa, et al.. Polymeric micelles containing reversibly phospholipid-modified anti-survivin siRNA: A promising strategy to overcome drug resistance in cancer. Cancer Letters, 2014, 343 (2), pp.224-231. ⟨10.1016/j.canlet.2013.09.037⟩. ⟨hal-02130786⟩
- Samuel Mussi, Rupa Sawant, Federico Perche, Mônica Oliveira, Ricardo Azevedo, et al.. Novel Nanostructured Lipid Carrier Co-Loaded with Doxorubicin and Docosahexaenoic Acid Demonstrates Enhanced in Vitro Activity and Overcomes Drug Resistance in MCF-7/Adr Cells. Pharmaceutical Research, 2014, 31 (8), pp.1882-1892. ⟨10.1007/s11095-013-1290-2⟩. ⟨hal-02130734⟩
- G. Salzano, R. Riehle, G. de Rosa, V.P. P Torchilin, Riehle Rdrhielde, et al.. Polymeric micelles containing reversibly phospholipid-modified anti-survivin siRNA: A promising strategy to overcome drug resistance in cancer. Cancer Letters, 2014, 343 (2), pp.224 - 231. ⟨10.1016/j.canlet.2013.09.037⟩. ⟨hal-02995789⟩
- Lin Zhu, Federico Perche, Tao Wang, Vladimir Torchilin. Matrix metalloproteinase 2-sensitive multifunctional polymeric micelles for tumor-specific co-delivery of siRNA and hydrophobic drugs. Biomaterials, 2014, 35 (13), pp.4213-4222. ⟨10.1016/j.biomaterials.2014.01.060⟩. ⟨hal-02130742⟩
- Federico Perche, S. Biswas, T. Wang, L. Zhu, V. Torchilin. Hypoxia-Targeted siRNA Delivery. Angewandte Chemie International Edition, 2014, 53 (13), pp.3362-3366. ⟨10.1002/anie.201308368⟩. ⟨hal-02130753⟩
- Tao Wang, Lin Zhu, Federico Perche, Anton Taigind, Vladimir P Torchilin. Matrix metalloproteinase 2-sensitive multifunctional polymeric micelles for tumor-specific co-delivery of siRNA and hydrophobic drugs. Biomaterials, 2014, 35 (13), pp.4213 - 4222. ⟨10.1016/j.biomaterials.2014.01.060⟩. ⟨hal-02995779⟩
- Swati Biswas, Pranali Deshpande, Federico Perche, Namita Dodwadkar, Shailendra Sane, et al.. Octa-arginine-modified pegylated liposomal doxorubicin: An effective treatment strategy for non-small cell lung cancer. Cancer Letters, 2013, 335 (1), pp.191-200. ⟨10.1016/j.canlet.2013.02.020⟩. ⟨hal-02130808⟩
- Lin Zhu, Federico Perche, Tao Wang, Anton Taigind, Vladimir P Torchilin, et al.. Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (42), pp.17047 - 17052. ⟨10.1073/pnas.1304987110⟩. ⟨hal-02995791⟩
- Federico Perche, Vladimir P Torchilin. Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting. Journal of Drug Delivery, 2013, 2013, pp.1 - 32. ⟨10.1155/2013/705265⟩. ⟨hal-02995820⟩
- Federico Perche, Vladimir Torchilin. Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting. Journal of Drug Delivery, 2013, 2013, pp.1-32. ⟨10.1155/2013/705265⟩. ⟨hal-02130868⟩
- Lin Zhu, Tao Wang, Federico Perche, Anton Taigind, Vladimir Torchilin. Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (42), pp.17047-17052. ⟨10.1073/pnas.1304987110⟩. ⟨hal-02130803⟩
- Swati Biswas, Pranali P Deshpande, Federico Perche, Namita S Dodwadkar, Shailendra D Sane, et al.. Octa-arginine-modified pegylated liposomal doxorubicin: An effective treatment strategy for non-small cell lung cancer. Cancer Letters, 2013, 335 (1), pp.191 - 200. ⟨10.1016/j.canlet.2013.02.020⟩. ⟨hal-02995795⟩
- Federico Perche, Niravkumar Patel, Vladimir Torchilin. Accumulation and toxicity of antibody-targeted doxorubicin-loaded PEG–PE micelles in ovarian cancer cell spheroid model. Journal of Controlled Release, 2012, 164 (1), pp.95-102. ⟨10.1016/j.jconrel.2012.09.003⟩. ⟨hal-02130810⟩
- Federico Perche, Nirav Patel, Vladimir P Torchilin. Accumulation and toxicity of antibody-targeted doxorubicin-loaded PEG–PE micelles in ovarian cancer cell spheroid model. Journal of Controlled Release, 2012, 164 (1), pp.95 - 102. ⟨10.1016/j.jconrel.2012.09.003⟩. ⟨hal-02995799⟩
- Federico Perche, Olivier Lambert, Mathieu Berchel, Paul-Alain Jaffres, Chantal Pichon, et al.. Gene transfer by histidylated lipopolyplexes: A dehydration method allowing preservation of their physicochemical parameters and transfection efficiency. International Journal of Pharmaceutics, 2012, 423 (1), pp.144 - 150. ⟨10.1016/j.ijpharm.2011.04.009⟩. ⟨hal-02995807⟩
- Federico Perche, Vladimir P Torchilin. Cancer cell spheroids as a model to evaluate chemotherapy protocols. Cancer Biology and Therapy, 2012, 13 (12), pp.1205 - 1213. ⟨10.4161/cbt.21353⟩. ⟨hal-02995802⟩
- Federico Perche, David Gosset, Mathieu Mével, Marie-Laure Miramon, Jean-Jacques Yaouanc, et al.. Selective gene delivery in dendritic cells with mannosylated and histidylated lipopolyplexes.. Journal of Drug Targeting, 2011, 19 (5), pp.315-25. ⟨10.3109/1061186X.2010.504262⟩. ⟨hal-00753554⟩
- Federico Perche, Thierry Benvegnu, Mathieu Berchel, Loic Lebegue, Chantal Pichon, et al.. Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA.. Nanomedicine: Nanotechnology, Biology and Medicine, 2011, 7 (4), pp.445-53. ⟨10.1016/j.nano.2010.12.010⟩. ⟨hal-00754373⟩
Communication dans un congrès1 document
- N Laroui, C Delehedde, C Goncalves, F Godin, Federico Perche, et al.. High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells. SFNano 2021, Dec 2021, Angers, France. ⟨hal-03668422⟩
Poster2 documents
- Federico Perche, R Clemençon, K Schulze, T Ebesen, Chantal Pichon. Neutral lipopolyplexes for in Vivo delivery of Conventional and replicative RNA vaccine. mRNA Health Conference 2020, Nov 2020, Boston (virtual), United States. ⟨hal-03668439⟩
- Pinpin Wang, Delphine Logeart, Lucie Pigeon, Cristine Gonçalves, Hervé Petite, et al.. Improved osteogenic commitment of BMP2 mRNA-transfected MSCs using NS1 mRNA. ASGCT 2019, Apr 2020, Washington, United States. ⟨hal-03668438⟩
Chapitre d'ouvrage1 document
- Federico Perche, S. Biswas, V. Torchilin. Stimuli-Sensitive Polymeric Nanomedicines for Cancer Imaging and Therapy. Handbook of polymers for pharmaceutical technologies, John Wiley & Sons, Inc., pp.311-344, 2015. ⟨hal-02130886⟩
Brevet2 documents
- Vladimir Torchilin, Swati Biswas, Federico Perche. HYPOXIA-TARGETED DELIVERY SYSTEM FOR PHARMACEUTICAL AGENTS. France, Patent n° : WO2015061321. 2015. ⟨hal-02130900⟩
- L. Zhu, Federico Perche, Vladimir Torchilin. COPOLYMERS FOR THE DELIVERY OF DRUGS INTO CELLS. France, Patent n° : WO2014085579. 2014. ⟨hal-02130892⟩